17 results on '"Stellato, Cristiana"'
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2. Digitally‐enabled, patient‐centred care in rhinitis and asthma multimorbidity: The ARIA‐MASK‐air ® approach
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Bousquet, Jean, Anto, Josep M., Sousa‐Pinto, Bernardo, Czarlewski, Wienczyslawa, Bedbrook, Anna, Haahtela, Tari, Klimek, Ludger, Pfaar, Oliver, Kuna, Piotr, Kupczyk, Maciej, Regateiro, Frederico S., Samolinski, Boleslaw, Valiulis, Arunas, Yorgancioglu, Arzu, Arnavielhe, Sylvie, Basagaña, Xavier, Bergmann, Karl C., Bosnic‐Anticevich, Sinthia, Brussino, Luisa, Canonica, G. Walter, Cardona, Victoria, Cecchi, Lorenzo, Chaves‐Loureiro, Claudia, Costa, Elisio, Cruz, Alvaro A., Gemicioglu, Bilun, Fokkens, Wytske J., Ivancevich, Juan Carlos, Kraxner, Helga, Kvedariene, Violeta, Larenas‐Linnemann, Désirée E., Laune, Daniel, Louis, Renaud, Makris, Michael, Maurer, Marcus, Melén, Erik, Micheli, Yann, Morais‐Almeida, Mario, Mullol, Joaquim, Niedoszytko, Marek, Okamoto, Yoshitaka, Papadopoulos, Nikolaos G., Patella, Vincenzo, Pham‐Thi, Nhân, Rouadi, Philip W., Sastre, Joaquin, Scichilone, Nicola, Sheikh, Aziz, Sofiev, Mikhail, Taborda‐Barata, Luis, Toppila‐Salmi, Sanna, Tsiligianni, Ioanna, Valovirta, Erkka, Ventura, Maria Teresa, Vieira, Rafael José, Zidarn, Mihaela, Amaral, Rita, Ansotegui, Ignacio J., Bédard, Annabelle, Benveniste, Samuel, Bewick, Michael, Bindslev‐Jensen, Carsten, Blain, Hubert, Bonini, Matteo, Bourret, Rodolphe, Braido, Fulvio, Carreiro‐Martins, Pedro, Charpin, Denis, Cherrez‐Ojeda, Ivan, Chivato, Tomas, Chu, Derek K., Cingi, Cemal, Del Giacco, Stefano, de Blay, Frédéric, Devillier, Philippe, De Vries, Govert, Doulaptsi, Maria, Doyen, Virginie, Dray, Gérard, Fontaine, Jean‐François, Gomez, R. Maximiliano, Hagemann, Jan, Heffler, Enrico, Hofmann, Maja, Jassem, Ewa, Jutel, Marek, Keil, Thomas, Kritikos, Vicky, Kull, Inger, Kulus, Marek, Lourenço, Olga, Mathieu‐Dupas, Eve, Menditto, Enrica, Mösges, Ralph, Murray, Ruth, Nadif, Rachel, Neffen, Hugo, Nicola, Stefania, O’Hehir, Robyn, Olze, Heidi, Palamarchuk, Yuliia, Pépin, Jean‐Louis, Pétré, Benoit, Picard, Robert, Pitsios, Constantinos, Puggioni, Francesca, Quirce, Santiago, Raciborski, Filip, Reitsma, Sietze, Roche, Nicolas, Rodriguez‐Gonzalez, Monica, Romantowski, Jan, Sá‐Sousa, Ana, Serpa, Faradiba S., Savouré, Marine, Shamji, Mohamed H., Sova, Milan, Sperl, Annette, Stellato, Cristiana, Todo‐Bom, Ana, Tomazic, Peter Valentin, Vandenplas, Olivier, Van Eerd, Michiel, Vasankari, Tuula, Viart, Frédéric, Waserman, Susan, Fonseca, Joao A., Zuberbier, Torsten, Bousquet, Jean, Anto, Josep M., Sousa‐Pinto, Bernardo, Czarlewski, Wienczyslawa, Bedbrook, Anna, Haahtela, Tari, Klimek, Ludger, Pfaar, Oliver, Kuna, Piotr, Kupczyk, Maciej, Regateiro, Frederico S., Samolinski, Boleslaw, Valiulis, Arunas, Yorgancioglu, Arzu, Arnavielhe, Sylvie, Basagaña, Xavier, Bergmann, Karl C., Bosnic‐Anticevich, Sinthia, Brussino, Luisa, Canonica, G. Walter, Cardona, Victoria, Cecchi, Lorenzo, Chaves‐Loureiro, Claudia, Costa, Elisio, Cruz, Alvaro A., Gemicioglu, Bilun, Fokkens, Wytske J., Ivancevich, Juan Carlos, Kraxner, Helga, Kvedariene, Violeta, Larenas‐Linnemann, Désirée E., Laune, Daniel, Louis, Renaud, Makris, Michael, Maurer, Marcus, Melén, Erik, Micheli, Yann, Morais‐Almeida, Mario, Mullol, Joaquim, Niedoszytko, Marek, Okamoto, Yoshitaka, Papadopoulos, Nikolaos G., Patella, Vincenzo, Pham‐Thi, Nhân, Rouadi, Philip W., Sastre, Joaquin, Scichilone, Nicola, Sheikh, Aziz, Sofiev, Mikhail, Taborda‐Barata, Luis, Toppila‐Salmi, Sanna, Tsiligianni, Ioanna, Valovirta, Erkka, Ventura, Maria Teresa, Vieira, Rafael José, Zidarn, Mihaela, Amaral, Rita, Ansotegui, Ignacio J., Bédard, Annabelle, Benveniste, Samuel, Bewick, Michael, Bindslev‐Jensen, Carsten, Blain, Hubert, Bonini, Matteo, Bourret, Rodolphe, Braido, Fulvio, Carreiro‐Martins, Pedro, Charpin, Denis, Cherrez‐Ojeda, Ivan, Chivato, Tomas, Chu, Derek K., Cingi, Cemal, Del Giacco, Stefano, de Blay, Frédéric, Devillier, Philippe, De Vries, Govert, Doulaptsi, Maria, Doyen, Virginie, Dray, Gérard, Fontaine, Jean‐François, Gomez, R. Maximiliano, Hagemann, Jan, Heffler, Enrico, Hofmann, Maja, Jassem, Ewa, Jutel, Marek, Keil, Thomas, Kritikos, Vicky, Kull, Inger, Kulus, Marek, Lourenço, Olga, Mathieu‐Dupas, Eve, Menditto, Enrica, Mösges, Ralph, Murray, Ruth, Nadif, Rachel, Neffen, Hugo, Nicola, Stefania, O’Hehir, Robyn, Olze, Heidi, Palamarchuk, Yuliia, Pépin, Jean‐Louis, Pétré, Benoit, Picard, Robert, Pitsios, Constantinos, Puggioni, Francesca, Quirce, Santiago, Raciborski, Filip, Reitsma, Sietze, Roche, Nicolas, Rodriguez‐Gonzalez, Monica, Romantowski, Jan, Sá‐Sousa, Ana, Serpa, Faradiba S., Savouré, Marine, Shamji, Mohamed H., Sova, Milan, Sperl, Annette, Stellato, Cristiana, Todo‐Bom, Ana, Tomazic, Peter Valentin, Vandenplas, Olivier, Van Eerd, Michiel, Vasankari, Tuula, Viart, Frédéric, Waserman, Susan, Fonseca, Joao A., and Zuberbier, Torsten
- Abstract
MASK‐air®, a validated mHealth app (Medical Device regulation Class IIa) has enabled large observational implementation studies in over 58,000 people with allergic rhinitis and/or asthma. It can help to address unmet patient needs in rhinitis and asthma care. MASK‐air® is a Good Practice of DG Santé on digitally‐enabled, patient‐centred care. It is also a candidate Good Practice of OECD (Organisation for Economic Co‐operation and Development). MASK‐air® data has enabled novel phenotype discovery and characterisation, as well as novel insights into the management of allergic rhinitis. MASK‐air® data show that most rhinitis patients (i) are not adherent and do not follow guidelines, (ii) use as‐needed treatment, (iii) do not take medication when they are well, (iv) increase their treatment based on symptoms and (v) do not use the recommended treatment. The data also show that control (symptoms, work productivity, educational performance) is not always improved by medications. A combined symptom‐medication score (ARIA‐EAACI‐CSMS) has been validated for clinical practice and trials. The implications of the novel MASK‐air® results should lead to change management in rhinitis and asthma.
