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Your search keyword '"Sadovnick, A D."' showing total 36 results
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36 results on '"Sadovnick, A D."'

6. A population-based study of multiple sclerosis in twins: Update

Author

Sadovnick, A. D., primary, Armstrong, H., additional, Rice, G. P. A., additional, Bulman, D., additional, Hashimoto, L., additional, Party, D. W., additional, Hashimoto, S. A., additional, Warren, S., additional, Hader, W., additional, Murrary, T. J., additional, Seland, T. P., additional, Metz, L., additional, Bell, R., additional, Duquette, P., additional, Gray, T., additional, Nelson, R., additional, Weinshenkar, B., additional, Brunt, D., additional, and Ebers, G. C., additional

Published
2004
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7. Reply

Author

Ebers, George C., primary, Sadovnick, A. D., additional, and Duquette, Pierre, additional

Published
2001
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35. Sex ratio of multiple sclerosis and clinical phenotype.

Author

Ramagopalan SV, Byrnes JK, Orton SM, Dyment DA, Guimond C, Yee IM, Ebers GC, and Sadovnick AD

Subjects
Canada epidemiology, Female, Humans, Longitudinal Studies, Male, Sex Factors, Time Factors, Multiple Sclerosis, Chronic Progressive epidemiology, Multiple Sclerosis, Relapsing-Remitting epidemiology, Phenotype
Abstract

Background and Purpose: In a longitudinal population-based dataset of patients with multiple sclerosis (MS), we have previously observed a substantial increase in the female to male sex ratio in Canada over the last 50 years. Here, we aimed to determine whether this change in sex ratio is related to the clinical course of MS., Methods: We calculated sex ratios by birth year in 11 868 patients with relapsing-remitting (RR) MS and 2825 patients with primary progressive (PP) MS identified as part of the Canadian Collaborative Project on the Genetic Susceptibility to MS., Results: Year of birth was a significant predictor for sex ratio in RR MS (P < 0.0001, chi(2) = 21.2; Spearman's rank correlation r = 0.67), but not for PP MS (P = 0.44, chi(2) = 0.6; Spearman's rank correlation r = 0.11)., Conclusions: An increase in the number of female RR MS patients over time accounts for the increasing sex ratio of MS. This has implications for pathogenesis, for assessment of clinical trial results and for disease prevention. The factors underlying the selective increase in MS in females need to be uncovered.

Published
2010
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36. Age of puberty and the risk of multiple sclerosis: a population based study.

Author

Ramagopalan SV, Valdar W, Criscuoli M, DeLuca GC, Dyment DA, Orton SM, Yee IM, Ebers GC, and Sadovnick AD

Subjects
Adolescent, Age Factors, Child, Female, Humans, Interviews as Topic, Likelihood Functions, Logistic Models, Male, Multiple Sclerosis etiology, Risk Factors, Sex Factors, Surveys and Questionnaires, Multiple Sclerosis epidemiology, Puberty
Abstract

Background and Purpose: Genetic and environmental factors have important roles in multiple sclerosis (MS) susceptibility. Given a potential role for sex hormones in MS, we have investigated whether or not the age of puberty influences the risk of developing MS in a population-based cohort., Methods: We identified 5493 MS index cases and 1759 spousal controls with age of puberty information from the Canadian Collaborative Project on Genetic Susceptibility to MS. Age of puberty was compared between index cases and controls, and any effect of age of puberty on the age of onset of MS was also investigated., Results: There were no significant differences between male index cases and controls with respect to age of puberty, P = 0.70. However, a significant difference was observed between female index cases and female controls, with average age of puberty being 12.4 and 12.6 years respectively, P = 0.00017, providing a relative risk decrease of 0.9 per year increase of age of puberty. There was no effect of the age of puberty on the age of MS onset in either sex., Conclusions: Earlier age at menarche increases the risk of MS in women. Whether this association is a surrogate for a disease causative factor or directly involved in MS disease aetiology needs to be uncovered.

Published
2009
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