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38 results on '"Smith, Melanie"'

2. Computer Vision Analysis of Rheumatoid Arthritis Synovium Reveals Lymphocytic Inflammation is Associated with Immunoglobulin Skewing in Blood

Author

Frezza, Damon, primary, DiCarlo, Edward, additional, Hale, Caryn, additional, Ramirez, Daniel, additional, Mehta, Bella, additional, Slater, David, additional, Habib, Saimun, additional, Frank NP, Mayu O., additional, Spolaore, Edoardo, additional, Smith, Melanie H., additional, Donlin, Laura, additional, Goodman, Susan, additional, Thompson, James R., additional, and Orange, Dana, additional

Published
2023
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3. A framework for linking hemispheric, full annual cycle prioritizations to local conservation actions for migratory birds

Author

DeLuca, William V., primary, Seavy, Nathaniel E., additional, Grand, Joanna, additional, Velásquez‐Tibatá, Jorge, additional, Taylor, Lotem, additional, Bowler, Cat, additional, Deppe, Jill L., additional, Knight, Erika J., additional, Lentijo, Gloria M., additional, Meehan, Timothy D., additional, Michel, Nicole L., additional, Saunders, Sarah P., additional, Schillerstrom, Nolan, additional, Smith, Melanie A., additional, Witko, Chad, additional, and Wilsey, Chad B., additional

Published
2023
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5. Integrating data types to estimate spatial patterns of avian migration across the Western Hemisphere

Author

Meehan, Timothy D., primary, Saunders, Sarah P., additional, DeLuca, William V., additional, Michel, Nicole L., additional, Grand, Joanna, additional, Deppe, Jill L., additional, Jimenez, Miguel F., additional, Knight, Erika J., additional, Seavy, Nathaniel E., additional, Smith, Melanie A., additional, Taylor, Lotem, additional, Witko, Chad, additional, Akresh, Michael E., additional, Barber, David R., additional, Bayne, Erin M., additional, Beasley, James C., additional, Belant, Jerrold L., additional, Bierregaard, Richard O., additional, Bildstein, Keith L., additional, Boves, Than J., additional, Brzorad, John N., additional, Campbell, Steven P., additional, Celis‐Murillo, Antonio, additional, Cooke, Hilary A., additional, Domenech, Robert, additional, Goodrich, Laurie, additional, Gow, Elizabeth A., additional, Haines, Aaron, additional, Hallworth, Michael T., additional, Hill, Jason M., additional, Holland, Amanda E., additional, Jennings, Scott, additional, Kays, Roland, additional, King, D. Tommy, additional, Mackenzie, Stuart A., additional, Marra, Peter P., additional, McCabe, Rebecca A., additional, McFarland, Kent P., additional, McGrady, Michael J., additional, Melcer, Ron, additional, Norris, D. Ryan, additional, Norvell, Russell E., additional, Rhodes, Olin E., additional, Rimmer, Christopher C., additional, Scarpignato, Amy L., additional, Shreading, Adam, additional, Watson, Jesse L., additional, and Wilsey, Chad B., additional

Published
2022
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9. Perceptions and practices for beta‐lactam antibiotic dosing, administration, and monitoring in critically ill patients: Current views and use among critical care and infectious diseases pharmacists

Author

Hammond, Drayton A., primary, McCreary, Erin K., additional, Rech, Megan A., additional, Smith, Melanie N., additional, Yeo, Qiu Min, additional, Lusardi, Katherine, additional, Rhodes, Nathaniel J., additional, Swanson, Joseph M., additional, and Bland, Christopher M., additional

Published
2019
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25. Exclusion of linkage to theCDL1 gene region on chromosome 3q26.3 in some familial cases of Cornelia de Lange syndrome

Author

Krantz, Ian D., primary, Tonkin, Emma, additional, Smith, Melanie, additional, Devoto, Marcella, additional, Bottani, Armand, additional, Simpson, Claire, additional, Hofreiter, Mary, additional, Abraham, Vinod, additional, Jukofsky, Lori, additional, Conti, Brian P., additional, Strachan, Tom, additional, and Jackson, Laird, additional

Published
2001
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36. Traditional versus virtual partial hospital programme for eating disorders: Feasibility and preliminary comparison of effects.

Author

Penwell TE, Smith M, Ortiz SN, Brooks G, and Thompson-Brenner H

Subjects
Humans, Feasibility Studies, Hospitals, Feeding and Eating Disorders therapy, Anorexia Nervosa therapy, Binge-Eating Disorder therapy
Abstract

