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The default mode network (DMN) typically exhibits deactivations during demanding tasks compared to periods of relative rest. In functional magnetic resonance imaging (fMRI) studies of episodic memory encoding, increased activity in DMN regions even predicts later forgetting in young healthy adults. This association is attenuated in older adults and, in some instances, increased DMN activity even predicts remembering rather than forgetting. It is yet unclear whether this phenomenon is due to a compensatory mechanism, such as self-referential or schema-dependent encoding, or whether it reflects overall reduced DMN activity modulation in older age. We approached this question by systematically comparing DMN activity during successful encoding and tonic, task-independent, DMN activity at rest in a sample of 106 young (18-35 yrs) and 111 older (60-80 yrs) healthy participants. Using voxel-wise multimodal analyses, we assessed the age-dependent relationship between DMN resting-state amplitude (mean percent amplitude of fluctuation, mPerAF) and DMN fMRI signals related to successful memory encoding, as well as their modulation by age-related hippocampal volume loss, while controlling for regional grey matter volume. Older adults showed lower resting-state DMN amplitudes and lower task-related deactivations. However, a negative relationship between resting-state mPerAF and subsequent memory effect within the precuneus was observed only in young, but not older adults. Hippocampal volumes showed no relationship with the DMN subsequent memory effect or mPerAF. Lastly, older adults with higher mPerAF in the DMN at rest tend to show higher memory performance, pointing towards the importance of a maintained ability to modulate DMN activity in old age.

Memory-related functional magnetic resonance imaging (fMRI) activations show age-related differences across multiple brain regions that can be captured in summary statistics like single-value scores. Recently, we described two single-value scores reflecting deviations from prototypical whole-brain fMRI activity of young adults during novelty processing and successful encoding. Here, we investigate the brain-behavior associations of these scores with age-related neurocognitive changes in 153 healthy older adults. All scores were associated with episodic recall performance. The memory network scores, but not the novelty network scores, additionally correlated with medial temporal gray matter and a composite measure comprising pro-active inhibition, episodic memory, tonic alertness, flexibility, and working memory. Our results thus suggest that novelty-network-based fMRI scores show high brain-behavior associations with episodic memory and that encoding-network-based fMRI scores additionally capture individual differences in global cognitive function. More generally, our results suggest that single-value scores of memory-related fMRI provide a comprehensive measure of individual differences in network dysfunction that may contribute to age-related cognitive decline.

Parnia et al. recently published suggestions for the study of death and experiences recalled in a near-death context. We have serious reservations about the authors' statements. In this commentary, we discuss the omissions and knowledge gaps inherent to the authors' paper, which among others include incorrect neurological claims about brain death and misunderstandings regarding the terminology of consciousness. Although we believe that (near-)death research deserves a framework guideline, the paper by Parnia and colleagues is misleading and, contrary to the authors' intention, hinders the scientific understanding of near-death experiences and the neural mechanisms occurring in the dying brain.

Hippocampal neuronal oscillations reflect different cognitive processes and can therefore be used to dissect the role of hippocampal subfields in learning and memory. In particular, it has been suggested that encoding and retrieval is associated with slow gamma (25-55 Hz) and fast gamma (60-100 Hz) oscillations, respectively, which appear in a nested manner at specific phases of the ongoing theta oscillations (4-12 Hz). However, the relationship between memory demand and the theta phase of gamma oscillations remains unclear. Here, we assessed the theta phase preference of gamma oscillations in the CA1 region, at the starting and junction zones of a T-maze, while rats were learning an appetitive task. We found that the theta phase preference of slow gamma showed a ~180° phase shift when animals switched from novice to skilled performance during task acquisition. This phase-shift was not present at the junction zone, where animals chose a right or left turn within the T-maze, suggesting that a recall/decision process had already taken place at the starting zone. Our findings indicate that slow gamma oscillations support both encoding and retrieval, depending on the theta phase at which they occur. These properties are particularly evident prior to cognitive engagement in an acquired spatial task.

Information learned in relation to oneself is typically better remembered, termed the self-reference effect (SRE). This study aimed to elucidate the developmental trajectory of the SRE in recollection and source memory from mid-childhood to young adulthood. In 2018-2019 in Baltimore, Maryland, 136 seven- to thirty-year-olds (77 female; approximately 80% White, 15% Asian American, 5% Black) viewed objects on one of two backgrounds and answered a self-referential or semantic question for each. A recognition test probed memory for objects and source details (inherent: question type; peripheral: background image). SRE increased with age for detailed recollection (r = .189), but not familiarity, and extended to inherent source memory. This suggests that self-referencing promotes richer memory in children and develops into young adulthood.

Previous research demonstrates that self-distancing helps in regulating negative emotions. Furthermore, adopting a distanced perspective when referring to the self has been shown to be a simple and effective way to regulate emotion. Moreover, previous research has demonstrated several mechanisms whereby the distanced perspective eventually leads to the decrease in negative emotions. Building on this literature, the present research proposed that a rational point of view induced by adopting a distanced perspective would play a critical role in this process. The results from two studies supported the proposition. Specifically, in recalling (Study 1) and writing (Study 2) about anger-provoking events, those who adopted a distanced perspective were more likely to take a rational point of view when reflecting on the event than did those who adopted a self-immersed perspective. Furthermore, such differences in the rational perspective were associated with the corresponding differences in negative affect.

