Search

Your search keyword '"Qin, Pei"' showing total 60 results
Start Over Author "Qin, Pei" Publisher wiley
60 results on '"Qin, Pei"'

2. Associations of body mass index trajectory, waist circumference trajectory, or both with type 2 diabetes mellitus risk in Chinese adults: The China‐PAR project

Author

Zhao, Yang, primary, Han, Minghui, additional, Qie, Ranran, additional, Zhang, Yanyan, additional, Wu, Yuying, additional, Fu, Xueru, additional, Zhang, Dongdong, additional, Kuang, Lei, additional, Qin, Pei, additional, Hu, Fulan, additional, Li, Jianxin, additional, Lu, Xiangfeng, additional, Hu, Dongsheng, additional, and Zhang, Ming, additional

Published
2024
Full Text
View/download PDF

3. Treatment strategies and pharmacist‐led medication management for Helicobacter pylori infection

Author

Yu‐Zhen Wang, Jie Chen, Shi‐Qin Pei, Chen Wang, Gang Han, Lian‐Di Kan, and Liu‐Cheng Li

Subjects
Drug Discovery
Abstract

Half of the world's population is Helicobacter pylori carrier. Updated guidelines and consensus have been issued across regions with the main aim of reducing social transmission and increasing H. pylori eradication rate. Although alternative therapies including traditional Chinese medicine and probiotics have also been used to improve H. pylori eradication rate in clinical practice, current mainstream treatment is still dependent on triple and quadruple therapies that includes antibacterial agents (e.g., amoxicillin and furazolidone) and proton pump inhibitor. Researches also assessed the eradication rate of optimized high-dose dual therapy in treating H. pylori infection. With the increase of antibiotic resistance rate, the treatment strategies for H. pylori infection are constantly adjusted and improved. Besides, low medication compliance is another key influencing factor for H. pylori treatment failure. Emerging studies indicate that pharmacists' intervention and new pharmaceutical care methods can enhance patient medication compliance, reduce adverse drug reactions, and improve H. pylori eradication rate. The purpose of this review is to summarize the advances in treating H. pylori infection and highlight the necessity of developing novel strategies to cope with the increasing challenges and to achieve personalized medication. Also, this review attaches great importance to pharmacists in optimizing H. pylori treatment outcomes as a routine part of therapy.

Published
2022

4. Risk factors for excess deaths during lockdown among older users of secondary care mental health services without confirmed COVID‐19: A retrospective cohort study

Author

Chen, Shanquan, Jones, Peter B, Underwood, Benjamin R, Fernandez-Egea, Emilio, Qin, Pei, Lewis, Jonathan R, Cardinal, Rudolf N, Chen, Shanquan [0000-0002-4724-4892], Jones, Peter B [0000-0002-0387-880X], Underwood, Benjamin R [0000-0003-3427-9487], Fernandez-Egea, Emilio [0000-0003-4128-8955], Qin, Pei [0000-0003-2303-0379], Lewis, Jonathan R [0000-0003-1821-3824], Cardinal, Rudolf N [0000-0002-8751-5167], Apollo - University of Cambridge Repository, Jones, Peter B. [0000-0002-0387-880X], Underwood, Benjamin R. [0000-0003-3427-9487], Fernandez‐Egea, Emilio [0000-0003-4128-8955], Lewis, Jonathan R. [0000-0003-1821-3824], and Cardinal, Rudolf N. [0000-0002-8751-5167]

Subjects
Mental Health Services, medicine.medical_specialty, 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Secondary Care, excess deaths, RESEARCH ARTICLE, lockdown, Secondary care, COVID‐19, Risk Factors, Humans, Medicine, Research article, retrospective cohort study, Retrospective Studies, SARS-CoV-2, business.industry, COVID-19, Retrospective cohort study, Mental health, Psychiatry and Mental health, Research centre, Family medicine, Communicable Disease Control, Geriatrics and Gerontology, business
Abstract

