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Your search keyword '"Oberlander, Tim F."' showing total 34 results
Start Over Author "Oberlander, Tim F." Publisher wiley
34 results on '"Oberlander, Tim F."'

1. Examining the interaction between prenatal stress and polygenic risk for attention‐deficit/hyperactivity disorder on brain growth in childhood: Findings from the DREAM BIG consortium

Author

López‐Vicente, Mónica, primary, Szekely, Eszter, additional, Lafaille‐Magnan, Marie‐Elyse, additional, Morton, J. Bruce, additional, Oberlander, Tim F., additional, Greenwood, Celia M. T., additional, Muetzel, Ryan L., additional, Tiemeier, Henning, additional, Qiu, Anqi, additional, Wazana, Ashley, additional, and White, Tonya, additional

Published
2024
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2. Prenatal serotonin reuptake inhibitor antidepressant exposure, SLC6A4 genetic variations, and cortisol activity in 6‐year‐old children of depressed mothers: A cohort study

Author

Zusman, Enav Z., primary, Chau, Cecil M. Y., additional, Bone, Jeffrey N., additional, Hookenson, Kaia, additional, Brain, Ursula, additional, Glier, Melissa B., additional, Grunau, Ruth E., additional, Weinberg, Joanne, additional, Devlin, Angela M., additional, and Oberlander, Tim F., additional

Published
2023
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10. Hub distribution of the brain functional networks of newborns prenatally exposed to maternal depression and SSRI anti-depressant

Author

Rotem‐Kohavi, Naama, Williams, Lynne J., Muller, Angela M., Abdi, Hervé, Virji‐Babul, Naznin, Bjornson, Bruce H., Brain, Ursula, Werker, Janet, Grunau, Ruth E., Miller, Steven P., and Oberlander, Tim F.

Abstract

Background : Prenatal maternal depression (PMD) and Selective Serotonin Reuptake Inhibitor (SSRI) antidepressants are associated with increased developmental risk in infants. Reports suggest that PMD is associated with hyperconnectivity of the insula and the amygdala, while SSRI-exposure is associated with hyperconnectivity of the auditory network in the infant brain. However, associations between functional brain organization and PMD and/or SSRI exposure are not well understood. Methods : We examined the relation between PMD or SSRI exposure and neonatal brain functional organization. Infants of control (n = 17), depressed SSRI-treated (n = 20) and depressed-only (HAM-D ≥ 8) (n = 16) women, underwent resting-state (rs)-fMRI at postnatal day 6. At 6 months temperament was assessed using infant behavioral questionnaire (IBQ). We applied GTA and partial least square regression (PLSR) to the resting-state time-series to assess group differences in modularity, and connector and provincial hubs. Results : Modularity was similar across all groups. The depressed-only group showed higher connector hub values in the left anterior-cingulate, insula, and caudate as well as higher provincial hub values in the amygdala compared to the control group. The SSRI group showed higher provincial hub values in Heschl’s gyrus relative to the depressed-only group. PLSR showed that newborns’ hub values predicted 10% of the variability in infant temperament at 6 months, suggesting different developmental patterns between groups. Conclusions : Prenatal exposures to maternal depression and SSRIs have differential impacts on neonatal functional brain organization. Hub values at 6 days predict variance in temperament between infant groups at 6 months of age.

Published
2020
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18. ISDN2014_0204: Performance‐ and questionnaire‐based tools for the evaluation of executive function in children and adolescents with fetal alcohol spectrum disorder

Author

McLachlan, Kaitlyn, primary, Pei, Jacqueline, additional, Kully‐Martens, Katrina, additional, Paolozza, Angelina, additional, Oberlander, Tim F., additional, Loock, Christine, additional, Andrew, Gail, additional, Reynolds, James, additional, and Rasmussen, Carmen, additional

Published
2015
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33. Hub distribution of the brain functional networks of newborns prenatally exposed to maternal depression and SSRI antidepressants.

