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1. A Malaysian consensus report on the diagnosis and treatment of Helicobacter pylori infection

Author

Khean‐Lee Goh, Yeong Yeh Lee, Alex Hwong‐Ruey Leow, Raja Affendi Raja Ali, Shiaw Hooi Ho, Sanjiv Mahadeva, Rosaida Hj Mohd Said, Raman Muthukaruppan Chettiar, and Hoi Poh Tee

Subjects
diagnosis, Helicobacter pylori infection, Malaysian consensus, peptic ulcer disease, treatment, Diseases of the digestive system. Gastroenterology, RC799-869
Abstract

Abstract Helicobacter pylori is one of the most common chronic bacterial infections in humans and responsible for 90% of duodenal ulcers and 70–90% of gastric ulcers. Despite this, many misconceptions regarding the appropriate diagnostic method and treatment strategies still exist in the Malaysian clinical practice. Under the initiative of the steering committee, an expert panel consisting of nine key opinion leaders in the field of gastroenterology convened to develop a set of consensus statements that are relevant to the Malaysian healthcare practice. The panel members reviewed the current evidence on the management of H. pylori infection, focusing on the best practices that are relevant to the Malaysian population based on clinical experience and published clinical evidence. Using the modified Delphi method, the panel achieved consensus in three areas of H. pylori infection management: indications for testing, diagnosis, and treatment. The panel proposed a set of 19 consensus statements, which were synthesized via two rounds of blinded voting and group discussions. The recommendations provided are relevant to the Malaysian population and can be used as a guide by physicians across various healthcare settings to facilitate appropriate diagnostic testing and treatment of H. pylori infection.

Published
2023
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2. Ten missteps in the management of inflammatory bowel disease in Asia: An expert report by the Asian Pacific Association of Gastroenterology Working Group on Inflammatory Bowel Disease

Author

Ahuja, Vineet, primary, Hilmi, Ida, additional, Ye, Byong Duk, additional, Ling, Khoon Lin, additional, Ng, Siew C., additional, Leong, Rupert W., additional, Kumar, Peeyush, additional, Khoo, Xin Hui, additional, Makharia, Govind K., additional, Sollano, Jose, additional, Pisespongsa, Pises, additional, Mustaffa, Nazri, additional, Banerjee, Rupa, additional, Leow, Alex Hwong‐Ruey, additional, Raja Ali, Raja Affendi, additional, Chuah, Sai Wei, additional, Palaniappan, Shanthi, additional, Ooi, Choon Jin, additional, and Leung, Wai K., additional

Published
2024
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3. Accuracy of physician gestalt in prediction of significant abdominal and pelvic injury in adult blunt trauma patients

Author

Rodriguez, Nicole M., primary, Mower, William R., additional, Raja, Ali S., additional, Gupta, Malkeet, additional, Montoy, Juan Carlos, additional, Parry, Blair, additional, Chan, Virginia, additional, Wong, Angela H. K., additional, Wilcox, James, additional, Quiñones, Alexandra, additional, and Rodriguez, Robert M., additional

Published
2023
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4. Implication of food insecurity on the gut microbiota and its potential relevance to a multi‐ethnic population in Malaysia

Author

RAJA AFFENDI RAJA ALI, Nor Hamizah Shafiee, Nurul Huda Razalli, Khairul Najmi Muhammad Nawawi, and Norfilza Mokhtar

Subjects
nutrition, Hepatology, gut microbiota, food insecurity, digestive, oral, and skin physiology, Gastroenterology, multi‐ethnic population, RC799-869, Diseases of the digestive system. Gastroenterology, diet
Abstract

