564 results on '"Mazzone A"'
Search Results
2. Effects of his bundle pacing on global work efficiency in post‐cardiac surgery patients
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Romagnolo, Davide, primary, Limite, Luca R., additional, El Sawaf, Basma, additional, Ingallina, Giacomo, additional, Gaspardone, Carlo, additional, Morciano, Davide A., additional, Paglino, Gabriele, additional, Mazzone, Patrizio, additional, Agricola, Eustachio, additional, and Della Bella, Paolo, additional
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- 2024
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3. Computational assessment of the use of graphene‐based nanosheets as PtII chemotherapeutics delivery systems
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Belletto, Daniele, primary, Vigna, Vincenzo, additional, Barretta, Pierraffaele, additional, Ponte, Fortuna, additional, Mazzone, Gloria, additional, Scoditti, Stefano, additional, and Sicilia, Emilia, additional
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- 2024
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4. Ruthenium complexes bearing nile red chromophore and one of its derivative: Theoretical evaluation of PDT‐related properties
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Barretta, Pierraffaele, primary, Scoditti, Stefano, additional, Belletto, Daniele, additional, Ponte, Fortuna, additional, Vigna, Vincenzo, additional, Mazzone, Gloria, additional, and Sicilia, Emilia, additional
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- 2024
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5. PI3K/mTOR inhibition induces tumour microenvironment remodelling and sensitises pS6high uterine leiomyosarcoma to PD‐1 blockade
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De Wispelaere, Wout, primary, Annibali, Daniela, additional, Tuyaerts, Sandra, additional, Messiaen, Julie, additional, Antoranz, Asier, additional, Shankar, Gautam, additional, Dubroja, Nikolina, additional, Herreros‐Pomares, Alejandro, additional, Baiden‐Amissah, Regina E. M., additional, Orban, Marie‐Pauline, additional, Delfini, Marcello, additional, Berardi, Emanuele, additional, Van Brussel, Thomas, additional, Schepers, Rogier, additional, Philips, Gino, additional, Boeckx, Bram, additional, Baietti, Maria Francesca, additional, Congedo, Luigi, additional, HoWangYin, Kiave Yune, additional, Bayon, Emilie, additional, Van Rompuy, Anne‐Sophie, additional, Leucci, Eleonora, additional, Tabruyn, Sebastien P., additional, Bosisio, Francesca, additional, Mazzone, Massimiliano, additional, Lambrechts, Diether, additional, and Amant, Frédéric, additional
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- 2024
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6. Atrial tachycardia ablation through the sub‐pulmonary ventricle in a patient with multiple malformations associated with congenitally corrected transposition of the great arteries and double‐sided slow‐pathway
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Preda, Alberto, primary, Testoni, Alessio, additional, Baroni, Matteo, additional, Mazzone, Patrizio, additional, and Gigli, Lorenzo, additional
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- 2024
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7. Can a “broken heart” successfully be transplanted? A brief report
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Giovannico, Lorenzo, primary, Fischetti, Giuseppe, additional, Mazzone, Federica, additional, Parigino, Domenico, additional, Savino, Luca, additional, Santeramo, Vincenzo, additional, Silva, Aline Maria, additional, di Bari, Nicola, additional, Acquaviva, Tommaso, additional, Fiore, Giuseppe, additional, Milano, Aldo Domenico, additional, and Bottio, Tomaso, additional
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- 2024
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8. Misconceptions on behavioral cough suppression therapy for pediatric nonspecific cough: A response to Weinberger and Buettner's commentary on Fujiki et al.
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Slovarp, Laurie, primary, Jette, Marie, additional, Reynolds, Jane, additional, Gillespie, Amanda I, additional, Barkmeier‐Kraemer, Julie, additional, Sandage, Mary, additional, Smith, Jaclyn, additional, Haines, Jemma, additional, Vertigan, Anne, additional, and Mazzone, Stuart, additional
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- 2024
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9. Identifying low cancer‐specific mortality risk lymph node‐positive radical prostatectomy patients
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Barletta, Francesco, primary, Tappero, Stefano, additional, Morra, Simone, additional, Incesu, Reha‐Baris, additional, Cano Garcia, Cristina, additional, Piccinelli, Mattia L., additional, Scheipner, Lukas, additional, Tian, Zhe, additional, Gandaglia, Giorgio, additional, Stabile, Armando, additional, Mazzone, Elio, additional, Terrone, Carlo, additional, Longo, Nicola, additional, Tilki, Derya, additional, Chun, Felix K. H., additional, de Cobelli, Ottavio, additional, Ahyai, Sascha, additional, Saad, Fred, additional, Shariat, Shahrokh F., additional, Montorsi, Francesco, additional, Briganti, Alberto, additional, and Karakiewicz, Pierre I., additional
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- 2024
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10. Triplet Excited State Mechanistic Study of meso‐Substituted Methylthio Bodipy Derivative: Time‐Resolved Optical and Electron Paramagnetic Resonance Spectral Studies
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Imran, Muhammad, primary, Kurganskii, Ivan, additional, Taddei, Maria, additional, Butera, Valeria, additional, Zhao, Jianzhang, additional, Fedin, Matvey V., additional, Di Donato, Mariangela, additional, and Mazzone, Gloria, additional
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- 2024
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11. From monocyte‐derived macrophages to resident macrophages—how metabolism leads their way in cancer
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Ammarah, Ummi, primary, Pereira‐Nunes, Andreia, additional, Delfini, Marcello, additional, and Mazzone, Massimiliano, additional
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- 2024
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12. Chronic cough: New guidelines, new approaches and new treatments
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Turner, Richard, primary, Mazzone, Stuart, additional, and Birring, Surinder, additional
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- 2024
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13. A longitudinal characterization of the adaptive and behavioral profile in Sotos syndrome
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Siracusano, Martina, primary, Dante, Caterina, additional, Sarnataro, Rachele, additional, Arturi, Lucrezia, additional, Riccioni, Assia, additional, Carloni, Elisa, additional, Cicala, Mariagrazia, additional, Gialloreti, Leonardo Emberti, additional, Galasso, Cinzia, additional, Conteduca, Giuseppina, additional, Coviello, Domenico, additional, and Mazzone, Luigi, additional
- Published
- 2024
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14. Acute inspiratory resistance training enhances endothelium‐dependent dilation and retrograde shear rate in healthy young adults
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Tavoian, Dallin, primary, Mazzone, Josie L., additional, Craighead, Daniel H., additional, and Bailey, E. Fiona, additional
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- 2024
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15. Variability of mpMRI diagnostic performance according to the upfront individual patient risk of having clinically significant prostate cancer
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Pellegrino, Francesco, primary, Stabile, Armando, additional, Sorce, Gabriele, additional, Mazzone, Elio, additional, Cannoletta, Donato, additional, Cirulli, Giuseppe Ottone, additional, Quarta, Leonardo, additional, Leni, Riccardo, additional, Robesti, Daniele, additional, Brembilla, Giorgio, additional, Gandaglia, Giorgio, additional, De Cobelli, Francesco, additional, Montorsi, Francesco, additional, and Briganti, Alberto, additional
- Published
- 2023
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16. Cough in Children and Adults: Diagnosis, Assessment and Management (CICADA). Summary of an updated position statement on chronic cough in Australia
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Marchant, Julie M, primary, Chang, Anne B, additional, Kennedy, Emma, additional, King, David, additional, Perret, Jennifer L, additional, Schultz, Andre, additional, Toombs, Maree R, additional, Versteegh, Lesley, additional, Dharmage, Shyamali C, additional, Dingle, Rebecca, additional, Fitzerlakey, Naomi, additional, George, Johnson, additional, Holland, Anne, additional, Rigby, Debbie, additional, Mann, Jennifer, additional, Mazzone, Stuart, additional, O'Brien, Mearon, additional, O'Grady, Kerry‐Ann, additional, Petsky, Helen L, additional, Pham, Jonathan, additional, Smith, Sheree MS, additional, Wurzel, Danielle F, additional, Vertigan, Anne E, additional, and Wark, Peter, additional
- Published
- 2023
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17. High filler content acrylonitrile‐butadiene‐styrene composites containing tungsten and bismuth oxides for effective lead‐free x‐ray radiation shielding
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Olivieri, Federico, primary, Avolio, Roberto, additional, Gentile, Gennaro, additional, Mazzone, Annamaria, additional, Rizzi, Rosanna, additional, Nacucchi, Michele, additional, Castaldo, Rachele, additional, Errico, Maria Emanuela, additional, Giannini, Cinzia, additional, Ambrosio, Luigi, additional, and Lavorgna, Marino, additional
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- 2023
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18. Comparative localization of colorectal sensory afferent central projections in the mouse spinal cord dorsal horn and caudal medulla dorsal vagal complex
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Wang, QingQing, primary, Caraballo, Sonia Garcia, additional, Rychkov, Grigori, additional, McGovern, Alice E., additional, Mazzone, Stuart B., additional, Brierley, Stuart M., additional, and Harrington, Andrea M., additional
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- 2023
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19. Witnessing bullying at work: Employee silence in higher education institutions
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Mazzone, Angela, primary, Karakolidis, Anastasios, additional, Pitsia, Vasiliki, additional, Freeney, Yseult, additional, and O’Higgins Norman, James, additional
