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Your search keyword '"Perego, Roberto"' showing total 13 results
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13 results on '"Perego, Roberto"'

1. The therapeutic potential of an allosteric non‐competitive CXCR1/2 antagonist for diabetic nephropathy

Author

Grasselli, Chiara, primary, Bombelli, Silvia, additional, D’Esposito, Vittoria, additional, Di Tolla, Michele Francesco, additional, L’Imperio, Vincenzo, additional, Rocchio, Francesca, additional, Miscione, Martina Sara, additional, Formisano, Pietro, additional, Pagni, Fabio, additional, Novelli, Rubina, additional, Ruffini, Pier Adelchi, additional, Aramini, Andrea, additional, Allegretti, Marcello, additional, Perego, Roberto, additional, and De Filippis, Lidia, additional

Published
2023
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2. The cross‐talk between Abl2 tyrosine kinase and TGFβ1 signalling modulates the invasion of clear cell Renal Cell Carcinoma cells

Author

De Marco, Sofia, primary, Torsello, Barbara, additional, Minutiello, Emanuela, additional, Morabito, Ivana, additional, Grasselli, Chiara, additional, Bombelli, Silvia, additional, Zucchini, Nicola, additional, Lucarelli, Giuseppe, additional, Strada, Guido, additional, Perego, Roberto A., additional, and Bianchi, Cristina, additional

Published
2022
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3. Hepcidin regulation in a mouse model of acute hypoxia

Author

Ravasi, Giulia, primary, Pelucchi, Sara, additional, Buoli Comani, Gaia, additional, Greni, Federico, additional, Mariani, Raffaella, additional, Pelloni, Irene, additional, Bombelli, Silvia, additional, Perego, Roberto, additional, Barisani, Donatella, additional, and Piperno, Alberto, additional

Published
2018
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4. Human urine biomarkers of renal cell carcinoma evaluated by ClinProt

Author

Bosso, N, Chinello, C, Picozzi, S, Gianazza, E, Mainini, V, Galbusera, C, Raimondo, F, Perego, R, Casellato, S, Rocco, F, Ferrero, S, Bosari, S, Mocarelli, P, Kienle, M, Magni, F, BOSSO, NICCOLO', CHINELLO, CLIZIA, GIANAZZA, ERICA, MAININI, VERONICA, GALBUSERA, CARMEN, RAIMONDO, FRANCESCA, PEREGO, ROBERTO, KIENLE, MARZIA DONATELLA, MAGNI, FULVIO, Bosso, N, Chinello, C, Picozzi, S, Gianazza, E, Mainini, V, Galbusera, C, Raimondo, F, Perego, R, Casellato, S, Rocco, F, Ferrero, S, Bosari, S, Mocarelli, P, Kienle, M, Magni, F, BOSSO, NICCOLO', CHINELLO, CLIZIA, GIANAZZA, ERICA, MAININI, VERONICA, GALBUSERA, CARMEN, RAIMONDO, FRANCESCA, PEREGO, ROBERTO, KIENLE, MARZIA DONATELLA, and MAGNI, FULVIO

Abstract

Renal cell carcinoma (RCC) is one of the major causes of cancer death and is radio- and chemoresistant. Urine of 29 healthy subjects and 39 clear cell RCC patients were analyzed using the ClinProt technique to search for possible biomarkers for early RCC diagnosis. A cluster of three signals (marker A= at m/z 1827 ± 8 Da, marker B = 1914 ± 8 Da and marker C = 1968 ± 8 Da) was able to discriminate patients from controls. A receiver operating characteristic curve analysis showed values of area under the curve (AUC) higher than 0.9 for marker A and B, corresponding to a sensitivity of 85-90% and a specificity of' 90%, while marker C gave a lower AUC (0.84) corresponding to sensitivity of 70% and specificity of 100%. The combination of three markers lead to an improvement in diagnostic efficacy, with specificity and sensitivity of 100% and 95%, respectively, in the training test and of 100% and of 85% in the test experiment. The efficacy of this cluster of signals to distinguish RCC patients grouped by tumor stage showed a sensibility of 100% for patients at the primary tumor 1 stage. One ofthe signals present in the cluster was identified as a fragment of Tamm-Horsfall protein. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Published
2008

5. Differential expression of AQP1 in microdomain-enriched membranes of Renal Cell Carcinoma

Author

Ticozzi Valerio, D, Raimondo, F, Pitto, M, Rocco, F, Bosari, S, Perego, R, Sarto, C, Di Fonzo, A, Bosso, N, Mocarelli, P, Kienle, M, Magni, F, RAIMONDO, FRANCESCA, PITTO, MARINA, PEREGO, ROBERTO, MOCARELLI, PAOLO, KIENLE, MARZIA DONATELLA, MAGNI, FULVIO, Ticozzi Valerio, D, Raimondo, F, Pitto, M, Rocco, F, Bosari, S, Perego, R, Sarto, C, Di Fonzo, A, Bosso, N, Mocarelli, P, Kienle, M, Magni, F, RAIMONDO, FRANCESCA, PITTO, MARINA, PEREGO, ROBERTO, MOCARELLI, PAOLO, KIENLE, MARZIA DONATELLA, and MAGNI, FULVIO