Food insecurity (FI) has an impact on food intake, and it can make it difficult for people to eat enough nutritious food at all times to sustain an active and healthy lifestyle. The COVID‐19 outbreak has hampered people's capacity to obtain nutritious and affordable food. Although FI has been studied in Malaysia, the extent to which it is linked to gut microbiota has yet to be discovered. This review aimed to compile evidence of the relationship between FI and gut microbial changes and their potential relevance to a multi‐ethnic population in Malaysia. FI is typically associated with cheaper and calorie‐dense foods because of the high cost of quality food and financial constraints that hinder food‐insecure people from adopting healthier dietary choices. As a result, they have started eating low‐quality food such as simple carbohydrates, fats, and processed foods. These poor eating habits can reduce microbial diversity and influence changes in the composition and function of the gut microbiota. This review also explores the impact of ethnicity on the variation in composition of gut microbiota. In conclusion, the findings of this review may be utilized to develop and implement diet‐related intervention programs to ensure that Malaysians get enough nutritious food to maintain a healthy gut microbiota and improve overall health.

Published
2022

5. The impact of diet and ethnicity on gut microbiota variation in irritable bowel syndrome: A multi‐center study

Author

Xin‐Hui Khoo, Chun‐Wie Chong, Abdul Malik Talha, Koshy Philip, Cindy Shuan‐Ju Teh, Adib Mat Isa, Mung Seong Wong, Deborah Chia‐Hsin Chew, Zhiqin Wong, Nor Syarahani Jusoh, Noorhuda Madihah Mohamed Maksum, Norfilza Mohd Mokhtar, Hazreen Abdul Majid, Raja Affendi Raja Ali, Yeong‐Yeh Lee, and Sanjiv Mahadeva

Subjects
Hepatology, Gastroenterology
Published
2023
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7. Consensus statements and recommendations on the management of mild‐to‐moderate gastroesophageal reflux disease in the Southeast Asian region

Author

Van Huy Tran, Somchai Leelakusolvong, Reuben Kong Min Wong, Monthira Maneerattanaporn, Khean-Lee Goh, Jose D. Sollano, Dadang Makmun, Yeong Yeh Lee, Raja Affendi Raja Ali, and Duc Trong Quach

Subjects
medicine.medical_specialty, Consensus, Nerd, RC799-869, Disease, Southeast asian, alginates, Weight loss, Internal medicine, Epidemiology, Medicine, Esophagus, mild‐to‐moderate gastroesophageal reflux disease, Hepatology, business.industry, Incidence (epidemiology), Gastroenterology, proton‐pump inhibitors, Diseases of the digestive system. Gastroenterology, medicine.disease, humanities, digestive system diseases, consensus recommendations, medicine.anatomical_structure, GERD, medicine.symptom, business
Abstract

This paper reports the proceedings from the first consensus meeting on the management of mild‐to‐moderate gastroesophageal reflux disease (GERD) in the Southeast Asian (SEA) region. Seventeen statements were drawn up by a steering committee that focused on epidemiology, mechanism of action, diagnostic investigations, and treatment. Voting on the recommendations used the Delphi method with two rounds of voting among the 10 panel members. The consensus panel agreed that GERD is mostly a mild disease in the SEA region with predominantly non‐erosive reflux disease (NERD). Complicated GERD and Barrett's esophagus are infrequently seen. The panel recommended endoscopy in patients with alarm or refractory symptoms but cautioned that the incidence of gastric cancer is higher in SEA. pH and impedance measurements were not recommended for routine assessment. The acid pocket is recognized as an important pathogenic factor in GERD. Lifestyle measures such as weight reduction, avoidance of smoking, reduction of alcohol intake, and elevation of the head of the bed were recommended but strict avoidance of specific foods or drinks was not. Alginates was recommended as the first‐line treatment for patients with mild‐to‐moderate GERD while recognizing that proton‐pump inhibitors (PPIs) remained the mainstay of treatment of GERD. The use of alginates was also recommended as adjunctive therapy when GERD symptoms were only partially responsive to PPIs., Algorithm for the management of mild‐to‐moderate gastroesophageal reflux disease in the Southeast Asian region derived from the consensus statements and recommendations of an expert panel.

