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4. Vibrational spectroscopy and phonon‐related properties of monoclinic GABA, a non‐proteinogenic inhibitory neurotransmitter amino acid

Author

Silva, José Barbosa, primary, Costa, Gabriel, additional, Silva, Mauricélio Bezerra, additional, Costa, Stefane Nunes, additional, Santos, Regina Cláudia Rodrigues, additional, Sales, Francisco Adilson Matos, additional, Valentini, Antoninho, additional, Caetano, Ewerton Wagner Santos, additional, and Freire, Valder Nogueira, additional

Published
2021
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6. Long-term efficacy and safety of eslicarbazepine acetate monotherapy for adults with newly diagnosed focal epilepsy: An open-label extension study

Author

Trinka, Eugen, Rocamora, Rodrigo, Chaves, João, Moreira, Joana, Ikedo, Fábio, Soares‐da‐Silva, Patrício, Estol, Conrado, Newton, Mark, Carne, Ross, Kowacs, Pedro, Petrova, Dorina, Syankov, Dimitar, Maslarov, Dimitar, Stanev, Slavi, Lasso, Jorge, Bašić, Silvio, Bar, Michal, Vyskočilová, Dana, Pazdera, Ladislav, Haldre, Sulev, Kaarina Kälviäinen, Reetta, Peltola, Jukka, Georges Maillard, Louis, Deckert‐Schmitz, Maria, Springub, Joachim, Barcs, Gábor, Ménes, Andrea, Tóth, Marianna, Giallonardo, Anna Teresa, Paganini, Marco, Asmane, Santa, Logina, Lnara, Meilute Lescinskiene, Loreta, Cruz, Ana, Umeres, Hugo, Czapiński, Piotr, Trzebińska‐Frydrychowska, Ewa, Sales, Francisco, Falup‐Pecurariu, Cristian Gavril, Silviu Manescu, Emilian, Roceanu, Adina‐Maria, Odinak, Miroslav, Tretyakova, Evgeniya, Volkova, Larisa, Lebedeva, Anna, Lipatova, Liudmila, Bogdanov, Enver, Vladimirovna Polezhaeva, Tatiana, Gebauer‐Bukurov, Ksenija, Jovanovic‐Mihajlovic, Natalija, Milovanovic, Maja, Spasic, Mirjana, Lipovský, L'Ubomír, Perichtová, Magdaléna, Chamilová, Jana, Balaguer, Ernest, Ugarte, Antonio, Dubenko, Andriy, Kharchuk, Sergii, Moroz, Svitlana, Shkrobot, Svitlana, Mar'yenko, Lidiya, Litovchenko, Tetyana, and Cock, Hannah

Subjects
Male, 0301 basic medicine, Time Factors, focal seizures, Epilepsy, 0302 clinical medicine, Responder rate, Dibenzazepines, Medicine, antiseizure medication, Aged, 80 and over, Incidence (epidemiology), responder rate, Middle Aged, Treatment Outcome, Carbamazepine, Neurology, Tolerability, Retention, carbamazepine, Full‐length Original Research, retention, seizure freedom rate, Anticonvulsants, Female, Seizure freedom rate, medicine.drug, Adult, medicine.medical_specialty, Adolescent, Newly diagnosed, Focal seizures, Young Adult, 03 medical and health sciences, Double-Blind Method, Internal medicine, Humans, Adverse effect, Aged, Antiseizure medication, business.industry, medicine.disease, Discontinuation, 030104 developmental biology, Eslicarbazepine acetate, Epilepsies, Partial, Neurology (clinical), business, 030217 neurology & neurosurgery
Abstract

Objective: To assess the efficacy, safety, and tolerability of eslicarbazepine acetate (ESL) monotherapy during long-term treatment. Methods: An open-label extension (OLE) study was conducted in adults completing a phase 3, randomized, double-blind, noninferiority trial, during which they had received monotherapy with either once-daily ESL or twice-daily controlled-release carbamazepine (CBZ-CR) for newly diagnosed focal epilepsy. In the OLE study, all patients received ESL (800-1600 mg/d) for 2 years. Primary efficacy outcome was retention time (from baseline of the OLE study). Secondary efficacy assessments included seizure freedom rate (no seizures during the OLE study) and responder rate (≥50% seizure frequency reduction from baseline of double-blind trial). Safety assessments included evaluation of treatment-emergent adverse events (TEAEs). Results: Of 206 randomized patients, 96 who received ESL in the double-blind trial (ESL/ESL) and 88 who received CBZ-CR in the double-blind trial (CBZ-CR/ESL) were treated with ESL monotherapy (89.3% overall). Treatment retention time was similar between groups, with low probability of ESL withdrawal overall (80% in both groups throughout the study. Incidence of serious TEAEs was similar between groups (7.3% vs 5.7%; 0% vs 1.1% possibly related), as were the incidences of TEAEs considered at least possibly related to treatment (17.7% vs 18.2%) and TEAEs leading to discontinuation (3.1% vs 4.5%). The types of TEAEs were generally consistent with the known safety profile of ESL. Significance: ESL monotherapy was efficacious and generally well tolerated over the long term, including in patients who transitioned from CBZ-CR monotherapy. No new safety concerns emerged. info:eu-repo/semantics/publishedVersion

Published
2020

7. Gelastic seizures: a retrospective study in five tertiary hospital centres

Author

Loução de Amorim, Isabel, additional, Pereira, Cristina, additional, Sequeira, João, additional, Rocha, Helena, additional, Peralta, Ana Rita, additional, Rego, Ricardo, additional, Bentes, Carla, additional, Bento, Conceição, additional, Sales, Francisco, additional, Robalo, Conceição, additional, and Pimentel, José, additional

Published
2020
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11. The EPILEPSIAE database: An extensive electroencephalography database of epilepsy patients

Author

Klatt, Juliane, primary, Feldwisch‐Drentrup, Hinnerk, additional, Ihle, Matthias, additional, Navarro, Vincent, additional, Neufang, Markus, additional, Teixeira, Cesar, additional, Adam, Claude, additional, Valderrama, Mario, additional, Alvarado‐Rojas, Catalina, additional, Witon, Adrien, additional, Le Van Quyen, Michel, additional, Sales, Francisco, additional, Dourado, Antonio, additional, Timmer, Jens, additional, Schulze‐Bonhage, Andreas, additional, and Schelter, Bjoern, additional

Published
2012
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15. Amoxicillin, a potential epileptogenic drug.

Author

Raposo J, Teotónio R, Bento C, and Sales F

Subjects
Electroencephalography, Epilepsy physiopathology, Humans, Amoxicillin adverse effects, Anti-Bacterial Agents adverse effects, Epilepsy chemically induced, beta-Lactams adverse effects
Abstract

Beta-lactams are known to cause a wide spectrum of neurotoxic manifestations including epileptic seizures. The neurotoxicity of penicillin was first reported in 1945 by Johnson and Walker and is believed to exert an inhibitory effect on gamma-aminobutyric acid transmission of cortical pyramidal cells, due to its beta-lactam ring structure. Epileptogenicity is also a feature of the semisynthetic beta-lactams including aminopenicillins. In this report, we present a patient with a recurrent history of discrete body twitching/jerks of epileptic nature in the context of amoxicillin exposure. The EEG revealed intermittent generalized short bursts of beta-frequency polyspikes. This electro-clinical picture was reversed by amoxicillin discontinuation.

Published
2016
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