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Your search keyword '"Negro S"' showing total 11 results
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11 results on '"Negro S"'

1. The influence of visions on cooperation among interest organizations in fragmented socio-technical systems

Author

Dynamics of Innovation Systems, Organisations and Sustainability, Sustainable Energy, Innovation Studies, Energy and Resources, Wesche, J. P., Negro, S. O., Brugger, H. I., Eichhammer, W., Hekkert, M. P., Dynamics of Innovation Systems, Organisations and Sustainability, Sustainable Energy, Innovation Studies, Energy and Resources, Wesche, J. P., Negro, S. O., Brugger, H. I., Eichhammer, W., and Hekkert, M. P.

Published
2024

3. OMERE: A Long‐Term Observatory of Soil and Water Resources, in Interaction with Agricultural and Land Management in Mediterranean Hilly Catchments

Author

Molénat, J., primary, Raclot, D., additional, Zitouna, R., additional, Andrieux, P., additional, Coulouma, G., additional, Feurer, D., additional, Grunberger, O., additional, Lamachère, J.M., additional, Bailly, J.S., additional, Belotti, J.L., additional, Ben Azzez, K., additional, Ben Mechlia, N., additional, Ben Younès Louati, M., additional, Biarnès, A., additional, Blanca, Y., additional, Carrière, D., additional, Chaabane, H., additional, Dagès, C., additional, Debabria, A., additional, Dubreuil, A., additional, Fabre, J.C., additional, Fages, D., additional, Floure, C., additional, Garnier, F., additional, Geniez, C., additional, Gomez, C., additional, Hamdi, R., additional, Huttel, O., additional, Jacob, F., additional, Jenhaoui, Z., additional, Lagacherie, P., additional, Le Bissonnais, Y., additional, Louati, R., additional, Louchart, X., additional, Mekki, I., additional, Moussa, R., additional, Negro, S., additional, Pépin, Y., additional, Prévot, L., additional, Samouelian, A., additional, Seidel, J.L., additional, Trotoux, G., additional, Troiano, S., additional, Vinatier, F., additional, Zante, P., additional, Zrelli, J., additional, Albergel, J., additional, and Voltz, M., additional

Published
2018
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9. IMMUNOREACT 7: Regular aspirin use is associated with immune surveillance activation in colorectal cancer.

Author

Simoni O, Scarpa M, Castagliuolo I, Stepanyan A, Angriman I, Kotsafti A, Nacci C, Scognamiglio F, Negro S, D'Angelo A, Chiminazzo V, Businello G, Ruffolo C, Salmaso R, Franzato B, Gruppo M, Pilati P, Scapinello A, Pozza A, Stecca T, Massani M, Cataldo I, Brignola S, Dei Tos AP, Ceccon C, Guzzardo V, Vignotto C, Facci L, Maretto I, Agostini M, Marchegiani F, Becherucci G, Zizzo M, Bordignon G, Merenda R, Pirozzolo G, Recordare A, Pozza G, Godina M, Mondi I, Verdi D, Lio CD, Laurino L, Saadeh L, Rivella G, Guerriero S, Romiti C, Portale G, Cipollari C, Spolverato YC, Noaro G, Cola R, Candioli S, Gavagna L, Ricagna F, Ortenzi M, Guerrieri M, Tagliente G, Tomassi M, Tedeschi U, Salmaso B, Buzzi G, Parini D, Prando D, Zuin M, Bergamo F, Zagonel V, Porzionato A, Cavallin F, Camillo BD, Cristoforo LD, Bao QR, Pucciarelli S, Bardini R, Spolverato G, Fassan M, and Scarpa M

Subjects
Humans, Female, Male, Aged, Middle Aged, Retrospective Studies, B7-1 Antigen metabolism, B7-1 Antigen genetics, B7-H1 Antigen metabolism, Cell Line, Tumor, Aspirin therapeutic use, Colorectal Neoplasms immunology, Colorectal Neoplasms pathology, Colorectal Neoplasms genetics, Tumor Microenvironment immunology, Immunologic Surveillance drug effects, Lymphocytes, Tumor-Infiltrating immunology, Lymphocytes, Tumor-Infiltrating drug effects
Abstract