Author

Rotem-Kohavi N, Williams LJ, Muller AM, Abdi H, Virji-Babul N, Bjornson BH, Brain U, Werker JF, Grunau RE, Miller SP, and Oberlander TF

Subjects
Adult, Antidepressive Agents therapeutic use, Brain drug effects, Brain Mapping methods, Child Development drug effects, Depressive Disorder physiopathology, Depressive Disorder psychology, Female, Humans, Infant, Infant, Newborn, Magnetic Resonance Imaging methods, Neural Pathways diagnostic imaging, Neural Pathways drug effects, Pregnancy, Pregnancy Complications drug therapy, Pregnancy Complications psychology, Temperament drug effects, Brain physiopathology, Depressive Disorder drug therapy, Mothers psychology, Pregnancy Complications physiopathology, Prenatal Exposure Delayed Effects physiopathology, Selective Serotonin Reuptake Inhibitors therapeutic use
Abstract

Background: Prenatal maternal depression (PMD) and selective serotonin reuptake inhibitor (SSRI) antidepressants are associated with increased developmental risk in infants. Reports suggest that PMD is associated with hyperconnectivity of the insula and the amygdala, while SSRI exposure is associated with hyperconnectivity of the auditory network in the infant brain. However, associations between functional brain organization and PMD and/or SSRI exposure are not well understood., Methods: We examined the relation between PMD or SSRI exposure and neonatal brain functional organization. Infants of control (n = 17), depressed SSRI-treated (n = 20) and depressed-only (HAM-D ≥ 8) (n = 16) women, underwent resting-state functional magnetic resonance imaging at postnatal Day 6. At 6 months, temperament was assessed using Infant Behavioral Questionnaire (IBQ). We applied GTA and partial least square regression (PLSR) to the resting-state time series to assess group differences in modularity, and connector and provincial hubs., Results: Modularity was similar across all groups. The depressed-only group showed higher connector hub values in the left anterior cingulate, insula, and caudate as well as higher provincial hub values in the amygdala compared to the control group. The SSRI group showed higher provincial hub values in Heschl's gyrus relative to the depressed-only group. PLSR showed that newborns' hub values predicted 10% of the variability in infant temperament at 6 months, suggesting different developmental patterns between groups., Conclusions: Prenatal exposures to maternal depression and SSRIs have differential impacts on neonatal functional brain organization. Hub values at 6 days predict variance in temperament between infant groups at 6 months of age., (© 2019 Wiley Periodicals, Inc.)

Published
2019
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34. Factors impacting decisions to decline or adhere to antidepressant medication in perinatal women with mood and anxiety disorders.

Author

Misri S, Eng AB, Abizadeh J, Blackwell E, Spidel A, and Oberlander TF

Subjects
Adult, Anxiety Disorders drug therapy, Depressive Disorder drug therapy, Female, Humans, Postpartum Period drug effects, Pregnancy, Pregnancy Complications drug therapy, Prospective Studies, Severity of Illness Index, Treatment Outcome, Young Adult, Antidepressive Agents therapeutic use, Anxiety Disorders psychology, Depressive Disorder psychology, Patient Compliance psychology, Postpartum Period psychology, Pregnancy Complications psychology
Abstract

Purpose: To identify specific quantitative and qualitative factors that govern the decision to adhere or decline antidepressant medication in antenatal women with moderate-to-severe mood and anxiety disorders., Methods: Fifty women (30 adherers, 20 decliners) were recruited between 18 and 34 weeks gestation in a tertiary care clinic for perinatal mothers. They were prospectively monitored 4 weeks apart up to 1-month postpartum on the: Hamilton Anxiety Scale, Hamilton Depression Scale, Mood Disorders Insight Scale, Antidepressant Compliance Questionnaire, Penn State Worry Questionnaire, and NEO Personality Inventory. Qualitative interviews were conducted at baseline. Hierarchical linear modeling determined illness trajectories of the two groups., Results: Significantly different course of illness was observed in adherers versus decliners. Adherers had healthier attitudes toward depression and compliance with medication (P < .005). Decliners had less illness insight (P < .001) and cited fear of fetal exposure, and thought medication was unwarranted., Conclusions: Pregnant women experienced significantly divergent illness trajectories depending on if they accepted antidepressant medication therapy for their illness. Risk perception, attitudes, and illness insight impacted decisions surrounding adherence and decline., (© 2013 Wiley Periodicals, Inc.)

Published
2013
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