1. Improved Synthesis of 2′-Amino-LNA
- Author
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Lotte-Emilie Larsen, Christoph Rosenbohm, Mads Sølvsten Sørensen, Troels Koch, Signe M. Christensen, and Jesper Wengel
- Subjects
Phosphoramidite ,Stereochemistry ,Chemistry ,Molecular Conformation ,Oligonucleotides ,Late stage ,General Medicine ,Oligonucleotides, Antisense ,Amides ,Biochemistry ,Combinatorial chemistry ,Genetics ,Nucleic acid ,Molecular Medicine ,Indicators and Reagents ,Phosphoric Acids ,Amines - Abstract
2′-Amino-LNA phosphoramidite (10) was synthesised by means of a new strategy, which is convergent with the synthesis of 2′-oxy-LNA up until a late stage intermediate (1).
- Published
- 2004
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