Published
2021
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9. Asian Pacific Association of Gastroenterology (APAGE) Inflammatory Bowel Disease (IBD) Working Party guidelines on IBD management during the COVID‐19 pandemic

Author

Marcellus Simadibrata, Choon Jin Ooi, Rupert W. Leong, Siew C. Ng, Khoon Lin Ling, Wai K. Leung, Kai Chun Wu, Pises Pisespongsa, Min Hu Chen, Ida Hilmi, Sai Wei Chuah, Shu-Chen Wei, Deng-Chyang Wu, Raja Affendi Raja Ali, Tadakazu Hisamatsu, Govind K. Makharia, Jose D. Sollano, Vineet Ahuja, Rupa Banerjee, Zhi Hua Ran, and Byong Duk Ye

Subjects
medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), RC799-869, Leading Article, inflammatory bowel diseases, Inflammatory bowel disease, 03 medical and health sciences, 0302 clinical medicine, COVID‐19, Pandemic, medicine, Intensive care medicine, Personal protective equipment, ulcerative colitis, Crohn's disease, Hepatology, Leading Articles, business.industry, Social distance, Gastroenterology, Diseases of the digestive system. Gastroenterology, medicine.disease, Ulcerative colitis, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, business
Abstract

The COVID‐19 pandemic, secondary to SARS‐CoV‐2, has resulted in high mortality and morbidity worldwide. As inflammatory bowel disease (IBD) is a chronic disease, and most patients are on long‐term immunosuppressive agents, there is understandable concern, particularly in terms of therapy. In view of this, experts in IBD across the Asia Pacific region were invited to put together recommendations based on their experience and the currently available data. In general, most IBD therapies (with a few exceptions) can be continued safely, and the general consensus is that maintaining disease control should remain the main principle of management. In addition, social distancing measures and the appropriate use of personal protective equipment should be strictly adhered to. During the current pandemic, face‐to‐face clinic follow ups and non‐urgent procedures should be kept to a minimum., This is a concerted effort by the members of the Asian Pacific Association of Gastroenterology Inflammatory Bowel Disease (IBD) Workgroup members to provide guidance on IBD management (all‐in‐one succinct review paper) during the difficult COVID‐19 pandemic.

Published
2020
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10. Malaysian Society of Gastroenterology and Hepatology consensus statement on metabolic dysfunction‐associated fatty liver disease

Author

Chan, Wah‐Kheong, primary, Tan, Soek‐Siam, additional, Chan, Siew‐Pheng, additional, Lee, Yeong‐Yeh, additional, Tee, Hoi‐Poh, additional, Mahadeva, Sanjiv, additional, Goh, Khean‐Lee, additional, Ramli, Anis Safura, additional, Mustapha, Feisul, additional, Kosai, Nik Ritza, additional, and Raja Ali, Raja Affendi, additional

Published
2022
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12. Mobile app helps trainees manage emergencies at the bedside

Author

Chu, Andrew L., primary, Keschner, Yonatan G., additional, Lai, Lucinda, additional, Baugh, Joshua J., additional, Baugh, Christopher W., additional, Biddinger, Paul D., additional, Raja, Ali S., additional, Isselbacher, Eric M., additional, and Conley, Jared, additional

Published
2021
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13. Best practices on immunomodulators and biologic agents for ulcerative colitis and Crohn's disease in Asia

Author

Marcellus Simadibrata, Ida Hilmi, Siew C. Ng, Wee Chian Lim, Khean-Lee Goh, Richard Geary, Nazri Mustaffa, Colitis, Pises Pisespongsa, Wai K. Leung, Min Hu Chen, Sai Wei Chuah, Byong Duk Ye, Rupa Banerjee, Jose D. Sollano, Evan G. Ong, Rupert W. Leong, Rungsun Rerknimitr, Vineet Ahuja, Tadakazu Hisamatsu, David E. Ong, Murdani Abdullah, Khoon Lin Ling, Deng-Chyang Wu, Qin Ouyang, Zhi Hua Ran, Govind K. Makharia, Shu-Chen Wei, Julajak Limsrivilai, Choon Jin Ooi, Dong Il Park, Raja Affendi Raja Ali, Janaka de Silva, and Suk-Kyun Yang

