17 results on '"Signorelli C."'
Search Results
2. Long-term health-related quality of life in young childhood cancer survivors and their parents
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Fardell, JE, Wakefield, CE, De Abreu Lourenco, R, Signorelli, C, McCarthy, M, McLoone, J, Osborn, M, Gabriel, M, Anazodo, A, Alvaro, F, Lockwood, L, Walwyn, T, Skeen, J, Tillemans, R, Cohn, RJ, and ANZCHOG Survivorship Group
- Subjects
1103 Clinical Sciences, 1112 Oncology and Carcinogenesis, 1114 Paediatrics and Reproductive Medicine ,Oncology & Carcinogenesis ,humanities - Abstract
Purpose Few studies have investigated the health-related quality of life (HRQoL) of young childhood cancer survivors and their parents. This study describes parent and child cancer survivor HRQoL compared to population norms and identifies factors influencing child and parent HRQoL. Methods We recruited parents of survivors who were currently 5 years postdiagnosis. Parents reported on their child's HRQoL (Kidscreen-10), and their own HRQoL (EQ-5D-5L). Parents rated their resilience and fear of cancer recurrence and listed their child's cancer-related late effects. Results One hundred eighty-two parents of survivors (mean age = 12.4 years old and 9.7 years postdiagnosis) participated. Parent-reported child HRQoL was significantly lower than population norms (48.4 vs. 50.7, p < .009). Parents most commonly reported that their child experienced sadness and loneliness (18.1%). Experiencing more late effects and receiving treatments other than surgery were associated with worse child HRQoL. Parents’ average HRQoL was high (0.90) and no different to population norms. However 38.5% of parents reported HRQoL that was clinically meaningfully different from perfect health, and parents experienced more problems with anxiety/depression (43.4%) than population norms (24.7%, p < .0001). Worse child HRQoL, lower parent resilience, and higher fear of recurrence was associated with worse parent HRQoL. Conclusions Parents report that young survivors experience small but significant ongoing reductions in HRQoL. While overall mean levels of HRQoL were no different to population norms, a subset of parents reported HRQoL that was clinically meaningfully different from perfect health. Managing young survivors’ late effects and improving parents’ resilience through survivorship may improve HRQoL in long-term survivorship.
- Published
- 2021
3. A cost-effective approach to increasing participation in patient-reported outcomes research in cancer: A randomized trial of video invitations.
- Author
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Signorelli, C, Wakefield, CE, McLoone, JK, Mateos, MK, Aaronson, NK, Lavoipierre, A, Cohn, RJ, ANZCHOG Survivorship Study Group, Signorelli, C, Wakefield, CE, McLoone, JK, Mateos, MK, Aaronson, NK, Lavoipierre, A, Cohn, RJ, and ANZCHOG Survivorship Study Group
- Abstract
Maximizing participation in cancer research is important to improve the validity and generalizability of research findings. We conducted a four-arm randomized controlled trial to test the impact of a novel video invitation on participant response. We invited childhood cancer survivors and parents of survivors <16 years to complete questionnaires. We compared response rates to an invitation letter (control) vs receiving the letter plus a video invitation on a flash drive presented by a childhood cancer survivor, a pediatric oncologist or a researcher. We explored factors associated with viewing the video and examined the impact of enclosing the USB on study costs. Overall 54% (634/1176) of questionnaires were returned. Participants who received a video invitation on a USB were more likely to return the questionnaire than those who did not (58% vs 47%, P < .001). Participation rate did not significantly differ by video presenter. Forty-seven percent of participants who received a USB reported watching the video, of whom 48% reported that the video influenced their decision to participate. Participants with a lower income (OR = 0.43, 95% CI = 0.25-0.74, P = .002) were more likely to report watching the video. Participants who received a video invitation required significantly fewer reminder calls than those who only received a written invitation (mean = 1.6 vs 1.1 calls, P < .001), resulting in a 25% recruitment cost-saving for the study. Adding a USB with a video study invitation to recruitment packages is a cost-effective way of improving study participation. This is important in an era of declining study participation and underrepresentation of vulnerable populations in research.