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- 2023
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20. The expression pattern of cytokeratin 6a in epithelial cells of different origin in dermo‐epidermal skin substitutes in vivo
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Michalak‐Micka, Katarzyna, primary, Tenini, Celina, additional, Böttcher‐Haberzeth, Sophie, additional, Mazzone, Luca, additional, Pontiggia, Luca, additional, Klar, Agnes S., additional, Moehrlen, Ueli, additional, and Biedermann, Thomas, additional
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- 2023
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21. Prediction of large‐for‐gestational age at 36 weeks’ gestation: two‐dimensional vsthree‐Dimensionalvs magnetic resonance imaging
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Mazzone, E., primary, Kadji, C., additional, Cannie, M. M., additional, Badr, D. A., additional, and Jani, J. C., additional
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- 2023
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22. The associations among sexual assault, posttraumatic stress, drinking to cope with anxiety and alcohol use based on gender identity and sexual orientation
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Kilimnik, Chelsea D., primary, García‐Ramírez, Grisel, additional, Salamanca, Nashalys K., additional, Mazzone, G. Mitchell, additional, Mullican, K. Nicole, additional, Davis, Kelly Cue, additional, Orchowski, Lindsay M., additional, Leone, Ruschelle M., additional, Kaysen, Debra, additional, and Gilmore, Amanda K., additional
- Published
- 2023
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23. Clinical outcomes of left atrial appendage occlusion in patients with previous intracranial or gastrointestinal bleeding: Insights from the LOGIC (Left atrial appendage Occlusion in patients with Gastrointestinal or IntraCranial bleeding) International Multicenter Registry
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Francesco Gallo, Federico Ronco, Gianpiero D'Amico, Domenico G. Della Rocca, Patrizio Mazzone, Stefano Bordignon, Gavino Casu, Francesco Giannini, Sergio Berti, Rodney P. Horton, Giuseppe D'Angelo, Lukas Urbanek, Pierluigi Merella, Rossella Ruggiero, Maria Rita Romeo, Francesco Bosica, Boris Schmidt, Enrico Atzori, Marco Barbierato, Andrea Natale, and Sakis Themistoclakis
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History ,Polymers and Plastics ,Radiology, Nuclear Medicine and imaging ,General Medicine ,Business and International Management ,Cardiology and Cardiovascular Medicine ,Industrial and Manufacturing Engineering - Published
- 2023
24. Outcomes of transvenous lead extraction of very old leads using bidirectional rotational mechanical sheaths: Results of a multicentre study
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Federico Migliore, Raimondo Pittorru, Pietro Bernardo Dall'Aglio, Manuel De Lazzari, Giovanni Rovaris, Elena Piazzi, Alessia Dentico, Alessandra Ferrieri, Giuseppe D'Angelo, Alessandra Marzi, Basma El Sawaf, Emanuele Bertaglia, Sabino Iliceto, Gino Gerosa, Vincenzo Tarzia, Domenico Carretta, and Patrizio Mazzone
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Physiology (medical) ,Cardiology and Cardiovascular Medicine - Abstract
Lead dwell time10 years is a recognized predictor for transvenous lead extraction (TLE) failure and complications. Data on the efficacy and safety of TLE using the bidirectional rotational mechanical sheaths in patients with very old leads are lacking. In this multicenter study, we reported the outcomes of transvenous rotational mechanical lead extraction in patients with leads implanted for ≥10 years.A total of 441 leads (median: 159 months [135-197]; range: 120-487) in 189 consecutive patients were removed with the Evolution RL sheaths (Cook Medical, Bloomingtom, IN, USA) and mechanical ancillary tools supporting the procedures.The main indication for TLE was infection in 74% of cases. Complete procedural success rate, clinical success rate, per lead were 94.8% and 98.2%, respectively. Failure of lead extraction was seen in 1.8% of leads. The additional use of a snare via the femoral approach was required in 9% of patients. Lead dwell time was the only predictor of incomplete led removal (odds ratio: 1.009; 95% confidence interval [CI]: 1.003-1.014; p = .002). Four major complication (2%) were encountered. During a mean time follow-up of 31 ± 27 months, 21 patients (11%) died. No procedure-related mortality occurred. Predictors of mortality included severe left ventricular systolic dysfunction (hazard ratio [HR]: 8.06; 95% CI: 2.99-21.73; p = .001), TLE for infection (HR: 8.0; 95% CI: 1.04-62.5; p = .045), diabetes (HR: 3.7; 95% CI: 1.48-9.5; p = .005), and previous systemic infection (HR: 3.1; 95% CI: 1.17-8.24; p = .022). Incomplete lead removal or failure lead extraction did not impact on survival during follow-up.Our findings demonstrated that the use of bidirectional rotational TLE mechanical sheaths combined with different mechanical tools and femoral approach allows reasonable success and safety in patients with very old leads at experienced specialized centers.
- Published
- 2022
25. Cognitive, adaptive and behavioral profile in Sotos syndrome children with 5q35 microdeletion or intragenic variants
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Siracusano, Martina, primary, Riccioni, Assia, additional, Frattale, Ilaria, additional, Arturi, Lucrezia, additional, Dante, Caterina, additional, Galasso, Cinzia, additional, Gialloreti, Leonardo Emberti, additional, Conteduca, Giuseppina, additional, Testa, Barbara, additional, Malacarne, Michela, additional, Coviello, Domenico, additional, and Mazzone, Luigi, additional
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- 2023
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26. Cell‐based experimental strategies for myelin repair in multiple sclerosis
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Maximiliano Borda, Jorge B. Aquino, and Graciela L. Mazzone
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Adult ,Oligodendroglia ,Cellular and Molecular Neuroscience ,Multiple Sclerosis ,Remyelination ,Humans ,Neuroglia ,Myelin Sheath - Abstract
Multiple sclerosis (MS) is an autoimmune demyelinating disorder of the central nervous system (CNS), diagnosed at a mean age of 32 years. CNS glia are crucial players in the onset of MS, primarily involving astrocytes and microglia that can cause/allow massive oligodendroglial cells death, without immune cell infiltration. Current therapeutic approaches are aimed at modulating inflammatory reactions during relapsing episodes, but lack the ability to induce very significant repair mechanisms. In this review article, different experimental approaches based mainly on the application of different cell types as therapeutic strategies applied for the induction of myelin repair and/or the amelioration of the disease are discussed. Regarding this issue, different cell sources were applied in various experimental models of MS, with different results, both in significant improvements in remyelination and the reduction of neuroinflammation and glial activation, or in neuroprotection. All cell types tested have advantages and disadvantages, which makes it difficult to choose a better option for therapeutic application in MS. New strategies combining cell-based treatment with other applications would result in further improvements and would be good candidates for MS cell therapy and myelin repair.
- Published
- 2022
27. Combining PSA and PET features to select candidates for salvage lymph node dissection in recurrent prostate cancer
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Carlo A. Bravi, Axel Heidenreich, Nicola Fossati, Giorgio Gandaglia, Nazareno Suardi, Elio Mazzone, Armando Stabile, Vito Cucchiara, Daniar Osmonov, Klaus‐Peter Juenemann, R. Jeffrey Karnes, Alexander Kretschmer, Alexander Buchner, Christian Stief, Andreas Hiester, Peter Albers, Gaëtan Devos, Steven Joniau, Hendrik Van Poppel, Bernhard Grubmüller, Shahrokh Shariat, Derya Tilki, Markus Graefen, Inderbir S. Gill, Alexander Mottrie, Pierre I. Karakiewicz, Francesco Montorsi, Alberto Briganti, and David Pfister
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salvage lymph node dissection ,androgen deprivation therapy ,General Medicine ,PSMA PET scan ,metastasis‐directed therapy ,neoplasm recurrence ,prostate cancer - Abstract
OBJECTIVE: To evaluate the relationship between pre-operative PSA value, 68Ga-prostate-specific-membrane-antigen (PSMA) PET performance and oncologic outcomes after salvage lymph node dissection (sLND) for biochemical recurrent prostate cancer (PCa). PATIENTS AND METHODS: The study included 164 patients diagnosed with ≤2 pelvic lymph-node recurrence(s) of PCa documented on 68Ga-PSMA PET scan and treated with pelvic ± retroperitoneal sLND at 11 high-volume centres between 2012 and 2019. Pathologic findings were correlated to PSA values at time of sLND, categorized in early (1.5 ng/ml). Clinical recurrence (CR)-free survival after sLND was calculated using multivariable analyses and plotted over pre-operative PSA value. RESULTS: Median [interquartile range (IQR)] PSA at sLND was 1.1 (0.6, 2.0) ng/ml, and 131 (80%) patients had one positive spot at PET scan. All patients received pelvic sLND, whereas 91 (55%) men received also retroperitoneal dissection. Median (IQR) number of node removed was 15 (6, 28). The rate of positive pathology increased as a function of pre-operative PSA value, with highest rates for patients with pre-operative PSA > 1.5 ng/ml (pelvic-only sLNDs: 84%; pelvic + retroperitoneal sLNDs: 90%). After sLND, PSA ≤ 0.3 ng/ml was detected in 67 (41%) men. On multivariable analyses, pre-operative PSA was associated with PSA response (p
- Published
- 2022
28. Cognitive, adaptive and behavioral profile in Sotos syndrome children with 5q35 microdeletion or intragenic variants
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Martina Siracusano, Assia Riccioni, Ilaria Frattale, Lucrezia Arturi, Caterina Dante, Cinzia Galasso, Leonardo Emberti Gialloreti, Giuseppina Conteduca, Barbara Testa, Michela Malacarne, Domenico Coviello, and Luigi Mazzone
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Genetics ,Genetics (clinical) - Published
- 2023
29. Proficiency‐based progression training for robotic surgery skills training: a randomized clinical trial
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De Groote, R., Puliatti, S., Amato, M., Mazzone, E., Rosiello, G., Farinha, R., Paludo, A., Desender, L., Van Cleynenbreugel, B., Bunting, B. P., Mottrie, A., Gallagher, A. G., Larcher, A., Uvin, P., Decoene, J., Tuyten, T., D'Hondt, M., Hubert, N., Chatzopoulos, C., and De Troyer, B.
