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Your search keyword '"McGuire, Philip K."' showing total 14 results
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14 results on '"McGuire, Philip K."'

1. Effect of D‐amino acid oxidase activator (DAOA; G72) on brain function during verbal fluency

Author

Prata, Diana P., primary, Papagni, Sergio A., additional, Mechelli, Andrea, additional, Fu, Cynthia H.Y., additional, Kambeitz, Joseph, additional, Picchioni, Marco, additional, Kane, Fergus, additional, Kalidindi, Sridevi, additional, McDonald, Colm, additional, Kravariti, Eugenia, additional, Toulopoulou, Timothea, additional, Bramon, Elvira, additional, Walshe, Muriel, additional, Murray, Robin, additional, Collier, David A., additional, and McGuire, Philip K., additional

Published
2011
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2. Superior temporal lobe dysfunction and frontotemporal dysconnectivity in subjects at risk of psychosis and in first‐episode psychosis

Author

Crossley, Nicolas A., primary, Mechelli, Andrea, additional, Fusar‐Poli, Paolo, additional, Broome, Matthew R., additional, Matthiasson, Pall, additional, Johns, Louise C., additional, Bramon, Elvira, additional, Valmaggia, Lucia, additional, Williams, Steven C.R., additional, and McGuire, Philip K., additional

Published
2009
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4. Increased inferior frontal activation during word generation: A marker of genetic risk for schizophrenia but not bipolar disorder?

Author

Costafreda, Sergi G., primary, Fu, Cynthia H.Y., additional, Picchioni, Marco, additional, Kane, Fergus, additional, McDonald, Colm, additional, Prata, Diana P., additional, Kalidindi, Sridevi, additional, Walshe, Muriel, additional, Curtis, Vivienne, additional, Bramon, Elvira, additional, Kravariti, Eugenia, additional, Marshall, Nicolette, additional, Toulopoulou, Timothea, additional, Barker, Gareth J., additional, David, Anthony S., additional, Brammer, Michael J., additional, Murray, Robin M., additional, and McGuire, Philip K., additional

Published
2009
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13. Effect of D-amino acid oxidase activator (DAOA; G72) on brain function during verbal fluency.

Author

Prata DP, Papagni SA, Mechelli A, Fu CH, Kambeitz J, Picchioni M, Kane F, Kalidindi S, McDonald C, Kravariti E, Toulopoulou T, Bramon E, Walshe M, Murray R, Collier DA, and McGuire PK

Subjects
Adult, Brain Mapping, Female, Genotype, Humans, Intracellular Signaling Peptides and Proteins, Magnetic Resonance Imaging, Male, Middle Aged, Nerve Net physiology, Neuroimaging, Brain physiology, Carrier Proteins genetics, Glutamic Acid metabolism, Polymorphism, Single Nucleotide, Verbal Behavior physiology
Abstract

Background: The D-Amino acid oxidase activator (G72 or DAOA) is believed to play a key role in the regulation of central glutamatergic transmission which is seen to be altered in psychosis. It is thought to regulate D-amino acid oxidase (DAO), which metabolizes D-serine, a co-agonist of NMDA-type glutamate receptors and to be involved in dendritic arborization. Linkage, genetic association and expression studies have implicated the G72 gene in both schizophrenia and bipolar disorder., Aims: To examine the influence of G72 variation on brain function in the healthy population., Method: Fifty healthy volunteers were assessed using functional magnetic resonance imaging while performing a verbal fluency task. Regional brain activation and task-dependent functional connectivity during word generation was compared between different rs746187 genotypes., Results: G72 rs746187 genotype had a significant effect on activation in the left postcentral and supramarginal gyri (FWE P < 0.05), and on the task-dependent functional coupling of this region with the retrosplenial cingulate gyrus (FWE P < 0.05)., Conclusions: Our results may reflect an effect of G72 on glutamatergic transmission, mediated by an influence on D-amino acid oxidase activity, on brain areas particularly relevant to the hypoglutamatergic model of psychosis., (Copyright © 2011 Wiley Periodicals, Inc.)

Published
2012
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14. Lexical and sentential processing in British Sign Language.

Author

MacSweeney M, Campbell R, Woll B, Brammer MJ, Giampietro V, David AS, Calvert GA, and McGuire PK

Subjects
Adolescent, Adult, Female, Functional Laterality, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Photic Stimulation, Brain Mapping, Persons With Hearing Impairments, Sign Language, Speech physiology, Visual Perception physiology
Abstract

Studies of spoken and written language suggest that the perception of sentences engages the left anterior and posterior temporal cortex and the left inferior frontal gyrus to a greater extent than non-sententially structured material, such as word lists. This study sought to determine whether the same is true when the language is gestural and perceived visually. Regional neural activity was measured using functional MRI while Deaf and hearing native signers of British Sign Language (BSL) detected semantic anomalies in well-formed BSL sentences and when they detected nonsense signs in lists of unconnected BSL signs. Processing BSL sentences, when contrasted with signed lists, was reliably associated with greater activation in the posterior portions of the left middle and superior temporal gyri and in the left inferior frontal cortex, but not in the anterior temporal cortex, which was activated to a similar extent whether lists or sentences were processed. Further support for the specificity of these areas for processing the linguistic-rather than visuospatial-features of signed sentences came from a contrast of hearing native signers and hearing sign-naïve participants. Hearing signers recruited the left posterior temporal and inferior frontal regions during BSL sentence processing to a greater extent than hearing non-signers. These data suggest that these left perisylvian regions are differentially associated with sentence processing, whatever the modality of the linguistic input., (Hum Brain Mapp, 2005. (c) 2005 Wiley-Liss, Inc.)

Published
2006
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