Subjects
Crohn's disease, medicine.medical_specialty, Hepatology, business.industry, Gastroenterology, Biosimilar, Disease, medicine.disease, Inflammatory bowel disease, Ulcerative colitis, digestive system diseases, Infliximab, 03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, Adalimumab, medicine, 030211 gastroenterology & hepatology, Colitis, Intensive care medicine, business, medicine.drug
Abstract

The Asia-Pacific Working Group on Inflammatory Bowel Disease was established in Cebu, Philippines, under the auspices of the Asia-Pacific Association of Gastroenterology with the goal of improving inflammatory bowel disease care in Asia. This consensus is carried out in collaboration with Asian Organization for Crohn's and Colitis. With biologic agents and biosimilars becoming more established, it is necessary to conduct a review on existing literature and establish a consensus on when and how to introduce biologic agents and biosimilars in conjunction with conventional treatments for ulcerative colitis and Crohn's disease in Asia. These statements also address how pharmacogenetics influences the treatments of ulcerative colitis and Crohn's disease and provides guidance on response monitoring and strategies to restore loss of response. Finally, the review includes statements on how to manage treatment alongside possible hepatitis B and tuberculosis infections, both common in Asia. These statements have been prepared and voted upon by members of inflammatory bowel disease workgroup employing the modified Delphi process. These statements do not intend to be all-encompassing, and future revisions are likely as new data continue to emerge.

Published
2019
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15. Consensus statements and recommendations on the management of mild‐to‐moderate gastroesophageal reflux disease in the Southeast Asian region

Author

Goh, Khean‐Lee, primary, Lee, Yeong‐Yeh, additional, Leelakusolvong, Somchai, additional, Makmun, Dadang, additional, Maneerattanaporn, Monthira, additional, Quach, Duc Trong, additional, Raja Ali, Raja Affendi, additional, Sollano, Jose D, additional, Tran, Van Huy, additional, and Wong, Reuben Kong‐Min, additional

Published
2021
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16. The revised Approved Instructional Resources score: An improved quality evaluation tool for online educational resources