- Published
- 2021
4. Paediatric surgery for childhood cancer: Lasting experiences and needs of children and parents.
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Gabriel, MG, Wakefield, CE, Vetsch, J, Karpelowsky, JS, Darlington, A-SE, Cohn, RJ, Signorelli, C, ANZCHOG Survivorship Study Group, Gabriel, MG, Wakefield, CE, Vetsch, J, Karpelowsky, JS, Darlington, A-SE, Cohn, RJ, Signorelli, C, and ANZCHOG Survivorship Study Group
- Abstract
OBJECTIVE: Surgery for paediatric cancer presents many stresses on patients and families. The authors aimed to understand the long-term impact of childhood cancer surgery on survivors and parents. METHODS: The study recruited participants from 11 Australia/New Zealand hospitals for telephone interviews. The authors used descriptive statistics to analyse participants' quantitative distress ratings and conducted thematic analysis of shared surgical experiences and needs. RESULTS: Of 32 participants (n = 17 survivors, n = 15 parents), survivors' mean age at surgery was 6.9 (SD = 5.17) and parents' children were 2.1 years old (SD = 1.41) at time of surgery. Survivors had surgery on average 15.2 years ago (SD = 6.72) and parents' children 11.5 years ago (SD = 3.94). Parents and survivors rated surgery as highly distressing. Pre-operatively, survivors recalled experiencing fear and pain mainly associated with pre-operative procedures. Post-operatively, survivors reported immobility and some lasting behavioural disturbances. Parents described pre- and intra-operative anxiety and stress and some lasting post-operative psychological disturbances. Experiences appeared to improve with clear/consistent communication from hospital staff, proximity to hospital, and with support for parents and children post-operatively. CONCLUSIONS: Surgical treatment for childhood cancer can have a lasting impact for survivors and parents. Better information provision may improve families' surgical experience whilst reducing anxiety, distress and physical discomfort.
- Published
- 2019
5. Recruiting primary care physicians to qualitative research: Experiences and recommendations from a childhood cancer survivorship study
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Signorelli, C, Wakefield, CE, Fardell, JE, Thornton-Benko, E, Emery, J, McLoone, JK, Cohn, RJ, Signorelli, C, Wakefield, CE, Fardell, JE, Thornton-Benko, E, Emery, J, McLoone, JK, and Cohn, RJ
- Abstract
BACKGROUND: Primary care physicians (PCPs) are essential for healthcare delivery but can be difficult to recruit to health research. Low response rates may impact the quality and value of data collected. This paper outlines participant and study design factors associated with increased response rates among PCPs invited to participate in a qualitative study at Sydney Children's Hospital, Australia. PROCEDURE: We invited 160 PCPs by post, who were nominated by their childhood cancer patients in a survey study. We followed-up by telephone, email, or fax 2 weeks later. RESULTS: Without any follow-up, 32 PCPs opted in to the study. With follow-up, a further 42 PCPs opted in, with email appearing to be the most effective method, yielding a total of 74 PCPs opting in (46.3%). We reached data saturation after 51 interviews. On average, it took 34.6 days from mail-out to interview completion. Nonrespondents were more likely to be male (P = 0.013). No survivor-related factors significantly influenced PCPs' likelihood of participating. Almost double the number of interviews were successfully completed if scheduled via email versus phone. Those requiring no follow-up did not differ significantly to late respondents in demographic/survivor-related characteristics. CONCLUSION: PCP factors associated with higher opt in rates, and early responses, may be of interest to others considering engaging PCPs and/or their patients in cancer-related research, particularly qualitative or mixed-methods studies. Study resources may be best allocated to email follow-up, incentives, and personalization of study documents linking PCPs to patients. These efforts may improve PCP participation and the representativeness of study findings.
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- 2018
6. Technical variables of ACL surgical reconstruction: effect on post-operative static laxity and clinical implication
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Zaffagnini, S., primary, Signorelli, C., additional, Bonanzinga, T., additional, Roberti Di Sarsina, T., additional, Grassi, A., additional, Budeyri, A., additional, Marcheggiani Muccioli, G. M., additional, Raggi, F., additional, Bragonzoni, L., additional, Lopomo, N., additional, and Marcacci, M., additional
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- 2016
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7. Does meniscus removal affect ACL-deficient knee laxity? An in vivo study
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Zaffagnini, S., primary, Signorelli, C., additional, Bonanzinga, T., additional, Grassi, A., additional, Galán, H., additional, Akkawi, I., additional, Bragonzoni, L., additional, Cataldi, F., additional, and Marcacci, M., additional
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- 2016
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8. Two different approaches for novel extracapsular cranial cruciate ligament reconstruction: an in vitro kinematics study
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Cinti, F., primary, Signorelli, C., additional, Lopomo, N., additional, Baracchi, M., additional, Del Magno, S., additional, Foglia, A., additional, Zaffagnini, S., additional, and Pisoni, L., additional
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- 2015
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9. Do pre‐operative knee laxity values influence post‐operative ones after anterior cruciate ligament reconstruction?