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- 2023
3. Legends of Allergy: Gianni Marone
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Triggiani, Massimo, primary, Casolaro, Vincenzo, additional, and Stellato, Cristiana, additional
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- 2023
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4. Digitally‐enabled, patient‐centred care in rhinitis and asthma multimorbidity: The ARIA‐MASK‐air ® approach
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Bousquet, Jean, primary, Anto, Josep M., additional, Sousa‐Pinto, Bernardo, additional, Czarlewski, Wienczyslawa, additional, Bedbrook, Anna, additional, Haahtela, Tari, additional, Klimek, Ludger, additional, Pfaar, Oliver, additional, Kuna, Piotr, additional, Kupczyk, Maciej, additional, Regateiro, Frederico S., additional, Samolinski, Boleslaw, additional, Valiulis, Arunas, additional, Yorgancioglu, Arzu, additional, Arnavielhe, Sylvie, additional, Basagaña, Xavier, additional, Bergmann, Karl C., additional, Bosnic‐Anticevich, Sinthia, additional, Brussino, Luisa, additional, Canonica, G. Walter, additional, Cardona, Victoria, additional, Cecchi, Lorenzo, additional, Chaves‐Loureiro, Claudia, additional, Costa, Elisio, additional, Cruz, Alvaro A., additional, Gemicioglu, Bilun, additional, Fokkens, Wytske J., additional, Ivancevich, Juan Carlos, additional, Kraxner, Helga, additional, Kvedariene, Violeta, additional, Larenas‐Linnemann, Désirée E., additional, Laune, Daniel, additional, Louis, Renaud, additional, Makris, Michael, additional, Maurer, Marcus, additional, Melén, Erik, additional, Micheli, Yann, additional, Morais‐Almeida, Mario, additional, Mullol, Joaquim, additional, Niedoszytko, Marek, additional, Okamoto, Yoshitaka, additional, Papadopoulos, Nikolaos G., additional, Patella, Vincenzo, additional, Pham‐Thi, Nhân, additional, Rouadi, Philip W., additional, Sastre, Joaquin, additional, Scichilone, Nicola, additional, Sheikh, Aziz, additional, Sofiev, Mikhail, additional, Taborda‐Barata, Luis, additional, Toppila‐Salmi, Sanna, additional, Tsiligianni, Ioanna, additional, Valovirta, Erkka, additional, Ventura, Maria Teresa, additional, Vieira, Rafael José, additional, Zidarn, Mihaela, additional, Amaral, Rita, additional, Ansotegui, Ignacio J., additional, Bédard, Annabelle, additional, Benveniste, Samuel, additional, Bewick, Michael, additional, Bindslev‐Jensen, Carsten, additional, Blain, Hubert, additional, Bonini, Matteo, additional, Bourret, Rodolphe, additional, Braido, Fulvio, additional, Carreiro‐Martins, Pedro, additional, Charpin, Denis, additional, Cherrez‐Ojeda, Ivan, additional, Chivato, Tomas, additional, Chu, Derek K., additional, Cingi, Cemal, additional, Del Giacco, Stefano, additional, de Blay, Frédéric, additional, Devillier, Philippe, additional, De Vries, Govert, additional, Doulaptsi, Maria, additional, Doyen, Virginie, additional, Dray, Gérard, additional, Fontaine, Jean‐François, additional, Gomez, R. Maximiliano, additional, Hagemann, Jan, additional, Heffler, Enrico, additional, Hofmann, Maja, additional, Jassem, Ewa, additional, Jutel, Marek, additional, Keil, Thomas, additional, Kritikos, Vicky, additional, Kull, Inger, additional, Kulus, Marek, additional, Lourenço, Olga, additional, Mathieu‐Dupas, Eve, additional, Menditto, Enrica, additional, Mösges, Ralph, additional, Murray, Ruth, additional, Nadif, Rachel, additional, Neffen, Hugo, additional, Nicola, Stefania, additional, O’Hehir, Robyn, additional, Olze, Heidi, additional, Palamarchuk, Yuliia, additional, Pépin, Jean‐Louis, additional, Pétré, Benoit, additional, Picard, Robert, additional, Pitsios, Constantinos, additional, Puggioni, Francesca, additional, Quirce, Santiago, additional, Raciborski, Filip, additional, Reitsma, Sietze, additional, Roche, Nicolas, additional, Rodriguez‐Gonzalez, Monica, additional, Romantowski, Jan, additional, Sá‐Sousa, Ana, additional, Serpa, Faradiba S., additional, Savouré, Marine, additional, Shamji, Mohamed H., additional, Sova, Milan, additional, Sperl, Annette, additional, Stellato, Cristiana, additional, Todo‐Bom, Ana, additional, Tomazic, Peter Valentin, additional, Vandenplas, Olivier, additional, Van Eerd, Michiel, additional, Vasankari, Tuula, additional, Viart, Frédéric, additional, Waserman, Susan, additional, Fonseca, Joao A., additional, and Zuberbier, Torsten, additional
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- 2023
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5. In memoriam: Lawrence M. Lichtenstein (1934–2022)
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Marone, Gianni, primary, Triggiani, Massimo, additional, Casolaro, Vincenzo, additional, Stellato, Cristiana, additional, de Paulis, Amato, additional, Holgate, Stephen T., additional, Akdis, Cezmi A., additional, and Galli, Stephen J., additional
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- 2022
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6. Development and validation of combined symptom‐medication scores for allergic rhinitis*
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Sousa‐Pinto, Bernardo, primary, Azevedo, Luís Filipe, additional, Jutel, Marek, additional, Agache, Ioana, additional, Canonica, G. Walter, additional, Czarlewski, Wienczyslawa, additional, Papadopoulos, Nikolaos G., additional, Bergmann, Karl‐Christian, additional, Devillier, Philippe, additional, Laune, Daniel, additional, Klimek, Ludger, additional, Anto, Aram, additional, Anto, Josep M., additional, Eklund, Patrik, additional, Almeida, Rute, additional, Bedbrook, Anna, additional, Bosnic‐Anticevich, Sinthia, additional, Brough, Helen A., additional, Brussino, Luisa, additional, Cardona, Victoria, additional, Casale, Thomas, additional, Cecchi, Lorenzo, additional, Charpin, Denis, additional, Chivato, Tomás, additional, Costa, Elisio M., additional, Cruz, Alvaro A., additional, Dramburg, Stephanie, additional, Durham, Stephen R., additional, De Feo, Giulia, additional, Gerth van Wijk, Roy, additional, Fokkens, Wystke J., additional, Gemicioglu, Bilun, additional, Haahtela, Tari, additional, Illario, Maddalena, additional, Ivancevich, Juan Carlos, additional, Kvedariene, Violeta, additional, Kuna, Piotr, additional, Larenas‐Linnemann, Désirée E., additional, Makris, Michael, additional, Mathieu‐Dupas, Eve, additional, Melén, Erik, additional, Morais‐Almeida, Mario, additional, Mösges, Ralph, additional, Mullol, Joaquim, additional, Nadeau, Kari C., additional, Pham‐Thi, Nhân, additional, O’Hehir, Robyn, additional, Regateiro, Frederico S., additional, Reitsma, Sietze, additional, Samolinski, Boleslaw, additional, Sheikh, Aziz, additional, Stellato, Cristiana, additional, Todo‐Bom, Ana, additional, Tomazic, Peter Valentin, additional, Toppila‐Salmi, Sanna, additional, Valero, Antonio, additional, Valiulis, Arunas, additional, Ventura, Maria Teresa, additional, Wallace, Dana, additional, Waserman, Susan, additional, Yorgancioglu, Arzu, additional, De Vries, Govert, additional, van Eerd, Michiel, additional, Zieglmayer, Petra, additional, Zuberbier, Torsten, additional, Pfaar, Oliver, additional, Almeida Fonseca, João, additional, and Bousquet, Jean, additional