WHAT IS KNOWN ABOUT ON THE SUBJECT?: Alternative option was developed to improve care due to the increasing costs of care cost and the number of people diagnosed with dementia. Reminiscence therapy is a commonly implemented alternative option used in long-term care facilities. Reminiscence therapy is designed for cognitive decline that is also known as life review. WHAT THIS PAPER ADDS TO EXISTING KNOWLEDGE?: Reminiscence therapy, known as psychosocial interventions in dementia care, can be used to assist people with dementia recollect prior events, activities, and experiences in order to improve their cognitive, mood, and overall well-being. Reminiscence therapy increased cognitive function and quality of life and reduced depressive and neuropsychiatric symptoms among people with dementia. Reminiscence therapy may be considered a useful non-pharmacological intervention for people with dementia living in nursing homes or other long-term care facilities. The development of a global standard protocol for the application of reminiscence therapy may be necessary for future randomized controlled trials (RCTs). ABSTRACT: Introduction Reminiscence therapy is an alternative to pharmaceutical intervention provided during long-term care, especially for individuals with dementia. However, the effects of reminiscence therapy in dementia care remain inconclusive. Aim The goal of this study is to examine the effects of reminiscence therapy implementation in people with dementia. Design Systematic literature review and meta-analysis were conducted in accordance with the PRISMA guidelines. Methods This study searched systematically using 6 databases. The eligibility criteria included patients with dementia, applied reminiscence therapy, randomized controlled trials or quasi-experimental studies, and published in the English language. The PEDro scale was used to assess the methodological quality of the included studies. The meta-analysis was performed using a random-effects model to calculate the pooled effects of reminiscence therapy. Stata 16.0 was used for statistical analysis. Result A total of 29 studies met the eligibility criteria, including 3102 participants. Overall, reminiscence therapy increased cognitive functions and quality of life and decreased depression and neuropsychiatric symptoms. Implication for Practice Reminiscence therapy may be considered a useful non-pharmacological intervention for people with dementia living in nursing homes or other long-term care facilities. A standard protocol for reminiscence therapy may be necessary for future studies.

The incidental acquisition of multimodal associations is a key memory function for everyday life. While the posterior parietal cortex has been frequently shown to be involved for these memory functions, ventral and dorsal regions revealed differences in their functional recruitment and the precise difference in multimodal memory processing with respect to the associative process has not been differentiated. Using an incidental multimodal learning task, we isolated the associative process during multimodal learning and recollection. The result of the present functional magnetic resonance imaging (fMRI) study demonstrated that during both learning and recollection a clear functional differentiation between ventral and dorsal posterior parietal regions was found and can be related directly to the associative process. The recruitment of a ventral region, the angular gyrus, was specific for learning and recollection of multimodal associations. In contrast, a dorsal region, the superior parietal lobule, could be attributed to memory guided attentional processing. Independent of the memory stage, we assumed a general role for the angular gyrus in the generation of associative representations and updating of fixed association, episodic memory.

Recollection of personal past events differs across the lifespan. Older individuals recall fewer episodic details and convey more semantic information than young. Here we examine how gray matter volumes in temporal lobe regions integral to episodic and semantic memory (hippocampus and temporal poles, respectively) are related to age differences in autobiographical recollection. Gray matter volumes were obtained in healthy young (n = 158) and old (n = 105) adults. The temporal pole was demarcated and hippocampus segmented into anterior and posterior regions to test for volume differences between age groups. The Autobiographical Interview was administered to measure episodic and semantic autobiographical memory. Volume associations with episodic and semantic autobiographical memory were then assessed. Brain volumes were smaller for older adults in the posterior hippocampus. Autobiographical memory was less episodic and more semanticized for older versus younger adults. Older adults also showed positive associations between temporal pole volumes and episodic autobiographical recall; in the young, temporal pole volume was positively associated with performance on standard laboratory measures of semantic memory. Exploratory analyses revealed that age-related episodic autobiographical memory associations with anterior hippocampal volumes depended on sex. These findings suggest that age differences in brain structures implicated in episodic and semantic memory may portend reorganization of neural circuits to support autobiographical memory in later life.

Parental elaborative reminiscing supports young children's autobiographical memory, narrative, and socioemotional skills.This study is an adolescent follow-up of a reminiscing intervention in which 115 primary-caregiver mothers of toddlers were randomly assigned to a control group (n = 59) or to receive training in elaborative reminiscing (n = 56) for the next year.At age 15, 93 of the now-adolescents (81%) were invited to narrate a turning point in their lives and to report on their personality traits and well-being. Turning-point narratives were coded for causal coherence (connections between past events and present self) and thematic coherence (elaboration and resolutions).Adolescents whose mothers were in the intervention group told more causally coherent turning-point narratives and reported fewer emotional problems than control participants, covarying for baseline measures and personality traits.Maternal elaborative reminiscing in early childhood appears to have long-term benefits for adolescents' causal coherence in turning-point narratives and well-being.