Funder: UK National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre, Funder: NIHR Applied Research Collaboration East of England, Objective: To investigate factors contributing to excess deaths of older patients during the initial 2020 lockdown beyond those attributable to confirmed COVID‐19. Methods: Retrospective cohort study comparing patients treated between 23 March 2020 and 14 June 2020, deemed exposed to the pandemic/lockdown, to patients treated between 18 December 2019 and 10 March 2020, deemed to be unexposed. Data came from electronic clinical records from secondary care mental health services in Cambridgeshire and Peterborough NHS Foundation Trust (CPFT), UK (catchment area population ∼0.86 million). Eligible patients were aged 65 years or over at baseline with at least 14 days' follow‐up, excluding patients diagnosed with confirmed or suspected SARS‐CoV‐2 infection. The primary outcome was all‐cause mortality. Findings: In the two cohorts, 3,073 subjects were exposed to lockdown and 4,372 subjects were unexposed; the cohorts were followed up for an average of 74 and 78 days, respectively. After controlling for confounding by sociodemographic factors, smoking status, mental comorbidities, and physical comorbidities, patients with dementia suffered an additional 53% risk of death (HR = 1.53, 95% CI = 1.02–2.31), and patients with severe mental illness suffered an additional 123% risk of death (HR = 2.23, 95% CI = 1.42–3.49). No significant additional mortality risks were identified from physical comorbidities, potentially due to low statistical power in that respect. Conclusion: During lockdown people with dementia or severe mental illness had a higher risk of death without confirmed COVID‐19. These data could inform future health service responses and policymaking to help prevent avoidable excess death during future outbreaks of this or a similar infectious disease.

Published
2021

7. Associations of systemic inflammation markers with identification of pulmonary nodule and incident lung cancer in Chinese population

Author

Tian, Ting, primary, Lu, Jing, additional, Zhao, Wei, additional, Wang, Zhongming, additional, Xu, Hai, additional, Ding, Yuqing, additional, Guo, Wen, additional, Qin, Pei, additional, Zhu, Wenfang, additional, Song, Ci, additional, Ma, Hongxia, additional, Zhang, Qun, additional, and Shen, Hongbing, additional

Published
2022
Full Text
View/download PDF

11. Integrated analysis of probability of type 2 diabetes mellitus with polymorphisms and methylation ofKCNQ1gene: A nested case‐control study

Author

Hu, Fulan, primary, Zhang, Yanyan, additional, Qin, Pei, additional, Zhao, Yang, additional, Liu, Dechen, additional, Zhou, Qionggui, additional, Tian, Gang, additional, Li, Quanman, additional, Guo, Chunmei, additional, Wu, Xiaoyan, additional, Qie, Ranran, additional, Huang, Shengbing, additional, Han, Minghui, additional, Li, Yang, additional, Zhang, Ming, additional, and Hu, Dongsheng, additional

Published
2021
Full Text
View/download PDF

13. Association of metabolic score for insulin resistance and its 6‐year change with incident type 2 diabetes mellitus

Author

Zhang, Ming, primary, Liu, Dechen, additional, Qin, Pei, additional, Liu, Yu, additional, Sun, Xizhuo, additional, Li, Honghui, additional, Wu, Xiaoyan, additional, Zhang, Yanyan, additional, Han, Minghui, additional, Qie, Ranran, additional, Huang, Shengbing, additional, Li, Yang, additional, Wu, Yuying, additional, Yang, Xingjin, additional, Feng, Yifei, additional, Zhao, Yang, additional, Hu, Dongsheng, additional, and Hu, Fulan, additional

Published
2021
Full Text
View/download PDF

16. Association of TG / HDLC ratio trajectory and risk of type 2 diabetes: A retrospective cohort study in China

Author

Zhang, Yanyan, primary, Qin, Pei, additional, Lou, Yanmei, additional, Zhao, Ping, additional, Li, Xue, additional, Qie, Ranran, additional, Wu, Xiaoyan, additional, Han, Minghui, additional, Huang, Shengbing, additional, Zhao, Yang, additional, Liu, Dechen, additional, Wu, Yuying, additional, Li, Yang, additional, Yang, Xingjin, additional, Feng, Yifei, additional, Wang, Changyi, additional, Ma, Jianping, additional, Peng, Xiaolin, additional, Chen, Hongen, additional, Zhao, Dan, additional, Xu, Shan, additional, Wang, Li, additional, Luo, Xinping, additional, Zhang, Ming, additional, Hu, Dongsheng, additional, and Hu, Fulan, additional

Published
2020
Full Text
View/download PDF

18. Low‐Density Lipoprotein Cholesterol/High‐Density Lipoprotein Cholesterol Ratio and Carotid Intima‐Media Thickness: A Cohort Study in China

Author

Qin, Pei, primary, Shi, Jing, additional, Cao, Liming, additional, Li, Xue, additional, Lou, Yanmei, additional, Wang, Changyi, additional, Ma, Jianping, additional, Wang, Li, additional, Peng, Xiaolin, additional, Chen, Hongen, additional, Xu, Shan, additional, Zhao, Ping, additional, Hu, Dongsheng, additional, and Hu, Fulan, additional

