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Your search keyword '"Sgaramella, Nicola"' showing total 12 results
Start Over Author "Sgaramella, Nicola" Publisher wiley
12 results on '"Sgaramella, Nicola"'

8. Patients with high c-MYC-expressing squamous cell carcinomas of the tongue show better survival than those with low- and medium-expressing tumours

Author

Strindlund, Klas, primary, Troiano, Giuseppe, additional, Sgaramella, Nicola, additional, Coates, Philip J., additional, Gu, Xiaolian, additional, Boldrup, Linda, additional, Califano, Luigi, additional, Fahraeus, Robin, additional, Muzio, Lorenzo Lo, additional, Ardito, Fatima, additional, Colella, Giuseppe, additional, Tartaro, Gianpaolo, additional, Franco, Renato, additional, Norberg-Spaak, Lena, additional, Saadat, Mohammad, additional, and Nylander, Karin, additional

Published
2017
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9. High expression of podoplanin in squamous cell carcinoma of the tongue occurs predominantly in patients ≤40 years but does not correlate with tumour spread

Author

Sgaramella, Nicola, primary, Lindell Jonsson, Eva, additional, Boldrup, Linda, additional, Califano, Luigi, additional, Coates, Philip J, additional, Tartaro, Gianpaolo, additional, Lo Muzio, Lorenzo, additional, Fåhraeus, Robin, additional, Colella, Giuseppe, additional, Dell'Aversana Orabona, Giovanni, additional, Loljung, Lotta, additional, Santagata, Mario, additional, Rossiello, Riccardo, additional, Wilms, Torben, additional, Danielsson, Karin, additional, Laurell, Göran, additional, and Nylander, Karin, additional

Published
2015
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11. Patients with high c-MYC-expressing squamous cell carcinomas of the tongue show better survival than those with low- and medium-expressing tumours

Author

Luigi Califano, Lena Norberg-Spaak, Xiaolian Gu, Nicola Sgaramella, Linda Boldrup, Robin Fåhraeus, Klas Strindlund, Renato Franco, Fatima Ardito, Mohammad Saadat, Karin Nylander, Gianpaolo Tartaro, Giuseppe Troiano, Lorenzo Lo Muzio, Philip J. Coates, Giuseppe Colella, Strindlund, Kla, Troiano, Giuseppe, Sgaramella, Nicola, Coates, Philip J, Gu, Xiaolian, Boldrup, Linda, Califano, Luigi, Fahraeus, Robin, Muzio, Lorenzo Lo, Ardito, Fatima, Colella, Giuseppe, Tartaro, Gianpaolo, Franco, Renato, Norberg Spaak, Lena, Saadat, Mohammad, and Nylander, Karin

Subjects
squamous cell carcinoma, Adult, Male, 0301 basic medicine, Oncology, Cancer Research, medicine.medical_specialty, medicine.medical_treatment, Cell, Growth control, Biology, Pathology and Forensic Medicine, Proto-Oncogene Proteins c-myc, Young Adult, 03 medical and health sciences, 0302 clinical medicine, tongue, Tongue, Internal medicine, medicine, Humans, Gene, radiotherapy, Aged, Aged, 80 and over, Squamous Cell Carcinoma of Head and Neck, Middle Aged, Tongue Neoplasms, Gene Expression Regulation, Neoplastic, Survival Rate, Radiation therapy, c-MYC, 030104 developmental biology, medicine.anatomical_structure, Otorhinolaryngology, Head and Neck Neoplasms, Apoptosis, 030220 oncology & carcinogenesis, Carcinoma, Squamous Cell, Cancer research, Periodontics, Female, Oral Surgery
Abstract

Background: c-MYC is a potent oncoprotein with roles in a wide range of cellular processes such as differentiation, apoptosis and growth control. Deregulation of the MYC gene is commonly seen in human tumours resulting in overexpression of the protein. Here we studied expression of c-MYC in correlation to clinical outcome in patients with primary squamous cell carcinoma of the mobile tongue. Methods: Immunohistochemistry was used to identify c-MYC in a group of 104 tongue squamous cell carcinomas with an antibody directed against the N-terminal part of the protein. Staining was evaluated by multiplying the percentage of c-MYC-expressing cells with staining intensity, giving a quick score for each tumour. Results: All 104 tumours expressed c-MYC at varying levels. Quantitation according to per cent of positive cells and staining intensity revealed that most (15/21; 71%) high-expressing tumours were seen in males. Within the group of high c-MYC-expressing tumours, the majority were alive 2 and 5 years after treatment. Conclusions: The present findings show that expression of c-MYC has prognostic value in squamous cell carcinoma of the tongue, and could be useful in choice of therapy.

Published
2017

12. High podoplanin and low E-cadherin levels correlate with better prognosis in adenoid cystic carcinoma.

Author

van der Wal JE, Sgaramella N, Norberg Spaak L, Zborayova K, and Nylander K

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Carcinoma, Adenoid Cystic pathology, Carcinoma, Mucoepidermoid mortality, Carcinoma, Mucoepidermoid pathology, Child, Child, Preschool, Female, Follow-Up Studies, Humans, Infant, Infant, Newborn, Kaplan-Meier Estimate, Male, Middle Aged, Prognosis, Salivary Gland Neoplasms pathology, Young Adult, Antigens, CD metabolism, Biomarkers, Tumor metabolism, Cadherins metabolism, Carcinoma, Adenoid Cystic mortality, Membrane Glycoproteins metabolism, Salivary Glands pathology
Abstract

Objectives: As tumour spread is a complicating event for malignant salivary gland tumours, we decided to study factors related to cell adhesion and lymph vessel formation in two of the three most common malignant salivary gland tumours, mucoepidermoid carcinoma (MEC) and adenoid cystic carcinoma (ACC), to clarify the clinical relevance and potential usefulness of these factors. We also included a group of polymorphous adenocarcinoma (PAC) as this tumour, in common with ACC often shows perineural growth, but in contrast to ACC has an overall good prognosis., Material and Methods: Eighteen patients with ACC, 15 with MEC, and six with PAC were included. Protein expression of podoplanin and E-cadherin was evaluated as percentage of cells expressing the protein and intensity of expression. Ki-67 expression was included in the study as a marker of proliferative activity., Results: Looking at podoplanin, significantly more ACCs were high expressing compared with both MECs ( P  = .001) and PACs ( P  = .028). Also when looking at Ki-67 expression, significantly more ACCs were high expressing compared with MECs ( P  = .003). Significantly better survival was also seen for ACCs with high podoplanin ( P  = .022) and low E-cadherin expression ( P  = .021), respectively., Conclusions: Our findings show that ACCs express significantly higher levels of podoplanin compared with both MECs and PACs and that high levels are correlated to better survival. Even though the group of PACs analysed was small, these tumours, despite their tendency to perineural spread, which they have in common with ACC, differ from ACCs concerning expression of factors with a known connection to tumour spread., Competing Interests: None declared.

Published
2019
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