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Your search keyword '"Richmond, M."' showing total 54 results
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12. A reply

Author

Sawyer, R. J., primary, Richmond, M. N., additional, Jarratt, J., additional, and Hickey, J., additional

Published
2001
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24. LAND ANIMALS

Author

Richmond M

Subjects
History and Philosophy of Science, business.industry, General Neuroscience, Environmental resource management, Public policy, Business, Environmental planning, General Biochemistry, Genetics and Molecular Biology
Published
1973

49. Mauritian cynomolgus macaques with M3M4 MHC genotype control SIVmac251 infection.

Author

Li H, Omange RW, Czarnecki C, Correia-Pinto JF, Crecente-Campo J, Richmond M, Li L, Schultz-Darken N, Alonso MJ, Whitney JB, Plummer FA, and Luo M

Subjects
Animals, Female, Macaca fascicularis immunology, Mauritius, Simian Acquired Immunodeficiency Syndrome genetics, Simian Immunodeficiency Virus physiology, CD4-Positive T-Lymphocytes immunology, Haplotypes, Macaca fascicularis genetics, Simian Acquired Immunodeficiency Syndrome virology, Viral Load
Abstract

Background: Understanding natural HIV control may lead to new preventative or therapeutic strategies. Several protective major histocompatibility complex (MHC) genotypes were found in humans and rhesus macaques. Here, we report a simian immunodeficiency virus (SIV) controller MHC genotype in Mauritian cynomolgus macaques (MCMs)., Methods: Twelve MHC-genotyped MCMs were infected with SIVmac251 and monitored for viral loads and CD4+ T-cell counts., Results: Two macaques with M3M4 genotype exhibited the lowest peak viral loads (log plasma SIV RNA copies/mL), nearly 3 logs lower than those in most macaques with other MHC haplotype combinations, and set point viral loads below the level of detection limit by RT-qPCR (<2 log RNA copies/mL). They maintained healthy CD4+ T-cell counts of >500 cells/μL blood, while CD4 counts in the vast majority of other macaques were below this level., Conclusions: The M3M4 MHC genotype may confer enhanced control of SIV replication in MCMs., (© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)

Published
2017
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50. Etomidate for rapid-sequence intubation in young children: hemodynamic effects and adverse events.

Author

Guldner G, Schultz J, Sexton P, Fortner C, and Richmond M

Subjects
Child, Preschool, Etomidate adverse effects, Humans, Hypnotics and Sedatives adverse effects, Vomiting etiology, Etomidate therapeutic use, Hemodynamics drug effects, Hypnotics and Sedatives therapeutic use, Intubation methods
Abstract

Objectives: Physicians commonly use etomidate for adult rapid-sequence intubation (RSI), but the manufacturer does not recommend its use for children under 10 years of age due to a lack of data. The authors present their experience with etomidate for pediatric RSI in order to further develop its risk-benefit profile in this age group., Methods: Trained abstractors reviewed the medical records for all children under 10 years old who received etomidate for RSI between July 1996 and April 2001., Results: 105 children, with an average age of 3 (+/-2.9) years, received a median dose of 0.32 (+/-0.12) mg/kg of etomidate. The systolic blood pressure increased an average of 4 mm Hg (95% CI = -3.3 to 9.2); the diastolic blood pressure increased 7 mm Hg (95% CI = -3.1 to 11) within 10 minutes of receiving etomidate. The heart rate increased an average of 10 beats/min (95% CI = 4.0 to 17.4). Complications included three patients who vomited within 10 minutes of etomidate administration. There were no cases of documented myoclonus, status epilepticus, or new-onset seizures. Thirty-eight patients received corticosteroids during the hospital course, none for suspected adrenal insufficiency. Three patients died, all from severe brain injury., Conclusions: In children less than 10 years old, etomidate seems to produce minimal hemodynamic changes, and appears to have a low risk of clinically important adrenal insufficiency, myoclonus, and status epilepticus. The association between etomidate and emesis (observed in less than 3% of enrolled patients) remains unclear. For clinical situations in which minimal blood pressure changes during RSI are critical, etomidate appears to have a favorable risk-benefit profile for children under 10 years old.

Published
2003
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