10 results on '"Rojo-Martínez, G"'
Search Results
2. Anti‐oxidized low‐density lipoprotein antibody levels are associated with the development of type 2 diabetes mellitus
- Author
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Garrido‐Sánchez, L., primary, Cardona, F., additional, García‐Fuentes, E., additional, Rojo‐Martínez, G., additional, Gómez‐Zumaquero, J. M., additional, Picón, M. J., additional, Soriguer, F., additional, and Tinahones, F. J., additional
- Published
- 2008
- Full Text
- View/download PDF
3. The −30G>A Polymorphism of the Glucokinase Gene Promoter Is Associated With Obesity in a Population From Southern Spain
- Author
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Gómez-Zumaquero, Juan M., primary, Rojo-Martínez, G., additional, García-Escobar, E., additional, Martín-Nuñez, Gracia M., additional, Haro, J., additional, Esteva, I., additional, de Adana, M. Ruiz, additional, Cuesta, Antonio L., additional, Olveira, G., additional, Morcillo, S., additional, and Soriguer, F., additional
- Published
- 2008
- Full Text
- View/download PDF
4. Incidence of type 2 diabetes in southern Spain (Pizarra Study)
- Author
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Soriguer, F., primary, Rojo-Martínez, G., additional, Almaraz, M. C., additional, Esteva, I., additional, Ruiz de Adana, M. S., additional, Morcillo, S., additional, Valdés, S., additional, García-Fuentes, E., additional, García-Escobar, E., additional, Cardona, I., additional, Gomez-Zumaquero, J. M., additional, and Olveira-Fuster, G., additional
- Published
- 2008
- Full Text
- View/download PDF
5. Association between exposure to air pollution and blood lipids in the general population of Spain.
- Author
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Valdés S, Doulatram-Gamgaram V, Maldonado-Araque C, García-Escobar E, García-Serrano S, Oualla-Bachiri W, García-Vivanco M, Garrido JL, Gil V, Martín-Llorente F, Calle-Pascual A, Castaño L, Delgado E, Menéndez E, Franch-Nadal J, Gaztambide S, Girbés J, Chaves FJ, Galán-García JL, Aguilera-Venegas G, Vallvé JC, Amigó N, Guardiola M, Ribalta J, and Rojo-Martínez G
- Subjects
- Male, Adult, Humans, Nitrogen Dioxide analysis, Spain epidemiology, Cross-Sectional Studies, Particulate Matter analysis, Lipids, Lipoproteins analysis, Environmental Exposure adverse effects, Air Pollution adverse effects, Air Pollution analysis, Air Pollutants analysis
- Abstract
Background and Aims: We aimed to assess the associations of exposure to air pollutants and standard and advanced lipoprotein measures, in a nationwide sample representative of the adult population of Spain., Methods: We included 4647 adults (>18 years), participants in the national, cross-sectional, population-based di@bet.es study, conducted in 2008-2010. Standard lipid measurements were analysed on an Architect C8000 Analyzer (Abbott Laboratories SA). Lipoprotein analysis was made by an advanced
1 H-NMR lipoprotein test (Liposcale®). Participants were assigned air pollution concentrations for particulate matter <10 μm (PM10 ), <2.5 μm (PM2.5 ) and nitrogen dioxide (NO2 ), corresponding to the health examination year, obtained by modelling combined with measurements taken at air quality stations (CHIMERE chemistry-transport model)., Results: In multivariate linear regression models, each IQR increase in PM10 , PM2.5 and NO2 was associated with 3.3%, 3.3% and 3% lower levels of HDL-c and 1.3%, 1.4% and 1.1% lower HDL particle (HDL-p) concentrations (p < .001 for all associations). In multivariate logistic regression, there was a significant association between PM10 , PM2.5 and NO2 concentrations and the odds of presenting low HDL-c (<40 mg/dL), low HDL-p (10 and NO 2 and low HDL-p in men (p for interaction .008 and .034), and between NO2 and low HDL-p in individuals with obesity (p for interaction .015)., Conclusions: Our study shows an association between the exposure to air pollutants and blood lipids in the general population of Spain, suggesting a link to atherosclerosis., (© 2023 The Authors. European Journal of Clinical Investigation published by John Wiley & Sons Ltd on behalf of Stichting European Society for Clinical Investigation Journal Foundation.)- Published
- 2024
- Full Text
- View/download PDF
6. Epigenetic changes in the metabolically healthy obese: A case-control versus a prospective study.
- Author
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Linares-Pineda TM, Boughanem H, Gutiérrez-Repiso C, Macías-González M, Andrés-León E, Rojo-Martínez G, Valdés S, Tinahones FJ, and Morcillo S
- Subjects
- Body Mass Index, Case-Control Studies, Epigenesis, Genetic, Humans, Obesity genetics, Prospective Studies, Risk Factors, Metabolic Syndrome, Obesity, Metabolically Benign genetics
