1. Effects of benzyl alcohol on transferrin and low density lipoprotein receptor mediated endocytosis in leukemic guinea pig B lymphocytes
- Author
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Jean Philippot, M. Vignes, Jacques Sainte-Marie, Michel Vidal, Alain Bienvenüe, Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM), Plasticité cérébrale (PC), Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS), Neurobiologie de l'audition-plasticité synaptique, Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de biologie et chimie des protéines [Lyon] (IBCP), Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)
- Subjects
MESH: Lipoproteins, LDL ,L2C cell ,Biochemistry ,chemistry.chemical_compound ,0302 clinical medicine ,Structural Biology ,Membrane fluidity ,MESH: Animals ,Inhibition ,chemistry.chemical_classification ,B-Lymphocytes ,MESH: Iron ,0303 health sciences ,Transferrin ,Endocytosis ,Lipoproteins, LDL ,MESH: Benzyl Alcohols ,Benzyl alcohol ,030220 oncology & carcinogenesis ,MESH: Endocytosis ,[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,MESH: Transferrin ,MESH: Benzyl Compounds ,Iron ,Guinea Pigs ,MESH: Leukemia, Experimental ,Biophysics ,Transferrin receptor ,Biology ,Receptor endocytosis ,MESH: Guinea Pigs ,Guinea pig ,03 medical and health sciences ,MESH: B-Lymphocytes ,Benzyl Compounds ,Receptors, Transferrin ,Genetics ,Animals ,Humans ,MESH: Receptors, Transferrin ,Molecular Biology ,Benzyl Alcohols ,030304 developmental biology ,Leukemia, Experimental ,MESH: Humans ,Cell Biology ,Molecular biology ,Receptors, LDL ,chemistry ,MESH: Receptors, LDL ,LDL receptor ,MESH: Benzyl Alcohol ,Lipoprotein - Abstract
International audience; We demonstrated that benzyl alcohol, a neutral local anesthetic drug, inhibits the uptake and degradation of lowdensity lipoprotein and endocytosis of transferrin receptors of guinea pig leukemic B lymphocytes (L2C). This inhibition is very rapid, concentration dependant and reversible by simple washing. Membrane fluidity of the living cells is also modified.
- Published
- 1990