Researchers investigated the use of an emotional support robot to improve the well-being of institutionalized older adults in Armenia. The autonomous assistant called Robin the Robot assessed the cognitive and psychosocial needs of elders in a nursing home in Armenia. Robin the Robot is a semi-autonomous robot that interprets facial expressions and conversational contextual clues to understand emotions from individuals, and then uses artificial intelligence to guide its responses and develop a therapeutic interaction with patients METHOD: The twelve-week study was a randomized control trial of using Robin the Robot as an intervention to improve well-being of older individuals in long-term nursing care facilities in Armenia. Upon enrollment, participants completed a brief demographics interview. Evaluation of study participants, both pre and post-test included: the International Short-Form of the Positive and Negative Affect Schedule (I-PANAS-SF)The use of emotional support robots improved memory and cognitive functions of the elders, as well as slight improvement in mood. This project made a significant contribution in improving health outcomes for the elderly, bringing more attention to nursing facilities, and contributing to research on health and prevention.

Psychosis is diagnosed based on disruptions in the structure and use of language, including reduced syntactic complexity, derailment, and tangentiality. With the development of computational analysis, natural language processing (NLP) techniques are used in many areas of life to make evaluations and inferences regarding people's thoughts, feelings and behavior. The present study explores morphological characteristic of schizophrenia inpatients using NLP. Transcripts of recorded stories by 49 male subjects (24 inpatients diagnosed with schizophrenia and 25 controls) about 14 Thematic Apperception Test (TAT) pictures were morphologically analyzed. Relative to the control group, the schizophrenic inpatients employed: (1) a similar ratio of nouns, but fewer verbs, adjectives and adverbs; (2) a higher ratio of lemmas to token (LTR) and type to token (TTR); (3) a smaller gap between LTR and TTR; and (4) greater use of the first person. The results were cross-verified using three well-known fitting classifier algorithms (Random Forest, XGBoost and a support vector machine). Tests of prediction accuracy, precision and recall found correct attribution of patients to the schizophrenia group at a rate of between 80 and 90%. Overall, the results suggest that the language of schizophrenic inpatients is significantly different from that of healthy controls, being morphologically less complex, more associative and more focused on the self. The findings support NLP analysis as a complementary addition to the traditional clinical psychosis evaluation for schizophrenia.

Interruptions lead to a deterioration of primary task performance. Applied research usually describes a delay in primary task resumption as an essential component of this performance deficit. Here, we investigate this approach using electrophysiological correlates of the focusing of attention within working memory, a process that is fundamental to switching between different tasks. A lateralized working memory task was frequently interrupted by either a high- or low-demanding arithmetic task and a subsequent retrospective cue indicated the working memory item required for later report. The detrimental effect of interruptions on primary task performance was most pronounced for high-demanding interruptions. After retro-cue presentation, fronto-central theta power (4–7 Hz) was lowest following high-demanding interruptions and posterior alpha power (8–14 Hz) was less suppressed in the two interruption conditions. These effects might be related to a deficit in attentional control processes following the retrospective cue. Furthermore, we introduce the suppression of posterior alpha power contralateral to the remembered primary task stimuli during the interruption phase as a temporal marker for primary task resumption. Especially for cognitively demanding interruption tasks, this effect seems to overlap in time with the processing of the interruption, which should contribute to the primary task performance deficit.

Scene Construction Theory suggests similar neural mechanisms for visual imagery and autobiographical memory, supporting the seeming scientific consensus that a loss of visual imagery affects autobiographical memory. Based on the Dual Coding Theory and the Reverse Hierarchy Model, we also assumed influences of visual imagery on recent visual memory and even verbal memory, although little evidence has been provided so far. Thus, in a sample of 67 congenital aphantasics (= persons without mental imagery) and 32 demographically matched controls, it was investigated whether deficits in visual imagery are associated with deficits in visual as well as verbal short-term and long-term memory. The memory tasks were theoretically selected based on task difficulty, retrieval condition, and subcategories of stimuli, as previous null findings were attributed to insensitive tasks that were solvable by aphantasics by means of non-visual alternative strategies. Significant group differences were found in all memory components, with aphantasics performing worse than non-aphantasics. Therefore, evidence was obtained for the influence of visual imagery on all memory components beyond autobiographical memory.

OBJECTIVE Self-defining memories (SDMs) are units of life-story analysis, whose features resemble elements from narrative identity's factorial structure. To bridge narrative-identity and personality-trait domains, we conducted a replication and extension of prior research. METHOD We linked four SDM features - affect, specificity, meaning making, and content - to the Big Three trait domains of personality and psychopathology in a small sample that was well-powered for multilevel modeling (133 participants, 1330 SDMs). RESULTS Affect SDM affect correlated with indices of Positive Emotionality and Negative Emotionality, and narrative themes of contamination were associated with Negative Emotionality. Specificity SDM specificity vs. overgenerality related to Constraint and Negative Emotionality indices, lending support to the executive dysfunction and emotional disorder theories of overgeneral autobiographical memory. (Tests of the avoidance thesis of overgeneral memory were inconclusive.) Meaning making Explicit meaning making in SDMs reflected adaptive personality. It moderated (or buffered) the link between SDMs' affect and chronic emotional distress. Content The links between SDM content and traits suggest that SDMs reflect personal goals, whose fulfillment or frustration relate to psychological health. CONCLUSIONS This research serves replication purposes as well as the purpose of connecting two major domains of personality: narrative identity and adaptive and maladaptive traits.

