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21 results on '"Schlossmacher, Michael"'

1. Defining the Riddle in Order to Solve It: There Is More Than One “Parkinson's Disease”

Author

Outeiro, Tiago F., primary, Alcalay, Roy N., additional, Antonini, Angelo, additional, Attems, Johannes, additional, Bonifati, Vincenzo, additional, Cardoso, Francisco, additional, Chesselet, Marie‐Françoise, additional, Hardy, John, additional, Madeo, Graziella, additional, McKeith, Ian, additional, Mollenhauer, Brit, additional, Moore, Darren J., additional, Rascol, Olivier, additional, Schlossmacher, Michael G., additional, Soreq, Hermona, additional, Stefanis, Leonidas, additional, and Ferreira, Joaquim J., additional

Published
2023
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2. Defining the Riddle in Order to Solve It: There Is More Than One “Parkinson's Disease”

Author

Outeiro, Tiago F., Alcalay, Roy N., Antonini, Angelo, Attems, Johannes, Bonifati, Vincenzo, Cardoso, Francisco, Chesselet, Marie-Françoise, Hardy, John, Madeo, Graziella, McKeith, Ian, Mollenhauer, Brit, Moore, Darren J., Rascol, Olivier, Schlossmacher, Michael G., Soreq, Hermona, Stefanis, Leonidas, Ferreira, Joaquim J., Outeiro, Tiago F., Alcalay, Roy N., Antonini, Angelo, Attems, Johannes, Bonifati, Vincenzo, Cardoso, Francisco, Chesselet, Marie-Françoise, Hardy, John, Madeo, Graziella, McKeith, Ian, Mollenhauer, Brit, Moore, Darren J., Rascol, Olivier, Schlossmacher, Michael G., Soreq, Hermona, Stefanis, Leonidas, and Ferreira, Joaquim J.

Abstract

Background: More than 200 years after James Parkinsondescribed a clinical syndrome based on his astute observations, Parkinson's disease (PD) has evolved into a complex entity, akin to the heterogeneity of other complex human syndromes of the central nervous system such as dementia, motor neuron disease, multiple sclerosis, and epilepsy. Clinicians, pathologists, and basic science researchers evolved arrange of concepts andcriteria for the clinical, genetic, mechanistic, and neuropathological characterization of what, in their best judgment, constitutes PD. However, these specialists have generated and used criteria that are not necessarily aligned between their different operational definitions, which may hinder progress in solving the riddle of the distinct forms of PD and ultimately how to treat them. Objective: This task force has identified current in consistencies between the definitions of PD and its diverse variants in different domains: clinical criteria, neuropathological classification, genetic subtyping, biomarker signatures, and mechanisms of disease. This initial effort for “defining the riddle” will lay the foundation for future attempts to better define the range of PD and its variants, as has been done and implemented for other heterogeneous neurological syndromes, such as stroke and peripheral neuropathy. We strongly advocate for a more systematic and evidence-based integration of our diverse disciplines by looking at well-defined variants of the syndrome of PD. Conclusion: Accuracy in defining endophenotypes of “typical PD” across these different but interrelated disciplines will enable better definition of variants and their stratification in therapeutic trials, a prerequisite for breakthroughs in the era of precision medicine. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on beh

Published
2023

4. Conversations With Dr. Oleh Hornykiewicz, Founding Father of the Dopamine Era in Parkinson's: How Do You Wish to Be Remembered?

Author

McGovern Institute for Brain Research at MIT, Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences, Schlossmacher, Michael G., Graybiel, Ann M, McGovern Institute for Brain Research at MIT, Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences, Schlossmacher, Michael G., and Graybiel, Ann M

