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Your search keyword '"Pei, Lixia"' showing total 18 results
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18 results on '"Pei, Lixia"'

2. Detailed overview of incidence and management of cytokine release syndrome observed with teclistamab in the MajesTEC‐1 study of patients with relapsed/refractory multiple myeloma

Author

Martin, Thomas G., primary, Mateos, Maria Victoria, additional, Nooka, Ajay, additional, Banerjee, Arnob, additional, Kobos, Rachel, additional, Pei, Lixia, additional, Qi, Ming, additional, Verona, Raluca, additional, Doyle, Margaret, additional, Smit, Jennifer, additional, Sun, Weili, additional, Trancucci, Danielle, additional, Uhlar, Clarissa, additional, van de Donk, Niels W. C. J., additional, and Rodriguez, Cesar, additional

Published
2023
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18. A sensitive method for determination of furanodiene in rat plasma using liquid chromatography/tandem mass spectrometry and its application to a pharmacokinetic study.

Author

Pei L, Liu S, Zheng J, and Chen X

Subjects
Animals, Area Under Curve, Male, Random Allocation, Rats, Rats, Sprague-Dawley, Reproducibility of Results, Sensitivity and Specificity, Chromatography, High Pressure Liquid methods, Furans blood, Furans pharmacokinetics, Heterocyclic Compounds, 2-Ring blood, Heterocyclic Compounds, 2-Ring pharmacokinetics, Tandem Mass Spectrometry methods
Abstract

Furanodiene, a sesquiterpene component extracted from the essential oil of the rhizome of Curcuma wenyujin Y.H. Chen et C. Ling (Wen Ezhu), is widely used in traditional Chinese medicine. A sensitive analytical method was established and validated for furanodiene in rat plasma, which was further applied to assess the pharmacokinetics of furanodiene in rats receiving a single dose of furanodiene. Liquid chromatography tandem mass spectrometry (LC/MS/MS) in multiple reaction monitoring mode was used in the method and costundide was used as internal standard. A simple protein precipitation based on methanol was employed. The simple sample cleanup increased the throughput of the method substantially. The method was validated over the range of 1-1000 ng/mL with a correlation coefficient >0.99. The lower limit of quantification was 1 ng/mL for furanodiene in plasma. Intra- and inter-day accuracies for furanodiene were 88-115 and 102-107%, and the inter-day precision less than 14.4%. After a single oral dose of 10 mg/kg of furanodiene, the mean peak plasma concentration of furanodiene was 66.9 ± 23.4 ng/mL at 1 h, the area under the plasma concentration-time curve (AUC(0-10 h)) was 220 ± 47.8 h ng/mL, and the elimination half-life was 1.53 ± 0.06 h. After an intravenous adminstration of furanodiene at a dosage of 5 mg/kg, the area under the plasma concentration-time curve was 225 ± 76.1 h⋅ng/mL, and the elimination half-life was 2.40 ± 1.18 h. Based on this result, the oral bioavailability of furanodiene in rats at 10 mg/kg is 49.0%., (Copyright © 2011 John Wiley & Sons, Ltd.)

Published
2012
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