1. New perspectives on the calculation of bioaccumulation metrics for active substances in living organisms
- Author
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Christelle Lopes, Sandrine Charles, Patrice Carpentier, Vanessa Mazerolles, Aude Ratier, Gauthier Multari, Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Direction de l'évaluation des produits réglementés (DEPR), Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), ANSES (2020-CRD-06), ANR-18-CE34-0013,APPROve,Démarche intégrée pour proposer la protéomique dans la surveillance : accumulation, devenir et multimarqueurs(2018), ANR-17-EURE-0018,H2O'LYON,School of Integrated Watershed Sciences(2017), and Anses, 14 rue Pierre et Marie Curie, 94701 Maisons-Alfort Cedex, France
- Subjects
010504 meteorology & atmospheric sciences ,Interface (Java) ,Computer science ,Bayesian inference ,Geography, Planning and Development ,User-friendly web platform ,Environmental risk asessment ,010501 environmental sciences ,MESH: Risk Assessment ,Ecotoxicology ,Risk Assessment ,01 natural sciences ,Web tool ,010104 statistics & probability ,0101 mathematics ,ComputingMilieux_MISCELLANEOUS ,0105 earth and related environmental sciences ,General Environmental Science ,Toxicokinetic models ,Reproducibility of Results ,General Medicine ,Data science ,Uncertainties ,MESH: Bioaccumulation ,Bioaccumulation ,MESH: Reproducibility of Results ,Risk analysis (engineering) ,MESH: Ecotoxicology ,[SDE]Environmental Sciences ,MESH: Environmental Monitoring ,Environmental Monitoring - Abstract
Today, only few ready-to-use and convenient decision-making tools are available in ecotoxicology concerning accumulation and effects of chemical substances on organisms, accounting for exposure situations that are known to be complex (routes of exposure, metabolism, mixtures, etc.). This paper presents new perspectives on the generic calculation of bioaccumulation metrics via the innovative web tool MOSAICbioacc (http://mosaic.univ-lyon1.fr/bioacc). MOSAICbioacc provides all kind of bioaccumulation metrics associated with their uncertainty whatever the species-compound combination. MOSAICbioacc expects accumulation-depuration data as inputs, even with complex exposure and clearance patterns, to quickly perform their relevant analysis. MOSAICbioacc intends to facilitate the daily work of regulators, or any ecotoxicologist, who will freely benefit from a user-friendly on-line interface that automatically fits toxicokinetic models without needs for users to invest in the technical aspects to get bioaccumulation metrics estimates. MOSAICbioacc also provides all results in a fully transparent way to ensure reproducibility.
- Published
- 2021