Abstract

Human aquaporin-1 (AQP1) is the most studied member of the aquaporin family, acting as molecular water channel. It is also considered a differentiation marker for proximal renal tubular cells, from which clear cells renal cell carcinoma (RCC) originates, playing an important role in urine formation. We therefore studied AQP1 expression at the proteomic level in RCC and normal tissues, mainly focusing on microdomain-enriched membranes in which AQP1 is highly concentrated. Subcellular fractions were prepared through differential centrifugation, and microdomain-enriched fractions were purified from a plasma membrane-enriched fraction by 1% Triton X-100 treatment followed by ultracentrifugation in sucrose gradient. After SDS-PAGE and Western blot analyses with antibodies against AQP1, lower expression levels of AQP1 isoforms were observed in each subcellular fraction of RCC compared to fractions from normal kidney tissues. The presence of AQP1 in the immunoreactive bands was verified by MALDI-TOF-MS and LC-ESI-MS/MS analysis. Glycosylation of AQP1 was also investigated using N-glycosidase F, confirming the presence of a N-glycosylated isoform of AQP1 in the 35-45-kDa region. These results highlight an under-expression of AQP1 protein and its glycosylated isoforms in homogenate and subcellular fraction obtained from RCC tissue compared to adjacent normal cortex. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Published
2007

7. Human urine biomarkers of renal cell carcinoma evaluated by ClinProt

Author

Bosso, Niccolò, primary, Chinello, Clizia, additional, Picozzi, Stefano Carlo Maria, additional, Gianazza, Erica, additional, Mainini, Veronica, additional, Galbusera, Carmen, additional, Raimondo, Francesca, additional, Perego, Roberto, additional, Casellato, Stefano, additional, Rocco, Francesco, additional, Ferrero, Stefano, additional, Bosari, Silvano, additional, Mocarelli, Paolo, additional, Kienle, Marzia Galli, additional, and Magni, Fulvio, additional

Published
2008
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8. Differential expression of AQP1 in microdomain‐enriched membranes of renal cell carcinoma

Author

Ticozzi‐Valerio, Davide, primary, Raimondo, Francesca, additional, Pitto, Marina, additional, Rocco, Francesco, additional, Bosari, Silvano, additional, Perego, Roberto, additional, Sarto, Cecilia, additional, Di Fonzo, Andrea, additional, Bosso, Niccolò, additional, Mocarelli, Paolo, additional, Galli‐Kienle, Marzia, additional, and Magni, Fulvio, additional

Published
2007
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9. Characterization of heat shock protein 27 phosphorylation sites in renal cell carcinoma

Author

Tremolada, Lucia, primary, Magni, Fulvio, additional, Valsecchi, Cristina, additional, Sarto, Cecilia, additional, Mocarelli, Paolo, additional, Perego, Roberto, additional, Cordani, Nicoletta, additional, Favini, Paolo, additional, Galli Kienle, Marzia, additional, Sanchez, Jean‐Charles, additional, Hochstrasser, Denis F., additional, and Corthals, Garry L., additional

Published
2005
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10. Expanding the proteome two-dimensional gel electrophoresis reference map of human renal cortex by peptide mass fingerprinting

Author

Magni, Fulvio, primary, Sarto, Cecilia, additional, Valsecchi, Cristina, additional, Casellato, Stefano, additional, Ferrero Bogetto, Stefano, additional, Bosari, Silvano, additional, Di Fonzo, Andrea, additional, Perego, Roberto A., additional, Corizzato, Matteo, additional, Doro, Giancarlo, additional, Galbusera, Carmen, additional, Rocco, Francesco, additional, Mocarelli, Paolo, additional, and Kienle, Marzia Galli, additional

Published
2005
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12. Expression of heat shock protein 27 in human renal cell carcinoma

Author

Sarto, Cecilia, primary, Valsecchi, Cristina, additional, Magni, Fulvio, additional, Tremolada, Lucia, additional, Arizzi, Carmelo, additional, Cordani, Nicoletta, additional, Casellato, Stefano, additional, Doro, Giancarlo, additional, Favini, Paolo, additional, Perego, Roberto A., additional, Raimondo, Francesca, additional, Ferrero, Stefano, additional, Mocarelli, Paolo, additional, and Galli-Kienle, Marzia, additional

Published
2004
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