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Your search keyword '"Nordström, Tanja"' showing total 10 results
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10 results on '"Nordström, Tanja"'

2. Specific adolescent prodromal symptoms associated with onset of psychosis in the Northern Finland Birth Cohort 1986

Author

Palomäki, Johanna, Therman, Sebastian, Kerkelä, Martta, Järvelin, Marjo-Riitta, Jones, Peter, Murray, Graham K, Nordström, Tanja, Heinimaa, Markus, Miettunen, Jouko, Veijola, Juha, Riekki, Tiina, Palomäki, Johanna [0000-0003-1373-2801], Therman, Sebastian [0000-0001-9407-4905], and Apollo - University of Cambridge Repository

Subjects
Adult, Young Adult, Psychotic Disorders, Adolescent, prodromal, Humans, Prodromal Symptoms, birth cohort, predictor, psychosis, Prospective Studies, general population, Finland
Abstract

BACKGROUND: Several psychological symptoms in adolescence associate with later development of psychosis. However, it is unclear which symptoms specifically predict psychotic disorders rather than psychiatric disorders in general. We conducted a prospective study comparing how specific adolescent psychotic-like symptoms, predicted psychotic and non-psychotic hospital-treated psychiatric disorders in the population-based Northern Finland Birth Cohort 1986 (NFBC1986). METHODS: At age 15-16 years, 6632 members of the NFBC1986 completed the PROD-screen questionnaire. New hospital-treated mental disorders of the NFBC1986 participants were detected between age 17 and 30 years from the Finnish Care Register for Health Care. Multiple covariates were used in the analysis. RESULTS: During the follow-up, 1.1% of the participants developed a psychotic and 3.2% a non-psychotic psychiatric disorder. Three symptoms were specifically associated with onset of psychosis compared to non-psychotic psychiatric disorders: 'Difficulty in controlling one's speech, behaviour or facial expression while communicating' (adjusted OR 4.00; 95% CI 1.66-9.92), 'Difficulties in understanding written text or heard speech' (OR 2.25; 1.12-4.51), and 'Difficulty or uncertainty in making contact with other people' (OR 2.20; 1.03-4.67). Of these, the first one remained statistically significant after Bonferroni correction for multiple comparisons. CONCLUSION: To our knowledge, this is the first general-population-based prospective study exploring psychiatric symptoms predicting the onset of hospital-treated first-episode psychosis in comparison to non-psychotic disorders. We found three symptoms related with difficulties in social interaction which predicted onset of psychosis. This is a novel finding and should be replicated.

Published
2022
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3. Specific adolescent prodromal symptoms associated with onset of psychosis in the Northern Finland Birth Cohort 1986

Author

Palomäki, Johanna, primary, Therman, Sebastian, additional, Kerkelä, Martta, additional, Järvelin, Marjo‐Riitta, additional, Jones, Peter, additional, Murray, Graham K., additional, Nordström, Tanja, additional, Heinimaa, Markus, additional, Miettunen, Jouko, additional, Veijola, Juha, additional, and Riekki, Tiina, additional

Published
2022
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7. Maternal cigarette smoking during pregnancy predicts drug use via externalizing behavior in two community‐based samples of adolescents

Author

Lotfipour, Shahrdad, primary, Ferguson, Eamonn, additional, Leonard, Gabriel, additional, Miettunen, Jouko, additional, Perron, Michel, additional, Pike, G. Bruce, additional, Richer, Louis, additional, Séguin, Jean R., additional, Veillette, Suzanne, additional, Jarvelin, Marjo‐Riitta, additional, Moilanen, Irma, additional, Mäki, Pirjo, additional, Nordström, Tanja, additional, Pausova, Zdenka, additional, Veijola, Juha, additional, and Paus, Tomáš, additional

Published
2014
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9. Young people at risk for psychosis: case finding and sample characteristics of the Oulu Brain and Mind Study

Author

Veijola, Juha, primary, Mäki, Pirjo, additional, Jääskeläinen, Erika, additional, Koivukangas, Jenni, additional, Moilanen, Irma, additional, Taanila, Anja, additional, Nordström, Tanja, additional, Hurtig, Tuula, additional, Kiviniemi, Vesa, additional, Mukkala, Sari, additional, Heinimaa, Markus, additional, Lindholm, Päivi, additional, Jones, Peter B., additional, Barnett, Jennifer H., additional, Murray, Graham K., additional, and Miettunen, Jouko, additional

Published
2012
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10. Early adversity and brain response to faces in young adulthood.

Author

Lieslehto J, Kiviniemi V, Mäki P, Koivukangas J, Nordström T, Miettunen J, Barnett JH, Jones PB, Murray GK, Moilanen I, Paus T, and Veijola J

Subjects
Adolescent, Brain diagnostic imaging, Brain Mapping, Cerebrovascular Circulation physiology, Cohort Studies, Female, Finland, Gene Expression, Humans, Magnetic Resonance Imaging, Male, Neuropsychological Tests, Oxygen blood, RNA, Messenger metabolism, Young Adult, Adult Survivors of Child Adverse Events, Brain physiology, Facial Recognition physiology, Receptors, Glucocorticoid metabolism
Abstract

Early stressors play a key role in shaping interindividual differences in vulnerability to various psychopathologies, which according to the diathesis-stress model might relate to the elevated glucocorticoid secretion and impaired responsiveness to stress. Furthermore, previous studies have shown that individuals exposed to early adversity have deficits in emotion processing from faces. This study aims to explore whether early adversities associate with brain response to faces and whether this association might associate with the regional variations in mRNA expression of the glucocorticoid receptor gene (NR3C1). A total of 104 individuals drawn from the Northern Finland Brith Cohort 1986 participated in a face-task functional magnetic resonance imaging (fMRI) study. A large independent dataset (IMAGEN, N = 1739) was utilized for reducing fMRI data-analytical space in the NFBC 1986 dataset. Early adversities were associated with deviant brain response to fearful faces (MANCOVA, P = 0.006) and with weaker performance in fearful facial expression recognition (P = 0.01). Glucocorticoid receptor gene expression (data from the Allen Human Brain Atlas) correlated with the degree of associations between early adversities and brain response to fearful faces (R 2  = 0.25, P = 0.01) across different brain regions. Our results suggest that early adversities contribute to brain response to faces and that this association is mediated in part by the glucocorticoid system. Hum Brain Mapp 38:4470-4478, 2017. © 2017 Wiley Periodicals, Inc., (© 2017 Wiley Periodicals, Inc.)

Published
2017
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