7 results on '"Murtadha Al Khabori"'
Search Results
2. Management of adult acute lymphoblastic leukemia in the Gulf Cooperation Council (GCC) countries: A consensus report from the GCC Adult ALL Working Group
- Author
-
Feras Alfraih, Ahmed Absi, Mohamed Abuhaleeqa, Khalofa Alghamdi, Ahmad Alhuraiji, Murtadha Al‐Khabori, Zeyad Al‐Shaibani, Musa Alzahrani, Honar Cherif, Saleem Eldadah, Amr Hanbali, Ibraheem H. Motabi, and Hind Salama
- Subjects
acute lymphoblastic leukemia ,adult ,chemotherapy ,consensus ,standard of care ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Leukemia burden is growing in the Gulf Council Cooperation (GCC) countries. Nonetheless, there is no unified protocol for managing adult acute lymphoblastic leukemia (ALL) patients in the GCC‐countries. Therefore, the GCC Adult‐ALL Treaters working group developed this consensus to address the adult‐ALL treatment protocols in the GCC‐countries and related toxicities' management. Besides, the consensus aimed to highlight the current unmet needs and treatment gaps and provide recommendations to optimize adult‐ALL care and patient‐centered communication. A three‐step modified Delphi method to develop evidence‐based recommendations through two‐voting rounds and in‐between virtual meetings are used in the manuscript development. A 12 experts' panel from five GCC‐countries and two international experts were invited to participate in this consensus. This consensus consisted of 35‐statements that highlighted the experts' recommendations to optimize ALL adults' care in the first line setting and manage pediatric or pediatric‐inspired regimens‐related toxicities. Besides, guidance was provided for future research direction and improve patient‐centered communication. In conclusion, the adult‐ALL management landscape is evolving, and the current evidence highlights better response and survival outcomes with pediatric or pediatric‐inspired regiments. Therefore, protocols are needed to optimize the adult‐ALL management in the GCC and tailored clinical‐trials findings according to the GCC patients' characteristics and local‐healthcare infrastructure.
- Published
- 2024
- Full Text
- View/download PDF
3. Measurement of hematopoietic progenitor cells using XN2000 hematology analyzer
- Author
-
Alshaima Al Jamalani, Ahoud Al Saadi, Rua Al Zaabi, Jamal Al Qassabi, Anil Pathare, Murtadha Al-Khabori, and Sahimah Al Mamari
- Subjects
Spectrum analyzer ,medicine.medical_treatment ,Clinical Biochemistry ,CD34 ,Antigens, CD34 ,Bone Marrow Cells ,Hematopoietic stem cell transplantation ,Sensitivity and Specificity ,Immunophenotyping ,Flow cytometry ,Hematology analyzer ,medicine ,Humans ,Blood Cells ,Chromatography ,medicine.diagnostic_test ,Chemistry ,Biochemistry (medical) ,Hematopoietic Stem Cell Transplantation ,Reproducibility of Results ,Hematology ,General Medicine ,Flow Cytometry ,Hematopoietic Stem Cells ,Tissue Donors ,Peripheral blood ,Apheresis ,Blood Component Removal ,Hematopoietic progenitor cells ,Biomarkers - Abstract
Introduction Stem cell enumeration by the hematopoietic progenitor cells (HPC) mode is a novel method available from Sysmex XN2000 hematology analyzer. A small amount of blood (190 μL) is required, and the results are available in a few minutes without manual gating or presample treatment. The present study compares stem cell measurements using XN2000 analyzer HPC mode and FC500 flow cytometry analyzer using peripheral blood (PB) specimens and apheresis products. Methods In this prospective study, CD34-positive cell counts were enumerated using an FC500 flow cytometry analyzer and compared with XN2000 Sysmex analyzer (XN-HPC mode) in the same samples. Results were compared using Bland-Altman plots. Results A total of 103 samples were used. In the PB samples, the median HPC count and CD34-positive cells were 83.5 × 106 /L and 78.0 × 106 /L, respectively. The mean Bland-Altman difference was 4.5 × 106 /L (Limits: -51.7 to 60.7 × 106 /L), with a Pearson's correlation of 0.79. In the apheresis products, the median HPC count and CD34-positive cells were 1468 × 106 /L (IQR: 1049 - 1960 × 106 /L) and 1327 × 106 /L (IQR: 910 - 2001 × 106 /L), respectively. The mean Bland-Altman difference was 179.0 × 106 /L (Limits: -2022.2 - 2380.2 × 106 /L), with a Pearson's correlation of 0.58. Conclusion The XN-HPC mode has an excellent correlation and minimal disagreement for stem cell enumeration in PB compared with flow cytometry and could replace it. There is high disagreement in apheresis products, and therefore, the XN-HPC mode cannot be recommended.