Author

Grock, Andrew, primary, Jordan, Jaime, additional, Zaver, Fareen, additional, Colmers‐Gray, Isabelle N., additional, Krishnan, Keeth, additional, Chan, Teresa, additional, Thoma, Brent, additional, Alexander, Charlotte, additional, Alkhalifah, Mohammed, additional, Almehlisi, Abdulaziz S., additional, Alqahtani, Saeed, additional, Anderson, Scott, additional, Anderson, Shelaina, additional, Andrews, Colin, additional, Andruko, Jocelyn, additional, Antony, Nikytha, additional, Aryal, Diptesh, additional, Backus, Barbra, additional, Baird, Jennifer, additional, Baker, Andrew, additional, Batty, Sarah, additional, Baylis, Jared, additional, Beaumont, Braeden, additional, Belcher, Chris, additional, Benavides, Brent, additional, Benham, Michael, additional, Botta, Julian, additional, Berger Pelletier, Elyse, additional, Bouchard, Nicholas, additional, Brazil, Victoria, additional, Brumfield, Emily, additional, Bryson, Anthony, additional, Bunchit, Wisarut, additional, Butler, Kat, additional, Buzikievich, Lindy, additional, Calcara, David, additional, Carey, Rob, additional, Carrillo, Maria Rosa, additional, Carroll, Stephen, additional, Lyons, Casey, additional, Cassidy, Louise, additional, Challen, Kirsty, additional, Chan, Kathryn, additional, Chaplin, Tim, additional, Chatham‐Zvelebil, Natasha, additional, Chen, Eric, additional, Chen, Lucy, additional, Chhabra, Sushant, additional, Chin, Alvin, additional, Chochi, Eric, additional, Choudhri, Tina, additional, Christensen, Jeremy, additional, Connors, Kimberly, additional, Coppersmith, Veronica, additional, Cosgrove, Abby, additional, Costello, Gregory, additional, Cullison, Kevin, additional, D'Alessandro, Andrew, additional, Wit, Kerstin, additional, Decock, Marie, additional, Delbani, Rayan, additional, Denq, William, additional, Deutscher, Julianna, additional, Devine, Brendan, additional, Dorsett, Maia, additional, Duda, Taylor, additional, Dueweke, Justin, additional, Dunphy, Teresa, additional, Dyer, Sean, additional, Eastley, Karthryn T., additional, Edmonds, Marcia, additional, Edwards, Ken, additional, Ehrman, Robert, additional, Elkhalidy, Youness, additional, Fedor, Preston, additional, Ficiur, Brian, additional, Flynn, Caley, additional, Fraser, Bill, additional, Fu, Meagan, additional, Fukakusa, James, additional, Funk, Eric, additional, Gaco, Damjan, additional, Gawlik, Viktor, additional, Ghaffarian, Kenn, additional, Gharahbaghian, Laleh, additional, Griffith, Andrew, additional, Griffith, Phil, additional, Gronowski, Tanner, additional, Grossman, Cathy, additional, Gucwa, Jaroslaw, additional, Gupta, Pawan, additional, Gustafson, Alexandra, additional, Guy, Andrew, additional, Haas, Mary, additional, Haciski, Stanislaw, additional, Hajdinjak, Emina, additional, Hall, Andrew K, additional, Hammock, Regina, additional, Hansel, Jan, additional, Hart, Alexander, additional, Hattin, Larissa, additional, Herb, Brandon, additional, Hilbert, SueLin, additional, Hill, Jeff, additional, Hill, Jesse, additional, Ho, Amy, additional, House, Emily, additional, House, Nina, additional, Huang, Simon York Ming, additional, Huffman, James, additional, Inboriboon, Charlie, additional, Ireland, Alex, additional, Jamal, Ali, additional, Jamil, Mohammad Ali, additional, Jansen, Victor, additional, Jarou, Zach, additional, Jia, Vivian, additional, Johnston, Levi, additional, Kalnow, Drew, additional, Kapur, Puneet, additional, Kelly, Seth, additional, Kelson, Kyle, additional, Kent, William, additional, Khakhkhar, Rishi, additional, Khurana, Jaasmit, additional, Kilp, Ashley, additional, Knapp, Scott, additional, Kohler, Sebastian, additional, Kruhlak, Ivanna, additional, Lalani, Nadim, additional, Lam, Samantha, additional, Lank, Patrick, additional, Laurie, Zander, additional, Lea, Kristina, additional, Leber, Ernest, additional, Lee, Ching‐Hsing, additional, Lenes, Haakon, additional, Lenora, Nilantha, additional, Leontowicz, Jesse, additional, Lien, Kelly, additional, Lin, Michelle, additional, Lin, Yingchun, additional, Little, Andrew, additional, Liu, Harry, additional, Liu, Ivy, additional, Liu, Steve, additional, Louka, Stephanie, additional, Lovell, Elise, additional, Lowe, David, additional, Lubberdink, Ashley, additional, Luc, Jessica, additional, Ma, Sheng‐Hsiang, additional, MacLeod, Hugh, additional, Mancuso, Nick, additional, Maneshi, Anali, additional, May, Jesse, additional, Mayo, John, additional, McDonnell, Mike, additional, McLellan, Susan, additional, McQuarrie, Carolyn, additional, Mead, Therese, additional, Meeuwisse, Cory, additional, Meloy, Patrick, additional, Menzies, Perry, additional, Messman, Anne, additional, Miazga, Stephen, additional, Mills, Logan, additional, Mix, Allan, additional, Montag, Steve, additional, Moore, Brendan, additional, Morgenstern, Justin, additional, Mott, Sarah, additional, Mukherj, P, additional, Mulla, Ali, additional, Nandalal, Sheena, additional, Nikel, Taylor, additional, Nood, Julia, additional, Nugent, Sean, additional, Oakland, Morgan, additional, Oberholzer, Werner, additional, Otugo, Onyeka, additional, Oyedokun, Taofiq Segun, additional, Pardhan, Alim, additional, Patel, Kinjal, additional, Paterson, Quinten, additional, Patocka, Catherine, additional, Patterson, Christine, additional, Pearlman, James, additional, Pelletier‐Bui, Alexis, additional, Phan, Marc, additional, Poonja, Zafrina, additional, Powell, Aubrey, additional, Premkumar, Kamini, additional, Prosen, Gregor, additional, Puri, Vishal, additional, Quaife, Tanis, additional, Raffel, Ryan, additional, Raja, Ali, additional, Ramunno, Randi, additional, Rang, Louise, additional, Rannazzisi, Suzanne, additional, Regan, Shauna, additional, Rezaie, Salim R, additional, Ridderikhof, Milan, additional, Rogers, Vanessa, additional, Roh, Christine, additional, Rosenberg, Keith, additional, Roure, Marina, additional, Rudinsky, Sherri, additional, Rudner, Joshua, additional, Saleh, Adeeb, additional, Sanderson, Will, additional, Scheirer, Owen, additional, Schofield, Paul, additional, Schunk, Paul, additional, Schwarz, Evan, additional, Shahrabadi, Parisa, additional, Shappell, Eric, additional, Sheffield, Julia, additional, Singh, Manpreet, additional, Singson, Hector C, additional, Slessor, Dave, additional, Smith, Sam, additional, Sneath, Paula, additional, Sobehart, Robert, additional, Spearing, Kerry, additional, Stempien, James, additional, Sternard, Britni, additional, Stratton, Tara, additional, Stuart, Katherine, additional, Stuntz, Bob, additional, Susalla, Michael, additional, Sweeney, Colleen, additional, Swisher, Loice, additional, Swoboda, Henry, additional, Syed, Shahbaz, additional, Taira, Taku, additional, Tambe, Nikhil, additional, Tang, Richard, additional, Targonsky, Elisha, additional, Taylor, Alan, additional, Taylor, Rachel, additional, Taylor, Todd, additional, Ting, Paxton, additional, Tiwald, Gerhard, additional, Tran, Evelyn, additional, Tran, Kelvin, additional, Trickovic, Jason, additional, Trinquero, Paul, additional, Tyagi, Aaron, additional, Umana, Manrique, additional, Vallance, Patrick, additional, Van den Berg, Patricia, additional, van Diepen, Kelly, additional, Vargas, Luis, additional, Verbeek, Rene, additional, Viggers, Sandra, additional, Vlodaver, Zlata, additional, Wagner, Matthew, additional, Walji, Noorin, additional, Walter, Joe, additional, Wan, Miranda, additional, Wang, Rachel, additional, Wanner, Gregory, additional, Warawa, Wyatt, additional, Ward, Mike, additional, Weekes, Jennifer, additional, Weersink, Kristen, additional, Weessies, Cara, additional, Whalen‐Browne, Anna, additional, Whiteside, Brian, additional, Willis, Matthew, additional, Wilmer, Jonas, additional, Wong, Nelson, additional, Woodcroft, Mark, additional, Woods, Rob, additional, Yau, Lawrence, additional, Yee, Jessica, additional, Yeh, Calvin, additional, Yurkiw, Katherine, additional, and Zozula, Alexander, additional