Difficulty retrieving proper names is common in older adults, coinciding with the accumulation of aggregated proteins in mid-life. We investigated the ability of healthy older adults to retrieve the names of famous faces in relation to positron emission tomography measurements of amyloid-β plaques and tau neurofibrillary tangles. More tau in the left fusiform and parahippocampal gyrus was related to reduced proper name retrieval performance and this effect was potentiated by amyloid-β. These findings provide an explanation for a common complaint of older adults and link proper name retrieval to neural systems involved in face perception, memory, and naming This article is protected by copyright. All rights reserved.

A widely accepted view in memory research is that previously acquired information can be reactivated during sleep, leading to persistent memory storage. Recently, Targeted Memory Reactivation (TMR) has been developed as a technique whereby specific memories can be reactivated during sleep using a sensory stimulus linked to prior learning. TMR can improve various types of memory, raising the possibility that it may be useful for cognitive enhancement and clinical therapy. A major challenge for the expanded use of TMR is that experimenters must manually control stimulation timing and intensity, which is impractical in most settings. To address this limitation, we developed the SleepStim system for automated TMR in the home environment. SleepStim includes a smartwatch to collect movement and heart-rate data, plus a smartphone to emit auditory cues. A machine-learning model identifies periods of deep non-REM sleep and triggers TMR sounds within these periods. We tested whether this system could replicate the spatial-memory benefit of in-lab TMR. Participants learned the locations of objects on a grid, and then half of the object locations were reactivated during sleep over three nights. In an experiment with 61 participants, the TMR effect was nonsignificant but varied systematically with stimulus intensity; low-intensity but not high-intensity stimuli produced memory benefits. In a second experiment with 24 participants, we limited stimulus intensity and found that TMR reliably improved spatial memory, consistent with effects observed in laboratory studies. We conclude that SleepStim can effectively accomplish automated TMR and that avoiding sleep disruption is critical for TMR benefits.

Research has found mixed evidence for the production effect in childhood. Some studies have found a positive effect of production on word recognition and recall, while others have found the reverse. This paper takes a developmental approach to investigate the production effect. Children aged 2-6 years (n = 150) from a predominantly white population in Ottawa, Canada were trained on familiar words which were either seen, heard or produced, followed by a recall task. Results showed a developmental shift: younger participants showed a reverse production effect, recalling more words that were heard during training, while older children showed the typical production effect, recalling more produced words. The effect of production on recall is not unidirectional and varies by age.

People regularly outsource parts of their memory onto external memory stores like computers or smartphones. Such cognitive offloading can enhance subsequent memory performance, as referred to the saving-enhanced memory effect (Storm & Stone, 2015). The cognitive mechanisms of this effect are not clear to date, however similarities to list-method directed forgetting (LMDF) have been stated. Here, we examined in 52 participants the electrophysiological (EEG) correlates of the saving-enhanced memory effect and compared our results to earlier LMDF findings (Hanslmayr et al., 2012). For this purpose, EEG alpha power and alpha phase synchrony during the encoding of two word lists were compared as a function of saving or no-saving. We hypothesised that if saving-enhanced memory was related to LMDF, saving in comparison to no-saving between lists should reduce alpha power and alpha phase synchrony during List 2 encoding, two effects that have been related to List 2 encoding benefits and List 1 inhibition in the earlier LMDF work. The results showed no statistically significant saving-enhanced memory effect and no significant effects in EEG alpha power or alpha phase synchrony. Possible explanations for and implications of these non-significant findings are discussed.

Background: Recent evidence suggests that pain dampens attentional processes. However, much of this work has been based on higher-order attentional tasks that involve only spatial attention. Other aspects of the process through which pain engages and holds attention are relatively understudied, in particular, temporal attention. The present set of studies explored how naturally occurring pain (i.e. acute headache) and pain-valenced stimuli affect the ability to recall the second of two targets presented in rapid succession. Methods: Across both experiments participants were required to indicate the presence of a predefined probe (T2) and, in the dual task, identify a target (T1). The probe (T2) was placed in three different temporal proximities (ranging from 70 to 1000ms) following presentation of the target (T1). In Experiment 1, 36 participants completed a task that comprised a rapid stream of letters. Experiment 2 manipulated the threat value, and the complexity, of the stimuli by replacing letters with words. In the dual task condition, T1 was a word from one of four valence categories (neutral, positive, negative, pain). Results: Being in acute pain reduced the accuracy of identification. This reduction in performance occurred regardless of the temporal positioning of the probe, consistent with previous work that suggests pain has an overall dampening effect. Furthermore, when the valence category of the word was pain-related, T2 accuracy performance was negatively affected. Conclusion: These findings add to the previous evidence that pain has a general dampening effect on attention and that pain-related stimuli are difficult to disengage from. Significance: Pain captures attention to allow cognate resources to be directed appropriately in response. However, the temporal effects of this attentional capture are poorly understood. Findings indicate that acute headache pain has a negative impact on participants’ performance when identifying the second of two targets presented in close temporal proximity, and that pain-valenced stimuli exacerbate this effect. These findings demonstrate how pain affects early attention and highlights the potential role of disengagement, rather than orientation, of attention in the pain experience.