Objective: Minimal research has examined teletherapy for group or intensive eating disorder (ED) treatment, particularly partial hospital programme (PHP). This study compared treatment outcomes for individuals treated before and after a pandemic-driven implementation of virtual PHP., Method: Patients received care at ED treatment centres using the Renfrew Unified Treatment for Eating Disorders and Comorbidity. Patients treated with virtual PHP were compared to patients treated with traditional PHP. Measures of ED symptomology and behaviours, depressive symptoms, anxiety severity, anxiety sensitivity, experiential avoidance, mindfulness, and body mass index (BMI; reported for anorexia nervosa [AN] patients only) were collected at intake and discharge. Multiple regression analyses were conducted to examine the effect of treatment group on outcomes, controlling for intake score, comorbidity, discharge status, AN diagnosis, and step-down status., Results: Differences in treatment type were only found for binge eating frequency, with those in virtual PHP reporting significantly lower binge eating episodes at discharge than those in traditional PHP. Body mass index showed significantly less improvement in virtual PHP than in traditional PHP., Conclusions: Preliminary results suggest virtual PHP is feasible and effective, potentially increasing access to evidence-based, intensive ED treatment. However, additional research is needed to establish efficacious support for weight gain among individuals with AN in virtual programs., (© 2023 Eating Disorders Association and John Wiley & Sons Ltd.)

Published
2024
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37. One Year Into Dupilumab: Physician and Patient Experiences in Initiating Dupilumab for Pediatric Eosinophilic Esophagitis.

Author

Nguyen N, Burger C, Skirka S, White S, Smith M, Menard-Katcher C, Furuta GT, and Mehta P

Subjects
Humans, Child, Retrospective Studies, Antibodies, Monoclonal, Humanized therapeutic use, Glucocorticoids therapeutic use, Patient Outcome Assessment, Treatment Outcome, Eosinophilic Esophagitis drug therapy, Dermatologic Agents adverse effects
Abstract

In 2022, the US Food and Drug Administration approved dupilumab for treatment of eosinophilic esophagitis (EoE). The aims of this study were to report physician and patient perspectives on initiating dupilumab. A 2-pronged approach was used: (1) data on physician prescribing practices was gathered via retrospective chart review of EoE patients prescribed dupilumab and (2) pediatric patients on dupilumab were approached to complete a questionnaire regarding reasons for initiation. During this time, 42 patients were prescribed dupilumab. From the physician's perspective, the primary reasons for dupilumab included nonresponse to topical corticosteroids (TCS) (52%), nonadherence (28%), adverse effects (10%), or to treat multiple atopic diseases (5%). The median dupilumab initiation time, from day prescribed to first injection, was 37 days [interquartile range (IQR) 37]. Almost all required prior authorization (PA) (98%), while 17% required letter of appeal and 2% required peer-to-peer. Fifteen patients (36%) completed the questionnaire portion of the study. From the patient's perspective, the primary reasons for dupilumab initiation included nonresponse to TCS (27%), nonadherence to TCS (27%), concern about adverse effects of TCS (7%), and treatment of multiple atopic diseases (33%). In conclusion, physicians are prescribing dupilumab primarily for nonresponse to TCS and almost all required PA with a long delay to starting dupilumab., Competing Interests: Dr Furuta is co-founder of EnteroTrack. Dr Nguyen has served as a consultant for Regeneron and EvoEndo. The remaining authors report no conflicts of interest., (Copyright © 2023 by European Society for European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition.)

Published
2023
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38. Early, focal changes in cartilage cellularity and structure following surgically induced meniscal destabilization in the mouse.

Author

David MA, Smith MK, Pilachowski RN, White AT, Locke RC, and Price C

Subjects
Animals, Male, Mice, Inbred C57BL, Random Allocation, Cartilage, Articular pathology, Chondrocytes pathology, Tibial Meniscus Injuries pathology
Abstract

Post-traumatic osteoarthritis (PTOA) is an accelerated form of osteoarthritic cartilage degeneration affecting approximately 20-50% of patients experiencing joint injury. Currently PTOA is incurable; to better understand the etiology of PTOA and to develop rational anti-osteoarthritic therapies, it is critical to understand the spatiotemporal initiation and the progression of PTOA. In this study, we employed semi-quantitative histological scoring and quantitative damage analysis to examine disease progression in the murine destabilization of the medial meniscus (DMM) model of PTOA from early (3 days) through late- (112 days) disease timepoints. We observed significant, progressive articular cartilage (AC) cellular, and structural changes in the medial compartments of injured joints as early as 3 days. Spatially within the joint, cartilage damage (erosions) were observed anteriorly at 84 days. Furthermore, a drastic loss in chondrocyte number (by 3 days), surface damage (at 7 days), and cartilage erosion (at 84 days) was found to co-localize to the specific region of the medial tibial plateau AC that experienced a change in meniscal coverage due to meniscal extrusion following DMM. Taken together, these results suggest that DMM-mediated extrusion of the medial meniscus leads to rapid, spatially dependent changes in AC cellularity and structure, and precipitates the focal degeneration of cartilage associated with PTOA. Importantly, this study suggests that joint instability injuries may trigger immediate (<3 days) processes within a small population of chondrocytes that directs the initiation and progression of PTOA, and that development of chondroprotective strategies for preventing and/or delaying PTOA-related cartilage degeneration are best targeted toward these immediately early processes following joint injury. © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:537-547, 2017., (© 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.)

Published
2017
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