Published
2021
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18. Consensus and contentious statements on the use of probiotics in clinical practice: A south east Asian gastro-neuro motility association working team report

Author

James Guoxian Huang, Yeong Yeh Lee, Marcellus Simadibrata, Khoon Lin Ling, Sutep Gonlachanvit, Chong Yuen Wong, Yee Kian Yin, Kuck Meng Chong, Andrew Seng Boon Chua, Jane D. Ricaforte-Campos, Somchai Leelakusolvong, Yock Young Dan, Raja Affendi Raja Ali, Christina Ong, Choon Jin Ooi, Warren Wei Rhen Lee, Jose D. Sollano, Kok Ann Gwee, Ida Hilmi, Seng Hock Quak, Murdani Abdullah, and Kewin Tien Ho Siah

Subjects
medicine.medical_specialty, Hepatology, business.industry, Intestinal immunity, Gastroenterology, medicine.disease, Inflammatory bowel disease, Clinical Practice, 03 medical and health sciences, 0302 clinical medicine, Gastro, 030220 oncology & carcinogenesis, medicine, Health maintenance, 030211 gastroenterology & hepatology, Intensive care medicine, business, South east asian, Irritable bowel syndrome
Abstract

The concept of consuming microorganisms in the treatment of a medical condition and in health maintenance has gained much attraction, giving rise to an abundance of medical claims and of health supplements. This study identified relevant clinical questions on the therapeutic use of probiotics and reviewed the literature in irritable bowel syndrome, inflammatory bowel disease, impaired intestinal immunity, liver disease, intestinal infections, and common childhood digestive disorders. Statements were developed to address these clinical questions. A panel of experienced clinicians was tasked to critically evaluate and debate the available data. Both consensus and contentious statements are presented to provide to clinicians a perspective on the potential of probiotics and importantly their limitations.

Published
2018
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23. Asian Pacific Association of Gastroenterology (APAGE) Inflammatory Bowel Disease (IBD) Working Party guidelines on IBD management during the COVID‐19 pandemic

Author

Ling, Khoon Lin, primary, Hilmi, Ida, additional, Raja Ali, Raja Affendi, additional, Leong, Rupert W L, additional, Leung, Wai Keung, additional, Ng, Siew Chien, additional, Wu, Kai Chun, additional, Chen, Min Hu, additional, Ran, Zhi Hua, additional, Hisamatsu, Tadakazu, additional, Ahuja, Vineet, additional, Makharia, Govind K, additional, Banerjee, Rupa, additional, Wei, Shu Chen, additional, Wu, Deng Chyang, additional, Pisespongsa, Pises, additional, Ye, Byong Duk, additional, Sollano, Jose, additional, Simadibrata, Marcellus, additional, Chuah, Sai Wei, additional, and Ooi, Choon Jin, additional

Published
2020
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27. Gut microbiota in early life and its influence on health and disease: A position paper by the Malaysian Working Group on Gastrointestinal Health

Author

Intan Hakimah Ismail, Noorizan Abdul Majid, Way Seah Lee, Yeong Yeh Lee, Syafinaz Amin Nordin, Sze Yee Chong, Siti Asma' Hassan, and Raja Affendi Raja Ali

Subjects
0301 basic medicine, Allergy, medicine.medical_specialty, biology, business.industry, digestive, oral, and skin physiology, 030106 microbiology, Disease, Gut flora, medicine.disease, biology.organism_classification, digestive system, Inflammatory bowel disease, Obesity, Infantile colic, law.invention, 03 medical and health sciences, Probiotic, 030104 developmental biology, law, Pediatrics, Perinatology and Child Health, Medicine, Position paper, business, Intensive care medicine
Abstract

The role of gut microbiota in early life and its impact on gut health and subsequent diseases remain unclear. There is a lack of research and awareness in this area, especially in the Asia-Pacific region, including Malaysia. This paper reports the position of a Malaysian Working Group on some key issues surrounding gut microbiota in early life and its role in gut health and diseases, as well as experts' stand on probiotics and prebiotics. The group reached a consensus that certain factors, including elective caesarean; premature deliveries; complementary feeding; use of antibiotics, prebiotics and/or probiotics; and exposure to the external environmental, have an impact on gut microbiota in early life. However, as evidence is lacking, especially from the Asia-Pacific region, further studies are needed to understand how gut microbiota in early life affects subsequent diseases, including allergy, inflammatory bowel disease, obesity and infantile colic. Lastly, although beneficial in acute diarrhoeal disease and probably allergic eczema, probiotics (and/or prebiotics) should be used cautiously in other gut dysbiotic conditions until more data are available.

