Search

Your search keyword '"Roubos, E W"' showing total 21 results
Start Over Author "Roubos, E W" Publisher wiley
21 results on '"Roubos, E W"'

21. The amygdala, a relay station for switching on and off pain.

Author

Rouwette T, Vanelderen P, Roubos EW, Kozicz T, and Vissers K

Subjects
Analgesics pharmacology, Animals, Corticotropin-Releasing Hormone pharmacology, Corticotropin-Releasing Hormone physiology, Humans, Neuralgia drug therapy, Receptors, Corticotropin-Releasing Hormone physiology, CRF Receptor, Type 1, Amygdala physiology, Neuralgia physiopathology
Abstract

Neuropathic pain is strongly associated with mood disorders like anxiety and depression. Corticotropin-releasing factor (CRF) plays a prominent role in these disorders as it is up-regulated in limbic structures such as the amygdala, upon experimentally induced neuropathy. This review discusses recent literature on the role of CRF in pain processing and highlights the amygdala as a potential hot spot in supraspinal descending pain control. Many studies have demonstrated analgesic effects of CRF following local and systemic administration, but more recently also hyperalgesic effects were shown upon endogenous amygdalar CRF increase or by blocking the CRF type 1 receptor (CRFR1). On the basis of the reviewed literature, we postulate a central mechanism for pain control in which the amygdala plays a critical role by switching on and off chronic pain. In this mechanism, upon pain stimuli, CRFR1 in the amygdala is activated by CRF to induce hyperalgesia. When the activated CRFR1 is internalized (pain initiation), it triggers the translocation of the cytoplasmic CRF type 2 receptor (CRFR2) to the plasma membrane. Here, CRFR2 can be recruited by either high (pharmacological) concentrations of CRF or by endogenous CRFR2 ligands, the urocortins, leading to analgesia (pain termination). This on-off switching of pain is completed by redistribution of the CRF receptors to their initial activity state. We furthermore propose that in neuropathic pain, this mechanism is dysregulated and causes a state of permanent hyperalgesia, and present an integrative (patho)physiological model for the way disturbed CRF receptor signalling in the amygdala could initiate neuropathic pain., (© 2011 European Federation of International Association for the Study of Pain Chapters.)

Published
2012
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results