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Your search keyword '"Machida, Y."' showing total 25 results
Start Over Author "Machida, Y." Publisher wiley
25 results on '"Machida, Y."'

3. ChemInform Abstract: A Novel Orally Active Inhibitor of IL-1 Generation: Synthesis and Structure-Activity Relationships of 3-(4-Hydroxy-1-naphthalenyl)-2- propenoic Acid Derivatives.

Author

TANAKA, M., primary, CHIBA, K., additional, OKITA, M., additional, KANEKO, T., additional, TAGAMI, K., additional, HIBI, S., additional, OKAMOTO, Y., additional, SHIROTA, H., additional, GOTO, M., additional, OBAISHI, H., additional, SAKURAI, H., additional, MACHIDA, Y., additional, and YAMATSU, I., additional

Published
2010
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4. ChemInform Abstract: Studies on Orally Active Cephalosporins. Part 2. Synthesis and Structure-Activity Relations of New ((E) or (Z) 3-Substituted Carbamoyloxy)-1-propenylcephalosporins.

Author

NEGI, S., primary, SASHO, M., additional, YAMANAKA, M., additional, SUGIYAMA, I., additional, KOMATSU, Y., additional, TSURUOKA, A., additional, KAMADA, A., additional, TSUKADA, I., additional, HIRUMA, R., additional, KATSU, K., additional, and MACHIDA, Y., additional

Published
2010
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10. ChemInform Abstract: Studies on Orally Active Cephalosporins. Part 1. Synthesis and Structure‐Activity Relationships of New 3‐Substituted Carbamoyloxymethyl Cephalosporins.

Author

NEGI, S., primary, YAMANAKA, M., additional, SUGIYAMA, I., additional, KOMATSU, Y., additional, SASHO, M., additional, TSURUOKA, A., additional, KAMADA, A., additional, TSUKADA, I., additional, HIRUMA, R., additional, KATSU, K., additional, and MACHIDA, Y., additional

Published
1995
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24. Expressions of ezrin, ERK, STAT3, and AKT in tongue cancer and association with tumor characteristics and patient survival.

Author

Noi M, Mukaisho KI, Murakami S, Koshinuma S, Machida Y, Yamori M, Nakayama T, Ogawa T, Nakata Y, Shimizu T, Yamamoto G, and Sugihara H

Subjects
Adult, Aged, Aged, 80 and over, Carcinoma, Squamous Cell metabolism, Carcinoma, Squamous Cell mortality, Carcinoma, Squamous Cell pathology, Carcinoma, Squamous Cell surgery, Female, Follow-Up Studies, Humans, Male, Middle Aged, Prognosis, Survival Rate, Tongue Neoplasms metabolism, Tongue Neoplasms pathology, Tongue Neoplasms surgery, Biomarkers, Tumor metabolism, Cytoskeletal Proteins metabolism, Mitogen-Activated Protein Kinase 1 metabolism, Mitogen-Activated Protein Kinase 3 metabolism, Proto-Oncogene Proteins c-akt metabolism, STAT3 Transcription Factor metabolism, Tongue Neoplasms mortality
Abstract

Background: Ezrin, ERK, STAT3, and AKT are proteins that are overexpressed in various types of cancer, although their expressions in tongue cancer has received less focus. This study aimed to address associations between the expression levels of these proteins and with characteristics of the tumor and patient survival., Methods: We performed immunohistochemical staining of ezrin, ERK, STAT3, and AKT in tumors from patients with tongue carcinoma in situ (CIS, n = 17) and tongue squamous cell carcinoma (SCC, n = 46). Statistical differences between the SCC versus the CIS cohorts were estimated by calculations of bivariate odds ratios of low versus high expression of the proteins. Fisher's exact tests were used to appraise interassociations between the proteins, as well as expression levels versus patient and tumor characteristics. Survival based on Kaplan-Meier statistics in combination log-rank tests were used to address potential effects of the patient and tumor characteristics versus 5-year survival rate., Results: The relative high: low expression of all four proteins in the two cohorts differed, and particularly ERK was markedly overexpressed in the SCC versus the CIS cohort (odds ratio = 45.3, p < .01). The relative high: low expression each protein versus patient and tumor characteristics; showed associations between AKT expression and T stage (p = .002) plus node metastases (p = .12), and between ERK expression and drinking (p = .01) and smoking history (p = .01). There was no significant difference observed between ERK and the three other molecules, nor any significant difference between the degree of expression of each protein and the 5-year disease-specific survival rate., Conclusion: Ezrin, ERK, STAT3, and AKT appear to be involved in the progress from carcinoma in situ in the tongue into squamous cell carcinoma. ERK in particular is overexpressed, suggesting that ERK may be a novel therapeutic target for preventing tongue cancer., (© 2020 The Authors. Clinical and Experimental Dental Research published by John Wiley & Sons Ltd.)

Published
2020
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25. The enzyme defects in hereditary tyrosinaemia type I.

Author

Furukawa N, Hayano T, Sato N, Inoue F, Machida Y, Kinugasa A, Imashuku S, Kusunoki T, and Takamatisu T

Subjects
Humans, Infant, Newborn, Kidney enzymology, Liver enzymology, Phenylpyruvic Acids metabolism, Amino Acid Metabolism, Inborn Errors enzymology, Hydrolases deficiency, Tyrosine blood
Published
1984
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