- Published
- 2021
4. Transfusion knowledge of medical and surgical specialty board residents: a cohort study
- Author
-
Hilal Al-Sabti, Arwa Z. Al-Riyami, Louis D. Wadsworth, Khalil Al-Farsi, I Al-Nomani, Murtadha Al-Khabori, and S M Panchatcharam
- Subjects
Further education ,medicine.medical_specialty ,Demographics ,business.industry ,Specialty board ,Transfusion medicine ,Hematology ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,Transfusion reaction ,Family medicine ,medicine ,030212 general & internal medicine ,business ,Surgical Specialty ,Multiple choice ,Cohort study - Abstract
Objectives This study was conducted to assess transfusion knowledge between different specialty board residents and to identify areas of need for further education. Background Physicians' knowledge of transfusion medicine (TM) is critical for patients' safety. Many clinicians who are involved in day-to-day transfusion practice have little or no formal training in TM. There are no studies to assess physician's TM knowledge locally. Methods A comprehensive anonymous survey was developed to assess baseline TM knowledge of all the residents. The survey is composed of different sections, including a questionnaire on resident's demographics, resident's self-reflection on their TM knowledge and 30 multiple choice questions addressing basic and clinical TM knowledge in two major domains: component selection and transfusion practice and transfusion safety and transfusion reactions. Finally, the residents' opinion on educational needs was assessed. Results A total of 130 residents were surveyed. The lowest score obtained among the two major domains assessed was in the transfusion safety and transfusion reaction domain, with a mean score of 4·34 of 15 (SD ± 3·27). The mean score obtained on component selection and transfusion practice was 7·1 of 15 (SD ± 3·74). A substantial proportion of the residents (74·7%) admitted minimal baseline knowledge in the field of TM. Finally, 94·5% of the residents admitted the need for more education during residency, whereas 49·5% thought additional education is required during the first year of practice. Conclusion This survey shows serious TM knowledge deficiency and indicates the need for additional education among all physicians during training.
- Published
- 2018
5. The pneumatic tube system does not affect complete blood count results; a validation study at a tertiary care hospital
- Author
-
Shahina Daar, R. M. Al-Hadhrami, Murtadha Al-Khabori, Khalil Al-Farsi, H. M. Davis, I. S. Al-Azwani, S. Alkindi, and Arwa Z. Al-Riyami
- Subjects
Validation study ,medicine.medical_specialty ,Coefficient of determination ,Oman ,Correlation coefficient ,Point-of-Care Systems ,Clinical Biochemistry ,Transportation ,White blood cell ,medicine ,Humans ,Blood Specimen Collection ,medicine.diagnostic_test ,Tertiary Healthcare ,business.industry ,beta-Thalassemia ,Biochemistry (medical) ,Complete blood count ,Hematology ,General Medicine ,Tertiary care hospital ,Pneumatic tube ,Confidence interval ,Blood Cell Count ,Surgery ,medicine.anatomical_structure ,Case-Control Studies ,business ,Nuclear medicine - Abstract
SummaryIntroduction Effect of the pneumatic tube system (PTS) on sample quality is controversial. Herein we aim at evaluating the impact of sample transportation via the PTS on complete blood count (CBC) results. Methods Duplicate CBC samples from normal donors and anemic patients were sent in parallel to the laboratory for testing through the PTS and the courier (CO). We used scatter plots, Bland–Altman plots, correlation coefficient (r), and coefficient of determination for the validation. Results A total of 115 samples (donors: 59, patients: 56) were tested. There was excellent correlation between both methods for red blood cell parameters (r range = 0.9213–0.9958) and platelet count. White blood cell (WBC) count and differential count showed similar results (r range = 0.8605–0.9821) for all, with exception of basophils which showed modest correlation (r = 0.4827 for patients and 0.5758 for normal donors). Most of the differences in measurement of all CBC parameters were within the 95% confidence interval of the mean difference on Bland–Altman plots. Conclusion Modern PTS can be safely used for transporting CBC samples.