Music listening provides one of the most significant abstract rewards for humans because hearing music activates the dopaminergic mesolimbic system. Given the strong link between reward, dopamine, and memory, we aimed here to investigate the hypothesis that dopamine-dependent musical reward can drive memory improvements. Twenty-nine healthy participants of both sexes provided reward ratings of unfamiliar musical excerpts that had to be remembered following a consolidation period under three separate conditions: after the ingestion of a dopaminergic antagonist, a dopaminergic precursor, or a placebo. Linear mixed modeling of the intervention data showed that the effect of reward on memory-i.e., the greater the reward experienced while listening to the musical excerpts, the better the memory recollection performance-was modulated by both dopaminergic signaling and individual differences in reward processing. Greater pleasure was consistently associated with better memory outcomes in participants with high sensitivity to musical reward, but this effect was lost when dopaminergic signaling was disrupted in participants with average or low musical hedonia. Our work highlights the flexibility of the human dopaminergic system, which can enhance memory formation not only through explicit and/or primary reinforcers but also via abstract and aesthetic rewards such as music.

Objective Patient reported outcome measures (PROMs) for assessment of chronic rhinosinusitis (CRS) employ a variety of recall periods and response scales for reporting CRS symptom burden. CRS patient perspective is unknown with respect to recall periods and response scales in PROMs. Design Cross-sectional study. Setting Tertiary rhinology clinic. Participants 63 adults with CRS. Main outcome measures Participants were asked to choose which CRS symptom recall period - one day, two weeks, one month, or greater than one month - was most reflective of their current disease state and best to base treatment recommendations (including surgery) upon. Participants were also asked to report on which of six response scales (one visual analogue scale [VAS] and five Likert scales ranging from four to eight items) was easiest to use and understand, and most preferred. Results A majority of participants felt the current state of their CRS symptoms was best reflected by a recall period of two weeks to one month; however, patients preferred that recommendations about treatments, including endoscopic sinus surgery, be determined by symptoms experienced over at least a one-month period. Participants generally found the VAS and seven-item Likert scale to be the easiest to use and understand, and their most preferred scales. No patient characteristics associated with preferences for recall periods or response scales. Conclusion Future PROMs for CRS symptoms should consider assessment of symptoms over a one-month time frame and use either a VAS or seven-item Likert response scale to optimally balance reflection of current disease state, need for intervention and patient preference.

Psychological interventions often use guided discovery and other techniques for diagnostic exploration and intervention planning. This way, memories may arise in the person, which may be true or false. False memories of earlier events can be harmful and result in real suffering, similar to actual traumatic memories. Based on cognitive psychological and psycho-traumatological findings, there is pronounced dissent in the academic disciplines regarding the conceptualization, relevance and research of false memories. This review contributes to the basic question of how often false beliefs and false memories may be induced within the frame of different interactional techniques. A systematic review has been conducted of 59 articles from (quasi-)experimental studies and two qualitative sources from 30 data bases. Three main methods of memory induction provide the basis for reporting: imagination inflation, false feedback, and memory implantation. Due to the conceptual and methodological diversity of the studies, the results appear to be heterogeneous. Free and guided imagery, as well as suggestive statements, could induce false beliefs or false memories in, on average, 20%-50% of the participants who underwent experimental manipulation concerning false past events. A false belief induction may occur after dream interpretation or hypnosis in more than 50% of participants. Personalized suggestion is more effective in inducing memory than the general plausibility of the suggested events. Further research questions are which therapeutic actions seem appropriate in cases of harmful false memories. This depends not only on whether there are veridical elements in the false memory but also on the quality and meaning of the memory for the person's life and ability to cope with burdens.

This study investigated age-dependent improvements of monitoring and control in 7/8- and 9/10-year-old children. We addressed prospective (judgments of learning and restudy selections) and retrospective metacog- nitive skills (confidence judgments and withdrawal of answers). Children (N = 305) completed a paired-asso- ciate learning task twice, with a 1-year delay. Results revealed improvements in retrospective, but not in prospective monitoring and control. Furthermore, control remained suboptimal, seemingly a consequence of overoptimistic monitoring. Both age groups showed stronger monitoring-based control at the second com- pared to the first assessment. The comparison with a cross-sectional sample (N = 144) revealed that improve- ments in retrospective monitoring can be mainly attributed to naturally occurring development, whereas retrospective control seemed to improve due to increased task familiarity.