Published
2017
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28. Blunt Traumatic Aortic Injury in the Pan‐scan Era

Author

Yu, Louis, primary, Baumann, Brigitte M., additional, Raja, Ali S., additional, Mower, William R., additional, Langdorf, Mark I., additional, Medak, Anthony J., additional, Anglin, Deirdre R., additional, Hendey, Gregory W., additional, Nishijima, Daniel, additional, and Rodriguez, Robert M., additional

Published
2019
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30. In Reply

Author

Bennett, Christopher L., primary, Raja, Ali S., additional, Kass, Dara, additional, Gross, Nate, additional, and Mills, Angela M., additional

Published
2019
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34. Consensus and contentious statements on the use of probiotics in clinical practice: A south east Asian gastro-neuro motility association working team report

Author

Gwee, Kok-Ann, primary, Lee, Warren Wei-Rhen, additional, Ling, Khoon Lin, additional, Ooi, Choon Jin, additional, Quak, Seng Hock, additional, Dan, Yock Young, additional, Siah, Kewin Tien-Ho, additional, Huang, James Guoxian, additional, Chua, Andrew Seng Boon, additional, Hilmi, Ida Normiha, additional, Raja Ali, Raja Affendi, additional, Ong, Christina, additional, Simadibrata, Marcellus, additional, Abdullah, Murdani, additional, Sollano, Jose D, additional, Leelakusolvong, Somchai, additional, Gonlachanvit, Sutep, additional, Lee, Yeong Yeh, additional, Ricaforte-Campos, Jane D, additional, Yin, Yee Kian, additional, Chong, Kuck-Meng, additional, and Wong, Chong Yuen, additional

Published
2018
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40. The 2016 Academic Emergency Medicine Consensus Conference, “Shared Decision Making in the Emergency Department: Development of a Policy‐relevant Patient‐centered Research Agenda” Diagnostic Testing Breakout Session Report

Author

Barrett, Tyler W., primary, Rising, Kristin L., additional, Bellolio, M. Fernanda, additional, Hall, M. Kennedy, additional, Brody, Aaron, additional, Dodd, Kenneth W., additional, Grieser, Mira, additional, Levy, Phillip D., additional, Raja, Ali S., additional, Self, Wesley H., additional, Weingarten, Gail, additional, Hess, Erik P., additional, and Hollander, Judd E., additional

Published
2016
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45. Knowledge Translation and Barriers to Imaging Optimization in the Emergency Department: A Research Agenda

Author

Probst, Marc A., primary, Dayan, Peter S., additional, Raja, Ali S., additional, Slovis, Benjamin H., additional, Yadav, Kabir, additional, Lam, Samuel H., additional, Shapiro, Jason S., additional, Farris, Coreen, additional, Babcock, Charlene I., additional, Griffey, Richard T., additional, Robey, Thomas E., additional, Fortin, Emily M., additional, Johnson, Jamlik O., additional, Chong, Suzanne T., additional, Davenport, Moira, additional, Grigat, Daniel W., additional, and Lang, Eddy L., additional

Published
2015
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50. A Consensus Parameter for the Evaluation and Management of Angioedema in the Emergency Department

Author

Moellman, Joseph J., primary, Bernstein, Jonathan A., additional, Lindsell, Christopher, additional, Banerji, Aleena, additional, Busse, Paula J., additional, Camargo, Carlos A., additional, Collins, Sean P., additional, Craig, Timothy J., additional, Lumry, William R., additional, Nowak, Richard, additional, Pines, Jesse M., additional, Raja, Ali S., additional, Riedl, Marc, additional, Ward, Michael J., additional, Zuraw, Bruce L., additional, Diercks, Deborah, additional, Hiestand, Brian, additional, Campbell, Ronna L., additional, Schneider, Sandra, additional, and Sinert, Richard, additional

Published
2014
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