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- 2022
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7. Validity, reliability, and responsiveness of daily monitoring visual analog scales in MASK‐air®
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Sousa‐Pinto, Bernardo, primary, Eklund, Patrik, additional, Pfaar, Oliver, additional, Klimek, Ludger, additional, Zuberbier, Torsten, additional, Czarlewski, Wienczyslawa, additional, Bédard, Annabelle, additional, Bindslev‐Jensen, Carsten, additional, Bedbrook, Anna, additional, Bosnic‐Anticevich, Sinthia, additional, Brussino, Luisa, additional, Cardona, Victoria, additional, Cruz, Alvaro A., additional, Vries, Govert, additional, Devillier, Philippe, additional, Fokkens, Wytske J., additional, Fuentes‐Pérez, José Miguel, additional, Gemicioğlu, Bilun, additional, Haahtela, Tari, additional, Huerta‐Villalobos, Yunen Rocío, additional, Ivancevich, Juan Carlos, additional, Kull, Inger, additional, Kuna, Piotr, additional, Kvedariene, Violeta, additional, Larenas Linnemann, Désirée E., additional, Laune, Daniel, additional, Makris, Michael, additional, Melén, Erik, additional, Morais‐Almeida, Mário, additional, Mösges, Ralph, additional, Mullol, Joaquim, additional, O'Hehir, Robyn E., additional, Papadopoulos, Nikolaos G., additional, Pereira, Ana Margarida, additional, Prokopakis, Emmanuel P., additional, Psarros, Fotis, additional, Regateiro, Frederico S., additional, Reitsma, Sietze, additional, Samolinski, Boleslaw, additional, Scichilone, Nicola, additional, Silva, Jane, additional, Stellato, Cristiana, additional, Todo‐Bom, Ana, additional, Tomazic, Peter Valentin, additional, Salmi, Sanna Toppila, additional, Valero, Antonio, additional, Valiulis, Arunas, additional, Valovirta, Erkka, additional, Eerd, Michiel, additional, Ventura, Maria Teresa, additional, Yorgancioglu, Arzu, additional, Basagaña, Xavier, additional, Antó, Josep M., additional, Bousquet, Jean, additional, and Fonseca, João Almeida, additional
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- 2021
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8. Validity, reliability, and responsiveness of daily monitoring visual analog scales in MASK-air (R)
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Sousa-Pinto, Bernardo, Eklund, Patrik, Pfaar, Oliver, Klimek, Ludger, Zuberbier, Torsten, Czarlewski, Wienczyslawa, Bedard, Annabelle, Bindslev-Jensen, Carsten, Bedbrook, Anna, Bosnic-Anticevich, Sinthia, Brussino, Luisa, Cardona, Victoria, Cruz, Alvaro A., de Vries, Govert, Devillier, Philippe, Fokkens, Wytske J., Miguel Fuentes-Perez, Jose, Gemicioglu, Bilun, Haahtela, Tari, Rocio Huerta-Villalobos, Yunen, Carlos Ivancevich, Juan, Kull, Inger, Kuna, Piotr, Kvedariene, Violeta, Larenas Linnemann, Desiree E., Laune, Daniel, Makris, Michael, Melen, Erik, Morais-Almeida, Mario, Moesges, Ralph, Mullol, Joaquim, O'Hehir, Robyn E., Papadopoulos, Nikolaos G., Pereira, Ana Margarida, Prokopakis, Emmanuel P., Psarros, Fotis, Regateiro, Frederico S., Reitsma, Sietze, Samolinski, Boleslaw, Scichilone, Nicola, da Silva, Jane, Stellato, Cristiana, Todo-Bom, Ana, Tomazic, Peter Valentin, Salmi, Sanna Toppila, Valero, Antonio, Valiulis, Arunas, Valovirta, Erkka, van Eerd, Michiel, Ventura, Maria Teresa, Yorgancioglu, Arzu, Basagana, Xavier, Anto, Josep M., Bousquet, Jean, Fonseca, Joao Almeida, Sousa-Pinto, Bernardo, Eklund, Patrik, Pfaar, Oliver, Klimek, Ludger, Zuberbier, Torsten, Czarlewski, Wienczyslawa, Bedard, Annabelle, Bindslev-Jensen, Carsten, Bedbrook, Anna, Bosnic-Anticevich, Sinthia, Brussino, Luisa, Cardona, Victoria, Cruz, Alvaro A., de Vries, Govert, Devillier, Philippe, Fokkens, Wytske J., Miguel Fuentes-Perez, Jose, Gemicioglu, Bilun, Haahtela, Tari, Rocio Huerta-Villalobos, Yunen, Carlos Ivancevich, Juan, Kull, Inger, Kuna, Piotr, Kvedariene, Violeta, Larenas Linnemann, Desiree E., Laune, Daniel, Makris, Michael, Melen, Erik, Morais-Almeida, Mario, Moesges, Ralph, Mullol, Joaquim, O'Hehir, Robyn E., Papadopoulos, Nikolaos G., Pereira, Ana Margarida, Prokopakis, Emmanuel P., Psarros, Fotis, Regateiro, Frederico S., Reitsma, Sietze, Samolinski, Boleslaw, Scichilone, Nicola, da Silva, Jane, Stellato, Cristiana, Todo-Bom, Ana, Tomazic, Peter Valentin, Salmi, Sanna Toppila, Valero, Antonio, Valiulis, Arunas, Valovirta, Erkka, van Eerd, Michiel, Ventura, Maria Teresa, Yorgancioglu, Arzu, Basagana, Xavier, Anto, Josep M., Bousquet, Jean, and Fonseca, Joao Almeida
- Abstract
Background MASK-air (R) is an app that supports allergic rhinitis patients in disease control. Users register daily allergy symptoms and their impact on activities using visual analog scales (VASs). We aimed to assess the concurrent validity, reliability, and responsiveness of these daily VASs. Methods Daily monitoring VAS data were assessed in MASK-air (R) users with allergic rhinitis. Concurrent validity was assessed by correlating daily VAS values with those of the EuroQol-5 Dimensions (EQ-5D) VAS, the Control of Allergic Rhinitis and Asthma Test (CARAT) score, and the Work Productivity and Activity Impairment Allergic Specific (WPAI-AS) Questionnaire (work and activity impairment scores). Intra-rater reliability was assessed in users providing multiple daily VASs within the same day. Test-retest reliability was tested in clinically stable users, as defined by the EQ-5D VAS, CARAT, or VAS Work (i.e., VAS assessing the impact of allergy on work). Responsiveness was determined in users with two consecutive measurements of EQ-5D-VAS or VAS Work indicating clinical change. Results A total of 17,780 MASK-air (R) users, with 317,176 VAS days, were assessed. Concurrent validity was moderate-high (Spearman correlation coefficient range: 0.437-0.716). Intra-rater reliability intraclass correlation coefficients (ICCs) ranged between 0.870 (VAS assessing global allergy symptoms) and 0.937 (VAS assessing allergy symptoms on sleep). Test-retest reliability ICCs ranged between 0.604 and 0.878-VAS Work and VAS asthma presented the highest ICCs. Moderate/large responsiveness effect sizes were observed-the sleep VAS was associated with lower responsiveness, while the global allergy symptoms VAS demonstrated higher responsiveness. Conclusion In MASK-air (R), daily monitoring VASs have high intra-rater reliability and moderate-high validity, reliability, and responsiveness, pointing to a reliable measure of symptom loads.
