Search

Your search keyword '"Reinhardt, H."' showing total 58 results
Start Over Author "Reinhardt, H." Publisher wiley
58 results on '"Reinhardt, H."'

1. Noninvasive minimal residual disease assessment in relapsed/refractory large B‐cell lymphoma using digital droplet PCR

Author

Heger, Jan‐Michel, primary, d'Hargues, Yannick, additional, Kleinert, Fanni, additional, Mattlener, Julia, additional, Weiss, Jonathan, additional, Franzen, Fabian, additional, Becker, Christian, additional, Becker, Kerstin, additional, Gödel, Philipp, additional, Schmiel, Marcel, additional, Meinel, Jörn, additional, Flümann, Ruth, additional, Simon, Florian, additional, Reinhardt, H. Christian, additional, Borchmann, Peter, additional, Borchmann, Sven, additional, Balke‐Want, Hyatt, additional, Knittel, Gero, additional, and von Tresckow, Bastian, additional

Published
2024
Full Text
View/download PDF

2. Outcomes of CMML patients undergoing allo‐HCT are significantly worse compared to MDS—a study of the CMWP of the EBMT

Author

Rovó, Alicia, primary, Gras, Luuk, additional, Piepenbroek, Brian, additional, Kröger, Nicolaus, additional, Reinhardt, H. Christian, additional, Radujkovic, Aleksandar, additional, Blaise, Didier, additional, Kobbe, Guido, additional, Niityvuopio, Riitta, additional, Platzbecker, Uwe, additional, Sockel, Katja, additional, Hunault‐Berger, Mathilde, additional, Cornelissen, J. J., additional, Forcade, Edouard, additional, Bourhis, Jean Henri, additional, Chalandon, Yves, additional, Kinsella, Francesca, additional, Nguyen‐Quoc, Stéphanie, additional, Maertens, Johan, additional, Elmaagacli, Ahmet, additional, Mordini, Nicola, additional, Hayden, Patrick, additional, Raj, Kavita, additional, Drozd‐Sokolowska, Joanna, additional, de Wreede, Liesbeth C., additional, McLornan, Donal P., additional, Robin, Marie, additional, Yakoub‐Agha, Ibrahim, additional, and Onida, Francesco, additional

Published
2023
Full Text
View/download PDF

5. AATF/Che-1 acts as a phosphorylation-dependent molecular modulator to repress p53-driven apoptosis

Author

Hoepker, Katja, Hagmann, Henning, Khurshid, Safiya, Chen, Shuhua, Hasskamp, Pia, Seeger-Nukpezah, Tamina, Schilberg, Katharina, Heukamp, Lukas, Lamkemeyer, Tobias, Sos, Martin L., Thomas, Roman K., Lowery, Drew, Roels, Frederik, Fischer, Matthias, Liebau, Max C., Resch, Ulrike, Kisner, Tuelay, Roether, Fabian, Bartram, Malte P., Mueller, Roman Ulrich, Fabretti, Francesca, Kurschat, Peter, Schumacher, Bjoern, Gaestel, Matthias, Medema, Rene H., Yaffe, Michael B., Schermer, Bernhard, Reinhardt, H. Christian, Benzing, Thomas, Hoepker, Katja, Hagmann, Henning, Khurshid, Safiya, Chen, Shuhua, Hasskamp, Pia, Seeger-Nukpezah, Tamina, Schilberg, Katharina, Heukamp, Lukas, Lamkemeyer, Tobias, Sos, Martin L., Thomas, Roman K., Lowery, Drew, Roels, Frederik, Fischer, Matthias, Liebau, Max C., Resch, Ulrike, Kisner, Tuelay, Roether, Fabian, Bartram, Malte P., Mueller, Roman Ulrich, Fabretti, Francesca, Kurschat, Peter, Schumacher, Bjoern, Gaestel, Matthias, Medema, Rene H., Yaffe, Michael B., Schermer, Bernhard, Reinhardt, H. Christian, and Benzing, Thomas