Background: Long-term daily use of aspirin reduces incidence and mortality due to colorectal cancer (CRC). This study aimed to analyze the effect of aspirin on the tumor microenvironment, systemic immunity, and on the healthy mucosa surrounding cancer., Methods: Patients with a diagnosis of CRC operated on from 2015 to 2019 were retrospectively analyzed (METACCRE cohort). Expression of mRNA of immune surveillance-related genes (PD-L1, CD80, CD86, HLA I, and HLA II) in CRC primary cells treated with aspirin were extracted from Gene Expression Omnibus-deposited public database (GSE76583). The experiment was replicated in cell lines. The mucosal immune microenvironment of a subgroup of patients participating in the IMMUNOREACT1 (ClinicalTrials.gov NCT04915326) project was analyzed with immunohistochemistry and flow cytometry., Results: In the METACCRE Cohort, 12% of 238 patients analyzed were aspirin users. Nodal metastasis was significantly less frequent (p = .008) and tumor-infiltrating lymphocyte infiltration was higher (p = .02) among aspirin users. In the CRC primary cells and selected cell lines, CD80 mRNA expression was increased following aspirin treatment (p = .001). In the healthy mucosa surrounding rectal cancer, the ratio of CD8/CD3 and epithelial cells expressing CD80 was higher in aspirin users (p = .027 and p = .034, respectively)., Conclusions: These data suggested that regular aspirin use may have an active role in enhancing immunosurveillance against CRC., (© 2024 American Cancer Society.)

Published
2024
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10. An agonist of the CXCR4 receptor is therapeutic for the neuroparalysis induced by Bungarus snakes envenoming.

Author

Stazi M, Fabris F, Tan KY, Megighian A, Rubini A, Mattarei A, Negro S, D'Este G, Lista F, Rossetto O, Tan CH, and Montecucco C

Subjects
Animals, Bungarus, Disease Models, Animal, Mice metabolism, Paralysis drug therapy, Receptors, CXCR4 drug effects, Receptors, CXCR4 therapeutic use, Bungarotoxins antagonists & inhibitors, Paralysis etiology, Receptors, CXCR4 agonists
Published
2022
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11. Melatonin promotes regeneration of injured motor axons via MT 1 receptors.

Author

Stazi M, Negro S, Megighian A, D'Este G, Solimena M, Jockers R, Lista F, Montecucco C, and Rigoni M

Subjects
Animals, Axons metabolism, Axons pathology, Cells, Cultured, Disease Models, Animal, Extracellular Signal-Regulated MAP Kinases metabolism, Mice, Inbred C57BL, Mice, Transgenic, Motor Neurons metabolism, Motor Neurons pathology, Peripheral Nerve Injuries metabolism, Peripheral Nerve Injuries pathology, Phosphorylation, Rats, Wistar, Receptor, Melatonin, MT1 metabolism, Sciatic Nerve injuries, Sciatic Nerve metabolism, Sciatic Nerve pathology, Signal Transduction, Spider Venoms toxicity, Time Factors, Mice, Rats, Axons drug effects, Melatonin pharmacology, Motor Neurons drug effects, Nerve Regeneration drug effects, Peripheral Nerve Injuries drug therapy, Receptor, Melatonin, MT1 agonists, Sciatic Nerve drug effects
Abstract

Melatonin is an ancient multi-tasking molecule produced by the pineal gland and by several extrapineal tissues. A variety of activities has been ascribed to this hormone in different physiological and pathological contexts, but little is known about its role in peripheral neuroregeneration. Here, we have exploited two different types of injury to test the capability of melatonin to stimulate regeneration of motor axons: (a) the acute and reversible presynaptic degeneration induced by the spider neurotoxin α-Latrotoxin and (b) the compression/transection of the sciatic nerve. We found that in both cases melatonin administration accelerates the process of nerve repair. This pro-regenerative action is MT 1 -mediated, and at least in part due to a sustained activation of the ERK1/2 pathway. These findings reveal a receptor-mediated, pro-regenerative action of melatonin in vivo that holds important clinical implications, as it posits melatonin as a safe candidate molecule for the treatment of a number of peripheral neurodegenerative conditions., (© 2020 The Authors. Journal of Pineal Research published by John Wiley & Sons Ltd.)

Published
2021
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