- Subjects
#Urology ,basic skills training ,proficiency-based progression ,robotic surgery ,surgical simulation ,training ,Urology - Published
- 2022
30. Development of an organ procurement team in South Australia in response to <scp>COVID</scp> ‐19
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Damian Joseph Gimpel, Gareth Crouch, Malgorzata Szpytma, Annette Mazzone, Robert A. Baker, and Jayme S. Bennetts
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Adult ,Tissue and Organ Procurement ,Victoria ,South Australia ,COVID-19 ,Humans ,Surgery ,General Medicine ,Middle Aged ,Pandemics - Abstract
Due to the nature of border closures and quarantine requirements in Australia during the COVID-19 pandemic, the feasibility of interstate travel for organ retrieval created complex logistics. An organ procurement service in South Australia, to procure heart and lungs of local donors, was commenced to mitigate the impact of the travel restrictions imposed due to COVID-19. The purpose of this review was to examine the initial data and feasibility of the service.A single unit, multi-site retrospective review from April 2020-August 2021 of all organ retrievals undertaken by the Flinders Medical Centre cardiothoracic service across Adelaide metropolitan area. Data was prospectively collected and analysed from the DonateLife South Australian centralized database. All data was de identified.A total of 25 organ procurements had been undertaken across 17 months since commencing the program. Total of 9 hearts and 16 bilateral lungs were procured with median age of donor of hearts 49 years (IQR 35.5-51. 5) and 60 years (IQR 44-72) for lung donation. Six organs were donated after determination of circulatory death and 19 after neurological determination of death. Median ischaemic time for heart donation was 4.4 h (IQR 3.0-5.8) and lung donation 4.4 h (IQR 3.4-6.1). All organs procured by the local South Australian team were successfully transplanted at the recipient site. Recipient sites included 8 in Victoria, 10 in New South Wales, 4 in Western Australia and 3 in Queensland.The necessity of flexibility within the field of cardiothoracic surgery is evident during the COVID-19 pandemic. The implementation of an organ retrieval service in South Australia has been successful with no apparent increased risk to successful transplant outcomes.
- Published
- 2022
31. Does previous prostate surgery affect multiparametric magnetic resonance imaging accuracy in detecting clinically significant prostate cancer? Results from a single institution series
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Francesco Pellegrino, Armando Stabile, Elio Mazzone, Gabriele Sorce, Francesco Barletta, Mario De Angelis, Giorgio Brembilla, Giorgio Gandaglia, Francesco De Cobelli, Francesco Montorsi, and Alberto Briganti
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Image-Guided Biopsy ,Male ,Oncology ,Urology ,Prostate ,Humans ,Prostatic Neoplasms ,Multiparametric Magnetic Resonance Imaging ,Neoplasm Grading ,Magnetic Resonance Imaging ,Retrospective Studies - Abstract
Multiparametric MRI (mpMRI) has demonstrated high diagnostic accuracy for clinically significant PCa (csPCa). However, the accuracy of this test in men that received a previous prostatic surgery is still controversial. We aimed at assessing the effect of previous prostatic surgery on the detection of csPCa in a tertiary referral center.We relied on a cohort of 311 men with a positive mpMRI (prostate imaging - reporting and data system [PI-RADS] ≥ 3) who underwent a targeted (TBx) plus concomitant systematic random biopsy (SBx) at a single tertiary referral center between 2017 and 2020. The study outcome was to compare the detection of csPCa (Gleason score ≥ 3 + 4) between the two groups (no previous prostate surgery [Group 1] vs. previous prostate surgery [Group 2]). Multivariable logistic regression analysis (MVA) was used to assess the relationship between previous prostate surgery and the detection of csPCa at TBx, after taking into account potential clinical confounders.Overall, 24 (8%) patients received a previous prostate surgery before undergoing mpMRI. Median prostate-specific antigen density was 0.15 versus 0.08 ng/ml/cc, in Group 1 versus 2, respectively. The most frequent finding at mpMRI was in Group 1 versus 2, PI-RADS 4 (55%) versus PI-RADS 3 and 4 (42% each). The majority of patients were biopsy naïve in both Groups 1 (66%) and 2 (71%). The overall detection of csPCa in Group 1 versus 2 was 83% versus 75%, respectively. Differently, the detection of csPCa at TBx in Groups 1 versus 2 was 76% versus 71%, respectively. At MVA, previous prostate surgery (odds ratio: 0.65; p = 0.02) was significantly associated with lower csPCa detection at TBx, after accounting for potential confounders.The presence of previous prostate surgery significantly decreases the accuracy of mpMRI in detecting csPCa. These results should be taken into account when assessing patients with a history of prostatic surgery and a suspicious lesion at mpMRI, to better select those who might avoid an unnecessary biopsy.
- Published
- 2022
32. Left atrial appendage occlusion after thromboembolic events or left atrial appendage sludge during anticoagulation therapy: Is two better than one? Real‐world experience from a tertiary care hospital
- Author
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Margonato, Davide, primary, Preda, Alberto, additional, Ingallina, Giacomo, additional, Rizza, Vincenzo, additional, Fierro, Nicolai, additional, Radinovic, Andrea, additional, Ancona, Francesco, additional, Patti, Giuseppe, additional, Agricola, Eustachio, additional, Bella, Paolo Della, additional, and Mazzone, Patrizio, additional
- Published
- 2023
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33. Left Atrial Appendage Occlusion in High Bleeding Risk Patients
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Pierluigi Merella, Giovanni Lorenzoni, Alessandro P. Delitala, Filomena Sechi, Federica Decandia, Graziana Viola, Paola Berne, Gianluca Deiana, Patrizio Mazzone, and Gavino Casu
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Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Objectives. The aim of this study was to investigate the outcomes of left atrial appendage occlusion (LAAO) in high bleeding risk patients suffering atrial fibrillation (AF) and to analyze the different antithrombotic therapies following the intervention. Background. Methods. This monocentric study included 68 patients with nonvalvular AF with an absolute contraindication to OAT or at high bleeding risk. Follow-up was done with a clinical visit at 3-6-12 months. Results. Successful LAAO was achieved in 67/68 patients. At discharge, 32/68 patients were on dual antiplatelet therapy (APT), 34/68 were without any antithrombotic therapy or with a single antiplatelet drug, and 2/68 were on anticoagulant therapy. At three-month follow-up visit, 73.6% of the patients did not receive dual APT, of whom 14.7% had no thrombotic therapy and 58.9% were on single antiplatelet therapy. During a follow-up of 1.4 ± 0.9 years, 3/62 patients had late adverse effects (2 device-related thrombus without clinical consequences and 1 extracranial bleeding). The device-related thrombosis was not related to the antithrombotic therapy. Conclusions. LAAO is feasible and safe and prevents stroke in patients with AF with contraindication to oral anticoagulant therapy. After LAAO, single antiplatelet therapy seems to be a safe alternative to dual antiplatelet therapy, especially in patients at high bleeding risk. No benefit has been observed with dual APT.
- Published
- 2019
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34. Left atrial appendage occlusion after thromboembolic events or left atrial appendage sludge during anticoagulation therapy: Is two better than one? Real‐world experience from a tertiary care hospital
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Davide Margonato, Alberto Preda, Giacomo Ingallina, Vincenzo Rizza, Nicolai Fierro, Andrea Radinovic, Francesco Ancona, Giuseppe Patti, Eustachio Agricola, Paolo Della Bella, and Patrizio Mazzone
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Cardiology and Cardiovascular Medicine - Published
- 2023
35. Working on the dirty side—the ipsilateral subclavian access for temporary pacing after lead extraction
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David Zweiker, Francesco Melillo, Giuseppe D’Angelo, Andrea Radinovic, Alessandra Marzi, Lorenzo Cianfanelli, Savino Altizio, Luca R. Limite, Gabriele Paglino, Antonio Frontera, Kenzaburo Nakajima, Luigia Brugliera, Lorenzo Malatino, Paolo Della Bella, and Patrizio Mazzone
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cardiovascular implantable electrical device ,Transvenous lead extraction ,subclavian access ,pocket infection ,Cardiology and Cardiovascular Medicine - Abstract
Temporary pacing is necessary in pacemaker-dependent patients after transvenous lead extraction (TLE) for cardiac implantable electronic device infection. In case of unavailability of other accesses, we propose to use the ipsilateral subclavian access (ISA) combined with a standard permanent active fixation lead for the temporary pacemaker and present preliminary data.We consecutively enrolled patients undergoing TLE who received a temporary pacemaker using the ISA between August 2016 and April 2020 at our centre.During the observation period, 36 patients undergoing TLE for pocket infection (72.2%), endocarditis (25.0%) or other causes received a temporary pacemaker over the ISA. Their mean age was 77.0 ± 10.7 years, and 13.9% were female. Complete TLE was achieved in 94.4%. There were no major periprocedural complications. Intra-hospital mortality was 11.1%. Pocket revision was performed in 19.4%. During long-term follow-up (23 ± 13 months), 8.3% had a relapse of local pocket infection and 2.8% needed rehospitalization for reintervention.Temporary pacing using a standard permanent active fixation lead using the ISA is a convenient alternative to conventional venous accesses. However, risks of implanting a lead into a previously infected area have to be taken into account.
