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3 results on '"Raluca M. Simons"'

1. Assessment of brain age in posttraumatic stress disorder: Findings from the ENIGMA PTSD and brain age working groups

Author

Ashley N. Clausen, Kelene A. Fercho, Molly Monsour, Seth Disner, Lauren Salminen, Courtney C. Haswell, Emily Clarke Rubright, Amanda A. Watts, M. Nicole Buckley, Adi Maron‐Katz, Anika Sierk, Antje Manthey, Benjamin Suarez‐Jimenez, Bunmi O. Olatunji, Christopher L. Averill, David Hofmann, Dick J. Veltman, Elizabeth A. Olson, Gen Li, Gina L. Forster, Henrik Walter, Jacklynn Fitzgerald, Jean Théberge, Jeffrey S. Simons, Jessica A. Bomyea, Jessie L. Frijling, John H. Krystal, Justin T. Baker, K. Luan Phan, Kerry Ressler, Laura K. M. Han, Laura Nawijn, Lauren A. M. Lebois, Lianne Schmaal, Maria Densmore, Martha E. Shenton, Mirjam vanZuiden, Murray Stein, Negar Fani, Raluca M. Simons, Richard W. J. Neufeld, Ruth Lanius, Sanne vanRooij, Saskia B.J. Koch, Serena Bonomo, Tanja Jovanovic, Terri deRoon‐Cassini, Timothy D. Ely, Vincent A. Magnotta, Xiaofu He, Chadi G. Abdallah, Amit Etkin, Christian Schmahl, Christine Larson, Isabelle M. Rosso, Jennifer Urbano Blackford, Jennifer S. Stevens, Judith K. Daniels, Julia Herzog, Milissa L. Kaufman, Miranda Olff, Richard J. Davidson, Scott R. Sponheim, Sven C. Mueller, Thomas Straube, Xi Zhu, Yuval Neria, Lee A. Baugh, James H. Cole, Paul M. Thompson, and Rajendra A. Morey

Subjects
aging, machine learning, mega‐analysis, neuroimaging, posttraumatic stress disorder, trauma, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

Abstract Background Posttraumatic stress disorder (PTSD) is associated with markers of accelerated aging. Estimates of brain age, compared to chronological age, may clarify the effects of PTSD on the brain and may inform treatment approaches targeting the neurobiology of aging in the context of PTSD. Method Adult subjects (N = 2229; 56.2% male) aged 18–69 years (mean = 35.6, SD = 11.0) from 21 ENIGMA‐PGC PTSD sites underwent T1‐weighted brain structural magnetic resonance imaging, and PTSD assessment (PTSD+, n = 884). Previously trained voxel‐wise (brainageR) and region‐of‐interest (BARACUS and PHOTON) machine learning pipelines were compared in a subset of control subjects (n = 386). Linear mixed effects models were conducted in the full sample (those with and without PTSD) to examine the effect of PTSD on brain predicted age difference (brain PAD; brain age − chronological age) controlling for chronological age, sex, and scan site. Results BrainageR most accurately predicted brain age in a subset (n = 386) of controls (brainageR: ICC = 0.71, R = 0.72, MAE = 5.68; PHOTON: ICC = 0.61, R = 0.62, MAE = 6.37; BARACUS: ICC = 0.47, R = 0.64, MAE = 8.80). Using brainageR, a three‐way interaction revealed that young males with PTSD exhibited higher brain PAD relative to male controls in young and old age groups; old males with PTSD exhibited lower brain PAD compared to male controls of all ages. Discussion Differential impact of PTSD on brain PAD in younger versus older males may indicate a critical window when PTSD impacts brain aging, followed by age‐related brain changes that are consonant with individuals without PTSD. Future longitudinal research is warranted to understand how PTSD impacts brain aging across the lifespan.