Published
2020
Full Text
View/download PDF

19. Chinese visceral adiposity index: A reliable indicator of visceral fat function associated with risk of type 2 diabetes

Author

Han, Minghui, primary, Qin, Pei, additional, Li, Quanman, additional, Qie, Ranran, additional, Liu, Leilei, additional, Zhao, Yang, additional, Liu, Dechen, additional, Zhang, Dongdong, additional, Guo, Chunmei, additional, Zhou, Qionggui, additional, Tian, Gang, additional, Huang, Shengbing, additional, Wu, Xiaoyan, additional, Li, Yang, additional, Yang, Xingjin, additional, Feng, Yifei, additional, Liu, Yu, additional, Li, Honghui, additional, Sun, Xizhuo, additional, Chen, Qing, additional, Wang, Tieqiang, additional, Chen, Xiaoliang, additional, Hu, Dongsheng, additional, and Zhang, Ming, additional

Published
2020
Full Text
View/download PDF

20. Dose‐response associations between serum creatinine and type 2 diabetes mellitus risk: A Chinese cohort study and meta‐analysis of cohort studies

Author

Qin, Pei, primary, Lou, Yanmei, additional, Cao, Liming, additional, Shi, Jing, additional, Tian, Gang, additional, Liu, Dechen, additional, Zhou, Qionggui, additional, Guo, Chunmei, additional, Li, Quanman, additional, Zhao, Yang, additional, Liu, Feiyan, additional, Wu, Xiaoyan, additional, Qie, Ranran, additional, Han, Minghui, additional, Huang, Shengbing, additional, Zhao, Ping, additional, Wang, Changyi, additional, Ma, Jianping, additional, Peng, Xiaolin, additional, Xu, Shan, additional, Chen, Hongen, additional, Zhao, Dan, additional, Zhang, Ming, additional, Hu, Dongsheng, additional, and Hu, Fulan, additional

Published
2020
Full Text
View/download PDF

21. Baseline serum albumin and its dynamic change is associated with type 2 diabetes risk: A large cohort study in China

Author

Hu, Fulan, primary, Lou, Yanmei, additional, Shi, Jing, additional, Cao, Liming, additional, Wang, Changyi, additional, Ma, Jianping, additional, Peng, Xiaolin, additional, Xu, Shan, additional, Chen, Hongen, additional, Zhao, Dan, additional, Zhao, Yang, additional, Guo, Chunmei, additional, Liu, Dechen, additional, Zhou, Qionggui, additional, Li, Quanman, additional, Liu, Feiyan, additional, Tian, Gang, additional, Wu, Xiaoyan, additional, Qie, Ranran, additional, Han, Minghui, additional, Huang, Shengbing, additional, Zhao, Ping, additional, Zhang, Ming, additional, Hu, Dongsheng, additional, and Qin, Pei, additional

Published
2020
Full Text
View/download PDF

22. Obstructive sleep apnea and risk of type 2 diabetes mellitus: A systematic review and dose‐response meta‐analysis of cohort studies

Author

Qie, Ranran, primary, Zhang, Dongdong, additional, Liu, Leilei, additional, Ren, Yongcheng, additional, Zhao, Yang, additional, Liu, Dechen, additional, Liu, Feiyan, additional, Chen, Xu, additional, Cheng, Cheng, additional, Guo, Chunmei, additional, Li, Quanman, additional, Zhou, Qionggui, additional, Tian, Gang, additional, Han, Minghui, additional, Huang, Shengbing, additional, Wu, Xiaoyan, additional, Qin, Pei, additional, Li, Jianxin, additional, Cao, Jie, additional, Zhang, Ming, additional, Huang, Jianfeng, additional, Lu, Jie, additional, Li, Honghui, additional, Wang, Jian, additional, Cheng, Ruirong, additional, and Hu, Dongsheng, additional

Published
2020
Full Text
View/download PDF

23. Association of total sedentary behaviour and television viewing with risk of overweight/obesity, type 2 diabetes and hypertension: A dose–response meta‐analysis

Author

Guo, Chunmei, primary, Zhou, Qionggui, additional, Zhang, Dongdong, additional, Qin, Pei, additional, Li, Quanman, additional, Tian, Gang, additional, Liu, Dechen, additional, Chen, Xu, additional, Liu, Leilei, additional, Liu, Feiyan, additional, Cheng, Cheng, additional, Qie, Ranran, additional, Han, Minghui, additional, Huang, Shengbing, additional, Wu, Xiaoyan, additional, Zhao, Yang, additional, Ren, Yongcheng, additional, Zhang, Ming, additional, Liu, Yu, additional, and Hu, Dongsheng, additional

