1. Prevalence and etiology of low bone mineral density in juvenile systemic lupus erythematosus
- Author
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Andrea S. Doria, Earl D. Silverman, Derek Stephens, David L. Gilday, Pascal N. Tyrrell, Eshetu G. Atenafu, and Sandrine Compeyrot-Lacassagne
- Subjects
Male ,musculoskeletal diseases ,medicine.medical_specialty ,Adolescent ,Immunology ,Osteoporosis ,Lupus nephritis ,Cohort Studies ,Absorptiometry, Photon ,Rheumatology ,Adrenal Cortex Hormones ,Bone Density ,Risk Factors ,Internal medicine ,Prevalence ,medicine ,Humans ,Lupus Erythematosus, Systemic ,Immunology and Allergy ,Pharmacology (medical) ,Child ,Bone mineral ,Univariate analysis ,Lupus erythematosus ,Dose-Response Relationship, Drug ,business.industry ,musculoskeletal, neural, and ocular physiology ,musculoskeletal system ,medicine.disease ,Osteopenia ,Bone Diseases, Metabolic ,Endocrinology ,Multivariate Analysis ,Disease Progression ,Female ,business ,Body mass index ,Kidney disease - Abstract
Objective Studies of adults with systemic lupus erythematosus (SLE) have frequently demonstrated the presence of decreased bone mineral density (BMD). However, there have been few investigations in pediatric patients to date. This study was undertaken to determine the prevalence of low BMD in patients with juvenile SLE and to identify associated risk factors. Methods We studied 64 consecutive patients with juvenile SLE in whom routine dual x-ray absorptiometry (DXA) scanning was performed. Lumbar spine osteopenia was defined as a BMD Z score of
- Published
- 2007