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Signorelli, C., primary, Bonanzinga, T., additional, Lopomo, N., additional, Marcheggiani Muccioli, G. M., additional, Bignozzi, S., additional, Filardo, G., additional, Zaffagnini, S., additional, and Marcacci, M., additional
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- 2013
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10. Oral, colonic-release low-molecular-weight heparin: an initial open study of Parnaparin-MMX for the treatment of mild-to-moderate left-sided ulcerative colitis
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PASTORELLI, L., primary, SAIBENI, S., additional, SPINA, L., additional, SIGNORELLI, C., additional, CELASCO, G., additional, DE FRANCHIS, R., additional, and VECCHI, M., additional
- Published
- 2008
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11. Sleep Disturbances in Childhood Cancer Survivors
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Selena Russo, Jordana K. McLoone, Christina Signorelli, Joanna E. Fardell, Claire E. Wakefield, Richard J. Cohn, Russo, S, Fardell, J, Signorelli, C, Wakefield, C, Mcloone, J, and Cohn, R
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Medical education ,Male ,Gerontology ,Childhood cancer ,MEDLINE ,03 medical and health sciences ,Sleep Apnea Syndrome ,Sleep Apnea Syndromes ,0302 clinical medicine ,Quality of life (healthcare) ,Neoplasms ,Surveys and Questionnaires ,Surveys and Questionnaire ,Humans ,Medicine ,Survivors ,030212 general & internal medicine ,Health Psychology ,business.industry ,Hematology ,Sleep in non-human animals ,Clinical Psychology ,Oncology ,030220 oncology & carcinogenesis ,Pediatrics, Perinatology and Child Health ,Quality of Life ,Neoplasm ,Female ,Survivor ,M-PSI/08 - PSICOLOGIA CLINICA ,business ,Human - Published
- 2016
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12. Relationship between survivorship care plans and unmet information needs, quality of life, satisfaction with care, and propensity to engage with, and attend, follow-up care.
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Hill RE, Mercieca-Bebber R, Fardell JE, Wakefield CE, Signorelli C, Webber K, and Cohn RJ
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- Adult, Child, Humans, Aged, Survivorship, Quality of Life, Cross-Sectional Studies, Personal Satisfaction, Patient Care Planning, Aftercare, Neoplasms therapy
- Abstract
Background: The impact of survivorship care plans (SCPs) on the proximal and distal outcomes of adult and childhood cancer survivors, and parent proxies, is unclear. This study aimed to determine the relationship between SCP receipt and these outcomes., Methods: A cross-sectional survey of adult and childhood cancer survivors (and parent proxies for survivors aged younger than 16 years) across Australia and New Zealand was conducted. Multivariate regression models were fitted to measure the impact of SCP receipt on proximal (unmet information needs and propensity to engage with, and attend, cancer-related follow-up care) and distal outcomes (quality of life and satisfaction with cancer-related follow-up care) with control for cancer history and sociodemographic factors., Results: Of 1123 respondents, 499 were adult cancer survivors and 624 were childhood cancer survivors (including 222 parent proxies). We found that SCP receipt was predictive of greater attendance at, and awareness of, cancer-related follow-up care (adult: odds ratio [OR], 2.46; 95% CI, 1.18-5.12; OR, 2.38; 95% CI, 1.07-5.29; child/parent: OR, 2.61; 95% CI, 1.63-4.17; OR, 1.63; 95% CI, 1.06-2.50; respectively). SCP receipt also predicted fewer unmet information needs related to "follow-up care required" and "possible late effects" (adult: OR, 0.44; 95% CI, 0.20-0.96; OR, 0.29; 95% CI, 0.13-0.64; child/parent: OR, 0.46; 95% CI, 0.30-0.72; OR, 0.57; 95% CI, 0.38-0.85; respectively). In terms of distal outcomes, SCP receipt predicted a better global quality of life for adult cancer survivors (β, 0.08; 95% CI, -0.01-7.93), proxy-reported health-related quality of life (β, 0.15; 95% CI, 0.44-7.12), and satisfaction with follow-up care for childhood cancer survivors (OR, 2.93; 95% CI, 1.64-5.23)., Conclusions: Previous studies have shown little impact of SCPs on distal end points. Results suggest that SCPs may be beneficial to cancer survivors' proximal and distal outcomes., (© 2023 The Authors. Cancer published by Wiley Periodicals LLC on behalf of American Cancer Society.)