Published
2019
Full Text
View/download PDF

25. An Efficient and Environmentally Friendly Method for Directly Converting Trityl and Benzyl Ethers to the Corresponding Acetates

Author

Qing-Shan Zhang, Ning-Ning Liu, Qin-Pei Wu, Wei-yuan Yuan, and Pan Yu

Subjects
Green chemistry, chemistry.chemical_compound, Benzyl ether, chemistry, Acid sensitive, Organic chemistry, Alcohol, General Chemistry, Environmentally friendly, Benzyl acetate, Direct transformation
Abstract

Acid sensitive benzyl and trityl ethers are frequently used as protecting groups to mask alcohols. They are also needed to be transformed into more stable ester groups toward acids in multistep synthesis. A mild and efficient one-pot protocol for the selective transformation of benzyl and trityl ethers into their corresponding acetates was successfully developed. Several distinct advantages to this procedure include direct transformation, minimal generation of waste, a non-aqueous workup and the recovery and recycling of the benzyl acetate and trityl alcohol by-products, which were readily recovered in greater than 90% yields.

Published
2014

28. Cocaine detection by structure-switch aptamer-based capillary zone electrophoresis

Author

Ying-Lin Zhou, Cai Tie, Xin-Xiang Zhang, and Qin-Pei Deng

Subjects
Chromatography, Oligonucleotide, Aptamer, Clinical Biochemistry, Biochemistry, Small molecule, Combinatorial chemistry, Fluorescence, Analytical Chemistry, chemistry.chemical_compound, Fluorescein amidite, Capillary electrophoresis, chemistry, Duplex (building), Nucleic acid
Abstract

Aptamers, which are nucleic acid oligonucleotides that can bind targets with high affinity and specificity, have been widely applied as affinity probes in capillary electrophoresis (CE). Due to relative weak interaction between aptamers and small molecules, the application of aptamer-based CE is still limited in certain compounds. A new strategy that is based on the aptamer structure-switch concept was designed for small molecule detection by a novel CE method. A carboxyfluorescein (fluorescein amidite, FAM) label DNA aptamer was first incubated with partial complementary strand (CS), and then the free aptamer and the aptamer-CS duplex were well separated and determined by metal cation mediated CE/laser-induced fluorescence. When the target was introduced into the incubated sample, the hybridized form was destabilized, resulting in the changes of the fluorescence intensities of the free aptamer and the aptamer-CS duplex. The length of CS was investigated and 12 mer CS showed the best sensitivity for the detection of cocaine. The presented CE-LIF method, which combines the separation power of CE with the specificity of interactions occurring between target, aptamer, and CS, could be a universal detection strategy for other aptamer-specified small molecules.

Published
2012

29. Chemiluminescently labeled aptamers as the affinity probe for interaction analysis by capillary electrophoresis

Author

Qin-Pei Deng, Ying-Lin Zhou, Hong-Yi Li, Xin-Xiang Zhang, and De-Wen Zhang

Subjects
Luminescent Agents, Chromatography, Oligonucleotide, Chemistry, Aptamer, Clinical Biochemistry, Electrophoresis, Capillary, Aptamers, Nucleotide, Biochemistry, Analytical Chemistry, law.invention, Dissociation constant, Electrophoresis, Capillary electrophoresis, Isothiocyanates, Covalent bond, law, Luminescent Measurements, Binding site, Chemiluminescence
Abstract

Aptamers are nucleic acid oligonucleotides, which can recognize targets with high affinity and specificity. Fluorescently labeled aptamers have been used as affinity probes in CE for interaction analysis. In this study, a method of labeling aptamers chemiluminescently with isoluminol isothiocyanate (ILITC) through covalent bonds was proposed and realized. The ILITC-labeled aptamers were characterized by HPLC-MS and purified by HPLC. After desalination, the ILITC-labeled aptamers were employed as the affinity probe for interaction analysis in CE coupled with chemiluminescence detection (CE-CL) by interface of end column reaction mode, the apparatus of which was home-designed and setup. CE-CL experiment conditions, including buffer pH, concentrations of horseradish peroxidase and H(2)O(2), were optimized first. The system of thrombin and its 29-mer aptamer was chosen as the model. Binding parameters, namely the dissociation constant (K(d)) and the binding site number (n), were calculated. The K(d) obtained was 124.0+/-6.9 nM in agreement with the reported values. Thus, interaction analysis method based on chemiluminescently labeled aptamers as the affinity probe in CE-CL has been established. This method can be widely applied due to the ease and universality of the labeling method, simplicity of CE-CL apparatus and combination with aptamers for a wide range of targets.

