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Your search keyword '"Renata Paprocka"' showing total 2 results
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2 results on '"Renata Paprocka"'

1. ChemInform Abstract: 2-Allylaminothiazole and 2-Allylaminodihydrothiazole Derivatives: Synthesis, Characterization, and Evaluation of Bioactivity

Author

Renata Kołodziejska, Renata Studzińska, Aleksandra Karczmarska-Wódzka, Beata Augustyńska, Marcin Wróblewski, Renata Paprocka, Bożena Modzelewska-Banachiewicz, and Anna Kozakiewicz

Subjects
chemistry.chemical_compound, Chemistry, Condensation, Acetal, Organic chemistry, General Medicine
Abstract

2-Allylaminodihydrothiazole derivatives (III) are synthesized by condensation of allylthiourea (I) with haloesters (II) in alkaline medium, whereas 2-allylaminothiazole derivatives (V) are obtained by condensation of (I) with chlorooxoesters (IV) via acetal as intermediate compound, both of them with good yields.

Published
2016
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2. Reactions ofN3-Substituted Amidrazones withcis-1,2-Cyclohexanedicarboxylic Anhydride and Biological Activities of the Products

Author

Renata Paprocka, Beata Morak-Młodawska, Teresa Bobkiewicz-Kozłowska, Jolanta Kutkowska, Michał Zimecki, Grzegorz Lewandowski, Joanna Marciniak, Marzena Ucherek, Michał Szulc, Bożena Modzelewska-Banachiewicz, and Teresa Kamińska

Subjects
Cyclohexanecarboxylic Acids, Pharmaceutical Science, Mass spectrometry, Antiviral Agents, Anhydrides, Cell Line, Lethal Dose 50, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Animals, Humans, Organic chemistry, Dicarboxylic Acids, Cell Proliferation, Molecular Structure, Chemistry, Anti-Inflammatory Agents, Non-Steroidal, Hydrazones, Amides, Combinatorial chemistry, Anti-Bacterial Agents, Elemental analysis, Triazole derivatives, Isoindole
Abstract

A series of novel compounds were synthesized in reactions of N(3) -substituted amidrazones with cis-1,2-cyclohexanedicarboxylic anhydride: linear, isoindole, and triazole derivatives. All new structures were confirmed by H(1) NMR and IR spectrometry as well as elemental analysis. Potential biological effects of new compounds were predicted with the Prediction of Activity Spectra for Substances (PASS) program. Antiviral, antibacterial, analgesic, and anti-inflammatory activities were experimentally verified.

Published
2012
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