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13 results on '"Takahiro Tokuda"'

1. Clinical Impact of Baseline Frailty Status and Residual Mitral Regurgitation After Transcatheter Edge‐to‐Edge Repair: Insights From the OCEAN‐Mitral Registry

Author

Takahiro Tokuda, Masanori Yamamoto, Ai Kagase, Testuro Shimura, Ryo Yamaguchi, Mike Saji, Masahiko Asami, Yusuke Enta, Masaki Nakashima, Shinichi Shirai, Masaki Izumo, Shingo Mizuno, Yusuke Watanabe, Makoto Amaki, Kazuhisa Kodama, Junichi Yamaguchi, Yoshifumi Nakajima, Toru Naganuma, Hiroki Bota, Yohei Ohno, Masahiro Yamawaki, Hiroshi Ueno, Kazuki Mizutani, Toshiaki Otsuka, Shunsuke Kubo, and Kentaro Hayashida

Subjects
Clinical Frailty Scale, residual mitral regurgitation, risk stratification, transcatheter edge‐to‐edge repair, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Background The Clinical Frailty Scale (CFS) is a useful frailty marker for predicting clinical outcomes in patients undergoing invasive therapy. However, the clinical impact of CFS after transcatheter edge‐to‐edge repair in patients with mitral regurgitation (MR) remains unclear. This study aimed to elucidate the association between the baseline frail status defined by the CFS and clinical outcomes with or without postprocedural MR ≥2+ (post‐MR ≥2+) after transcatheter edge‐to‐edge repair. Methods and Results Based on a Japanese multicenter registry (OCEAN [Optimized Catheter Valvular Intervention]‐Mitral), data from 2078 patients with MR who underwent transcatheter edge‐to‐edge repair were analyzed. The patients were classified into 5 groups: CFS 1 to 3, 4, 5, 6, and ≥7. The procedural and clinical outcomes and post‐MR ≥2+ were compared among the groups. All‐cause mortality for up to 2 years was explored using Cox proportional hazards regression analysis. Although the rates of acute procedural success and post‐MR ≥2+ were similar, all‐cause mortality at 2 years was significantly increased across the 5 CFS categories (15.5%, 23.8%, 27.7%, 34.6%, and 48.8%, respectively, P

Published
2024
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2. Utility and safety of a novel method using a Wingman catheter for patients with lower extremity arterial disease complicated with severely calcified lesions: Wingman's bevel tip inner catheter removal technique—A prospective cohort study

Author

Takahiro Tokuda, Keisuke Hirano, Akinobu Takemura, and Yasuhiro Oba

Subjects
endovascular treatment, lower extremity arterial disease, severely calcified lesion, Wingman catheter, Medicine
Abstract

Abstract Background and Aims In cases of lower extremity artery disease (LEAD) accompanied by heavily calcified lesions, endovascular treatment becomes necessary at times. To effectively address these challenging calcified lesions, we developed an innovative approach named WINNER (Wingman's bevel tip inner catheter removal) technique. This study investigated the effectiveness and safety of a novel method using the WINNER technique. Methods This was a two‐center, prospective observational study. We analyzed the clinical data of patients with LEAD complicated with severely calcified lesions who underwent the WINNER technique between January 2021 and December 2022. We investigated the patients' characteristics, target lesions, and intervention results in terms of crossing device rates and periprocedural complications. Results A total of 35 patients were treated using the WINNER technique for LEAD complicated by severely calcified lesions. Key patient characteristics were a mean age of 75 ± 9 years, 83% male, 71% hemodialysis, 60% chronic limb‐threatening ischemia, and mean lesion length of 147 ± 88 mm. Using the WINNER technique, a device crossing was achieved in 34 patients (97.1%). Wire perforation occurred in one patient, and WINNER catheter rupture occurred in three patients. Conclusions The WINNER technique is useful for treating severely calcified lesions, and we should consider using this technique to cross devices for lesions with severe calcifications.

