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Your search keyword '"Panagiotis Papanagiotou"' showing total 5 results
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5 results on '"Panagiotis Papanagiotou"'

1. Endovascular Treatment of Very Elderly Patients Aged ≥90 With Acute Ischemic Stroke

Author

Lukas Meyer, Maria Alexandrou, Fabian Flottmann, Milani Deb‐Chatterji, Nuran Abdullayev, Volker Maus, Maria Politi, Kathleen Bernkopf, Christian Roth, Andreas Kastrup, Uta Hanning, Caspar Brekenfeld, Götz Thomalla, Christian Gerloff, Anastasios Mpotsaris, Panagiotis Papanagiotou, Jens Fiehler, and Hannes Leischner

Subjects
elderly, ischemic stroke, nonagenarians, thrombectomy, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Background Patients aged ≥90 were excluded or under‐represented in past thrombectomy trials; thus, uncertainty remains whether treatment benefits can be expected regardless of age. This study investigates outcome and safety of thrombectomy in nonagenarians to improve decision making in a real‐world setting. Methods and Results All currently available data of patients aged ≥90 enrolled in the GSR‐ET (German Stroke Registry–Endovascular Treatment) were combined with a smaller cohort from 3 tertiary stroke centers. Baseline characteristics, procedural (Thrombolysis in Cerebral Infarction scale) and functional outcomes (modified Rankin Scale; mRS), as well as complications (symptomatic intracranial hemorrhage, serious adverse events; SAEs) were analyzed. Good functional outcome was defined as mRS ≤3 at 90‐days. 203 patients with anterior circulation stroke and prestroke mRS ≤3 were included. The rate of successful recanalization (Thrombolysis in Cerebral Infarction scale ≥2b) was 75.9% (154/203). Good functional outcome (mRS ≤3) was observed in 21.6% (41 of 193) at 90‐days. In‐hospital mortality was 27.1% (55 of 203) and increased significantly at 90 days to 48.9% (93 of 190; P

Published
2020
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2. Impact of ASPECTS on computed tomography angiography source images on outcome after thrombolysis or endovascular therapy in large vessel occlusions

Author

Freimuth Brunner, Panagiotis Papanagiotou, Michael Winterhalter, Helmut Hildebrandt, Christian L. Roth, Katrin Wasser, and Andreas Kastrup

Subjects
Male, Orthohantavirus, medicine.medical_specialty, Databases, Factual, Computed Tomography Angiography, medicine.medical_treatment, Large vessel, 030204 cardiovascular system & hematology, Endovascular therapy, Brain Ischemia, 03 medical and health sciences, 0302 clinical medicine, Modified Rankin Scale, Humans, Medicine, Thrombolytic Therapy, In patient, Stroke, Aged, Thrombectomy, Computed tomography angiography, Aged, 80 and over, medicine.diagnostic_test, business.industry, Endovascular Procedures, Thrombolysis, Middle Aged, medicine.disease, 3. Good health, Surgery, Treatment Outcome, Neurology, Tissue Plasminogen Activator, Angiography, Female, Neurology (clinical), Radiology, Tomography, X-Ray Computed, business, 030217 neurology & neurosurgery
Abstract

BACKGROUND AND PURPOSE Endovascular therapy (ET) is superior to intravenous thrombolysis (IVT) in selected patients with anterior circulation large vessel occlusions. However, it is unclear if this positive effect also applies to patients with extensive early ischaemic changes. The aim of this study was to analyze the impact of the Alberta Stroke Program Early Computed Tomography Score (ASPECTS) on the CT angiography source images (SI) on outcome after ET or IVT. METHODS Using our prospectively obtained stroke database and the admission SI-ASPECTS divided into three groups (0-5, 6-7 and 8-10), primarily the rates of good outcome [modified Rankin Scale (mRS) ≤2 at discharge] after either ET (n = 255) or IVT (n = 479) were compared. RESULTS A favorable SI-ASPECTS (8-10) was present in 501 patients, 132 patients had a moderately favorable SI-ASPECTS (6-7) and 101 patients had an unfavorable SI-ASPECTS (0-5). Irrespective of the treatment modality, no patient with an unfavorable SI-ASPECTS had a good outcome and 38% died during hospital stay. Whilst significantly more patients with a favorable SI-ASPECTS had a good outcome after ET than after IVT (51% vs. 35%, P < 0.01), there was only a non-significant trend towards a good outcome after ET than after IVT in patients with a moderately favorable ASPECTS (25% vs. 14%, P = 0.1). CONCLUSION Patients with extensive early ischaemic changes on CT scans (SI- ASPECTS ≤5) might not profit from ET. The impact of ET on outcome in patients with moderately favorable SI-ASPECTS should be addressed in further trials.

Published
2016
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