- Published
- 2022
- Full Text
- View/download PDF
7. Stress hyperglycaemia in hospitalized patients with coronary artery disease and type 2 diabetes risk.
- Author
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Colomo N, Linares F, Rubio-Martín E, Moreno MJ, de Mora M, García AM, González AM, Rojo-Martínez G, Valdés S, Ruiz de Adana MS, Olveira G, and Soriguer F
- Subjects
- Aged, Blood Glucose metabolism, Coronary Artery Disease diagnosis, Fasting blood, Female, Glucose Intolerance etiology, Glycated Hemoglobin metabolism, Hospitalization, Humans, Male, Coronary Artery Disease therapy, Diabetes Mellitus, Type 2 diagnosis, Diabetic Angiopathies diagnosis, Hyperglycemia psychology, Stress, Psychological complications
- Abstract
Aims: (i) To evaluate glucometabolic status of patients without known diabetes hospitalized due to coronary artery disease (CAD), (ii) to assess markers of systemic inflammation determined during admission and to evaluate their relationship with glucometabolic status and (iii) to analyse usefulness of HbA1c determined during admission in patients with CAD to detect abnormal glucose regulation (AGR)., Materials & Methods: We studied 440 patients with CAD admitted to the cardiology ward. Patients were grouped in four groups during admission according to clinical data, fasting plasma glucose and HbA1c: diabetes, HbA1c > 5·9%, stress hyperglycaemia (SH) and normal. In 199 subjects without known diabetes, an oral glucose tolerance test (OGTT) was performed 3 months after discharge, and they were reclassified according to WHO 1998 criteria. Biochemical and inflammatory markers were measured., Results: The OGTT showed that 27·4% of subjects without known diabetes at admission had diabetes, 11·2% had impaired fasting glucose + impaired glucose tolerance, 33·5% impaired glucose tolerance, 3·6% impaired fasting glucose, and 24·4% normal glucose metabolism. Odds ratio for having diabetes 3 months after discharge in HbA1c > 5·9% group was 5·91 (P < 0·0001) and in SH group was 1·82 (P = 0·38). The best HbA1c cut-off point to predict AGR was 5·85%. HbA1c levels during admission were highly predictive of having AGR (AUC ROC 0·76 [95% CI 0·67-0·84])., Conclusion: We reported a high prevalence of AGR in subjects with CAD. Stress hyperglycaemia in patients with CAD was not associated with an increased risk of diabetes 3 months later. HbA1c in patients hospitalized with CAD was a useful tool to detect AGR., (© 2013 Stichting European Society for Clinical Investigation Journal Foundation. Published by John Wiley & Sons Ltd.)
- Published
- 2013
- Full Text
- View/download PDF
8. Factors determining high-sensitivity C-reactive protein values in the Spanish population. Di@bet.es study.
- Author
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Rojo-Martínez G, Soriguer F, Colomo N, Calle A, Goday A, Bordiú E, Delgado E, Menéndez E, Ortega E, Urrutia I, Girbés J, Castaño L, Catalá M, Gaztambide S, and Valdés S
- Subjects
- Adult, Analysis of Variance, Biomarkers blood, C-Reactive Protein metabolism, Cardiovascular Diseases epidemiology, Diabetes Mellitus diagnosis, Female, Health Surveys, Humans, Logistic Models, Male, Middle Aged, Prevalence, Principal Component Analysis, Risk Factors, Spain epidemiology, Body Mass Index, C-Reactive Protein analysis, Cardiovascular Diseases metabolism, Diabetes Mellitus epidemiology, Insulin Resistance, Waist-Hip Ratio statistics & numerical data
- Abstract
Background: Although high-sensitivity C-reactive protein (hs-CRP) is currently used as a risk marker of cardiovascular disease, it has been suggested that genetic, clinical, biochemical or environmental factors could modify hs-CRP levels. The aim of this study was to investigate sources of interindividual hs-CRP variability in the Spanish population., Materials and Methods: A representative sample of the Spanish population within the di@bet.es study was used. Study variables included a clinical and demographic structured survey, a lifestyle survey, a physical examination, plasmatic hs-CRP and other biochemical parameters., Results: Median and interquartile range of plasma hs-CRP values were 1·73 ± 2·75 mg/dL. Thirty per cent of the study population had hs-CRP levels above 3 mg/dL and 38% from 1 to 3 mg/dL. Body mass index was the strongest factor associated with moderate and high hs-CRP levels. Age, sex, waist-to-hip ratio, weight increase, plasma lipid levels, glucose metabolism (HOMA-IR and abnormal glucose regulation categories), pharmacological treatment (lipid-lowering agents, psychotropic drugs and levothyroxine), smoking, physical activity, different dietary patterns, quality of life and educational level were all significantly associated with hs-CRP levels. Interactions were observed between variables. These interactions modulated the effect of previously described factors on hs-CRP., Conclusions: Thirty per cent of the Spanish population have hs-CRP levels considered to represent a cardiovascular risk. Different clinical, anthropometric, biochemical and environmental variables modulate hs-CRP levels. In addition, multiple interactions between variables complicate the interpretation of hs-CRP values., (© 2012 The Authors. European Journal of Clinical Investigation © 2012 Stichting European Society for Clinical Investigation Journal Foundation.)
