1. Soluble levels of sCD40L and s4‐1BB are associated with a poor prognosis in elderly patients with colorectal cancer
- Author
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Luciana Mata da Silva, Marina Cadena da Matta, Leuridan Cavalcante Torres, Petrus M. A. Lima, Maria Júlia Gonçalves de Mello, Nora Manoukian Forones, Jurema Telles de Oliveira Lima, Eduardo Jorge Abrantes da Fonte, Mário Rino Martins, Clara Cinthia Resende Lira, and Evandro Bezerra Cintra
- Subjects
Male ,Oncology ,medicine.medical_specialty ,Poor prognosis ,Colorectal cancer ,CD40 Ligand ,Lymph node metastasis ,Tumor Necrosis Factor Receptor Superfamily, Member 9 ,03 medical and health sciences ,0302 clinical medicine ,Immune system ,Internal medicine ,Biomarkers, Tumor ,medicine ,Humans ,Neoplasm Metastasis ,Stage (cooking) ,Aged ,business.industry ,Disease progression ,General Medicine ,Plasma levels ,medicine.disease ,Immune checkpoint ,Cross-Sectional Studies ,Case-Control Studies ,Lymphatic Metastasis ,030220 oncology & carcinogenesis ,Female ,030211 gastroenterology & hepatology ,Surgery ,Colorectal Neoplasms ,business - Abstract
BACKGROUND AND OBJECTIVES The prognosis of colorectal cancer (CRC) has improved in the last decades, however, a lower overall survival persists in the elderly. The understanding of immunity changes in the elderly with CRC will allow the emergence of new treatments with higher response rates. 4-1BB and CD40L, an immune checkpoint stimulator, play an important role in T-cell responses and platelets. Our aim was to characterize the soluble levels of CD40L and 4-1BB in CRC elderly patients. METHODS A cross-sectional study was performed in 41 patients with CRC and 35 healthy elderly controls. Patients with CRC were divided into three groups according to staging: 13 patients with advanced tumor restricted to the organ (stages II); 16 patients with lymph node metastasis (stage III); and 12 patients with distant metastasis (stage IV). RESULTS There were higher levels of soluble s4-1BB and sCD40L in CRC elderly stage II patients when compared with healthy controls (P = .0009 and P
- Published
- 2019
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