OBJECTIVE This study was undertaken to evaluate the influence that subject-specific factors have on intracranial interictal epileptiform discharge (IED) rates in persons with refractory epilepsy. METHODS One hundred fifty subjects with intracranial electrodes performed multiple sessions of a free recall memory task; this standardized task controlled for subject attention levels. We utilized a dominance analysis to rank the importance of subject-specific factors based on their relative influence on IED rates. Linear mixed-effects models were employed to comprehensively examine factors with highly ranked importance. RESULTS Antiseizure medication (ASM) status, time of testing, and seizure onset zone (SOZ) location were the highest-ranking factors in terms of their impact on IED rates. The average IED rate of electrodes in SOZs was 34% higher than the average IED rate of electrodes outside of SOZs (non-SOZ; p

Physical stress, such as from the cold-pressor test, has been robustly associated with altered memory retrieval, but it is less clear whether the same happens following psychosocial stress. Studies using psychosocial stressors report mixed effects on memory, leading to uncertainty about the common cognitive impact of both forms of stress. The current study uses a series of four carefully designed experiments, each differing by only a single critical factor to determine the effects of psychosocial stress on specific aspects of episodic memory. In three experiments, we induced psychosocial stress after participants encoded words, then assessed retrieval of those words after a prolonged delay. These experiments found no effect of post-encoding stress on recognition of neutral words or cued recall of word-pairs, but a small effect on recollection of semantically related words. There were, however, positive relationships within the stress group between measures of stress (cortisol in experiment 1 and self-reported-anxiety in experiment 3) and recollection of single word stimuli. In the fourth experiment, we found that psychosocial stress immediately before retrieval did not influence word recognition. Recollection, particularly for semantically related stimuli, may therefore be more susceptible to the effects of psychosocial stress, and future studies can assess how this relates to other forms of stress. Overall, our findings suggest that the effects of psychosocial stress on episodic memory may be more subtle than expected, warranting further exploration in larger studies.

One common and unfortunately overlooked obstacle to the detection of sexual abuse is non-disclosure by children. Non-disclosure in forensic interviews may be expressed via concealment in response to recall questions or via active denials in response to recognition (e.g., yes/no) questions. In two studies, we evaluated whether adults' ability to discern true and false denials of wrongdoing by children varied as a function of the types of interview question the children were asked. Results suggest that adults are not good at detecting deceptive denials of wrongdoing by children, even when the adults view children narrate their experiences in response to recall questions rather than provide one word answers to recognition questions. In Study 1, adults exhibited a consistent "truth bias," leading them toward believing children, regardless of whether the children's denials were true or false. In Study 2, adults were given base-rate information about the occurrence of true and false denials (50% of each). The information eliminated the adults' truth bias but did not improve their overall detection accuracy, which still hovered near chance. Adults did, however, perceive children's denials as slightly more credible when they emerged in response to recall rather than recognition questions, especially when children were honestly denying wrongdoing. Results suggest the need for caution when evaluating adults' judgments of children's veracity when the children fail to disclose abuse.

The Concealed Information Test (CIT) utilizes psychophysiological measures to detect crime-related knowledge in a suspect's memory. In other words, it can discriminate between knowledgeable (guilty) and unknowledgeable (innocent) suspects. The majority of CIT research is however conducted in controlled laboratory settings, which are more resistant to external influences than realistic forensic settings. Such influences include retroactive memory interferences which may threaten the validity of the CIT. One notable example is the misinformation effect - retroactive memory distortions caused by exposure to misleading information regarding a past event. The current study is a constructive replication of Volz et al. (J Forensic Sci 2017;63:1419) examining the effects of misleading information on the CIT. Participants underwent a three-stage experiment including a mock crime, exposure to misleading information, and a CIT. Results show that when misleading information was presented, explicit memory of the mock crime was reduced, but the physiological responses to the critical CIT items were only partially attenuated. This could suggest that the detection of crime-relevant information, using skin conductance and respiration measures, might be possible even when suspects are exposed to misleading information.

The present study examined resurgence of reinforced variability in college students, who completed a 3-phase computer-based variability task. In the first phase, baseline, points were delivered for drawing rectangles that sufficiently differed from previous rectangles in terms of a target dimension (size or location, counterbalanced) but were sufficiently similar in terms of the alternative dimension. In the second phase, alternative, points were only delivered for rectangles that were sufficiently different in terms of the alternative dimension, but repetitive in terms of the target dimension. In the third phase, extinction, no points were delivered. In baseline, participants made rectangles that were highly varied in terms of the target dimension and less varied in terms of the alternative dimension, and vice versa in the alternative phase. During extinction, levels of variability increased for the target dimension, providing evidence for resurgence of reinforced variability of a specific dimension of behavior. However, levels of variability also remained high for the alternative dimension, indicating that extinction-induced response variability may also have impacted the results. Although future research is needed to explore other explanations, the results of this study replicate prior research with pigeons and provide some support for the notion of variability as an operant.

