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Your search keyword '"Rocha, Eduardo M."' showing total 10 results
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10 results on '"Rocha, Eduardo M."'

1. LAMP3 induces ectopic TLR7 expression in salivary gland epithelial cells and amplifies type I IFN production in Sjögren's disease

Author

Nakamura, Hiroyuki, primary, Tanaka, Tsutomu, additional, Zheng, Changyu, additional, Afione, Sandra A., additional, Atsumi, Tatsuya, additional, Noguchi, Masayuki, additional, Oliveira, Fabiola Reis, additional, Motta, Ana Carolina F., additional, Chahud, Fernando, additional, Rocha, Eduardo M., additional, Warner, Blake M., additional, and Chiorini, John A., additional

Published
2024
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3. Association of Bone Morphogenetic Protein 6 With Exocrine Gland Dysfunction in Patients With Sjögren's Syndrome and in Mice

Author

Yin, Hongen, primary, Cabrera-Perez, Javier, additional, Lai, Zhenan, additional, Michael, Drew, additional, Weller, Melodie, additional, Swaim, William D., additional, Liu, Xibao, additional, Catalán, Marcelo A., additional, Rocha, Eduardo M., additional, Ismail, Nevien, additional, Afione, Sandra, additional, Rana, Noreen A., additional, Di Pasquale, Giovanni, additional, Alevizos, Ilias, additional, Ambudkar, Indu, additional, Illei, Gabor G., additional, and Chiorini, John A., additional

Published
2013
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9. Androgens and Dry Eye in Sjogren's Syndromea

Author

SULLIVAN, DAVID A., primary, WICKHAM, L. ALEXANDRA, additional, ROCHA, EDUARDO M., additional, KRENZER, KATHLEEN L., additional, SULLIVAN, BENJAMIN D., additional, STEAGALL, REBECCA, additional, CERMAK, JENNIFER M., additional, DANA, M. REZA, additional, ULLMAN, M. DAVID, additional, SATO, ELCIO H., additional, GAO, JIANPING, additional, ROCHA, FLAVIO J., additional, ONO, MASAFUMI, additional, SILVEIRA, LILIA A., additional, LAMBERT, ROSS WILLIAM, additional, KELLEHER, ROBIN S., additional, TOLLS, DOROTHY BAZZINOTTI, additional, and TODA, IKUKO, additional

Published
1999
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10. Amplified Type I Interferon Response in Sjögren's Disease via Ectopic Toll-Like Receptor 7 Expression in Salivary Gland Epithelial Cells Induced by Lysosome-Associated Membrane Protein 3.

Author

Nakamura H, Tanaka T, Zheng C, Afione SA, Atsumi T, Noguchi M, Oliveira FR, Motta ACF, Chahud F, Rocha EM, Warner BM, and Chiorini JA

Subjects
Animals, Mice, Humans, Signal Transduction, Female, Interferon-gamma metabolism, Cell Line, Salivary Glands, Minor immunology, Salivary Glands, Minor metabolism, Neoplasm Proteins, Lysosomal-Associated Membrane Protein 3, Sjogren's Syndrome immunology, Sjogren's Syndrome genetics, Sjogren's Syndrome metabolism, Interferon Type I metabolism, Epithelial Cells metabolism, Toll-Like Receptor 7 genetics, Toll-Like Receptor 7 metabolism, Salivary Glands metabolism, Salivary Glands immunology, Lysosomal Membrane Proteins genetics, Lysosomal Membrane Proteins metabolism
Abstract

Objective: Lysosome-associated membrane protein 3 (LAMP3) misexpression in salivary gland epithelial cells plays a causal role in the development of salivary gland dysfunction and autoimmunity associated with Sjögren's disease (SjD). This study aimed to clarify how epithelial LAMP3 misexpression is induced in SjD., Methods: To explore upstream signaling pathways associated with LAMP3 expression, we conducted multiple RNA sequencing analyses of minor salivary glands from patients with SjD, submandibular glands from a mouse model of SjD, and salivary gland epithelial cell lines. A hypothesis generated by the RNA sequencing analyses was further tested by in vitro and in vivo assays with gene manipulation., Results: Transcriptome analysis suggested LAMP3 expression was associated with enhanced type I interferon (IFN) and IFNγ signaling pathways in patients with SjD. In vitro studies showed that type I IFN but not IFNγ stimulation could induce LAMP3 expression in salivary gland epithelial cells. Moreover, we discovered that LAMP3 overexpression could induce ectopic Toll-like receptor 7 (TLR-7) expression and type I IFN production in salivary gland epithelial cells both in vitro and in vivo. TLR-7 knockout mice did not develop any SjD-related symptoms following LAMP3 induction., Conclusion: Epithelial LAMP3 misexpression can be induced through enhanced type I IFN response in salivary glands. In addition, LAMP3 can promote type I IFN production via ectopic TLR-7 expression in salivary gland epithelial cells. This positive feedback loop can contribute to maintaining LAMP3 misexpression and amplifying type I IFN production in salivary glands, which plays an essential role in the pathophysiology of SjD., (© 2024 The Author(s). Arthritis & Rheumatology published by Wiley Periodicals LLC on behalf of American College of Rheumatology. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA.)

Published
2024
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