- Published
- 2013
6. Successful management of severe hemolytic disease of the fetus due to anti-Jsb using intrauterine transfusions with serial maternal blood donations: a case report and a review of the literature
- Author
-
Sabah Al Mahrooqi, Arwa Z. Al Riyami, Mohammed Al Huneini, Tamima Al Dughaishi, Moza Al Salmani, Halima Al Balushi, Salam Alkindi, Nihal Al Riyami, Murtadha Al-Khabori, Saif Al Hosni, Sumaiya Al Hinai, Khalil Al-Farsi, Vaidyanathan Gowri, and Sabria Al Hashami
- Subjects
Fetus ,Pediatrics ,medicine.medical_specialty ,Pregnancy ,Blood transfusion ,Umbilical cord hematoma ,business.industry ,medicine.medical_treatment ,Immunology ,Hematology ,medicine.disease ,Erythropoietin ,Hydrops fetalis ,medicine ,Immunology and Allergy ,Gestation ,business ,medicine.drug ,Whole blood - Abstract
Background The management of pregnant women with anti-Jsb is challenging due to the paucity of antigen-negative blood for fetal and neonatal transfusion. Case Report A 29-year-old woman with anti-Jsb was referred for assessment of recurrent fetal losses. With the presence of the sister as a historically matched donor, she was planned for active surveillance for fetal anemia during pregnancy. Study Design and Methods The fetus remained well until 21 weeks of gestation when signs of fetal anemia and early hydrops fetalis were noted. Anti-Jsb titer was at 128. The sister's red blood cells (RBCs) were cross-match incompatible. Urgent intrauterine transfusion (IUT) was performed with washed irradiated maternal RBCs, donated after cessation of heparin. The mother was given intravenous iron (IV-Fe) and continued on weekly recombinant human erythropoietin (rHu-EPO). Results Repeated IUTs were needed every 1 to 3 weeks. Throughout a 7-week period, three maternal donations were performed with total donated whole blood volume of 1250 mL, supporting four IUTs. At 29 weeks of gestation, the procedure was complicated by umbilical cord hematoma necessitating urgent cesarean section. A male newborn was delivered, transfused at birth, and subsequently treated with phototherapy and five top-up transfusions. Conclusion This case represents a successful example of managing hemolytic disease of the fetus due to a rare antibody using maternal blood. It also supports previous data on safety of maternal donations during pregnancy and the use of combination of rHu-EPO and IV-Fe as a supportive measure.
- Published
- 2013
7. Differential Production of Midkine and Pleiotrophin by Innate APCs upon Stimulation through Nucleic Acid-Sensing TLRs
- Author
-
Elias A. Said, Sumaya Al-Dughaishi, Wadha Al-Hatmi, Iman Al-Reesi, Mohammed S. Al-Balushi, Atika Al-Bimani, Juma Z. Al-Busaidi, Marwa Al-Riyami, Murtadha Al-Khabori, Salam Al-Kindi, Francesco A. Procopio, Shadia Al-Sinawi, Aliyaa Al-Ansari, Crystal Y. Koh, Khalid Al-Naamani, and Ali A. Al-Jabri
- Subjects
Immunologic diseases. Allergy ,RC581-607 - Abstract
Midkine (MK) and pleiotrophin (PTN) belong to the same family of cytokines. They have similar sequences and functions. Both have important roles in cellular proliferation, tumors, and diseases. They regulate and are expressed by some immune cells. We have recently demonstrated MK production by some human innate antigen-presenting cells (iAPCs), i.e., monocyte-derived dendritic cells (MDDCs) and macrophages stimulated through Toll-like receptor (TLR)-4, and plasmacytoid dendritic cells (pDCs) stimulated through TLR 7. While PTN production was only documented in tissue macrophages. TLRs 3, 7, 8, and 9 are nucleic acid sensing (NAS) TLRs that detect nucleic acids from cell damage and infection and induce iAPC responses. We investigated whether NAS TLRs can induce MK and PTN production by human iAPCs, namely monocytes, macrophages, MDDCs, myeloid dendritic cells (mDCs), and pDCs. Our results demonstrated for the first time that PTN is produced by all iAPCs upon TLR triggering (p
- Published
- 2023
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.