Search

Your search keyword '"Nakano, Shin-ichi"' showing total 18 results
Start Over Author "Nakano, Shin-ichi" Publisher wiley
18 results on '"Nakano, Shin-ichi"'

1. A freshwater radiation of diplonemids

Author

Mukherjee, Indranil, primary, Salcher, Michaela M., additional, Andrei, Adrian‐Ştefan, additional, Kavagutti, Vinicius Silva, additional, Shabarova, Tanja, additional, Grujčić, Vesna, additional, Haber, Markus, additional, Layoun, Paul, additional, Hodoki, Yoshikuni, additional, Nakano, Shin‐ichi, additional, Šimek, Karel, additional, and Ghai, Rohit, additional

Published
2020
Full Text
View/download PDF

18. Basic fibroblast growth factor is pro-adipogenic in rat skeletal muscle progenitor clone, 2G11 cells.

Author

Nakano S, Nakamura K, Teramoto N, Yamanouchi K, and Nishihara M

Subjects
Adipose Tissue, Animals, CCAAT-Enhancer-Binding Protein-alpha genetics, CCAAT-Enhancer-Binding Protein-alpha metabolism, Cells, Cultured, Gene Expression drug effects, Male, PPAR gamma genetics, PPAR gamma metabolism, Rats, Wistar, Receptor, Fibroblast Growth Factor, Type 1, Receptor, Fibroblast Growth Factor, Type 2, Adipogenesis drug effects, Adipogenesis genetics, Cell Differentiation drug effects, Clone Cells cytology, Clone Cells metabolism, Fibroblast Growth Factor 2 pharmacology, Fibroblast Growth Factor 2 physiology, Muscle, Skeletal cytology, Stem Cells cytology, Stem Cells metabolism
Abstract

Intramuscular adipose tissue (IMAT) formation is a hallmark of marbling in cattle. IMAT is considered to originate from skeletal muscle progenitor cells with adipogenic potential. However, the mechanism involved in IMAT formation from these progenitor cells in vivo remains unclear. In the present study, among the growth factors tested, which were known to be expressed in skeletal muscle, we found only basic fibroblast growth factor (bFGF) has a pro-adipogenic effect on skeletal muscle derived adipogenic progenitor clone, 2G11 cells. Pre-exposure of 2G11 cells to bFGF did not affect initial gene expressions of CCAAT/enhancer-binding protein (C/EBP)β and C/EBPδ, while resulting in an enhancement of subsequent expressions of C/EBPα and proliferator-activated receptor gamma (PPARγ) during adipogenesis, indicating that bFGF is acting on the transcriptional regulation of C/EBPα and PPARγ. In addition, the effect of bFGF is mediated via two types of FGF receptor (FGFR) isoforms: FGFR1 and FGFR2 IIIc, and both receptors are prerequisite for bFGF to express its pro-adipogenic effect. These results suggest that bFGF plays an important role as a key trigger of IMAT formation in vivo., (© 2015 Japanese Society of Animal Science.)

Published
2016
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results