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10 results on '"Micha, Dimitra"'

2. Ocular characteristics and complications in patients with osteogenesis imperfecta: a systematic review

Author

Treurniet, Sanne, primary, Burger, Pia, additional, Ghyczy, Ebba A.E., additional, Verbraak, Frank D., additional, Curro‐ Tafili, Katie R., additional, Micha, Dimitra, additional, Bravenboer, Nathalie, additional, Ralston, Stuart H., additional, Vries, Ralph, additional, Moll, Annette C., additional, and Eekhoff, Elisabeth Marelise W., additional

Published
2021
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3. Mechanical stress regulates bone regulatory gene expression independent of estrogen and vitamin D deficiency in rats

Author

Nepal, Ashwini Kumar, primary, van Essen, Huib W., additional, van der Veen, Albert J., additional, van Wieringen, Wessel N., additional, Stavenuiter, Andrea W. D., additional, Cayami, Ferdy Kurniawan, additional, Pals, Gerard, additional, Micha, Dimitra, additional, Vanderschueren, Dirk, additional, Lips, Paul, additional, and Bravenboer, Nathalie, additional

Published
2020
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4. Diagnostic Value of Magnetic Resonance Imaging in Fibrodysplasia Ossificans Progressiva

Author

Botman, Esmée, primary, Teunissen, Bernd P, additional, Raijmakers, Pieter, additional, Graaf, Pim, additional, Yaqub, Maqsood, additional, Treurniet, Sanne, additional, Schoenmaker, Ton, additional, Bravenboer, Nathalie, additional, Micha, Dimitra, additional, Pals, Gerard, additional, Bökenkamp, Arend, additional, Netelenbos, J Coen, additional, Lammertsma, Adriaan A, additional, and Eekhoff, Elisabeth MW, additional

Published
2020
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9. Flare-Up After Maxillofacial Surgery in a Patient With Fibrodysplasia Ossificans Progressiva: An [18 F]-NaF PET/CT Study and a Systematic Review

Author

Eekhoff, E Marelise W, primary, Netelenbos, J Coen, additional, de Graaf, Pim, additional, Hoebink, Max, additional, Bravenboer, Nathalie, additional, Micha, Dimitra, additional, Pals, Gerard, additional, de Vries, Teun J, additional, Lammertsma, Adriaan A, additional, Raijmakers, Pieter GHM, additional, and van Es, Robert JJ, additional

Published
2017
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10. Mechanical stress regulates bone regulatory gene expression independent of estrogen and vitamin D deficiency in rats.

Author

Nepal AK, van Essen HW, van der Veen AJ, van Wieringen WN, Stavenuiter AWD, Cayami FK, Pals G, Micha D, Vanderschueren D, Lips P, and Bravenboer N

Subjects
25-Hydroxyvitamin D3 1-alpha-Hydroxylase metabolism, Animals, Bone Morphogenetic Proteins metabolism, Estrogen Receptor alpha metabolism, Extracellular Matrix Proteins metabolism, Female, Fibroblast Growth Factors metabolism, Genetic Markers, Rats, Wistar, Stress, Mechanical, Rats, Bone and Bones metabolism, Estrogens deficiency, Gene Expression Regulation, Phosphates metabolism, Vitamin D Deficiency metabolism
Abstract

Mechanical stress determines bone mass and structure. It is not known whether mechanical loading affects expression of bone regulatory genes in a combined deficiency of estrogen and vitamin D. We studied the effect of mechanical loading on the messenger RNA (mRNA) expression of bone regulatory genes during vitamin D and/or estrogen deficiency. We performed a single bout in vivo axial loading with 14 N peak load, 2 Hz frequency and 360 cycles in right ulnae of nineteen weeks old female control Wistar rats with or without ovariectomy (OVX), vitamin D deficiency and the combination of OVX and vitamin D deficiency (N = 10/group). Total bone RNA was isolated 6 hours after loading, and mRNA expression was detected of Mepe, Fgf23, Dmp1, Phex, Sost, Col1a1, Cyp27b1, Vdr, and Esr1. Serum levels of 25(OH)D, 1,25(OH) 2 D and estradiol were also measured at this time point. The effect of loading, vitamin D and estrogen deficiency and their interaction on bone gene expression was tested using a mixed effect model analysis. Mechanical loading significantly increased the mRNA expression of Mepe, and Sost, whereas it decreased the mRNA expression of Fgf23 and Esr1. Mechanical loading showed a significant interaction with vitamin D deficiency with regard to mRNA expression of Vdr and Esr1. Mechanical loading affected gene expression of Mepe, Fgf23, Sost, and Esr1 independently of vitamin D or estrogen, indicating that mechanical loading may affect bone turnover even during vitamin D deficiency and after menopause., (© 2020 The Authors. Journal of Orthopaedic Research® published by Wiley Periodicals LLC on behalf of Orthopaedic Research Society.)

Published
2021
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