Abstract

On May 26, 2020, Dr. Oleh Hornykiewicz died at the age of 93 years. His twin discoveries in the early 1960s of dopamine deficiency in the brains of subjects with Parkinson's disease and the amelioration of patients' symptoms by levodopa therapy represent milestone events in the history of medicine. These breakthroughs enabled much-needed relief for millions of patients suffering from neurological disorders every year and have given rise to the field of dopamine signaling in the regulation of complex behaviors in primates. What did Dr. Hornykiewicz, who was actively engaged in research until shortly before his 91st birthday, wish to pass on to younger scientists? What were his thoughts regarding the elusive cause of Parkinson's disease? How did he wish to be remembered? Here, the authors, one a former student and the other an admired colleague, recall messages conveyed by Dr. Hornykiewicz in public lectures; they also share the content of conversations and letters exchanged with him since 2004, as he began to reflect on his legacy. Through Dr. Hornykiewicz's own words and writings, the picture emerges of an extraordinarily committed scientist, who was exemplary in his professional integrity, who knew how to deploy a gallous sense of humor, who displayed little patience for physicians offering advice, and who kept any sense of pride over his monumental contributions private. When asked at the age of 91 years about the secrets of his long and fulfilled career in neuroscience, he identified himself as “a mad scientist.…I am someone who continuously fantasizes. I am someone who chases fantastical ideas and who keeps on dreaming…”, and as a man who was supported by the loving companionship of his wife, Christine. © 2020 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Published
2021

7. Biological confounders for the values of cerebrospinal fluid proteins in Parkinson's disease and related disorders

Author

Mollenhauer, Brit, primary, Parnetti, Lucilla, additional, Rektorova, Irena, additional, Kramberger, Milica G., additional, Pikkarainen, Maria, additional, Schulz-Schaeffer, Walter J., additional, Aarsland, Dag, additional, Svenningsson, Per, additional, Farotti, Lucia, additional, Verbeek, Marcel M., additional, and Schlossmacher, Michael G., additional

Published
2016
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11. P1-021: Diurnal and intersubject variability of cerebrospinal fluid biomarkers, Aβ-40/42, alpha-synuclein and DJ-1 in healthy volunteers

Author

Ereshefsky, Larry, primary, Frasier, Mark, additional, Yen, Mark, additional, Jhee, Stanford, additional, Marek, Kenneth, additional, Taylor, Peggy, additional, Sherman, Molly, additional, Caspell, Chelsea, additional, Coffey, Chris, additional, Schlossmacher, Michael, additional, and Sherer, Todd, additional

Published
2012
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12. Association of SNCA with Parkinson: Replication in the Harvard NeuroDiscovery Center Biomarker Study

Author

Ding, Hongliu, primary, Sarokhan, Alison K., additional, Roderick, Sarah S., additional, Bakshi, Rachit, additional, Maher, Nancy E., additional, Ashourian, Paymon, additional, Kan, Caroline G., additional, Chang, Sunny, additional, Santarlasci, Andrea, additional, Swords, Kyleen E., additional, Ravina, Bernard M., additional, Hayes, Michael T., additional, Sohur, U. Shivraj, additional, Wills, Anne-Marie, additional, Flaherty, Alice W., additional, Unni, Vivek K., additional, Hung, Albert Y., additional, Selkoe, Dennis J., additional, Schwarzschild, Michael A., additional, Schlossmacher, Michael G., additional, Sudarsky, Lewis R., additional, Growdon, John H., additional, Ivinson, Adrian J., additional, Hyman, Bradley T., additional, and Scherzer, Clemens R., additional

Published
2011
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13. Acid β-glucosidase mutants linked to gaucher disease, parkinson disease, and lewy body dementia alter α-synuclein processing

Author

Cullen, Valerie, primary, Sardi, S. Pablo, additional, Ng, Juliana, additional, Xu, You-Hai, additional, Sun, Ying, additional, Tomlinson, Julianna J., additional, Kolodziej, Piotr, additional, Kahn, Ilana, additional, Saftig, Paul, additional, Woulfe, John, additional, Rochet, Jean-Christophe, additional, Glicksman, Marcie A., additional, Cheng, Seng H., additional, Grabowski, Gregory A., additional, Shihabuddin, Lamya S., additional, and Schlossmacher, Michael G., additional

Published
2011
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20. Lewy body Parkinson's disease in a large pedigree with 77Parkin mutation carriers

Author

Pramstaller, Peter P., primary, Schlossmacher, Michael G., additional, Jacques, Thomas S., additional, Scaravilli, Francesco, additional, Eskelson, Cordula, additional, Pepivani, Imelda, additional, Hedrich, Katja, additional, Adel, Susanna, additional, Gonzales-McNeal, Melissa, additional, Hilker, Rüdiger, additional, Kramer, Patricia L., additional, and Klein, Christine, additional

Published
2005
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