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- 2021
9. Differentiation of COVID‐19 signs and symptoms from allergic rhinitis and common cold: An ARIA‐EAACI‐GA2LEN consensus
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Hagemann, Jan, primary, Onorato, Gabrielle L., additional, Jutel, Marek, additional, Akdis, Cezmi A., additional, Agache, Ioana, additional, Zuberbier, Torsten, additional, Czarlewski, Wienczyslawa, additional, Mullol, Joaquim, additional, Bedbrook, Anna, additional, Bachert, Claus, additional, Bennoor, Kazi S., additional, Bergmann, Karl‐Christian, additional, Braido, Fulvio, additional, Camargos, Paulo, additional, Caraballo, Luis, additional, Cardona, Victoria, additional, Casale, Thomas, additional, Cecchi, Lorenzo, additional, Chivato, Tomas, additional, Chu, Derek K., additional, Cingi, Cemal, additional, Correia‐de‐Sousa, Jaime, additional, del Giacco, Stefano, additional, Dokic, Dejan, additional, Dykewicz, Mark, additional, Ebisawa, Motohiro, additional, El‐Gamal, Yehia, additional, Emuzyte, Regina, additional, Fauquert, Jean‐Luc, additional, Fiocchi, Alessandro, additional, Fokkens, Wytske J., additional, Fonseca, Joao A., additional, Gemicioglu, Bilun, additional, Gomez, René‐Maximiliano, additional, Gotua, Maia, additional, Haahtela, Tari, additional, Hamelmann, Eckard, additional, Iinuma, Tomohisa, additional, Ivancevich, Juan Carlos, additional, Jassem, Ewa, additional, Kalayci, Omer, additional, Kardas, Przemyslaw, additional, Khaitov, Musa, additional, Kuna, Piotr, additional, Kvedariene, Violeta, additional, Larenas‐Linnemann, Desiree E., additional, Lipworth, Brian, additional, Makris, Michael, additional, Maspero, Jorge F., additional, Miculinic, Neven, additional, Mihaltan, Florin, additional, Mohammad, Yousser, additional, Montefort, Stephen, additional, Morais‐Almeida, Mario, additional, Mösges, Ralph, additional, Naclerio, Robert, additional, Neffen, Hugo, additional, Niedoszytko, Marek, additional, O’Hehir, Robyn E., additional, Ohta, Ken, additional, Okamoto, Yoshitaka, additional, Okubo, Kimi, additional, Panzner, Petr, additional, Papadopoulos, Nikolaos G., additional, Passalacqua, Giovanni, additional, Patella, Vincenzo, additional, Pereira, Ana, additional, Pfaar, Oliver, additional, Plavec, Davor, additional, Popov, Todor A., additional, Prokopakis, Emmanuel P., additional, Puggioni, Francesca, additional, Raciborski, Filip, additional, Reijula, Jere, additional, Regateiro, Frederico S., additional, Reitsma, Sietze, additional, Romano, Antonino, additional, Rosario, Nelson, additional, Rottem, Menachem, additional, Ryan, Dermot, additional, Samolinski, Boleslaw, additional, Sastre, Joaquin, additional, Solé, Dirceu, additional, Sova, Milan, additional, Stellato, Cristiana, additional, Suppli‐Ulrik, Charlotte, additional, Tsiligianni, Ioanna, additional, Valero, Antonio, additional, Valiulis, Arunas, additional, Valovirta, Erkka, additional, Vasankari, Tuula, additional, Ventura, Maria Teresa, additional, Wallace, Dana, additional, Wang, De Yun, additional, Williams, Siân, additional, Yorgancioglu, Arzu, additional, Yusuf, Osman M., additional, Zernotti, Mario, additional, Bousquet, Jean, additional, and Klimek, Ludger, additional
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- 2021
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10. Immune modulation via T regulatory cell enhancement: Disease‐modifying therapies for autoimmunity and their potential for chronic allergic and inflammatory diseases—An EAACI position paper of the Task Force on Immunopharmacology (TIPCO)
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Roth‐Walter, Franziska, primary, Adcock, Ian M., additional, Benito‐Villalvilla, Cristina, additional, Bianchini, Rodolfo, additional, Bjermer, Leif, additional, Boyman, Onur, additional, Caramori, Gaetano, additional, Cari, Luigi, additional, Fan Chung, Kian, additional, Diamant, Zuzana, additional, Eguiluz‐Gracia, Ibon, additional, Knol, Edward F., additional, Kolios, Antonios, additional, Levi‐Schaffer, Francesca, additional, Nocentini, Giuseppe, additional, Palomares, Oscar, additional, Redegeld, Frank, additional, Van Esch, Betty, additional, and Stellato, Cristiana, additional
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- 2021
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11. ARIA digital anamorphosis: Digital transformation of health and care in airway diseases from research to practice
