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Your search keyword '"Stone, Deborah L."' showing total 8 results
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8 results on '"Stone, Deborah L."'

1. Excess Serum Interleukin‐18 Distinguishes Patients With Pathogenic Mutations inPSTPIP1

Author

Stone, Deborah L., primary, Ombrello, Amanda, additional, Arostegui, Juan I., additional, Schneider, Corinne, additional, Dang, Vinh, additional, de Jesus, Adriana, additional, Girard‐Guyonvarc'h, Charlotte, additional, Gabay, Cem, additional, Lee, Wonyong, additional, Chae, Jae Jin, additional, Aksentijevich, Ivona, additional, Goldbach‐Mansky, Raphaela T., additional, Kastner, Daniel L., additional, and Canna, Scott W., additional

Published
2022
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2. Brief Report: Anakinra Use During Pregnancy in Patients With Cryopyrin-Associated Periodic Syndromes

Author

Chang, Zenas, primary, Spong, Catherine Y., additional, Jesus, Adriana A., additional, Davis, Michael A., additional, Plass, Nicole, additional, Stone, Deborah L., additional, Chapelle, Dawn, additional, Hoffmann, Patrycja, additional, Kastner, Daniel L., additional, Barron, Karyl, additional, Goldbach-Mansky, Raphaela T., additional, and Stratton, Pamela, additional

Published
2014
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3. Sustained response and prevention of damage progression in patients with neonatal‐onset multisystem inflammatory disease treated with anakinra: A cohort study to determine three‐ and five‐year outcomes

Author

Sibley, Cailin H., primary, Plass, Nikki, additional, Snow, Joseph, additional, Wiggs, Edythe A., additional, Brewer, Carmen C., additional, King, Kelly A., additional, Zalewski, Christopher, additional, Kim, H. Jeffrey, additional, Bishop, Rachel, additional, Hill, Suvimol, additional, Paul, Scott M., additional, Kicker, Patrick, additional, Phillips, Zachary, additional, Dolan, Joseph G., additional, Widemann, Brigitte, additional, Jayaprakash, Nalini, additional, Pucino, Frank, additional, Stone, Deborah L., additional, Chapelle, Dawn, additional, Snyder, Christopher, additional, Butman, John A., additional, Wesley, Robert, additional, and Goldbach‐Mansky, Raphaela, additional

Published
2012
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8. Anakinra use during pregnancy in patients with cryopyrin-associated periodic syndromes (CAPS).

Author

Chang Z, Spong CY, Jesus AA, Davis MA, Plass N, Stone DL, Chapelle D, Hoffmann P, Kastner DL, Barron K, Goldbach-Mansky RT, and Stratton P

Subjects
Adult, Antirheumatic Agents adverse effects, Clinical Protocols, Congenital Abnormalities, Female, Fetal Diseases chemically induced, Humans, Interleukin 1 Receptor Antagonist Protein adverse effects, Interviews as Topic, Kidney abnormalities, Kidney Diseases chemically induced, Kidney Diseases congenital, Pregnancy, Pregnancy Outcome, Young Adult, Antirheumatic Agents therapeutic use, Cryopyrin-Associated Periodic Syndromes drug therapy, Interleukin 1 Receptor Antagonist Protein therapeutic use
Abstract

Objective: To describe the pregnancy course and outcome, and use of anakinra, a recombinant selective IL-1 receptor blocker, during pregnancy in patients with cryopyrin-associated periodic syndromes (CAPS), including familial cold auto-inflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS) and neonatal onset multi-system inflammatory disease (NOMID). Methods: Women currently enrolled in natural history protocols (NCT00059748, and/or NCT00069329 under IND) who have been pregnant were included. Subjects underwent a structured, standardized interview with regards to maternal health, pregnancy and fetal outcomes. Medical records were reviewed. Results: Nine women (four with FCAS, one with MWS and four with NOMID) reported one to four pregnancies, each resulting in a total of fifteen FCAS, three MWS, and six NOMID pregnancies. Six births from FCAS mothers and three births from NOMID mothers occurred while patients were receiving anakinra. If a woman became pregnant while taking anakinra, the pre-pregnancy anakinra dose was continued. Anakinra dose was increased during one twin pregnancy. No preterm births or serious complications of pregnancy were observed. One fetus of the twin pregnancy had renal agenesis and suffered fetal demise. Genetic testing showed the deceased twin carried the same NLRP3 c.785T>C, p.V262A mutation as the mother. The other twin is healthy and mutation negative. Conclusions: Anakinra was continued during pregnancy in women with CAPS and provided significant, persistent CAPS symptom relief while continuing to prevent the long-term sequelae of CAPS. Anakinra was well tolerated. Although a causal relation between anakinra and renal agenesis seems unlikely, further safety data are needed.

Published
2014
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