1. Cerebral Microhemorrhages in Children With Congenital Heart Disease: Prevalence, Risk Factors, and Association With Neurodevelopmental Outcomes
- Author
-
Kristen N. Andersen, Sicong Yao, Brian R. White, Marin Jacobwitz, Jake Breimann, Jharna Jahnavi, Alexander Schmidt, Wesley B. Baker, Tiffany S. Ko, J. William Gaynor, Arastoo Vossough, Rui Xiao, Daniel J. Licht, and Evelyn K. Shih
- Subjects
cardiopulmonary bypass ,cerebral microhemorrhage ,congenital heart disease ,neurodevelopmental outcomes ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background Infants with congenital heart disease require early lifesaving heart surgery, which increases risk for brain injury and neurodevelopmental delay. Cerebral microhemorrhages (CMH) are frequently seen after surgery, but whether they are benign or constitute injury is unknown. Methods and Results One hundred ninety‐two infants with congenital heart disease undergoing cardiac surgery with cardiopulmonary bypass were evaluated with pre‐ (n=183) and/or postoperative (n=162) magnetic resonance imaging. Perioperative risk factors for CMH and neurodevelopmental outcomes were analyzed using linear regression. Eighteen‐month neurodevelopmental outcomes were assessed in a subset of patients (n=82). The most common congenital heart disease subtypes were hypoplastic left heart syndrome (37%) and transposition of the great arteries (33%). Forty‐two infants (23%) had CMH present on magnetic resonance imaging presurgery and 137 infants (85%) postsurgery. We found no significant risk factors for preoperative CMH. In multivariable analysis, neurodevelopmental duration (P
- Published
- 2025
- Full Text
- View/download PDF