- Published
- 2023
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13. Psychosocial care for cancer survivors: A global review of national cancer control plans.
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Mullen L, Signorelli C, Nekhlyudov L, Jacobsen PB, Gitonga I, Estapé T, Lim Høeg B, Miles A, Sade C, Mazariego C, Degi CL, Howard F, Manne S, Travado L, and Jefford M
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- Humans, Delivery of Health Care, Psycho-Oncology, Cancer Survivors, Psychiatric Rehabilitation, Neoplasms psychology
- Abstract
Objective: National Cancer Control Plans (NCCPs) are high-level policy documents that prioritise actions to be taken to improve cancer control activities. As the number of cancer survivors grows globally, there is an urgent need to assess whether and how psychosocial care across the cancer care continuum is included in NCCPs. This review aimed to ascertain the extent to which NCCPs referenced psycho-oncology care for cancer survivors in the post-treatment phase., Methods: NCCPs were obtained from the International Cancer Control Partnership (ICCP) portal (in November 2021) and reviewed in two phases. In Phase 1, all available NCCPs were screened to determine whether they mentioned psycho-oncology or survivorship. In Phase 2, reviewers extracted data from the NCCPs identified in Phase 1 on the degree that each plan articulated objectives/goals to improve psychosocial care in the post-treatment survivorship phase., Results: We screened 237 NCCPs. Of these, initial potential reference to psycho-oncology and survivorship content were identified in 97 plans (41%). In Phase 1, 57/97 (59%) had reference to psycho-oncology or survivorship content within defined criteria. In Phase 2, 27/97 (28%) had little mention of psycho-oncology specifically in survivorship, 47/97 (48%) had some (general or brief) mention, and the remaining 23/97 (24%) had substantial content/specific sections and clearly articulated goals and/or objectives. Common goals for improving psychosocial care in the post-treatment period included building capacity of healthcare professionals, implementing rehabilitation models, and increasing the utilisation of community services., Conclusions: Most NCCPs did not reference psycho-oncology and only one-quarter contained clear objectives specifically in the post-treatment survivorship phase., (© 2023 John Wiley & Sons Ltd.)
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- 2023
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14. After Action Reviews of COVID-19 response: Case study of a large tertiary care hospital in Italy.
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Sorbello S, Bossi E, Zandalasini C, Carioli G, Signorelli C, Ciceri F, Ambrosio A, Zangrillo A, and Odone A
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- COVID-19 Testing, Humans, Italy, SARS-CoV-2, Utilization Review, COVID-19, Tertiary Care Centers
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Background: After-Action Reviews (AARs) are management tools used to evaluate the response to public health emergencies at the national and subnational level. Aim of this study is to apply available AAR models to assess and critically appraise COVID-19 response of San Raffaele Scientific Institute, a large university hospital in Milan, Italy., Methods: We designed an AAR based on the key-informant interview format, following the methodology proposed by the 2019 World Health Organization Guidance for AAR. After systematic assessment of the hospital reorganization, we conducted 36 semi-structured interviews to professionals with executive, clinical, technical and administrative roles. We designed an ad-hoc questionnaire exploring four areas: (i) staff management; (ii) logistics and supplies; (iii) COVID-19 diagnosis and clinical management; (iv) communication., Results: Overall, the hospital response was evaluated as effective and sufficiently prompt. Participants stressed the relevance of: (i) strong governance and coordination; (ii) readiness and availability of healthcare personnel; (iii) definition of a model of care based on a multidisciplinary approach. Challenges were reported for communication management and staff training., Conclusions: This study is one of the first applications of the AAR to the COVID-19 response in hospital settings, which can be successfully adapted or scaled up to other settings in order to implement preparedness strategies for future public health emergencies., (© 2021 The Authors. The International Journal of Health Planning and Management published by John Wiley & Sons Ltd.)
- Published
- 2021
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15. Paediatric surgery for childhood cancer: Lasting experiences and needs of children and parents.