- Published
- 2013
- Full Text
- View/download PDF
9. Testosterone, SHBG and risk of type 2 diabetes in the second evaluation of the Pizarra cohort study.
- Author
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Soriguer F, Rubio-Martín E, Fernández D, Valdés S, García-Escobar E, Martín-Núñez GM, Esteva I, Almaraz MC, and Rojo-Martínez G
- Subjects
- Adolescent, Adult, Aged, Biological Availability, Cohort Studies, Female, Follow-Up Studies, Humans, Male, Middle Aged, Multivariate Analysis, Prospective Studies, Risk Factors, Sex Factors, Spain, Young Adult, Diabetes Mellitus, Type 2 blood, Sex Hormone-Binding Globulin metabolism, Testosterone blood
- Abstract
Aim: To evaluate the association between serum levels of testosterone, sex hormone-binding globulin (SHBG) and calculated bioavailable testosterone (bioT), and the risk of type 2 diabetes mellitus (T2D) in a prospective cohort from southern Spain (Pizarra study)., Research Design and Methods: The study was performed in the Pizarra Cohort Study, a prospective study started in 1995 with a follow-up of 11 years. Anthropometric and metabolic variables were measured at baseline and at 6 and 11 years of follow-up. Total testosterone (TT), SHBG and calculated bioT were determined at the 6-year follow-up., Results: The levels of TT and bioT in men were negatively associated with the risk of obesity, T2D and the metabolic syndrome. In women, the levels of TT and bioT were associated positively with the risk of insulin resistance. The levels of SHBG were associated negatively with the risk of T2D, obesity and insulin resistance in both men and women. For all groups, the association was higher at the 11-year follow-up., Conclusions: Low levels of testosterone and SHBG increase the risk of T2D in men, and high levels of testosterone increase the risk of insulin resistance in women. The association between TT levels and the risk of T2D is not completely independent of other variables, such as exposure time, adiposity, insulin resistance or SHBG levels. This study also shows that the different responses between men and women are probably because of the protective effect of SHBG, levels of which are higher in women than in men., (© 2011 The Authors. European Journal of Clinical Investigation © 2011 Stichting European Society for Clinical Investigation Journal Foundation.)
- Published
- 2012
- Full Text
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10. Effect of insulin analogues on 3t3-l1 adipogenesis and lipolysis.
- Author
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García-Escobar E, Rodríguez-Pacheco F, Haro-Mora JJ, Gomez-Zumaquero JM, Rubio-Martín E, Gutierrez-Repiso C, Soriguer F, and Rojo-Martínez G
- Subjects
- 3T3-L1 Cells drug effects, Adipocytes drug effects, Adipogenesis genetics, Analysis of Variance, Animals, Gene Expression Regulation, Humans, Insulin analogs & derivatives, Lipolysis genetics, Mice, Adipogenesis drug effects, Insulin pharmacology, Lipolysis drug effects
- Abstract
Background: Insulin has several biological functions besides glycaemic control. We investigated and compared the effects of six different commercial insulins on adipocyte cell differentiation, the lipolytic activity of differentiated cells, and the expression levels of genes involved in adipogenesis and associated with insulin activity., Materials and Methods: 3T3-L1 cells were induced to differentiate with six commercial insulins: glargine, lispro, aspart, detemir, NPH and regular recombinant human insulin (used as control). Cell differentiation, lipolysis and gene expression were measured at day 7 (D7) and day 10 (D10) after induction of differentiation in these cells., Results: The highest values of cell differentiation and lipolysis were found at D10 for all the insulins used. Preadipocyte differentiation differed at both times depending on the insulin used, with detemir insulin being the least adipogenic. The PPARγ mRNA level varied according to the insulin and was a good genetic marker of adipogenesis at D7. Cells treated with glargine insulin showed the highest lipolysis and HSL expression on both days. Gene expression levels of InsR, SREBP-1c and SCD-1 differed depending on the insulin studied., Conclusions: Detemir insulin was the least adipogenic of the insulins tested, whereas treatment with glargine insulin tended to produce the highest lipolysis levels. Under these experimental conditions, the modifications made in commercial insulins to improve glycaemic control also affect adipocyte differentiation, the lipolysis level of differentiated cells, and the expression of different genes that can modify metabolic pathways independently of glucose metabolism., (© 2011 The Authors. European Journal of Clinical Investigation © 2011 Stichting European Society for Clinical Investigation Journal Foundation.)
- Published
- 2011
- Full Text
- View/download PDF
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