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17 results on '"Murphy, Tara"'

1. Long‐term clinical and cost‐effectiveness of a therapist‐supported online remote behavioural intervention for tics in children and adolescents: extended 12‐ and 18‐month follow‐up of a single‐blind randomised controlled trial

Author

Hollis, Chris, primary, Hall, Charlotte L., additional, Khan, Kareem, additional, Jones, Rebecca, additional, Marston, Louise, additional, Le Novere, Marie, additional, Hunter, Rachael, additional, Andrén, Per, additional, Bennett, Sophie D., additional, Brown, Beverley J., additional, Chamberlain, Liam R., additional, Davies, E. Bethan, additional, Evans, Amber, additional, Kouzoupi, Natalia, additional, McKenzie, Caitlin, additional, Sanderson, Charlotte, additional, Heyman, Isobel, additional, Kilgariff, Joseph, additional, Glazebrook, Cristine, additional, Mataix‐Cols, David, additional, Serlachius, Eva, additional, Murray, Elizabeth, additional, and Murphy, Tara, additional

Published
2023
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2. European Society for the Study of Tourette Syndrome 2022 criteria for clinical diagnosis of functional tic‐like behaviours: International consensus from experts in tic disorders

Author

Pringsheim, Tamara, primary, Ganos, Christos, additional, Nilles, Christelle, additional, Cavanna, Andrea E., additional, Gilbert, Donald L., additional, Greenberg, Erica, additional, Hartmann, Andreas, additional, Hedderly, Tammy, additional, Heyman, Isobel, additional, Liang, Holan, additional, Malaty, Irene, additional, Malik, Osman, additional, Debes, Nanette Mol, additional, Vahl, Kirsten Muller, additional, Munchau, Alexander, additional, Murphy, Tara, additional, Nagy, Peter, additional, Owen, Tamsin, additional, Rizzo, Renata, additional, Skov, Liselotte, additional, Stern, Jeremy, additional, Szejko, Natalia, additional, Worbe, Yulia, additional, and Martino, Davide, additional

Published
2023
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3. The spectrum of functional tic‐like behaviours: Data from an international registry

Author

Martino, Davide, primary, Hedderly, Tammy, additional, Murphy, Tara, additional, Müller‐Vahl, Kirsten R., additional, Dale, Russell C., additional, Gilbert, Donald L., additional, Rizzo, Renata, additional, Hartmann, Andreas, additional, Nagy, Peter, additional, Anheim, Mathieu, additional, Owen, Tamsin, additional, Malik, Osman, additional, Duncan, Morvwen, additional, Heyman, Isobel, additional, Liang, Holan, additional, McWilliams, Andrew, additional, O'Dwyer, Shauna, additional, Fremer, Carolin, additional, Szejko, Natalia, additional, Han, Velda X., additional, Kozlowska, Kasia, additional, and Pringsheim, Tamara M., additional

Published
2022
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7. Practitioner review: Treatments for Tourette syndrome in children and young people: a systematic review

Author

Whittington, Craig, Pennant, Mary, Kendall, Tim, Glazebrook, Cris, Trayner, Penny, Groom, Madeleine J., Hedderly, Tammy, Heyman, Isobel, Jackson, Georgina M., Murphy, Tara, Rickards, Hugh, Robertson, Mary, Stern, Jeremy, and Hollis, Chris

Abstract

Background: Tourette syndrome (TS) and chronic tic disorder (CTD) affect 1–2% of children and young people, but the most effective treatment is unclear. To establish the current evidence base, we conducted a systematic review of interventions for children and young people. Methods: Databases were searched from inception to 1 October 2014 for placebo-controlled trials of pharmacological, behavioural, physical or alternative interventions for tics in children and young people with TS or CTD. Certainty in the evidence was assessed with the GRADE approach. Results: Forty trials were included [pharmacological (32), behavioural (5), physical (2), dietary (1)]. For tics/global score there was evidence favouring the intervention from four trials of a2-adrenergic receptor agonists [clonidine and guanfacine, standardised mean difference (SMD) = -0.71; 95% CI -1.03, -0.40; N = 164] and two trials of habit reversal training (HRT)/comprehensive behavioural intervention (CBIT) (SMD = -0.64; 95% CI -0.99, -0.29; N = 133). Certainty in the effect estimates was moderate. A post hoc analysis combining oral clonidine/guanfacine trials with a clonidine patch trial continued to demonstrate benefit (SMD = -0.54; 95% CI -0.92, -0.16), but statistical heterogeneity was high. Evidence from four trials suggested that antipsychotic drugs improved tic scores (SMD = -0.74; 95% CI -1.08, -0.40; N = 76), but certainty in the effect estimate was low. The evidence for other interventions was categorised as low or very low quality, or showed no conclusive benefit. Conclusions: When medication is considered appropriate for the treatment of tics, the balance of clinical benefits to harm favours a2-adrenergic receptor agonists (clonidine and guanfacine) as first-line agents. Antipsychotics are likely to be useful but carry the risk of harm and so should be reserved for when a2-adrenergic receptor agonists are either ineffective or poorly tolerated. There is evidence that HRT/CBIT is effective, but there is no evidence for HRT/CBIT alone relative to combining medication and HRT/CBIT. There is currently no evidence to suggest that the physical and dietary interventions reviewed are sufficiently effective and safe to be considered as treatments.