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Bousquet, Jean, primary, Anto, Josep M., additional, Bachert, Claus, additional, Haahtela, Tari, additional, Zuberbier, Torsten, additional, Czarlewski, Wienczyslawa, additional, Bedbrook, Anna, additional, Bosnic‐Anticevich, Sinthia, additional, Walter Canonica, G., additional, Cardona, Victoria, additional, Costa, Elisio, additional, Cruz, Alvaro A., additional, Erhola, Marina, additional, Fokkens, Wytske J., additional, Fonseca, Joao A., additional, Illario, Maddalena, additional, Ivancevich, Juan‐Carlos, additional, Jutel, Marek, additional, Klimek, Ludger, additional, Kuna, Piotr, additional, Kvedariene, Violeta, additional, Le, LTT, additional, Larenas‐Linnemann, Désirée E., additional, Laune, Daniel, additional, Lourenço, Olga M., additional, Melén, Erik, additional, Mullol, Joaquim, additional, Niedoszytko, Marek, additional, Odemyr, Mikaëla, additional, Okamoto, Yoshitaka, additional, Papadopoulos, Nikos G., additional, Patella, Vincenzo, additional, Pfaar, Oliver, additional, Pham‐Thi, Nhân, additional, Rolland, Christine, additional, Samolinski, Boleslaw, additional, Sheikh, Aziz, additional, Sofiev, Mikhail, additional, Suppli Ulrik, Charlotte, additional, Todo‐Bom, Ana, additional, Tomazic, Peter‐Valentin, additional, Toppila‐Salmi, Sanna, additional, Tsiligianni, Ioanna, additional, Valiulis, Arunas, additional, Valovirta, Erkka, additional, Ventura, Maria‐Teresa, additional, Walker, Samantha, additional, Williams, Sian, additional, Yorgancioglu, Arzu, additional, Agache, Ioana, additional, Akdis, Cezmi A., additional, Almeida, Rute, additional, Ansotegui, Ignacio J., additional, Annesi‐Maesano, Isabella, additional, Arnavielhe, Sylvie, additional, Basagaña, Xavier, additional, D. Bateman, Eric, additional, Bédard, Annabelle, additional, Bedolla‐Barajas, Martin, additional, Becker, Sven, additional, Bennoor, Kazi S., additional, Benveniste, Samuel, additional, Bergmann, Karl C., additional, Bewick, Michael, additional, Bialek, Slawomir, additional, E. 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- 2020
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12. Adherence to treatment in allergic rhinitis using mobile technology : The MASK Study
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Menditto, Enrica, Costa, Elisio, Midao, Luis, Bosnic-Anticevich, Sinthia, Novellino, Ettore, Bialek, Slawomir, Briedis, Vitalis, Mair, Alpana, Rajabian-Soderlund, Rojin, Arnavielhe, Sylvie, Bedbrook, Anna, Czarlewski, Wienczyslawa, Annesi-Maesano, Isabella, Anto, Josep M., Devillier, Philippe, De Vries, Govert, Keil, Thomas, Sheikh, Aziz, Orlando, Valentina, Larenas-Linnemann, Desiree, Cecchi, Lorenzo, De Feo, Giulia, Illario, M., Stellato, Cristiana, Fonseca, Joao, Malva, Joao, Morais-Almeida, Mario, Pereira, Ana Maria, Todo-Bom, Ana Maria, Kvedariene, Violeta, Valiulis, Arunas, Bergmann, Karl Christian, Klimek, Ludger, Moesges, Ralph, Pfaar, Oliver, Zuberbier, Torsten, Cardona, Vicky, Mullol, Joaquim, Papadopoulos, Nikos G., Prokopakis, Emmanuel P., Bewick, Mike, Ryan, Dermot, Roller-Wirnsberger, Regina E., Tomazic, Peter Valentin, Cruz, Alvaro A., Kuna, Piotr, Samolinski, Boleslaw, Fokkens, Wytske J., Reitsma, Sietze, Bosse, Isabelle, Fontaine, Jean-Francois, Laune, Daniel, Haahtela, Tari, Toppila-Salmi, Sanna, Bachert, Claus, Hellings, Peter W., Melen, Erik, Wickman, Magnus, Bindslev-Jensen, Carsten, Eller, Esben, O'Hehir, Robyn E., Cingi, Cemal, Gemicioglu, Bilun, Kalayci, Omer, Ivancevich, Juan Carlos, Bousquet, Jean, Bousquet, J., Hellings, P. 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A. M., Camuzat, T., Canfora, G., Canonica, G. W., Cardona, V., Carlsen, K. H., Carreiro-Martins, P., Carriazo, A. M., Carr, W., Cartier, C., Casale, T., Castellano, G., Cecchi, L., Cepeda, A. M., Chavannes, N. H., Chen, Y., Chiron, R., Chivato, T., Chkhartishvili, E., Chuchalin, A. G., Chung, K. F., Ciaravolo, M. M., Ciceran, A., Cingi, C., Ciprandi, G., Coehlo, A. C. Carvalho, Colas, L., Colgan, E., Coll, J., Conforti, D., De Sousa, J. Correia, Cortes-Grimaldo, R. M., Corti, F., Costa, E., Costa-Dominguez, Mc, Al Courbis, F., Cox, L., Crescenzo, M., Cruz, A. A., Custovic, A., Czarlewski, W., Dahlen, S. E., D'Amato, Dario, C., da Silva, J., Dauvilliers, Y., Darsow, U., De Blay, F., De Carlo, G., Dedeu, T., Emerson, M. De Fatima, De Feo, G., De Vries, G., De Martino, B., Rubina, N. P. Motta, Deleanu, D., Demoly, P., Denburg, Ja, Devillier, P., Ercolano, S. Di Capua, Di Carluccio, N., Didier, A., Dokic, D., Dominguez-Silva, M. G., Douagui, H., Dray, G., Dubakiene, R., Durham, S. R., Du Toit, G., Dykewicz, M. S., El-Gamal, Y., Eklund, Patrik, Eller, E., Emuzyte, R., Farrell, J., Farsi, A., De Mello, J. Ferreira, Jr., Ferrero, J., Fink-Wagner, A., Fiocchi, A., Fok-Kens, W. J., Fonseca, Ja, Fontaine, J. F., Forti, S., Fuentes-Perez, J. M., Galvez-Romero, J. L., Gamkrelidze, A., Garcia-Aymerich, J., Garcia-Cobas, C. Y., Garcia-Cruz, M. H., Gemicioglu, B., Genova, S., Christoff, G., Gereda, J. E., Van Wijk, R. Gerth, Gomez, R. M., Gomez-Vera, J., Diaz, S. Gonzalez, Gotua, M., Grisle, I., Guidacci, M., Guldemond, Na, Gutter, Z., Guzman, Ma, Haahtela, T., Hajjam, J., Hernandez, L., Houri-Hane, J O ' B, Huerta-Villalobos, Y. R., Humbert, M., Iaccarino, G., Ispayeva, Z., Ivancevich, J. C., Jares, Ej, Jassem, E., Johnston, S. L., Joos, G., Jung, K. S., Just, J., Jutel, M., Kaidashev, I., Kalayci, O., Kalyoncu, A. F., Karjalainen, J., Kardas, P., Keil, T., Keith, P. K., Khaitov, M., Khaltaev, N., Kleine-Tebbe, J., Klimek, L., Kowalski, M. L., Kuitunen, M., Kull, I., Kuna, P., Kupczyk, M., Kvedariene, V., Krzych-Falta, E., Lacwik, P., Larenas-Linnemann, D., Laune, D., Lauri, D., Lavrut, J., Le, L. T. T., Lessa, M., Levato, G., Li, J., Lieberman, P., Liplec, A., Lipworth, B., Carlsen, K. C. Lodrup, Louis, R., Lourenco, O., Luna-Pech, J. A., Magnan, A., Mahboub, B., Maier, D., Mair, A., Majer, I., Malva, J., Mandajieva, E., Manning, P., Keenoy, E. De Manuel, Marshall, G. D., Masjedi, M. R., Maspero, J. F., Mathieu-Dupas, E., Campos, J. J. Matta, Matos, Al, Maurer, M., Mavale-Manuel, S., Mayora, O., Medina-Avalos, M. A., Melen, E., Melo-Gomes, E., Meltzer, Eo, Menditto, E., Mercier, J., Miculinic, N., Mihaltan, F., Milenkovic, B., Moda, G., Mogica-Martinez, M. D., Mohammad, Y., Momas, I., Monte-Fort, S., Monti, R., Bogado, D. Mora, Morais-Almeida, M., Morato-Castro, Mosges, R., Mota-Pinto, A., Santo, P. Moura, Mullol, J., Munter, L., Muraro, A., Murray, R., Naclerio, R., Nadif, R., Nalin, M., Napoli, L., Namazova-Baranova, L., Neffen, H., Niedeberger, V., Nekam, K., Neou, A., Nieto, A., Nogueira-Silva, L., Nogues, M., Novellino, E., Nyembue, Td, O'Hehir, Re, Odzhakova, C., Ohta, K., Okamoto, Y., Okubo, K., Onorato, G. L., Cisneros, M. Ortega, Ouedraogo, S., Pali-Scholl, I., Palkonen, S., Panzner, P., Papadopoulos, N. G., Park, H. S., Papi, A., Passalacqua, G., Paulino, E., Pawankar, R., Pedersen, S., Pepin, J. L., Pereira, A. M., Persico, M., Pfaar, O., Phillips, J., Picard, R., Pigearias, B., Pin, I., Pitsios, C., Plavec, D., Pohl, W., Popov, T. A., Portejoie, F., Potter, P., Pozzi, A. C., Price, D., Prokopakis, E. P., Puy, R., Pugin, B., Ross, R. E. Pulido, Przemecka, M., Rabe, K. F., Raciborski, F., Raja-Bian-Soderlund, R., Reitsma, S., Ribeirinho, I., Rimmer, J., Riv-Ero-Yeverino, D., Rizzo, J. A., Rizzo, M. C., Robalo-Cordeiro, C., Rodenas, F., Rodo, X., Gonzalez, M. Rodriguez, Rodriguez-Manas, L., Rolland, C., Valle, S. Rodrigues, Rodriguez, M. Roman, Romano, A., Rodriguez-Zagal, E., Rolla, G., Roller-Wirnsberger, R. E., Romano, M., Rosado-Pinto, J., Rosario, N., Rottem, M., Ryan, D., Sagara, H., Salimaki, J., Samolinski, B., Sanchez-Borges, M., Sastre-Dominguez, J., Scadding, G. K., Schunemann, H. J., Scichilone, N., Schmid-Grendelmeier, P., Serpa, F. S., Shamai, S., Sheikh, A., Sierra, M., Simons, F. E. R., Sir-Oux, V., Sisul, J. C., Skrindo, I., Sole, D., Somekh, D., Sonder-Mann, M., Sooronbaev, T., Sova, M., Sorensen, M., Sorlini, M., Spranger, O., Stellato, C., Stelmach, R., Stukas, R., Sunyer, J., Strozek, J., Szylling, A., Tebyrica, Jn, Thibaudon, M., To, T., Todo-Bom, A., Tomazic, P. V., Toppila-Salmi, S., Trama, U., Triggiani, M., Ulrik, C. Suppli, Urrutia-Pereira, M., Valenta, R., Valero, A., Valiulis, A., Valovirta, E., Van Eerd, M., Van Ganse, E., Van Hague, M., Vandenplas, O., Ventura, M. T., Vezzani, G., Vasankari, T., Vatrella, A., Verissimo, M. T., Viart, F., Viegi, G., Vicheva, D., Vontetsianos, T., Wagenmann, M., Walker, S., Wallace, D., Wang, D. Y., Waserman, S., Werfel, T., Westman, M., Wickman, M., Williams, D. M., Williams, S., Wilson, N., Wright, J., Wroczynski, P., Yakovliev, P., Yawn, B. P., Yiallouros, P. K., Yorgancioglu, A., Yusuf, O. M., Zar, H. J., Zhang, L., Zhong, N., Zernotti, M. E., Zhanat, I., Zidarn, M., Zuberbier, T., Zubrinich, C., and Zurkuhlen, A.
- Abstract
Background: Mobile technology may help to better understand the adherence to treatment. MASK-rhinitis (Mobile Airways Sentinel NetworK for allergic rhinitis) is a patient-centred ICT system. A mobile phone app (the Allergy Diary) central to MASK is available in 22 countries. Objectives: To assess the adherence to treatment in allergic rhinitis patients using the Allergy Diary App. Methods: An observational cross-sectional study was carried out on all users who filled in the Allergy Diary from 1 January 2016 to 1 August 2017. Secondary adherence was assessed by using the modified Medication Possession Ratio (MPR) and the Proportion of days covered (PDC) approach. Results: A total of 12143 users were registered. A total of 6949 users reported at least one VAS data recording. Among them, 1887 users reported >= 7 VAS data. About 1195 subjects were included in the analysis of adherence. One hundred and thirty-six (11.28%) users were adherent (MPR >= 70% and PDC <= 1.25), 51 (4.23%) were partly adherent (MPR >= 70% and PDC = 1.50) and 176 (14.60%) were switchers. On the other hand, 832 (69.05%) users were non-adherent to medications (MPR <70%). Of those, the largest group was non-adherent to medications and the time interval was increased in 442 (36.68%) users. Conclusion and clinical relevance: Adherence to treatment is low. The relative efficacy of continuous vs on-demand treatment for allergic rhinitis symptoms is still a matter of debate. This study shows an approach for measuring retrospective adherence based on a mobile app. This also represents a novel approach for analysing medication-taking behaviour in a real-world setting.
