1. The function of human intercellular adhesion molecule-1 (ICAM-1) in the generation of an immune response
- Author
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Graeme J. Dougherty, Nancy Hogg, and Sarah Murdoch
- Subjects
Adult ,T-Lymphocytes ,T cell ,Immunology ,Intercellular Adhesion Molecule-1 ,Cell Communication ,Biology ,Lymphocyte Activation ,Monocytes ,Cell Line ,Immune system ,Cell–cell interaction ,Antigen ,Cell Adhesion ,medicine ,Humans ,Immunology and Allergy ,Cell adhesion ,Cell adhesion molecule ,Monocyte ,Antibodies, Monoclonal ,Molecular biology ,Cell biology ,medicine.anatomical_structure ,Antigens, Surface ,Binding Sites, Antibody ,Cell Adhesion Molecules - Abstract
Monoclonal antibody RR 1/1 directed against the putative LFA-1 ligand molecule intracellular adhesion molecule-1 (ICAM-1) was found to inhibit the T cell proliferative response to the antigen PPD. Interestingly, the percentage of unstimulated monocytes which expressed ICAM-1 on their surface appeared to vary greatly from person to person although the majority of monocytes did express high levels of ICAM-1 within their cytoplasm and surface expression could be rapidly induced on most cells by adherence to fibronectin. Resting T cells showed no evidence of surface or cytoplasmic ICAM-1 although expression was induced both within the cell and on the membrane as a result of activation with phytohemagglutinin or a combination of OKT3 and phorbol 12,13-dibutyrate. The significance of these findings with respect to the function of monocyte and T cell in the generation of an immune response is discussed.
- Published
- 1988
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