Published
2022
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2. Posttraumatic Stress Disorder and Conduct Problems: The Role of Self‐Control Demands

Author

Raluca M. Simons, Jeffrey S. Simons, Jessica A. Keith, and Kyle J. Walters

Subjects
Adult, Conduct Disorder, Male, 050103 clinical psychology, media_common.quotation_subject, Structural equation modeling, Self-Control, Stress Disorders, Post-Traumatic, 03 medical and health sciences, 0302 clinical medicine, Alcohol intoxication, medicine, Humans, Interpersonal Relations, 0501 psychology and cognitive sciences, Longitudinal Studies, Iraq War, 2003-2011, Veterans, media_common, Afghan Campaign 2001, Extramural, 05 social sciences, Self-control, medicine.disease, United States, 030227 psychiatry, Psychiatry and Mental health, Clinical Psychology, Posttraumatic stress, Mood, Regulatory control, Female, Psychology, Alcoholic Intoxication, Psychosocial, Clinical psychology
Abstract

We tested within- and between-person effects of posttraumatic stress disorder (PTSD) symptoms on conduct problems and alcohol intoxication via self-control demands using multilevel structural equation modeling in a longitudinal burst-design study of 251 U.S. veterans who participated in the recent wars in Iraq and Afghanistan. We theorized that experiencing PTSD symptoms engenders efforts to regulate mood, control thoughts, and inhibit or control behavior that is taxing to the individual (i.e., it places demands on self-control) and hypothesized that this process results in subsequent deficits in regulatory control that manifest in heightened intoxication and conduct problems associated with PTSD. At the within-person level, daytime PTSD symptoms, IRR = 1.09, and self-control demands, IRR = 1.12, exhibited within-person associations with nighttime conduct problems over and above nighttime intoxication. Consistent with our hypothesis, daytime increases in self-control demands mediated the associations between daytime PTSD symptoms and subsequent nighttime conduct problems. The indirect effect between daytime PTSD symptoms and nighttime intoxication via self-control demands was nonsignificant. At the between-person level, self-control demands mediated the associations between PTSD symptoms and conduct problems; however, the expected between-person associations with intoxication were nonsignificant. Drinking behavior is related to but cannot fully account for various difficulties in psychosocial functioning associated with PTSD. The present results suggest that dysregulated behavior may, ironically, stem from individuals' concerted efforts to control and manage overwhelming symptoms. Self-control demands may be a common factor that accounts for a broad range of functional impairments associated with PTSD.

Published
2020

3. Author response for 'Assessment of brain age in posttraumatic stress disorder: Findings from the ENIGMA PTSD and brain age working groups'

Author

null Ashley N. Clausen, null Kelene A. Fercho, null Molly Monsour, null Seth Disner, null Lauren Salminen, null Courtney C. Haswell, null Emily Clarke Rubright, null Amanda A. Watts, null M. Nicole Buckley, null Adi Maron‐Katz, null Anika Sierk, null Antje Manthey, null Benjamin Suarez‐Jimenez, null Bunmi O. Olatunji, null Christopher L. Averill, null David Hofmann, null Dick J. Veltman, null Elizabeth A. Olson, null Gen Li, null Gina L. Forster, null Henrik Walter, null Jacklynn Fitzgerald, null Jean Théberge, null Jeffrey S. Simons, null Jessica A. Bomyea, null Jessie L. Frijling, null John H. Krystal, null Justin T. Baker, null K. Luan Phan, null Kerry Ressler, null Laura K. M. Han, null Laura Nawijn, null Lauren A. M. Lebois, null Lianne Schmaal, null Maria Densmore, null Martha E. Shenton, null Mirjam Zuiden, null Murray Stein, null Negar Fani, null Raluca M. Simons, null Richard W. J. Neufeld, null Ruth Lanius, null Sanne Rooij, null Saskia B.J. Koch, null Serena Bonomo, null Tanja Jovanovic, null Terri deRoon‐Cassini, null Timothy D. Ely, null Vincent A. Magnotta, null Xiaofu He, null Chadi G. Abdallah, null Amit Etkin, null Christian Schmahl, null Christine Larson, null Isabelle M. Rosso, null Jennifer Urbano Blackford, null Jennifer S. Stevens, null Judith K. Daniels, null Julia Herzog, null Milissa L. Kaufman, null Miranda Olff, null Richard J. Davidson, null Scott R. Sponheim, null Sven C. Mueller, null Thomas Straube, null Xi Zhu, null Yuval Neria, null Lee A. Baugh, null James H. Cole, null Paul M. Thompson, and null Rajendra A. Morey

Published
2021

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