Abstract

Following genotoxic stress, cells activate a complex signalling network to arrest the cell cycle and initiate DNA repair or apoptosis. The tumour suppressor p53 lies at the heart of this DNA damage response. However, it remains incompletely understood, which signalling molecules dictate the choice between these different cellular outcomes. Here, we identify the transcriptional regulator apoptosis-antagonizing transcription factor (AATF)/Che-1 as a critical regulator of the cellular outcome of the p53 response. Upon genotoxic stress, AATF is phosphorylated by the checkpoint kinase MK2. Phosphorylation results in the release of AATF from cytoplasmic MRLC3 and subsequent nuclear translocation where AATF binds to the PUMA, BAX and BAK promoter regions to repress p53-driven expression of these pro-apoptotic genes. In xenograft experiments, mice exhibit a dramatically enhanced response of AATF-depleted tumours following genotoxic chemotherapy with adriamycin. The exogenous expression of a phospho-mimicking AATF point mutant results in marked adriamycin resistance in vivo. Nuclear AATF enrichment appears to be selected for in p53-proficient endometrial cancers. Furthermore, focal copy number gains at the AATF locus in neuroblastoma, which is known to be almost exclusively p53-proficient, correlate with an adverse prognosis and reduced overall survival. These data identify the p38/MK2/AATF signalling module as a critical repressor of p53-driven apoptosis and commend this pathway as a target for DNA damage-sensitizing therapeutic regimens. The EMBO Journal (2012) 31, 3961-3975. doi:10.1038/emboj.2012.236; Published online 21 August 2012

Published
2012

6. AATF/Che-1 acts as a phosphorylation-dependent molecular modulator to repress p53-driven apoptosis

Author

Höpker, Katja, primary, Hagmann, Henning, additional, Khurshid, Safiya, additional, Chen, Shuhua, additional, Hasskamp, Pia, additional, Seeger-Nukpezah, Tamina, additional, Schilberg, Katharina, additional, Heukamp, Lukas, additional, Lamkemeyer, Tobias, additional, Sos, Martin L, additional, Thomas, Roman K, additional, Lowery, Drew, additional, Roels, Frederik, additional, Fischer, Matthias, additional, Liebau, Max C, additional, Resch, Ulrike, additional, Kisner, Tülay, additional, Röther, Fabian, additional, Bartram, Malte P, additional, Müller, Roman Ulrich, additional, Fabretti, Francesca, additional, Kurschat, Peter, additional, Schumacher, Björn, additional, Gaestel, Matthias, additional, Medema, René H, additional, Yaffe, Michael B, additional, Schermer, Bernhard, additional, Reinhardt, H Christian, additional, and Benzing, Thomas, additional

Published
2012
Full Text
View/download PDF

30. ESTABLISHMENT OF AN EFFECTIVE ENDOMYCORRHIZAL ASSOCIATION ON CASSAVA IN FLOWING SOLUTION CULTURE AND ITS EFFECTS ON PHOSPHORUS NUTRITION

Author

Reinhardt H. Howeler, Colin J. Asher, and David Edwards

Subjects
Oryza sativa, biology, Physiology, Inoculation, Phosphorus, food and beverages, chemistry.chemical_element, Plant Science, Phosphate, biology.organism_classification, Vigna, chemistry.chemical_compound, Agronomy, chemistry, Dry matter, Cultivar, Phaseolus
Abstract

Summary Eight cassava (Manihot esculenta) cultivars were grown with or without mycorrhizal inoculation in flowing solution cultures containing approximately 0.1, 1, 10 or 100 μM phosphate. Rice (Oryza sativa), maize (Zea mays), cowpea (Vigna unguiculata) and French bean (Phaseolus vulgaris) were included in the experiment for comparative purposes. Cassava required a higher external phosphorus concentration for maximum yield (≥ 10 μM) than the other species (≥ 1 μM) regardless of the inoculation treatments. Roots of inoculated cassava plants were heavily infected with VA endophytes at 0.1 and 1 μM phosphate, but not at 10 or 100 μM. Non-inoculated cassava plants were free of infection, and no infections were observed in any treatment on the other species. At 1 μM phosphate, infection of cassava roots was associated with large increases in whole plant dry wt, concentration of phosphorous in tops and roots, and total phosphorus uptake. At 0.1 μM phosphate there were also substantial increases in phosphorus concentration in tops and roots but the infected cassava plants were still severely phosphorus deficient and growth was not improved. The results are discussed in relation to the present state of knowledge about the phosphorus nutrition of cassava.

Published
1982
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results