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Start Over Author "Sternby, H." Publisher wiley
3 results on '"Sternby, H."'

1. Lifetime alcohol intake, drinking patterns over time and risk of stomach cancer: A pooled analysis of data from two prospective cohort studies

Author

Jayasekara, H, MacInnis, RJ, Lujan-Barroso, L, Mayen-Chacon, A-L, Cross, AJ, Wallner, B, Palli, D, Ricceri, F, Pala, V, Panico, S, Tumino, R, Kuehn, T, Kaaks, R, Tsilidis, K, Sanchez, M-J, Amiano, P, Ardanaz, E, Chirlaque Lopez, MD, Merino, S, Rothwell, JA, Boutron-Ruault, M-C, Severi, G, Sternby, H, Sonestedt, E, Bueno-de-Mesquita, B, Boeing, H, Travis, R, Sandanger, TM, Trichopoulou, A, Karakatsani, A, Peppa, E, Tjonneland, A, Yang, Y, Hodge, AM, Mitchell, H, Haydon, A, Room, R, Hopper, JL, Weiderpass, E, Gunter, MJ, Riboli, E, Giles, GG, Milne, RL, Agudo, A, English, DR, Ferrari, P, Jayasekara, H, MacInnis, RJ, Lujan-Barroso, L, Mayen-Chacon, A-L, Cross, AJ, Wallner, B, Palli, D, Ricceri, F, Pala, V, Panico, S, Tumino, R, Kuehn, T, Kaaks, R, Tsilidis, K, Sanchez, M-J, Amiano, P, Ardanaz, E, Chirlaque Lopez, MD, Merino, S, Rothwell, JA, Boutron-Ruault, M-C, Severi, G, Sternby, H, Sonestedt, E, Bueno-de-Mesquita, B, Boeing, H, Travis, R, Sandanger, TM, Trichopoulou, A, Karakatsani, A, Peppa, E, Tjonneland, A, Yang, Y, Hodge, AM, Mitchell, H, Haydon, A, Room, R, Hopper, JL, Weiderpass, E, Gunter, MJ, Riboli, E, Giles, GG, Milne, RL, Agudo, A, English, DR, and Ferrari, P

Abstract

Alcohol consumption is causally linked to several cancers but the evidence for stomach cancer is inconclusive. In our study, the association between long-term alcohol intake and risk of stomach cancer and its subtypes was evaluated. We performed a pooled analysis of data collected at baseline from 491 714 participants in the European Prospective Investigation into Cancer and Nutrition and the Melbourne Collaborative Cohort Study. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated for incident stomach cancer in relation to lifetime alcohol intake and group-based life course intake trajectories, adjusted for potential confounders including Helicobacter pylori infection. In all, 1225 incident stomach cancers (78% noncardia) were diagnosed over 7 094 637 person-years; 984 in 382 957 study participants with lifetime alcohol intake data (5 455 507 person-years). Although lifetime alcohol intake was not associated with overall stomach cancer risk, we observed a weak positive association with noncardia cancer (HR = 1.03, 95% CI: 1.00-1.06 per 10 g/d increment), with a HR of 1.50 (95% CI: 1.08-2.09) for ≥60 g/d compared to 0.1 to 4.9 g/d. A weak inverse association with cardia cancer (HR = 0.93, 95% CI: 0.87-1.00) was also observed. HRs of 1.48 (95% CI: 1.10-1.99) for noncardia and 0.51 (95% CI: 0.26-1.03) for cardia cancer were observed for a life course trajectory characterized by heavy decreasing intake compared to light stable intake (Phomogeneity = .02). These associations did not differ appreciably by smoking or H pylori infection status. Limiting alcohol use during lifetime, particularly avoiding heavy use during early adulthood, might help prevent noncardia stomach cancer. Heterogeneous associations observed for cardia and noncardia cancers may indicate etiologic differences.

Published
2021

3. Mean muscle attenuation correlates with severe acute pancreatitis unlike visceral adipose tissue and subcutaneous adipose tissue.

Author

Sternby H, Mahle M, Linder N, Erichson-Kirst L, Verdonk RC, Dimova A, Ignatavicius P, Ilzarbe L, Koiva P, Penttilä A, Regnér S, Bollen TL, Brill R, Stangl F, Wohlgemuth WA, Singh V, Busse H, Michl P, Beer S, and Rosendahl J

Subjects
Adult, Aged, Body Composition, Female, Humans, Male, Middle Aged, Odds Ratio, ROC Curve, Radiographic Image Enhancement, Severity of Illness Index, Tomography, X-Ray Computed methods, Intra-Abdominal Fat diagnostic imaging, Intra-Abdominal Fat pathology, Muscles diagnostic imaging, Muscles pathology, Pancreatitis diagnostic imaging, Pancreatitis pathology, Subcutaneous Fat diagnostic imaging, Subcutaneous Fat pathology
Abstract

Background: Acute pancreatitis (AP) is a frequent disorder with considerable morbidity and mortality. Obesity has previously been reported to influence disease severity., Objective: The aim of this study was to investigate the association of adipose and muscle parameters with the severity grade of AP., Methods: In total 454 patients were recruited. The first contrast-enhanced computed tomography of each patient was reviewed for adipose and muscle tissue parameters at L3 level. Associations with disease severity were analysed through logistic regression analysis. The predictive capacity of the parameters was investigated using receiver operating characteristic (ROC) curves., Results: No distinct variation was found between the AP severity groups in either adipose tissue parameters (visceral adipose tissue and subcutaneous adipose tissue) or visceral muscle ratio. However, muscle mass and mean muscle attenuation differed significantly with p -values of 0.037 and 0.003 respectively. In multivariate analysis, low muscle attenuation was associated with severe AP with an odds ratio of 4.09 (95% confidence intervals: 1.61-10.36, p -value 0.003). No body parameter presented sufficient predictive capability in ROC-curve analysis., Conclusions: Our results demonstrate that a low muscle attenuation level is associated with an increased risk of severe AP. Future prospective studies will help identify the underlying mechanisms and characterise the influence of body composition parameters on AP., (© Author(s) 2019.)

Published
2019
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