- Author
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Gabriel MG, Wakefield CE, Vetsch J, Karpelowsky JS, Darlington AE, Cohn RJ, and Signorelli C
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- Adolescent, Adult, Anxiety psychology, Australia, Child, Child, Preschool, Fear psychology, Female, Humans, Infant, Male, Neoplasms psychology, New Zealand, Pain psychology, Stress, Psychological psychology, Young Adult, Cancer Survivors psychology, Neoplasms surgery, Parents psychology, Psychological Distress, Surgical Procedures, Operative psychology
- Abstract
Objective: Surgery for paediatric cancer presents many stresses on patients and families. The authors aimed to understand the long-term impact of childhood cancer surgery on survivors and parents., Methods: The study recruited participants from 11 Australia/New Zealand hospitals for telephone interviews. The authors used descriptive statistics to analyse participants' quantitative distress ratings and conducted thematic analysis of shared surgical experiences and needs., Results: Of 32 participants (n = 17 survivors, n = 15 parents), survivors' mean age at surgery was 6.9 (SD = 5.17) and parents' children were 2.1 years old (SD = 1.41) at time of surgery. Survivors had surgery on average 15.2 years ago (SD = 6.72) and parents' children 11.5 years ago (SD = 3.94). Parents and survivors rated surgery as highly distressing. Pre-operatively, survivors recalled experiencing fear and pain mainly associated with pre-operative procedures. Post-operatively, survivors reported immobility and some lasting behavioural disturbances. Parents described pre- and intra-operative anxiety and stress and some lasting post-operative psychological disturbances. Experiences appeared to improve with clear/consistent communication from hospital staff, proximity to hospital, and with support for parents and children post-operatively., Conclusions: Surgical treatment for childhood cancer can have a lasting impact for survivors and parents. Better information provision may improve families' surgical experience whilst reducing anxiety, distress and physical discomfort., (© 2019 John Wiley & Sons Ltd.)
- Published
- 2019
- Full Text
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16. Perceptions of future health and cancer risk in adult survivors of childhood cancer: Implications for engagement in follow-up care.
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Signorelli C, Wakefield CE, Fardell JE, Brierley ME, Darlington AS, Williamson J, Downie P, and Cohn RJ
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- Adult, Child, Health, Humans, Perception, Survivors, Aftercare, Neoplasms
- Published
- 2019
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17. Genetic testing for the risk of developing late effects among survivors of childhood cancer: Consumer understanding, acceptance, and willingness to pay.
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Georgiou G, Wakefield CE, McGill BC, Fardell JE, Signorelli C, Hanlon L, Tucker K, Patenaude AF, and Cohn RJ
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- Adolescent, Adult, Female, Genetic Predisposition to Disease, Humans, Male, Neoplasms mortality, Neoplasms psychology, Patient Acceptance of Health Care, Risk, Survivors, Young Adult, Genetic Testing economics, Genetic Testing methods, Health Knowledge, Attitudes, Practice, Neoplasms economics, Neoplasms genetics
- Abstract
Background: Genetic testing to determine cancer survivors' risk of developing late effects from their cancer treatment will be increasingly used in survivorship care. This 2-stage study with 64 survivors of childhood cancer and their parents investigated the preferences and acceptability of testing among those who may be at risk of developing late effects., Methods: The first stage (Stage 1) identified the most commonly perceived benefits and concerns regarding genetic testing for the risk of late effects among 24 participants. In Stage 2, during interviews, 20 survivors (55% of whom were female; mean age, 26.0 years [range, 18-39 years]; standard deviation [SD], 0.80) and 20 parents (55% of whom were male; mean age of child survivor, 14.2 years [range, 10-19 years]; SD, 0.79) rated the 7 most common benefits and concerns from those identified in Stage 1. Interviews were transcribed verbatim and analyzed. Decisional balance ratios were calculated by dividing the participants' average concerns scores with the average benefits scores., Results: Genetic testing for late effects was highly acceptable: 95% of participants leaned toward testing, and the majority (65.9%) would pay up to Australian $5000. The majority (97.2%) reported it was acceptable to wait for up to 6 months to receive results, and to be offered testing immediately after treatment or when the survivor reached adulthood (62.9%). Survivors and parents had a highly positive decisional balance (Mean (M), 0.5 [SD, 0.38] and M, 0.5 [SD, 0.39], respectively), indicating that perceived benefits outweighed concerns., Conclusions: Although to our knowledge clinical efficacy has yet to be clearly demonstrated, survivors and parents described positive interest in genetic testing for the risk of developing late effects. Perceived benefits outweighed harms, and the majority of participants would be willing to pay, and wait, for testing. Cancer 2016. © 2016 American Cancer Society. Cancer 2016;122:2876-2885. © 2016 American Cancer Society., (© 2016 American Cancer Society.)
- Published
- 2016
- Full Text
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