Published
2010

30. ChemInform Abstract: An Efficient and Environmentally Friendly Method for Directly Converting Trityl and Benzyl Ethers to the Corresponding Acetates

Author

Ning-Ning Liu, Wei-yuan Yuan, Qing-Shan Zhang, Qin-Pei Wu, and Pan Yu

Subjects
Primary (chemistry), Chemistry, General Medicine, Combinatorial chemistry, Environmentally friendly, Catalysis
Abstract

A simple one-pot procedure using HClO4 on silica as heterogeneous reusable catalyst allows the selective conversion of primary benzyl and trityl ethers into acetates.

Published
2015

31. ChemInform Abstract: Reductive Amination of Acetals by Anilines in the Presence of Triethylsilane and Iodine

Author

Xue-Lin Zhang, Qin-Pei Wu, Yong-Wei Wu, Qing-Shan Zhang, and Pan Yu

Subjects
chemistry.chemical_compound, chemistry, chemistry.chemical_element, Organic chemistry, General Medicine, Triethylsilane, Iodine, Reductive amination
Abstract

A mild, metal-free approach for the direct reductive N-alkylation of aromatic amines with acetals using the iodine-triethylsilane reductive system is described.

Published
2015

32. ChemInform Abstract: A Multicomponent Reaction of Acetals for the Preparation of Quinolines

Author

Xue-Lin Zhang, Qin-Pei Wu, and Qing-Shan Zhang

Subjects
chemistry.chemical_classification, chemistry.chemical_compound, chemistry, Alkyne, Organic chemistry, General Medicine, Dimethoxymethane, Diphenylacetylene
Abstract

No products are obtained when an internal alkyne diphenylacetylene or unsubstituted dimethoxymethane are used as substrates.

Published
2014

36. ChemInform Abstract: An Atom-Efficient and Powerful Method for Direct Esterification of Silyl Ethers Catalyzed by HClO4-SiO2

Author

Qin-Pei Wu, Yi-Nan Shu, Ti-Jian Du, Yunzheng Li, Xiao-Dong Xi, Xi Chen, Qing-Shan Zhang, and Hai-Xia Liu

Subjects
Silylation, Chemistry, Organic chemistry, Atom (order theory), General Medicine, Environmentally friendly, Catalysis
Abstract

The fluoride-free one-pot method is environmentally friendly since the silyl protecting groups are transformed into acetates as the sole byproducts, which are readily recoverable and converted back to silyl chlorides as protecting agents by treatment with conc.

Published
2011

37. ChemInform Abstract: Synthesis and Antitumor Activity of Novel 2′,3′-Diethanethio-2′,3′,5′-trideoxy-5′-triazolonucleoside Analogues

Author

Jin-Lan Yu, Hongquan Yin, Xiao-Dong Xi, Qin-Pei Wu, Yan-Hong Liu, Yunzheng Li, Qing-Shan Zhang, and Ning-Ning Liu

Subjects
Antitumor activity, chemistry.chemical_compound, chemistry, Stereochemistry, Nucleic acid, General Medicine, Derivative (chemistry)
Abstract

A series of novel triazoloribonucleosides (VII) is synthesized by the route described for the preparation of derivative (VI) and evaluated for antitumor activity.

Published
2010

42. Mild, Efficient, and Selective Cleavage of Trityl Ethers with Antimony Trichloride

Author

Yuan Wang, Wei Chen, Hua Liu, and Qin-Pei Wu

Subjects
Antimony trichloride, Chemistry, Organic Chemistry, chemistry.chemical_element, General Medicine, Chemical synthesis, Combinatorial chemistry, Uridine, Catalysis, Selective cleavage, chemistry.chemical_compound, Hydrolysis, Antimony, Nucleic acid, Organic chemistry, Lewis acids and bases
Abstract

Selective detritylation is quite crucial in synthetic chemistry. A mild and efficient procedure for selective hydrolysis of trityl ethers in the presence of other frequently used hydroxy protecting groups: TBDPS, Bz, Bn, Ac and Ts with antimony trichloride was described and 5′‐trityl uridine was detritylated smoothly too.

Published
2006

Catalog

Books, media, physical & digital resources
See catalog results