- Published
- 2022
36. Tools supporting polypharmacy management in Italy: Factors determining digital technologies' intention to use in clinical practice
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Elisabetta Catrini, Lucrezia Ferrario, Antonino Mazzone, Luca Varalli, Federico Gatti, Lorella Cannavacciuolo, Cristina Ponsiglione, Emanuela Foglia, Catrini, Elisabetta, Ferrario, Lucrezia, Mazzone, Antonino, Varalli, Luca, Gatti, Federico, Cannavacciuolo, Lorella, Ponsiglione, Cristina, and Foglia, Emanuela
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Technology Acceptance Model ,General Medicine ,digital technology ,drug–drug interaction ,polypharmacy ,INTERCheckWEB ,clinical appropriatene - Abstract
Background and aims: INTERCheckWEB is one of the most outstanding digital technologies, that could be implemented at the hospital level, supporting the clinicians in the evaluation of the therapy appropriateness, reducing the potentially inappropriate prescriptions, for the improvement of the clinical decision-making process. The paper aims at investigating the relationship between clinicians' behaviors towards digital decision support system in therapy appropriateness for elderly patients in polytherapy in medical departments, defining the factors that could influence clinicians to use INTERCheckWEB, for supporting drugs' prescription. Methods: A questionnaire was administered to 70 clinicians referring to Internal Medicine wards, of four Italian hospitals. The authors assessed how perceived usefulness, perceived ease of use, image, and output quality, would affect INTERCheckWeb intention to use. Inferential statistics, by means of a regression analysis, were conducted to define the main aspects useful to understand the factors impacting on such digital technology adoption in clinical practice. Results: The regression analysis reported that image, perceived ease of use and perceived usefulness, as well as the moderator effect of the voluntary use between the perceived usefulness and the intention to use, are the factors that most influence the use of INTERCheckWEB (adjusted R 2 = 0.870). Conclusions: Results demonstrated that clinicians would use INTERCheckWEB, when available, to identify all the information on situations that could be dangerous for the patients, thus limiting the drug-drug interactions, optimizing the overall patient's clinical pathway. Furthermore, the implementation of INTERCheckWEB could also contribute to the proper management of COVID-19 patients, since both hospitalized and symptomatic COVID-19 patients are frequently older, with comorbidities.
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- 2022
37. Outcomes of transvenous lead extraction of very old leads using bidirectional rotational mechanical sheaths: Results of a multicentre study
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Migliore, Federico, primary, Pittorru, Raimondo, additional, Dall'Aglio, Pietro Bernardo, additional, De Lazzari, Manuel, additional, Rovaris, Giovanni, additional, Piazzi, Elena, additional, Dentico, Alessia, additional, Ferrieri, Alessandra, additional, D'Angelo, Giuseppe, additional, Marzi, Alessandra, additional, Sawaf, Basma El, additional, Bertaglia, Emanuele, additional, Iliceto, Sabino, additional, Gerosa, Gino, additional, Tarzia, Vincenzo, additional, Carretta, Domenico, additional, and Mazzone, Patrizio, additional
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- 2022
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38. External validation of yonsei nomogram predicting chronic kidney disease development after partial nephrectomy: An international, multicenter study
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Abdel Raheem, Ali, primary, Landi, Isotta, additional, Alowidah, Ibrahim, additional, Capitanio, Umberto, additional, Montorsi, Francesco, additional, Larcher, Alessandro, additional, Derweesh, Ithaar, additional, Ghali, Fady, additional, Mottrie, Alexander, additional, Mazzone, Elio, additional, De Naeyer, Geert, additional, Campi, Riccardo, additional, Sessa, Francesco, additional, Carini, Marco, additional, Minervini, Andrea, additional, Raman, Jay D., additional, Rjepaj, Chris J., additional, Kriegmair, Maximilian C., additional, Autorino, Riccardo, additional, Veccia, Alessandro, additional, Mir, Maria Carmen, additional, Claps, Francesco, additional, Choi, Young Deuk, additional, Ham, Won Sik, additional, Santok, Glen Denmer, additional, Tadifa, John Paul, additional, Syling, Justin, additional, Furlan, Maria, additional, Simeone, Claudio, additional, Bada, Maida, additional, Celia, Antonio, additional, Carrión, Diego M., additional, Aguilera Bazan, Alfredo, additional, Ruiz, Cristina Ballesteros, additional, Malki, Manar, additional, Barber, Neil, additional, Hussain, Muddassar, additional, Micali, Salvatore, additional, Puliatti, Stefano, additional, Ghaith, Ahmed, additional, Hagras, Ayman, additional, Ghoneem, Ayman M., additional, Eissa, Ahmed, additional, Alqahtani, Abdulrahman, additional, Rumaih, Abdullah, additional, Alwahabi, Abdelaziz, additional, Alenzi, Mohammed Jayed, additional, Pavan, Nicola, additional, Traunero, Fabio, additional, Antonelli, Alessandro, additional, Porcaro, Antonio Benito, additional, Illiano, Ester, additional, Costantini, Elisabetta, additional, and Rha, Koon Ho, additional
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- 2022
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39. Nonsteroidal anti‐inflammatory drugs and pharyngitis
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Mazzone, Stuart B, primary, Kulasekaran, Anuradha, additional, Shea, Tim, additional, and Adegoke, Oluwajoba, additional
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- 2022
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40. Impact of AREDF‐UA during and after fetal spina bifida repair on postoperative, neonatal and 2‐year neurodevelopmental outcome
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Ruegg, L., primary, Vonzun, L., additional, Latal, B., additional, Moehrlen, U., additional, Mazzone, L., additional, Meuli, M., additional, Krähenmann, F., additional, and Ochsenbein‐Kölble, N., additional
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- 2022
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41. Vis–NIR Electrochromism and NIR–Green Electroluminochromism in Dual Functional Benzothiadiazole‐Arylamine Mixed‐Valence Compounds
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Corrente, Giuseppina Anna, primary, González, Dora A., additional, Aktas, Ece, additional, Capodilupo, Agostina Lina, additional, Mazzone, Gloria, additional, Ruighi, Francesco, additional, Accorsi, Gianluca, additional, Imbardelli, Daniela, additional, Rodriguez‐Seco, Cristina, additional, Martinez‐Ferrero, Eugenia, additional, Palomares, Emilio, additional, and Beneduci, Amerigo, additional
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- 2022
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42. Bullied, bystanders, and perpetrators in the workplace: The role of empathy in teachers and school leaders' experiences
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Angela Mazzone, Vasiliki Pitsia, Anastasios Karakolidis, and James O'Higgins Norman
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Developmental and Educational Psychology ,Education - Published
- 2021
43. Obstetric and neonatal outcomes after <scp>SARS‐CoV</scp> ‐2 infection in the first trimester of pregnancy: A prospective comparative study
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Federica Bevilacqua, Luca Bertero, Giovanni Di Perri, Marialuisa Bovetti, Chiara Benedetto, Jessica Cusato, Fulvio Borella, Giulio Mengozzi, Andrea Carosso, Raffaela Mazzone, Valeria Ghisetti, and Stefano Cosma
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medicine.medical_specialty ,Neonatal intensive care unit ,Infectious Disease Transmission ,COVID-19 ,SARS-CoV-2 ,outcome ,pregnancy ,vertical transmission ,Female ,Humans ,Infant, Newborn ,Infectious Disease Transmission, Vertical ,Pregnancy ,Pregnancy Outcome ,Pregnancy Trimester, First ,Prospective Studies ,Pregnancy Complications, Infectious ,Premature Birth ,Intrauterine growth restriction ,Preeclampsia ,medicine ,Vertical ,Rupture of membranes ,Adverse effect ,First ,Obstetrics ,business.industry ,Infectious ,Infant ,Obstetrics and Gynecology ,Newborn ,medicine.disease ,Pregnancy Complications ,Apgar score ,Pregnancy Trimester ,business ,Cohort study - Abstract
Objective(s) This prospective observational cohort study aimed to evaluate whether women with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during the first trimester of pregnancy are at higher risk of adverse obstetric and neonatal outcomes compared to negative patients. Study design Seromolecular testing for SARS-CoV-2 was performed at 12, 16, 21 weeks, and at delivery; the cohort was then subdivided into a first-trimester SARS-CoV-2-positive (case) group and a SARS-CoV-2-negative (control) group. The primary outcome was a composite adverse obstetric outcome, defined as the presence of either abortion, preterm delivery, preterm prelabor rupture of membranes, preeclampsia, intrauterine growth restriction, stillbirth; and a composite measure of adverse neonatal events, including either 1- and 5-min Apgar score ≤ 7, neonatal intensive care unit admission and congenital birth defects. Maternal symptoms and antibody titer were secondarily assessed. Results A total of 17 of 164 women tested positive for SARS-CoV-2 (10.3%) in the first trimester. One SARS-CoV-2-positive patient who gave birth at another hospital was excluded. Composite adverse obstetric outcome was observed in 6.2% (1/16) SARS-CoV-2-positive and 10.5% (11/105) SARS-CoV-2-negative women; composite adverse neonatal outcome in 12.5% (2/16) and 7.6% (8/105), respectively. In the newborns of women who had developed IgG antibodies, the same antibodies were detected in arterial cord blood and the nasopharyngeal swab tested negative for SARS-CoV-2. No maternal pneumonia or hospital admission due to coronavirus disease-19 were recorded. Conclusion Asymptomatic or mildly symptomatic women during the first trimester of pregnancy did not experience significantly more adverse events than SARS-CoV-2-negative women.