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- 2019
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13. ARIA pharmacy 2018 Allergic rhinitis care pathways for community pharmacy AIRWAYS ICPs initiative (European Innovation Partnership on Active and Healthy Ageing, DG CONNECT and DG Sante) \nPOLLAR (Impact of Air POLLution on Asthma and Rhinitis)\nGARD Demonstration project
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Bosnic-Anticevich, Sinthia, Costa, Elisio, Menditto, Enrica, Lourenco, Olga, Novellino, Ettore, Bialek, Slawomir, Briedis, Vitalis, Buonaiuto, Roland, Chrystyn, Henry, Cvetkovski, Biljana, Di Capua, Stefania, Kritikos, Vicky, Mair, Alpana, Orlando, Valentina, Paulino, Ema, Salimaki, Johanna, Soderlund, Rojin, Tan, Rachel, Williams, Dennis M., Wroczynski, Piotr, Agache, Ioana, Ansotegui, Ignacio J., Anto, Josep M., Bedbrook, Anna, Bachert, Claus, Bewick, Mike, Bindslev-Jensen, Carsten, Brozek, Jan L., Canonica, Giorgio Walter, Cardona, Victoria, Carr, Warner, Casale, Thomas B., Chavannes, Niels H., de Sousa, Jaime Correia, Cruz, Alvaro A., Czarlewski, Wienczyslawa, De Carlo, Giuseppe, Demoly, Pascal, Devillier, Philippe, Dykewicz, Mark S., Gaga, Mina, El-Gamal, Yehia, Fonseca, Joao, Fokkens, Wytske J., Antonieta Guzman, Maria, Haahtela, Tari, Hellings, Peter W., Illario, Maddalena, Carlos Ivancevich, Juan, Just, Jocelyne, Kaidashev, Igor, Khaitov, Musa, Khaltaev, Nikolai, Keil, Thomas, Klimek, Ludger, Kowalski, Marek L., Kuna, Piotr, Kvedariene, Violeta, Larenas-Linnemann, Desiree E., Laune, Daniel, Le, Lan T. T., Carlsen, Karin C. Lodrup, Mahboub, Bassam, Maier, Dieter, Malva, Joao, Manning, Patrick J., Morais-Almeida, Mario, Moesges, Ralph, Mullol, Joaquim, Munter, Lars, Murray, Ruth, Naclerio, Robert, Nannazova-Baranove, Leyla, Nekann, Kristof, Nyembue, Tshipukane Dieudonne, Okubo, Kimi, O'Hehir, Robyn E., Ohta, Ken, Okamoto, Yoshitaka, Onorato, Gabrielle L., Palkonen, Susanna, Panzner, Petr, Papadopoulos, Nikolaos G., Park, Hae-Sim, Pawankar, Ruby, Pfaar, Oliver, Phillips, Jim, Plavec, Davor, Popov, Todor A., Potter, Paul C., Prokopakis, Emmanuel P., Roller-Wirnsberger, Regina E., Rottenn, Menachem, Ryan, Dermot, Sannolinski, Bolesfaw, Sanchez-Borges, Mario, Schunemann, Holger J., Sheikh, Aziz, Sisul, Juan Carlos, Somekh, David, Stellato, Cristiana, To, Teresa, Todo-Bonn, Ana Maria, Tonnazic, Peter Valentin, Toppila-Salmi, Sanna, Valero, Antonio, Valiulis, Arunas, Valovirta, Errka, Ventura, Maria Teresa, Wagennnann, Martin, Wallace, Dana, Wasernnan, Susan, Wickman, Magnus, Yiallouros, Panayiotis K., Yorgancioglu, Arzu, Yusuf, Osman M., Zar, Heather J., Zernotti, Mario E., Zhang, Luo, Zidarn, Mihaela, Zuberbier, Torsten, Bousquet, Jean, Bosnic-Anticevich, Sinthia, Costa, Elisio, Menditto, Enrica, Lourenco, Olga, Novellino, Ettore, Bialek, Slawomir, Briedis, Vitalis, Buonaiuto, Roland, Chrystyn, Henry, Cvetkovski, Biljana, Di Capua, Stefania, Kritikos, Vicky, Mair, Alpana, Orlando, Valentina, Paulino, Ema, Salimaki, Johanna, Soderlund, Rojin, Tan, Rachel, Williams, Dennis M., Wroczynski, Piotr, Agache, Ioana, Ansotegui, Ignacio J., Anto, Josep M., Bedbrook, Anna, Bachert, Claus, Bewick, Mike, Bindslev-Jensen, Carsten, Brozek, Jan L., Canonica, Giorgio Walter, Cardona, Victoria, Carr, Warner, Casale, Thomas B., Chavannes, Niels H., de Sousa, Jaime Correia, Cruz, Alvaro A., Czarlewski, Wienczyslawa, De Carlo, Giuseppe, Demoly, Pascal, Devillier, Philippe, Dykewicz, Mark S., Gaga, Mina, El-Gamal, Yehia, Fonseca, Joao, Fokkens, Wytske J., Antonieta Guzman, Maria, Haahtela, Tari, Hellings, Peter W., Illario, Maddalena, Carlos Ivancevich, Juan, Just, Jocelyne, Kaidashev, Igor, Khaitov, Musa, Khaltaev, Nikolai, Keil, Thomas, Klimek, Ludger, Kowalski, Marek L., Kuna, Piotr, Kvedariene, Violeta, Larenas-Linnemann, Desiree E., Laune, Daniel, Le, Lan T. T., Carlsen, Karin C. Lodrup, Mahboub, Bassam, Maier, Dieter, Malva, Joao, Manning, Patrick J., Morais-Almeida, Mario, Moesges, Ralph, Mullol, Joaquim, Munter, Lars, Murray, Ruth, Naclerio, Robert, Nannazova-Baranove, Leyla, Nekann, Kristof, Nyembue, Tshipukane Dieudonne, Okubo, Kimi, O'Hehir, Robyn E., Ohta, Ken, Okamoto, Yoshitaka, Onorato, Gabrielle L., Palkonen, Susanna, Panzner, Petr, Papadopoulos, Nikolaos G., Park, Hae-Sim, Pawankar, Ruby, Pfaar, Oliver, Phillips, Jim, Plavec, Davor, Popov, Todor A., Potter, Paul C., Prokopakis, Emmanuel P., Roller-Wirnsberger, Regina E., Rottenn, Menachem, Ryan, Dermot, Sannolinski, Bolesfaw, Sanchez-Borges, Mario, Schunemann, Holger J., Sheikh, Aziz, Sisul, Juan Carlos, Somekh, David, Stellato, Cristiana, To, Teresa, Todo-Bonn, Ana Maria, Tonnazic, Peter Valentin, Toppila-Salmi, Sanna, Valero, Antonio, Valiulis, Arunas, Valovirta, Errka, Ventura, Maria Teresa, Wagennnann, Martin, Wallace, Dana, Wasernnan, Susan, Wickman, Magnus, Yiallouros, Panayiotis K., Yorgancioglu, Arzu, Yusuf, Osman M., Zar, Heather J., Zernotti, Mario E., Zhang, Luo, Zidarn, Mihaela, Zuberbier, Torsten, and Bousquet, Jean
- Abstract
Pharmacists are trusted health care professionals. Many patients use over-the-counter (OTC) medications and are seen by pharmacists who are the initial point of contact for allergic rhinitis management in most countries. The role of pharmacists in integrated care pathways (ICPs) for allergic diseases is important. This paper builds on existing studies and provides tools intended to help pharmacists provide optimal advice/interventions/strategies to patients with rhinitis. The Allergic Rhinitis and its Impact on Asthma (ARIA)-pharmacy ICP includes a diagnostic questionnaire specifically focusing attention on key symptoms and markers of the disease, a systematic Diagnosis Guide (including differential diagnoses), and a simple flowchart with proposed treatment for rhinitis and asthma multimorbidity. Key prompts for referral within the ICP are included. The use of technology is critical to enhance the management of allergic rhinitis. However, the ARIA-pharmacy ICP should be adapted to local healthcare environments/situations as regional (national) differences exist in pharmacy care.
