1. Three Tyrosinase Inhibitors and Antioxidant Compounds from Salsola foetida
- Author
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M. Iqbal Choudhary, Khalid Mohammed Khan, Ahmed Abbaskhan, Mahmud Tareq Hassan Khan, Safdar Hayat, Ghulam M. Maharvi, Talat Makhmoor, Farzana Shaheen, and Atta-ur-Rahman
- Subjects
Salsola ,Antioxidant ,biology ,Traditional medicine ,Chemistry ,DPPH ,medicine.medical_treatment ,Tyrosinase ,Organic Chemistry ,biology.organism_classification ,Biochemistry ,Catalysis ,Inorganic Chemistry ,chemistry.chemical_compound ,Phytochemical ,Drug Discovery ,medicine ,Organic chemistry ,Physical and Theoretical Chemistry ,IC50 - Abstract
Phytochemical investigation on the whole plant of Salsola foetida resulted in the isolation of three new phenolic compounds 1, 2, and 3, which exhibit tyrosinase inhibition with moderate antioxidant activity. Compounds 1–3 inhibited tyrosinase with IC50 2.61, 1.85, and 0.40 μM, while exhibiting DPPH radical scavenging activity with IC50 383, 427 and 378 μM, respectively. The structures of 1, 2, and 3 were determined by modern spectroscopic techniques.
- Published
- 2003
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