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- 2021
44. Persistent left superior vena cava transvenous lead extraction: A European experience
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Mark M Gallagher, Alexander Breitenstein, Patrizio Mazzone, Jan Steffel, Christoph Starck, Manav Sohal, Elkin Gonzalez, Zaki Akhtar, Sergio Richter, Amir Zaidi, Omar Al-Razzo, Christopher A. Rinaldi, Francesco Melillo, Zia Zuberi, Vishal Mehta, University of Zurich, and Akhtar, Zaki
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Male ,Pacemaker, Artificial ,medicine.medical_specialty ,Vena Cava, Superior ,610 Medicine & health ,2705 Cardiology and Cardiovascular Medicine ,2737 Physiology (medical) ,Persistent Left Superior Vena Cava ,Superior vena cava ,Physiology (medical) ,medicine ,Humans ,General anaesthesia ,Persistent left superior vena cava ,Device Removal ,Aged ,Aged, 80 and over ,business.industry ,Healthy population ,medicine.disease ,Defibrillators, Implantable ,Transvenous lead ,Surgery ,Treatment Outcome ,medicine.anatomical_structure ,Ventricle ,10209 Clinic for Cardiology ,Right atrium ,Female ,Cardiology and Cardiovascular Medicine ,business ,Lead extraction - Abstract
Background Transvenous lead extraction (TLE) is rising in parallel to cardiac implantable electronic device implantations. Persistent left side superior vena cava (PLSVC) is a relatively common anatomical variant in the healthy population; TLE in patients with a PLSVC is rare. Method Data were collated from 6 European TLE institutes of 10 patients who had undergone lead extraction with a PLSVC. Patient demographics, procedural challenges and outcomes were reported. Results Ten patients aged 73.4 ± 7.8 years (60% male) underwent TLE of 20 leads (3 left ventricle, 10 right ventricle, 7 right atrium) with dwell time of 82.95 ± 39.1 months. Of the 10 cases, 4 had an infection indication and 5 were biventricular system extractions; 25% of the extracted leads were defibrillator leads. The majority of the procedures were completed in the cardiac catheterization suite (80%) under general anaesthesia (60%) by cardiologists (80%) using a rotational powered sheath (65%). The Tandem approach was used successfully in 3 cases. Complete procedural success was obtained in 100% of cases in the absence of complications within 127.4 ± 74.7 min. There was no 30-day mortality. Conclusion TLE in PLSVC is feasible albeit rare. Standard extraction techniques in experienced hands are associated with favorable outcomes; the Tandem procedure may be an additional technique to improve the safety and efficacy of TLE in PLSVC.
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- 2021
45. Nonsteroidal anti‐inflammatory drugs and pharyngitis
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Stuart B Mazzone, Anuradha Kulasekaran, Tim Shea, and Oluwajoba Adegoke
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Immunology ,Anti-Inflammatory Agents ,Humans ,Immunology and Allergy ,Pharyngitis - Published
- 2022
46. Transvenous lead extraction: The influence of age on patient outcomes in the PROMET study cohort
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Jan Steffel, Christoph Starck, Zaki Akhtar, Pia Lanmüller, Lisa W M Leung, Manav Sohal, Alexander Breitenstein, Elkin Gonzalez, Jürgen Eulert-Grehn, Mark M Gallagher, Giulia Domenichini, Ahmed I Elbatran, Patrizio Mazzone, Alessandra Marzi, Peter-Paul Delnoy, Omar Al-Razzo, and Francesco Melillo
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Adult ,Male ,medicine.medical_specialty ,Multivariate analysis ,Population ,Older patients ,Internal medicine ,Humans ,Medicine ,Major complication ,Risk factor ,education ,Device Removal ,Aged ,Retrospective Studies ,Aged, 80 and over ,education.field_of_study ,business.industry ,Age Factors ,General Medicine ,Middle Aged ,Electrodes, Implanted ,Transvenous lead ,Europe ,Propensity score matching ,Cohort ,Female ,Cardiology and Cardiovascular Medicine ,business - Abstract
BACKGROUND Cardiac implantable electronic device (CIED) therapy contributes to an improvement in morbidity and mortality across all patient demographics. Patient age is a recognized risk factor for unfavorable outcomes in invasive procedures. This is the largest series of non-laser transvenous lead extraction (TLE) evaluating the association between patient age and procedure outcomes. METHODS Data of 2205 (3849 leads) patients was collected retrospectively from six European TLE centers between January 2005-December 2018 in the PROMET study. Of these, 153 patients with 319 leads were excluded for incomplete data. A comparison of outcomes was performed between the age groups young [
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- 2021
47. Cell‐based experimental strategies for myelin repair in multiple sclerosis
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Borda, Maximiliano, primary, Aquino, Jorge B., additional, and Mazzone, Graciela L., additional
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- 2022
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48. On the origin of photodynamic activity of hypericin and its iodine‐containing derivatives
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De Simone, Bruna Clara, primary, Mazzone, Gloria, additional, Toscano, Marirosa, additional, and Russo, Nino, additional
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- 2022
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49. Combining PSA and PET features to select candidates for salvage lymph node dissection in recurrent prostate cancer
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Bravi, Carlo A., primary, Heidenreich, Axel, additional, Fossati, Nicola, additional, Gandaglia, Giorgio, additional, Suardi, Nazareno, additional, Mazzone, Elio, additional, Stabile, Armando, additional, Cucchiara, Vito, additional, Osmonov, Daniar, additional, Juenemann, Klaus‐Peter, additional, Karnes, R. Jeffrey, additional, Kretschmer, Alexander, additional, Buchner, Alexander, additional, Stief, Christian, additional, Hiester, Andreas, additional, Albers, Peter, additional, Devos, Gaëtan, additional, Joniau, Steven, additional, Van Poppel, Hendrik, additional, Grubmüller, Bernhard, additional, Shariat, Shahrokh, additional, Tilki, Derya, additional, Graefen, Markus, additional, Gill, Inderbir S., additional, Mottrie, Alexander, additional, Karakiewicz, Pierre I., additional, Montorsi, Francesco, additional, Briganti, Alberto, additional, and Pfister, David, additional
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- 2022
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50. Stroke prevention in patients from Latin American countries with non‐valvular atrial fibrillation: Insights from the GARFIELD‐AF registry