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- 2019
14. Basophil degranulation in response to IgE ligation is controlled by a distinctive circadian clock in asthma
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Spadaro, Giuseppe, primary, Giurato, Giorgio, additional, Stellato, Cristiana, additional, Marone, Gianni, additional, and Casolaro, Vincenzo, additional
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- 2019
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15. ARIA pharmacy 2018 “Allergic rhinitis care pathways for community pharmacy”
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Bosnic‐Anticevich, Sinthia, primary, Costa, Elisio, additional, Menditto, Enrica, additional, Lourenço, Olga, additional, Novellino, Ettore, additional, Bialek, Slawomir, additional, Briedis, Vitalis, additional, Buonaiuto, Roland, additional, Chrystyn, Henry, additional, Cvetkovski, Biljana, additional, Di Capua, Stefania, additional, Kritikos, Vicky, additional, Mair, Alpana, additional, Orlando, Valentina, additional, Paulino, Ema, additional, Salimäki, Johanna, additional, Söderlund, Rojin, additional, Tan, Rachel, additional, Williams, Dennis M., additional, Wroczynski, Piotr, additional, Agache, Ioana, additional, Ansotegui, Ignacio J., additional, Anto, Josep M., additional, Bedbrook, Anna, additional, Bachert, Claus, additional, Bewick, Mike, additional, Bindslev‐Jensen, Carsten, additional, Brozek, Jan L., additional, Canonica, Giorgio Walter, additional, Cardona, Victoria, additional, Carr, Warner, additional, Casale, Thomas B., additional, Chavannes, Niels H., additional, Correia de Sousa, Jaime, additional, Cruz, Alvaro A., additional, Czarlewski, Wienczyslawa, additional, De Carlo, Giuseppe, additional, Demoly, Pascal, additional, Devillier, Philippe, additional, Dykewicz, Mark S., additional, Gaga, Mina, additional, El‐Gamal, Yehia, additional, Fonseca, João, additional, Fokkens, Wytske J., additional, Guzmán, Maria Antonieta, additional, Haahtela, Tari, additional, Hellings, Peter W., additional, Illario, Maddalena, additional, Ivancevich, Juan Carlos, additional, Just, Jocelyne, additional, Kaidashev, Igor, additional, Khaitov, Musa, additional, Khaltaev, Nikolai, additional, Keil, Thomas, additional, Klimek, Ludger, additional, Kowalski, Marek L., additional, Kuna, Piotr, additional, Kvedariene, Violeta, additional, Larenas‐Linnemann, Désirée E., additional, Laune, Daniel, additional, Le, Lan T. T., additional, Lodrup Carlsen, Karin C., additional, Mahboub, Bassam, additional, Maier, Dieter, additional, Malva, Joao, additional, Manning, Patrick J., additional, Morais‐Almeida, Mário, additional, Mösges, Ralph, additional, Mullol, Joaquim, additional, Münter, Lars, additional, Murray, Ruth, additional, Naclerio, Robert, additional, Namazova‐Baranova, Leyla, additional, Nekam, Kristof, additional, Nyembue, Tshipukane Dieudonné, additional, Okubo, Kimi, additional, O'Hehir, Robyn E., additional, Ohta, Ken, additional, Okamoto, Yoshitaka, additional, Onorato, Gabrielle L., additional, Palkonen, Susanna, additional, Panzner, Petr, additional, Papadopoulos, Nikolaos G., additional, Park, Hae‐Sim, additional, Pawankar, Ruby, additional, Pfaar, Oliver, additional, Phillips, Jim, additional, Plavec, Davor, additional, Popov, Todor A., additional, Potter, Paul C., additional, Prokopakis, Emmanuel P., additional, Roller‐Wirnsberger, Regina E., additional, Rottem, Menachem, additional, Ryan, Dermot, additional, Samolinski, Bolesław, additional, Sanchez‐Borges, Mario, additional, Schunemann, Holger J., additional, Sheikh, Aziz, additional, Sisul, Juan Carlos, additional, Somekh, David, additional, Stellato, Cristiana, additional, To, Teresa, additional, Todo‐Bom, Ana Maria, additional, Tomazic, Peter Valentin, additional, Toppila‐Salmi, Sanna, additional, Valero, Antonio, additional, Valiulis, Arunas, additional, Valovirta, Errka, additional, Ventura, Maria Teresa, additional, Wagenmann, Martin, additional, Wallace, Dana, additional, Waserman, Susan, additional, Wickman, Magnus, additional, Yiallouros, Panayiotis K., additional, Yorgancioglu, Arzu, additional, Yusuf, Osman M., additional, Zar, Heather J., additional, Zernotti, Mario E., additional, Zhang, Luo, additional, Zidarn, Mihaela, additional, Zuberbier, Torsten, additional, and Bousquet, Jean, additional
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- 2019
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16. Comparing biologicals and small molecule drug therapies for chronic respiratory diseases: An EAACI Taskforce on Immunopharmacology position paper
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Roth-Walter, Franziska, primary, Adcock, Ian M., additional, Benito-Villalvilla, Cristina, additional, Bianchini, Rodolfo, additional, Bjermer, Leif, additional, Caramori, Gaetano, additional, Cari, Luigi, additional, Chung, Kian Fan, additional, Diamant, Zuzana, additional, Eguiluz-Gracia, Ibon, additional, Knol, Edward F., additional, Kolios, Antonios G. A., additional, Levi-Schaffer, Francesca, additional, Nocentini, Giuseppe, additional, Palomares, Oscar, additional, Puzzovio, Pier Giorgio, additional, Redegeld, Frank A., additional, van Esch, Betty C. A. M., additional, and Stellato, Cristiana, additional
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- 2019
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17. Basophil degranulation in response to IgE ligation is controlled by a distinctive circadian clock in asthma
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Vincenzo Casolaro, Cristiana Stellato, Gianni Marone, Giuseppe Spadaro, Giorgio Giurato, Spadaro, Giuseppe, Giurato, Giorgio, Stellato, Cristiana, Marone, Gianni, and Casolaro, Vincenzo
- Subjects
Adult ,Male ,Allergy ,Immunology ,Basophil Degranulation Test ,Basophil ,Immunoglobulin E ,Basophil degranulation ,Histamine Release ,Cell Degranulation ,Allergic inflammation ,basophil ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Asthma ,Basophils ,Clock ,Histamine ,Circadian Clocks ,medicine ,Humans ,Immunology and Allergy ,Circadian rhythm ,biology ,business.industry ,hemic and immune systems ,medicine.disease ,medicine.anatomical_structure ,030228 respiratory system ,chemistry ,biology.protein ,Female ,business ,030215 immunology - Abstract
Background Several factors may contribute to the circadian variability of clinical manifestations in asthma and allergy. Basophils play a pivotal role in allergic inflammation. However, evidence for a functional clock governing the effector function of these cells is sparse and contradictory. We have systematically sampled the 24-hour response of basophils to IgE- and non-IgE-dependent ligands in asthma to understand their possible contribution to the diurnal variations of allergic symptoms. Methods Leukocytes were collected every 4 hours for 24 hours from 10 patients with moderate, persistent asthma and 10 matched, nonallergic controls, and then incubated with concentrations of anti-IgE, formyl-methionyl-leucylphenylalanine (fMLP), or the Ca2+ ionophore, A23187. Histamine release (HR) was tested for time-of-day- or disease-related variability by conventional statistics and for 24-hour rhythmicity by the cosinor method. Results HR induced by anti-IgE was significantly increased at 08:00 vs. 20:00 in basophils from asthmatics but not controls. No significant differences were seen at any time in the response to A23187, while the response to fMLP was significantly higher at 08:00 vs. 20:00 in controls but not asthmatics. The basophil response to anti-IgE, but not fMLP or A23187, varied significantly across the 24 hours in asthma, and its amplitude, percent rhythm, and acrophase were comparable to those of peak expiratory flow or serum cortisol. Conclusion Using an integrated statistical approach, we show that basophil responsiveness undergoes significant circadian variability and that distinct patterns of rhythmicity can be recognized depending on the signal delivered, the activation parameters assessed, and the disease status.
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- 2019
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