Objective Case report notions of unexpected memory retrieval in patients with severe dementia near to death are starting to alter the central "irreversible" paradigm of dementia and locate dementia as a problem of memory retrieval, not consolidation. We suggest that the most likely central tenet of this paradoxical memory retrieval is the fluctuation of neuromodulators projecting from the brain stem to the medial prefrontal cortex and the hippocampus. The neuromodulation-centric explanation of this phenomenon aims to open the "irreversible" paradigm of dementia up for discussion and suggest a plausible treatment strategy by questioning how the devastating process of death fluctuates memory performance in severe dementia. Background Supporting demented patients, who are mostly unresponsive, without making demands or asking a question and regarding them as valuable human beings unexpectedly improve their memory performance around the time of death. New lucidity hypothesis Around the time of death, neurological signs (hyper-arousal and -attention) of demented people point out that neurotransmitter discharges are dramatically changed. Relatively resistant neuromodulator circuits to neurodegeneration can maintain optimal levels of arousal and attention for memory processing. In this way, unexpected episodes of lucidity can be triggered. Also, corticotropin-releasing peptides might increase mental clarity by increasing the excitability of the neuromodulator circuits. The science of memory retrieval is more complicated and nuanced than retrieval observations in case reports, but the rapid development of new techniques holds promise for future understanding of lucidity in severe dementia. Major challenge for the model There is no an animal or human model to test this hypothesis; however, the similarities between neurological signs (instantaneous cognitive fluctuations) of delirium and paradoxical lucidity could provide a unique window to understand neural events of terminal lucidity on a modified animal model of delirium. Likewise, similarities between unexpected consciousness signs of terminal lucidity and lucid dreaming suggest that lucid dreaming episodes might be considered a human model for terminal lucidity research.

Cognitive inhibition has been suggested to deteriorate in Alzheimer's disease. While numerous studies with different experimental paradigms found evidence on impaired inhibition in attention and memory, evidence in favour of intact memory inhibition has been reported with regard to the phenomenon of retrieval-induced forgetting (Moulin et al., 2002). Here, we adapted the previously used paradigm in order to reduce the contribution of non-inhibitory processes and examined whether retrieval-induced forgetting could still be observed in a sample of participants with diagnosed Alzheimer's disease. In contrast to the previous finding, we found that retrieval-induced forgetting only occurred in an age-matched control group. These results suggest that inhibitory deficits in Alzheimer's disease also generalize to memory inhibition that resolves interference occurring during retrieval, whereas effects of retrieval-induced forgetting may still occur when non-inhibitory causes, such as, blocking by previously retrieved content, are not precluded.

Although individuals with autism spectrum disorder (ASD) have been often shown to display similar memory performance on semantic memory tasks compared to typically developing (TD) children, there is ongoing debate about whether and how their ability to remember specific past events (i.e., episodic memory) is impaired. We assessed a sample of 62 children with ASD and 72 TD children, ranging in age between 8 and 12 years on 2 memory tasks. Participants encoded a series of images and their association with either where they appeared on the screen (item-space association task) or with the color of an image's border (item-color association task). Children with ASD showed worse memory in the item-space association task compared to their TD peers, but comparable memory for the item-color association task. These differences persisted when age, intellectual quotient, and general item recognition memory were accounted for statistically. We interpret these results in light of evidence for specific deficits along the dorsal stream affecting processing of spatiotemporal information in ASD. Autism Res 2020, 13: 1985-1997. © 2020 International Society for Autism Research and Wiley Periodicals LLC LAY SUMMARY: Episodic memory requires the ability to bind contextual details (such as color, location, etc.) to an item or event in order to remember the past with specific detail. Here, we compared children with autism spectrum disorder (ASD) and typically developing (TD) children on tasks examining episodic memory. Children with ASD recalled more poorly previously seen items and their associated space-related details, but they performed comparably to TD children on color details. We discuss the possible mechanisms that contribute to worse spatial processing/recall in ASD.

Behavioral data on episodic recollection in autism spectrum disorders (ASD) point limited relational memory functioning. However, the involvement of successive memory processes in the profile of episodic memory in ASD needs more study. Here, we used event-related potentials (ERP) to investigate the time course of episodic recollection with an associative recognition paradigm with picture pairs. Twenty-two participants with ASD and 32 with typical development (TD), all right-handed, were included. Behavioral results confirmed difficulties in correctly recognizing identical pairs in the ASD relative to TD group. We found an unexpected amplitude decrement on the P2 (220-270 msec) and FN400 (350-470 msec) potentials, suggesting diminished priming and familiarity effects in the ASD relative to TD group. However, ERP data revealed that the recognition of associative information relies on the same electrophysiological process (old/new effect in the 600-700-msec late positive component) in ASD participants as in TD ones, with a parietal extension in the ASD group. These results suggest that the electrophysiological processes of associative recognition are qualitatively similar in individuals with and without ASD but may differ quantitatively. This difference may be driven by the reduced early processing of picture pairs that may in turn lead to their diminished integration into the semantic memory system, being partially compensated by a greater involvement of associative memory during the recollection process. Other studies would be useful to go further in identifying these cognitive processes involved in atypical recognition in ASD and their neural substrates. Autism Res 2020, 13: 1998-2016. © 2020 International Society for Autism Research and Wiley Periodicals LLC LAY SUMMARY: We identified diminished performance on the associative recognition of picture pairs in adolescents and young adults with autism when compared to typical development. Electrophysiological data revealed qualitative similarities but quantitative differences between-group, with diminished priming and familiarity processes partially compensated by an enhanced parietal recollection process.