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Jerjes-Sanchez C., Corbalan R., Barretto A. C. P., Luciardi H. L., Allu J., Illingworth L., Pieper K. S., Kayani G., Fitzmaurice D. A., Goto S., Hacke W., Mantovani L. G., Turpie A. G. G., Gersh B. J., Gibbs H., Brodmann M., Cools F., Connolly S. J., Spyropoulos A., Eikelboom J., Hu D., Jansky P., Nielsen J. D., Ragy H., Raatikainen P., Le Heuzey J. -Y., Darius H., Keltai M., Kakkar S., Sawhney J. P. S., Agnelli G., Ambrosio G., Koretsune Y., Diaz C. J. S., ten Cate H., Atar D., Stepinska J., Panchenko E., Lim T. W., Jacobson B., Oh S., Vinolas X., Rosenqvist M., Steffel J., Angchaisuksiri P., Parkhomenko A., Al Mahmeed W., Chen K. N., Zhao Y. S., Zhang H. Q., Chen J. Z., Cao S. P., Wang D. W., Yang Y. J., Li W. H., Yin Y. H., Tao G. Z., Yang P., Chen Y. M., He S. H., Wang Y., Fu G. S., Li X., Wu T. G., Cheng X. S., Yan X. W., Zhao R. P., Chen M. S., Xiong L. G., Chen P., Jiao Y., Guo Y., Xue L., Wang F. Z., Li H., Yang Z. M., Bai C. L., Chen J., Chen J. Y., Chen X., Feng S., Fu Q. H., Gao X. J., Guo W. N., He R. H., He X. A., Hu X. S., Huang X. F., Li B., Li J., Li L., Li Y. H., Liu T. T., Liu W. L., Liu Y. Y., Lu Z. C., Luo X. L., Ma T. Y., Peng J. Q., Sheng X., Shi X. J., Sun Y. H., Tian G., Wang K., Wang L., Wu R. N., Xie Q., Xu R. Y., Yang J. S., Yang L. L., Yang Q., Ye Y., Yu H. Y., Yu J. H., Yu T., Zhai H., Zhan Q., Zhang G. S., Zhang Q., Zhang R., Zhang Y., Zheng W. Y., Zhou B., Zhou Z. H., Zhu X. Y., Jadhav P., Durgaprasad R., Ravi Shankar A. G., Rajput R. K., Bhargava K., Sarma R., Srinivas A., Roy D., Nagamalesh U. M., Chopda M., Kishore R., Kulkarni G., Chandwani P., Pothiwala R. A., Padinhare Purayil M., Shah S., Chawla K., Kothiwale V. A., Raghuraman B., Vijayaraghavan G., Vijan V. M., Bantwal G., Bisne V., Khan A., Gupta J. B., Kumar S., Jain D., Abraham S., Adak D., Barai A., Begum H., Bhattacharjee P., Dargude M., Davies D., Deshpande B., Dhakrao P., Dhyani V., Duhan S., Earath M., Ganatra A., Giradkar S., Jain V., Karthikeyan R., Kasala L., Kaur S., Krishnappa S., Lawande A., Lokesh B., Madarkar N., Meena R., More P., Naik D., Prashanth K., Rao M., Rao N. M., Sadhu N., Shah D., Sharma M., Shiva P., Singhal S., Suresh S., Vanajakshamma V., Panse S. G., Kanamori S., Yamamoto K., Kumagai K., Katsuda Y., Sadamatsu K., Toyota F., Mizuno Y., Misumi I., Noguchi H., Ando S., Suetsugu T., Minamoto M., Oda H., Shiraishi K., Adachi S., Chiba K., Norita H., Tsuruta M., Koyanagi T., Ando H., Higashi T., Okada K., Azakami S., Komaki S., Kumeda K., Murayama T., Matsumura J., Oba Y., Sonoda R., Goto K., Minoda K., Haraguchi Y., Suefuji H., Miyagi H., Kato H., Nakamura T., Nandate H., Zaitsu R., Fujiura Y., Yoshimura A., Numata H., Ogawa J., Tatematsu H., Kamogawa Y., Murakami K., Wakasa Y., Yamasawa M., Maekawa H., Abe S., Kihara H., Tsunoda S., Saito K., Fudo T., Obunai K., Tachibana H., Oba I., Kuwahata T., Higa S., Gushiken M., Eto T., Yoshida H., Ikeda D., Ishizawa M., Nakatsuka M., Murata K., Ogurusu C., Shimoyama M., Akutsu M., Takamura I., Hoshino F., Yokota N., Iwao T., Tsuchida K., Takeuchi M., Hatori Y., Kitami Y., Nakamura Y., Oyama R., Ageta M., Go Y., Mishima K., Unoki T., Morii S., Shiga Y., Sumi H., Nagatomo T., Sanno K., Fujisawa K., Atsuchi Y., Nagoshi T., Seto T., Tabuchi T., Kameko M., Nii K., Oshiro K., Takezawa H., Nagano S., Miyamoto N., Iwaki M., Fujii M., Okawa M., Abe M., Saito T., Mito T., Nagao K., Minami J., Mita T., Sakuma I., Taguchi T., Marusaki S., Doi H., Tanaka M., Fujito T., Matsuta M., Kusumoto T., Kakinoki S., Ashida K., Yoshizawa N., Agata J., Arasaki O., Manita M., Ikemura M., Fukuoka S., Murakami H., Matsukawa S., Hata Y., Taniguchi T., Ko T., Kubo H., Imamaki M., Akiyama M., Inagaki M., Odakura H., Ueda T., Katsube Y., Nakata A., Watanabe H., Techigawara M., Igarashi M., Taga K., Kimura T., Tomimoto S., Shibuya M., Nakano M., Ito K., Seo T., Hiramitsu S., Hosokawa H., Hoshiai M., Hibino M., Miyagawa K., Horie H., Sugishita N., Soma A., Neya K., Yoshida T., Mizuguchi M., Ishiguro M., Minagawa T., Wada M., Mukawa H., Okuda F., Nagasaka S., Abe Y., Adachi T., Akahane K., Amano T., Aoki K., Aoyama T., Arai H., Arima S., Arino T., Asano H., Asano T., Azuma J., Baba T., Betsuyaku T., Chibana H., Date H., Doiuchi J., Emura Y., Endo M., Fujii Y., Fujiki R., Fujisawa A., Fujisawa Y., Fukuda T., Fukui T., Furukawa N., Furukawa T., Furumoto W., Goto T., Hamaoka M., Hanazono N., Hasegawa K., Hatsuno T., Hayashi Y., Higuchi K., Hirasawa K., Hirayama H., Hirose M., Hirota S., Honda M., Ido T., Iiji O., Ikeda H., Ikeda K., Ikeoka K., Imaizumi M., Inaba H., Inoue T., Iseki F., Ishihara A., Ishioka N., Ito N., Iwase T., Kakuda H., Kamata J., Kanai H., Kanda H., Kaneko M., Kano H., Kasai T., Kato T., Kato Y., Kawada Y., Kawai K., Kawakami K., Kawakami S., Kawamoto T., Kawano S., Kim J., Kira T., Kitazawa H., Kitazumi H., Kito T., Kobayashi T., Koeda T., Kojima J., Komatsu H., Komatsu I., Koshibu Y., Kotani T., Kozuka T., Kumai Y., Kumazaki T., Maeda I., Maeda K., Maruyama Y., Matsui S., Matsushita K., Matsuura Y., Mineoi K., Mitsuhashi H., Miura N., Miyaguchi S., Miyajima S., Miyamoto H., Miyashita A., Miyata S., Mizuguchi I., Mizuno A., Mori T., Moriai O., Morishita K., Murai O., Nagai S., Nagata E., Nagata H., Nakagomi A., Nakahara S., Nakamura M., Nakamura R., Nakanishi N., Nakayama T., Nakazato R., Nanke T., Nariyama J., Niijima Y., Niinuma H., Nishida Y., Nishihata Y., Nishino K., Nishioka H., Nishizawa K., Niwa I., Nomura K., Nomura S., Nozoe M., Ogawa T., Ohara N., Okada M., Okamoto K., Okita H., Okuyama M., Ono H., Ono T., Pearce Y. O., Oriso S., Ota A., Otaki E., Saito Y., Sakai H., Sakamoto N., Sakamoto Y., Samejima Y., Sasagawa Y., Sasaguri H., Sasaki A., Sasaki T., Sato K., Sawano M., Seki S., Sekine Y., Seta Y., Sezaki K., Shibata N., Shiina Y., Shimono H., Shimoyama Y., Shindo T., Shinohara H., Shinohe R., Shinozuka T., Shirai T., Shiraiwa T., Shozawa Y., Suga T., Sugimoto C., Suzuki K., Suzuki S., Suzuki Y., Tada M., Taguchi A., Takagi T., Takagi Y., Takahashi K., Takahashi S., Takai H., Takanaka C., Take S., Takeda H., Takei K., Takenaka K., Tana T., Tanabe G., Taya K., Teragawa H., Tohyo S., Toru S., Tsuchiya Y., Tsuji T., Tsuzaki K., Uchiyama H., Ueda O., Ueyama Y., Wakaki N., Wakiyama T., Washizuka T., Watanabe M., Yamada T., Yamagishi T., Yamaguchi H., Yamamoto T., Yamaura M., Yamazoe M., Yasui K., Yokoyama Y., Yoshida K., Ching C. K., Foo C. G., Chow J. H., Chen D. D., Jaufeerally F. R., Lee Y. M., Lim G., Lim W. T., Thng S., Yap S. Y., Yeo C., Pak H. N., Kim J. -B., Kim J. H., Jang S. -W., Kim D. H., Ryu D. R., Park S. W., Kim D. -K., Choi D. J., Oh Y. S., Cho M. -C., Kim S. -H., Jeon H. -K., Shin D. -G., Park J. S., Park H. K., Han S. -J., Sung J. H., Cho J. -G., Nam G. -B., On Y. K., Lim H. E., Kwak J. J., Cha T. -J., Hong T. J., Park S. H., Yoon J. H., Kim N. -H., Kim K. -S., Jung B. C., Hwang G. -S., Kim C. -J., Kim D. B., Ahn J. J., An H. J., Bae H., Baek A. L., Chi W. J., Choi E. A., Choi E. H., Choi H. K., Choi H. S., Han S., Heo E. S., Her K. O., Hwang S. W., Jang E. M., Jang H. -S., Jang S., Jeon H. -G., Jeon S. R., Jeon Y. R., Jeong H. K., Jung I. -A., Kim H. J., Kim J. S., Kim J. A., Kim K. T., Kim M. S., Kim S. H., Kim Y. -I., Lee C. S., Lee E. H., Lee G. H., Lee H. Y., Lee H. -Y., Lee K. H., Lee K. R., Lee M. S., Lee M. -Y., Lee R. W., Lee S. E., Lee S. H., Lee S., Lee W. Y., Noh I. K., Park A. R., Park B. R., Park H. N., Park J. H., Park M., Park Y., Seo S. -Y., Shim J., Sim J. H., Sohn Y. M., Son W. S., Son Y. S., Song H. J., Wi H. K., Woo J. J., Ye S., Yim K. H., Yoo K. M., Yoon E. J., Yun S. Y., Chawanadelert S., Mongkolwongroj P., Kanokphatcharakun K., Cheewatanakornkul S., Laksomya T., Pattanaprichakul S., Chantrarat T., Rungaramsin S., Silaruks S., Wongcharoen W., Siriwattana K., Likittanasombat K., Katekangplu P., Boonyapisit W., Cholsaringkarl D., Chatlaong B., Chattranukulchai P., Santanakorn Y., Hutayanon P., Khunrong P., Bunyapipat T., Jai-Aue S., Kaewsuwanna P., Bamungpong P., Gunaparn S., Hongsuppinyo S., Inphontan R., Khattaroek R., Khunkong K., Kitmapawanont U., Kongsin C., Naratreekoon B., Ninwaranon S., Phangyota J., Phrommintikul A., Phunpinyosak P., Pongmorakot K., Poomiphol S., Pornnimitthum N., Pumprueg S., Ratchasikaew S., Sanit K., Sawanyawisuth K., Silaruks B., Sirichai R., Sriwichian A., Suebjaksing W., Sukklad P., Suttana T., Tangsirira A., Thangpet O., Tiyanon W., Vorasettakarnkij Y., Wisaratapong T., Wongtheptien W., Wutthimanop A., Yawila S., Altun A., Ozdogru I., Ozdemir K., Yilmaz O., Aydinlar A., Yilmaz M. B., Yeter E., Ongen Z., Cayli M., Pekdemir H., Ozdemir M., Sucu M., Sayin T., Demir M., Yorgun H., Ersanli M., Okuyan E., Aras D., Abdelrahman H., Aktas O., Alpay D., Aras F., Bireciklioglu M. F., Budeyri S., Buyukpapuc M., Caliskan S., Esen M., Felekoglu M. A., Genc D., Ikitimur B., Karaayvaz E. B., Karatas S. K., Okutucu S., Ozcelik E., Quisi A., Sag H., Sahiner L., Sayin B. Y., Seker T., Alkan D. U., Yildirim E., Yildirim R., Yilmaz F., Yuksekdag V., Vensentini N., Ingaramo A. C., Sambadaro G. A., Caputi V. F., Berman S. G., Dragotto P., Kleiban A. J., Centurion N., Giacomi G., Guerrero R. A. A., Conde D., Zapata G., Di Paola L. A., Ramos J. L., Dran R. D., Egido J., Fernandez A. A., Fosco M. J., Sassone S., Sinisi V. A., Cartasegna L. R., Berli M. A., Vilamajo O. A. G., Ferroni F., Alaguibe E. D., D'Amelio A. A., Arabetti C., Arias L., Belardi J. A., Bergesio L., Berli F., Berli M., Borchowiec S., Buzzetti C., Cabrini R., Campisi V., Cappi A. L., Carrizo R., Berra F. 