Published
2016

9. Practitioner Review: Treatments for Tourette syndrome in children and young people - a systematic review

Author

Whittington, Craig, primary, Pennant, Mary, additional, Kendall, Tim, additional, Glazebrook, Cristine, additional, Trayner, Penny, additional, Groom, Madeleine, additional, Hedderly, Tammy, additional, Heyman, Isobel, additional, Jackson, Georgina, additional, Jackson, Stephen, additional, Murphy, Tara, additional, Rickards, Hugh, additional, Robertson, Mary, additional, Stern, Jeremy, additional, and Hollis, Chris, additional

Published
2016
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16. The spectrum of functional tic-like behaviours: Data from an international registry.

Author

Martino D, Hedderly T, Murphy T, Müller-Vahl KR, Dale RC, Gilbert DL, Rizzo R, Hartmann A, Nagy P, Anheim M, Owen T, Malik O, Duncan M, Heyman I, Liang H, McWilliams A, O'Dwyer S, Fremer C, Szejko N, Han VX, Kozlowska K, and Pringsheim TM

Subjects
Adolescent, Young Adult, Humans, Female, Male, Retrospective Studies, Comorbidity, Tics, Autism Spectrum Disorder, Tic Disorders epidemiology, Tic Disorders drug therapy, Attention Deficit Disorder with Hyperactivity, Tourette Syndrome epidemiology
Abstract

Background and Purpose: Between 2019 and 2022, there was a marked rise in adolescents/young adults seeking urgent help for functional tic-like behaviours (FTLBs). Given the global scale of this phenomenon, we aimed to pool cases from different institutions in an international registry to better characterize this spectrum and facilitate future longitudinal observation., Methods: An international collaborative group from 10 tertiary referral centres for tic disorders collected retrospective data on FTLB patients who sought specialists' attention between the last quarter of 2019 and June 2022. An audit procedure was used for collection of data, which comprised demographics, course of presentation and duration, precipitating and predisposing factors, phenomenology, comorbidities, and pharmacological treatment outcome., Results: During the study period, we collected data on 294 patients with FTLBs, 97% of whom were adolescents and young adults and 87% of whom were female. FTLBs were found to have a peak of severity within 1 month in 70% of patients, with spontaneous remissions in 20%, and a very high frequency of complex movements (85%) and vocalizations (81%). Less than one-fifth of patients had pre-existing primary tic disorder, 66% had comorbid anxiety disorders, 28% comorbid depressive disorders, 24% autism spectrum disorder and 23% attention deficit/hyperactivity disorder. Almost 60% explicitly reported exposure to tic-related social media content. The vast majority of pharmacologically treated patients did not report benefit with tic-suppressing medications., Conclusions: Our data from the largest multicentre registry of FTLBs to date confirm substantial clinical differences from primary tic disorders. Social modelling was the most relevant contributing factor during the pandemic. Future longitudinal analyses from this database may help understand treatment approaches and responsiveness., (© 2022 European Academy of Neurology.)

Published
2023
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17. A practical comparison of two types of family intervention: an exploratory RCT of family day workshops and individual family work as a supplement to inpatient care for adults with anorexia nervosa.

Author

Whitney J, Murphy T, Landau S, Gavan K, Todd G, Whitaker W, and Treasure J

Subjects
Adult, Anorexia Nervosa psychology, Education, Female, Humans, London, Male, Middle Aged, Treatment Outcome, Anorexia Nervosa therapy, Caregivers psychology, Family psychology, Family Therapy methods, Inpatients psychology
Abstract

Background: Little is known about the outcome of involving families in the treatment of adults with anorexia nervosa. Carers of people with anorexia nervosa experience significant levels of distress. This may contribute to unhelpful behaviours which maintain the illness., Aims: To evaluate the effectiveness and acceptability of family workshops with educational and skills-based components as compared to individual family work., Method: An exploratory randomised controlled trial of two forms of family intervention was conducted for inpatients with anorexia nervosa (n = 48) and their family members on a specialised unit for adults., Results: In both groups, there was an improvement in patients' BMI and a reduction in carers' distress. There were no differences between groups., Conclusion: Preliminary findings suggest that workshop-based intervention with two families might be as effective as an individually focused family intervention. This may offer a more cost-effective intervention for this treatment-resistant group., (Copyright © 2011 John Wiley & Sons, Ltd and Eating Disorders Association.)

Published
2012
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