Our memories are made of detailed sensory information representing the puzzle pieces of our personal past. The type of memory integrating sensory features is referred to as relational memory. The main objective of this study was to investigate whether relational memory is affected in children with autism spectrum disorder (ASD) since altered relational memory may contribute to atypical episodic memory observed in ASD. We also examined the association between perceptual style and relational memory abilities. Children with ASD (n = 14) and typically developed (TD) children (n = 16, 9-15 years old) completed a memory task with three conditions: two single-feature conditions measuring memory for objects and locations, and one relational memory condition measuring memory for objects and their locations combined. The Children's embedded figures test was administered to measure perceptual style. The ASD group selected more incorrect stimuli (false alarms) than the TD group, resulting in a lower proportion of correctly recognized targets across all memory conditions. The ASD group did not display a more local perceptual style than the TD group. However, perceptual style was associated with improved memory abilities across conditions. Our findings indicate that the overall memory performance of children with ASD is less stable, leading them to more incorrect responses than TD children. This may be due to the executive demands of the memory tasks, rather than specific impairments in memory binding. Autism Res 2020, 13: 1959-1969. © 2020 International Society for Autism Research and Wiley Periodicals LLC LAY SUMMARY: The present study shows that children with autism have a less stable memory than typically developed children, which is reflected in a higher amount of incorrect memory responses. Overall, our results indicate that children with autism display difficulties in differentiating previously studied from novel information when solving both single-feature memory tasks and a relational memory task (requiring memory of combination of features). These difficulties may have implications for how children with autism remember episodes from their personal past.

A functional gradient has been proposed across the medial temporal lobes (MTL) such that the anterior MTL is thought to support processing of individual items (e.g., item memory and complex object perception), whereas the posterior MTL is thought to support item-context retrieval (e.g., source memory). Whereas functional imaging studies have provided evidence supporting this anatomical organization, results from structural analyses remain inconclusive. The current study examined the relationship between volume of MTL regions of interest (ROIs), and performance on a source memory task and a fine-grain complex object perception task, in healthy young adults (mean age = 21.5, range = 18-29). Using a semiautomated procedure, we segmented the parahippocampal and perirhinal cortices (PHC, PRC), posteromedial and anterolateral entorhinal cortices (pmERC, alERC), and posterior and anterior hippocampus (postHC, antHC) on high-resolution T2-weighted MRIs. Regional volumes were computed as proportions of intracranial volume, and as posterior-anterior volumetric ratios (PHC:PRC, pmERC:alERC, postHC:antHC). Partial-least squares regressions were applied to predict source and item memory, and perceptual discrimination accuracy, based on ROI and ratio volumes. In our ROI regressions, we found that postHC volume was positively correlated with a latent factor predicting source memory, and PRC and antHC volumes were negatively correlated to this latent factor. In our ratio regressions, we observed an effect relating the posterior-anterior distribution of gray matter across the MTL with source memory. Our results demonstrate differential associations between anterior and posterior MTL and source memory performance. Findings from this study highlight the importance of considering patterns of structure-behavior associations in the neurobiology of episodic memory.

In the present study, I examined whether the regular patterns of variables that referred to mental representation of the entire childhood in young adults might be associated with the different types of cultural selves proposed by Kagitcibasi's model of family change. In this model, three types of cultural selves (heteronomous-related self, autonomous-separated self, and autonomous-related self) are merged with culturally specific styles of parenting and childhood experience. Chinese, Russian, and Uzbekistani participants (N = 439) visualized their childhood on timelines. The exploratory factor analysis suggested a three-factor solution. Factor 1 combined memories of achievements and vicarious memories; that is, memories representing events that happened to other people. In my point of view, in contrast to "we-memories," vicarious memories portray a readiness to view other people as a valuable part of one's own life, but in the context of well-defined self-boundaries. Therefore, they denote the kind of relatedness which does not contradict autonomy. Because Factor 1 was found to be the most articulated in the Chinese sample, it was linked to the autonomous-related self, with the focus on directive function of autobiographical memory. Factor 2 was composed of the abundance of recollections, the early age of first memory, and prolonged childhood. Due to the highest scores being achieved on Factor 2 in the Russian sample, it was attributed to the autonomous-separated self, employing predominantly a self-reflective function of autobiographical memory. Factor 3 consisted of memories of attending social groups, positive emotional bias, and a tendency to mention one's own birth. Taking into account that the Uzbeks achieved the highest scores on this factor, it was interpreted as a mnemonic database of a heteronomous-related self, predominantly associated with social bonding and emotion regulation functions. Taken together, the findings highlight the assumption that childhood memories reveal a cultural self.

Visuospatial bootstrapping describes the observation that performance on a verbal memory task is enhanced by presenting the to-be-remembered material in a format with additional embedded spatial information. Thus far, it has only been reported in short-term memory tasks. Here, we report two experiments assessing the impact of spatial information on the learning of sequences in long-term memory. Experiment 1 used digits presented within a familiar numeric keypad as stimuli compared against single digits presented in one location. Experiment 2 used novel nonwords, which were either presented in an unchanging arrangement permitting the building-up of location knowledge or in a constantly changing arrangement. Both experiments demonstrated strong evidence that reliable spatial information facilitated sequence learning, particularly in later sequence positions. It is concluded that the incidental availability of spatialized information during study can facilitate learning of sequences of digits and nonwords. Furthermore, the spatial information can be learned during the task itself and does not need to be preexistent in long-term knowledge.