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R., Cardona G. R., Cornejo M. R., Salinas A., Santana G., Perez P. S., Castaneda A. C. T., Cortes R. T., Lenz K., Drexel H., Foechterle J., Hagn C., Podczeck-Schweighofer A., Huber K., Winkler M., Schneeweiss B., Gegenhuber A., Lang W., Eichinger-Hasenauer S., Kaserer P., Sykora J., Rasch H., Pichler M., Schaflinger E., Strohmer B., Breier R., Ebner K. -M., Eischer L., Freihoff F., Lischka-Lindner A., Mark T., Mirtl A., Said A., Stocklocker C., Vogel B., Vonbank A., Wohrer C., Zanolin D., Paparella G., Vandergoten P., Parque J. -L., Capiau L., Vervoort G., Wollaert B., Desfontaines P., Mairesse G., Boussy T., Godart P., De Wolf A., Voet J., Heyse A., Hollanders G., Anne W., Vercammen J., Purnode P., Blankoff I., Faes D., Balthazar Y., Beutels M., Marechal P., Verstraete S., Xhaet O., Striekwold H., Thoeng J., Hermans K., Alzand B., Ascoop A. -K., Banaeian F., Barbuto A. -M., Billiaux A. C., Blockmans M., Bouvy C., Brike C., Capiau H., Casier T., Bolado A. C. Y., De Cleen D., De Coninck M., de Vos M., de Weerdt N., Delforge M., Delvigne M., Denie D., Derycker K., Deweerd E., Dormal F., Drieghe S., Everaert M., Eykerman T., Feys E., Ghekiere M., Gits F., Hellemans S., Helvasto L., Jacobs C., Lips S., Mestdagh I., Nimmegeers J., Piamonte V., Pollet P., Postolache A., Raepers M., Raymenants E., Richa J., Rombouts H., Salembier J., Scheurwegs C., Semeraro O., Simons N., Smessaert C., Smolders W., Stockman I., Tahon S., Thyssen V., Tincani G., Van Durme F., Van Lier D., Vandekerckhove H., Vandekerckhove Y., Vandenbroeck D., Vandorpe A., Vanhalst E., Vanhauwaert B., Vantomme C., Vergauwen L., Verloove H., Vydt T., Weyn T., Reichert P., Spacek R., Machova V., Zidkova E., Ludka O., Olsr J., Kotik L., Plocova K., Racz B., Ferkl R., Hubac J., Kotik I., Monhart Z., Burianova H., Jerabek O., Pisova J., Petrova I., Dedek V., Honkova M., Podrazil P., Spinar J., Vitovec J., Novak M., Lastuvka J., Durdil V., Antonova P., Bockova L., Bultas J., Chlumsky J., Dastychova L., Drasnar T., Honek J., Horejsi M., Hubacova V., Janska L., Kopeckova I., Kratochvilova R., Krcova E., Labrova R., Lindourkova A., Lipoldova J., Lubanda H., Ludkova A., Mahdalikova L., Majernikova M., Michalik D., Potuznik P., Prochazkova E., Sulc A., Sveceny J., Valtova M., Zidek M., Zika J., Nielsen H., Husted S., Hintze U., Rasmussen S., Bremmelgaard A., Markenvard J., Boerger J., Solgaard J., Simonsen P., Loekkegaard T., Bruun M., Mertz J., Dominguez H., Skagen K., Egstrup K., Ibsen H., Raymond I., Bang-Hansen T., Ellervik C., Eriksen E., Jensen L., Jensen M., Leth M., Nygaard A., Park J., Schou M., Therkelsen A., Tilma J., Vesterager K., Airaksinen J., Arola O., Koistinen J., Nappila H., Peltomaki K., Rasanen V., Vasankari T., Galinier M., Gottwalles Y., Paganelli F., Loiselet P., Muller J. -J., Koujan M. 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P., Fedorowsky A., Casassus F., Berneau J. -B., Chemin F., Falvo N., Perron J. -M., Poulard J. -E., Barreau A., Beltra C., Corrihons E., Decarsin N., Dubois B., Ducasse E., Giry X., Kemmel A., Ledure S., Lemaire N., Robin F., Rosolin N., Sanchez D., Suissa A., Koniger G., Purr J., Gerbaulet U., Kellner B. -T., Kopf A., Schafer T., Zauzig H., Riegel P., Hohensee H., Eissfeller E., Eder W., Rehling G., Glatzel D., Zutz S., Heinz G. -U., Menke H., Pustelnik A., Sandow P., Ludwig N., Wiswedel H., Wildenauer W., Axthelm C., Schwarz T., Babyesiza A., Stuchlik G., Zimny H. -H., Kropp M., Kahl F., Caspar A., Omankowsky S., Lassig T., Hartmann H. -J., Lehmann G., Bindig H. -W., Hergdt G., Reimer D., Hauk J., Dorsch W., Dshabrailov J., Michel H., Rapp K. -A., Vormann R., Mayer P., Horstmeier U., Eissing V., Hey H., Leuchtgens H., Lilienweiss V., Kolitsch K., Schubert C., Lauer H., Buchner T., Brauer G., Kamin S., Muller K., Abdel-Qader M., Baumbach S., Ebert H. -H., Schwencke C., Schellong S., Bernhardt P., Karolyi L., Sievers B., Haverkamp W., Salbach P., Rohnisch J. -U., Schoen S., Erdle W., Mueller T., Mueller H., Mitrovic V., Babjakova Z., Bergner K., Boehme S., Bonin K., Buckert D., Busch F., Dichristin U., Diez S., Fleck A., Flint K., Floegel H., Fritz C., Frommhold R., Gehre J., Geyer J., Grytzmann A., Hahn M., Helgert K., Hubert K., Kirchner-Volker K., Klein V., Kroll D., Krueger A., Lehmann R., Mann L., Maselli A., Menken G., Mikes K., Mortan H., Nasser N., Nicolaus D., Plauskat A., Pomper L., Quietzsch A., Ravenhorst C., Reichelt C., Reimer C., Schaefer B., Scharrer S., Schirmer K., Schmidt K., Schoene R., Schulze J., Schuppe M., Simon S., Sommer S., Spranger K., Talkenberger A., Tauber K., Tetlak A., Toennishoff T., Voelkel-Babyesiza R., Voigts B., Weiser U., Wesendorf S., Wildenauer S., Wolf T., Wurziger J., Zak J., Zauzig H. -D., Ziefle S., Zincke S., Vangel S., Szalai G., Merkely B., Kancz S., Boda Z., Nagy A., Laszlo Z., Matoltsy A., Gaszner B., Polgar P., Habon T., Noori E., Juhasz G., Kanakaridisz N., Szentpeteri I., Juhasz F., Vertes A., Papp A., May Z., Ferenczi J., Egyutt M., Kis E., Engelthaler G., Szantai G., Fulop E., Gombos P., Gulyas D., Jen P., Kiralyhazine Gyorke E., Kovacs M., Kovacsne Levang S., Marianna S., Radics Z., Sydo N., Szalo R., Szilagyi A., Sztanyik F., Vandrus B., Tiraferri E., Santoro R., Testa S., Di Minno G., Moia M., Caimi T. 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G., Severi S., Capucci A., Lodigiani C., Salomone E., Serviddio G., Tondo C., Golino P., Mazzone C., Iacopino S., Pengo V., Galvani M., Moretti L., Ambrosino P., Banfi E., Biagioli V., Bianchi A., Boggian G., Breschi M., Brusorio S., Calcagnoli F., Campagna G., Carpenedo M., Ciabatta C., Ciliberti G., Cimmino G., D'Arienzo C., Di Gennaro L., Fedele M., Ferrini P. M., Granzow K., Guazzaloca G., Guerra F., Lo Buglio A., Longo S., Macellari F., Mesolella E., Mollica Poeta E., Occhilupo P., Oriana V., Rangel G., Salomone L., Scaccianoce A., Scarone C., Segreti L., Sottilota G., Villani R., Zecca C., Ruiter J. H., Klomps H., Bongaerts M., Pieterse M. G. C., Guldener C., Herrman J. -P., Lochorn G., Lucassen A., Adriaansen H., The S. H. K., Nierop P. R., Hoogslag P. A. M., Hermans W., Groenemeijer B. E., Terpstra W., Buiks C., Boersma L. V. A., Boersma-Slootweg M., Bosman F., Bosschaert M., Bruin S., Danse I., De Graaf J., de Graauw J., Debordes M., Dols S., Geerlings F., Gorrebeeck K., Jerzewski A., Jetten W., Kelderman M., Kloosterman T., Koomen E. M., Krikken J., Melman P., Mulder R., Pronk A., Stallinga-de Vos A., te Kaat J., Tonino P., Uppelschoten B., van de Loo R., van der Kley T., van Leeuwen G., van Putten J. J., Westerman L., Berge E., Sirnes P. A., Gjertsen E., Hole T., Erga K., Hallaraker A., Skjelvan G., Ostrem A., Ghezai B., Svilaas A., Christersson P., Oien T., Hoegh Henrichsen S., Berg-Johansen J., Otterstad J. E., Antonsen H., Ausen K., Claussen H., Dominguez I., Jekthammer A., Lensebraaten A. B., Nilsen V., O'Donovan M., Ringdalen K., Strand S., Korzeniak R., Gieroba A., Biedrzycka M., Ogorek M., Wozakowska-Kaplon B., Loboz-Grudzien K., Kosior J., Supinski W., Kuzniar J., Zaluska R., Hiczkiewicz J., Swiatkowska-Byczynska L., Kucharski L., Gruchala M., Minc P., Olszewski M., Kania G., Krzciuk M., Lajkowski Z., Ostrowska-Pomian B., Lewczuk J., Zinka E., Karczmarczyk A., Chmielnicka-Pruszczynska M., Trusz-Gluza M., Opolski G., Bronisz M., Glanowska G., Ruszkowski P., Jaworska K., Sciborski R., Okopien B., Kukla P., Wozniak-Skowerska I., Galbas K., Cymerman K., Jurowiecki J., Miekus P., Myszka W., Mazur S., Lysek R., Baszak J., Rusicka-Piekarz T., Raczak G., Domanska E., Nessler J., Lesnik J., Ambicka M., Andrzejewski D., Araminowicz J., Barszcz A., Bartkowiak R., Bartnik J., Basiak M., Bekieszczuk E., Bernat L., Biedrzycki L., Biernacka A., Blaszczyk D., Broton E., Brzozowski W., Brzustowska M., Bzymek R., Chmielowski A., Chojnowski P., Cichomski R., Cieslak K., Cieszynska A., Curyllo B., Czamara M., Danilowicz-Szymanowicz L., Dolecka B., Drelich L., Dudzik-Richter B., Dybala T., Dziuba M., Faron W., Figura-Chmielewska M., Frankiewicz A., Gadzinski W., Gasior E., Gosciniecka B., Gutknecht P., Guziewicz M., Jackun-Podlesna A., Jaguszewska G., Jankielewicz J., Jaremczuk-Kaczmarczyk A., Jargiello-Baszak M., Jarzebowski A., Jaskulska-Niedziela E., Jaworska-Drozdowska M., Kabat J., Kaczmarzyk-Radka A., Kalin K., Kaliszczak R., Kiliszek M., Klata M., Kluczewski M., Kobielusz-Gembala I., Kochanska E., Kociolek D., Kolodzinska A., Komlo A., Konopka A., Korczowska E., Kowal E., Kowalczyk H. K., Kremis E., Kruczyk D., Krzesiak-Lodyga A., Krzyzanowski M., Kurdzielewicz W., Kustrzycka-Kratochwil D., Lesniewska-Krynska D., Leszczynski J., Lewicka E., Lichota E., Lip K., Loboz-Rudnicka M., Luka J., Lysek-Jozefowicz A., Machnikowska M., Majewska K., Mariankowski R., Markiewicz A., Mazur M., Metzgier-Gumiela A., Miedlar E., Mielcarek M., Neubauer-Geryk J., Niedek J., Niemirycz-Makurat A., Nowak A., Nowak S., Opielowska-Nowak B., Ozgowicz M., Pawelska-Buczen A., Pawlik-Rak E., Piotrowicz R., Ptaszynski P., Raczynska A., Rogowski W., Romanek J., Romaszkiewicz R., Rostoff P., Roszczyk N., Rozewska-Furmanek D., Rychta J., Rzyczkowska B., Sidor A., Skalska J., Smichura M., Splawski M., Staneta P., Staniszewska E., Starak-Marciniak J., Stopyra-Poczatek M., Sukiennik-Kujawa M., Szafranski J., Szalecki P., Szczepanska A., Szkrobka W., Szuchnik E., Szulowska A., Szumczyk-Muszytowska G., Szwoch M., Traczyk T., Troszczynska M., Trzcinski G., Tybura S., Walasik P., Wegrzynowska M., Wesolowska K., Wieczorek W., Wierzbicka A., Wilczewski P., Wilgat-Szecowka M., Wojewoda P., Wojnowski L., Wrobel M., Zakutynska-Kowalczyk K., Zyczynska-Szmon M., Eltishcheva V., Libis R., Tereshchenko S., Popov S., Kamalov G., Belenky D., Zateyshchikova A., Kropacheva E., Kolesnikova A., Nikolaev K., Egorova L., Khokhlov A., Yakupov E., Poltavskaya M., Zateyshchikov D., Drapkina O., Vishnevsky A., Barbarash O., Miller O., Aleksandrova E., Chizhov P., Sergeev M., Shutemova E., Mazur E., Zrazhevskiy K., Novikova T., Kostenko V., Moiseeva Y., Polkanova E., Sobolev K., Rossovskaya M., Zubeeva G., Shapovalova Y., Nagibovich O., Edin A., Agakhanyan A., Batalov R., Belenkova Y., Bitakova F., Chugunnaya S., Dumikyan A., Erofeeva S., Gorbunova E., Gorshkova T., Gubanov A., Gurmach M., Ivanova Y., Kolesova T., Konyushenko D., Korneeva O., Kropova O., Kuchuk P., Kungurtseva O., Kupriyanova T., Kurylo B., Kuvanova M., Lebedeva O., Lileeva E., Machilskaya O., Medvedeva T., Monako G., Motylev I., Nagibovich G., Novikova E., Orlov Y., Osmolovskaya Y., Ovsannikova A., Platonov D., Rachkova S., Sinitsina O., Speshilova S., Suslova O., Ushakov A., Volodicheva O., Zemlianskaia O., Zhirov I., Zhuravleva E., Zotova I., Garcia P. 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J., Watson, E., Sarai, B., Ahmad, N., Willcock, W., Cairns, J., Sathananthan, S., de Kare-Silver, N., Gilliland, A., Strieder, E., Howitt, A., Vishwanathan, B., Bird, N., Gray, D., Clark, M., Bisatt, J., Litchfield, J., Fisher, E., Fooks, T., Kelsall, A. R., Alborough, E., Wakeling, J., Parfitt, M., Milne, K., Rogers, S., Priyadharshan, R., Oliver, J. L., Davies, E., Abushal, S., Jacobs, M., Hutton, C., Walls, N. I., Thompson, R., Chigbo, C., Zaidi, S. M. A., Howard, M., Butter, K. C., Barrow, S., Little, H., Haq, I. U., Gibbons, L., Glencross, S., Mcleod, A. J., Poland, K., Mulholland, C., Warke, A., Conn, P., Burns, G., Smith, R. N., Lowe, S., Kamath, R., Dau, H. S., Webster, J., Hodgins, I., Vercoe, S., Roome, P. C., Pinnock, H., Patel, J. R. A., Ali, A., Hart, N., Davies, R., Stuart, E., Neden, C. A., Danielsen, M., Heath, R., Sharma, P., Galloway, S., Hawkins, C., Oliver, R., Aylward, M., Mannion, S., Braddick, M., Edwards, D., Rothwell, A. 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A., Lincoln, T., Malone, E., Merliss, A., Merritt, D., Minardo, J., Mooso, B., Orosco, C., Palumbo, V., Parker, M., Parrott, T., Paserchia, S., Pearl, G., Peterson, J., Pickelsimer, N., Purcell, T., Raynor, J., Raziano, S., Richard, C., Richardson, T., Robertson, C., Sage, A., Sanghera, T., Shaw, P., Shoemaker, J., Smith, K., Stephanie, B., Thatcher, A., Theobald, H., Thompson, N., Treasure, L., Tripti, T., Verdi, C., and Worthy, V.
- Subjects
Registrie ,Male ,Latin Americans ,030204 cardiovascular system & hematology ,outcomes ,0302 clinical medicine ,Drug Prescription ,Retrospective Studie ,Risk Factors ,Atrial Fibrillation ,Antithrombotic ,Prospective Studies ,Registries ,030212 general & internal medicine ,Practice Patterns, Physicians' ,Stroke ,Anticoagulant ,Atrial fibrillation ,General Medicine ,Middle Aged ,Treatment Outcome ,Stroke prevention ,outcome ,Female ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,Human ,medicine.medical_specialty ,medicine.drug_class ,Clinical Investigations ,Hemorrhage ,antithrombotic treatment ,Drug Prescriptions ,03 medical and health sciences ,Internal medicine ,medicine ,Humans ,Mexico ,Aged ,Retrospective Studies ,Fibrillation ,business.industry ,Risk Factor ,Anticoagulants ,South America ,medicine.disease ,Drug Utilization ,Clinical trial ,Prospective Studie ,Latin American ,antithrombotic treatment, atrial fibrillation, Latin American, outcomes ,business - Abstract
Author(s): Jerjes-Sanchez, Carlos; Corbalan, Ramon; Barretto, Antonio CP; Luciardi, Hector L; Allu, Jagan; Illingworth, Laura; Pieper, Karen S; Kayani, Gloria; GARFIELD-AF Investigators | Abstract: BackgroundAtrial fibrillation (AF) is an important preventable cause of stroke. Anticoagulation (AC) therapy can reduce this risk. However, prescribing patterns and outcomes in patients with non-valvular AF (NVAF) from Latin American countries are poorly described.MethodsUsing data from the Global Anticoagulant Registry in the FIELD-AF (GARFIELD-AF), we examined the stroke prevention strategies and the 1-year outcomes in patients from four Latin American countries: Argentina, Brazil, Chile, and Mexico.ResultsA total of 4162 patients (2010-2014) were included in this analysis. At the time of AF diagnosis, 39.9% of patients were prescribed vitamin K antagonists (VKA) ± antiplatelet (AP) therapy, 21.8% non-VKA oral anticoagulant (NOAC) ± AP, 24.1% AP only and 14.1% no antithrombotic treatment. The proportion of moderate-high risk patients receiving no AC therapy at participating centers was highest in Mexico (46.4%) and lowest in Chile (14.3%). During 1-year follow-up, the rates of all-cause mortality, stroke/SE and major bleeding were: 5.77 (95% CI) (5.06-6.56), 1.58 (1.23-2.02), and 0.99 (0.72-1.36) and per 100 person-years, respectively, which are higher than the global rates across all countries in GARFIELD-AF. Unadjusted rates of all-cause mortality were highest in Argentina, 6.95 (5.43-8.90), and lowest in Chile, 4.01 (2.92-5.52).ConclusionsGARFIELD-AF results describes the marked variation in the baseline characteristics and patterns of antithrombotic treatments in patients with NVAF in four Latin American countries. Over one-third of patients with a moderate-to-high risk of stroke received no AC therapy, highlighting the need for improved management of patients according to national guideline. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362.
- Published
- 2019
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