Published
2023
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3. Predictors of recurrence based on intravascular ultrasound findings after Eluvia placement in symptomatic peripheral arterial disease: A retrospective study

Author

Takehiro Yamada, Takahiro Tokuda, Naoki Yoshioka, Akio Koyama, Ryusuke Nishikawa, Kiyotaka Shimamura, and Takuma Aoyama

Subjects
endovascular therapy, lower extremity artery disease, polymer‐coated paclitaxel‐eluting stent, predictor, Medicine
Abstract

Abstract Background and Aims Polymer‐coated drug‐eluting stents (Eluvia) have shown favorable clinical outcomes in real‐world registries. There are no reports on recurrent predictors after Eluvia placement based on intravascular ultrasound (IVUS) findings. Methods We analyzed clinical data from the ASIGARU PAD registry, a retrospective, multicenter, observational study that enrolled patients who underwent endovascular therapy for superficial femoral and proximal popliteal arteries lesions using Eluvia or drug‐coated balloon. The primary outcome was the identification of recurrent predictors, including IVUS parameters at 12 months. The rate of target lesion recurrence was also assessed. Results IVUS images were obtained in 54 of 65 cases. Seven recurrent cases (13.0%) were observed within 12 months. The random survival forest method presented eight predictive variables of recurrence: Clinical Frailty Scale (CFS), distal stent edge area, distal plaque burden, age, sex, distal external elastic membrane (EEM) area, minimum stent area (MSA), and distal lumen area. Furthermore, the partial dependence plot showed that frailty (CFS ≥ 6), smaller distal stent edge area, higher and lower distal plaque burden, older and younger age, female sex, smaller distal EEM area, smaller MSA, and smaller and larger distal lumen area predicted recurrence after Eluvia placement within 12 months. Conclusion CFS, distal stent edge area, distal plaque burden, age, sex, distal EEM area, MSA, and distal lumen area were significant recurrent predictors after Eluvia placement.

Published
2023
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4. Comparison of Long‐Term Clinical Outcomes of Lesions Exhibiting Focal and Segmental Peri‐Stent Contrast Staining

Author

Takahiro Tokuda, Masahiro Yamawaki, Mitsuyohi Takahara, Shinsuke Mori, Kenji Makino, Yosuke Honda, Hiroya Takafuji, Takuro Takama, Masakazu Tsutsumi, Yasunari Sakamoto, Hideyuki Takimura, Norihiro Kobayashi, Motoharu Araki, Keisuke Hirano, and Yoshiaki Ito

Subjects
peri‐stent contrast staining, segmental peri‐stent contrast staining, stent thrombosis, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

BackgroundPeri‐stent contrast staining (PSS) after metallic drug‐eluting stent deployment is associated with target lesion revascularization and very late stent thrombosis. However, the type of PSS that influences the clinical outcomes is unknown. Therefore, we aimed to reveal which PSS type was influencing clinical outcomes. Methods and ResultsThis study included 5580 de novo lesions of 4405 patients who were implanted with a first‐ or second‐generation drug‐eluting stent and who were evaluated using follow‐up angiography within 12 months after stent implantation. We compared the clinical outcomes of patients divided into focal PSS and segmental PSS groups for 6 years after stent implantation. Total PSS was observed in 97 lesions (2.2%), of which 42 and 55 lesions were focal and segmental PSS, respectively. Baseline characteristics were similar between groups, except for intraoperative chronic total occlusion (segmental PSS=47.3% versus focal PSS=11.9%, P=0.0001). The incidence of segmental PSS tended to be higher in patients with a first‐generation drug‐eluting stent (83.6% versus 16.4%, P=0.05). The cumulative incidence of stent thrombosis in the 6 years of segmental PSS group was significantly higher than that of the focal PSS group (13.9% versus 0%, P=0.04). The cumulative incidence of overall target lesion revascularization for restenosis, excluding target lesion revascularization procedures for stent thrombosis, was significantly higher in the segmental PSS group (38.0% versus 0%, P=0.01). ConclusionsThe incidence of segmental PSS tended to be higher in patients with a first‐generation drug‐eluting stent and appeared to be significantly associated with target lesion revascularization and stent thrombosis.

Published
2016
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6. Prognostic Value of Ventricular‐Arterial Coupling After Transcatheter Aortic Valve Replacement on Midterm Clinical Outcomes

Author

Hiroaki Yokoyama, Futoshi Yamanaka, Koki Shishido, Tomoki Ochiai, Shohei Yokota, Noriaki Moriyama, Yusuke Watanabe, Shinichi Shirai, Norio Tada, Motoharu Araki, Fumiaki Yashima, Toru Naganuma, Hiroshi Ueno, Minoru Tabata, Kazuki Mizutani, Kensuke Takagi, Masanori Yamamoto, Shigeru Saito, Kentaro Hayashida, Makoto Tanaka, Hikaru Tsuruta, Hiromu Hase, Nobuhiro Yoshijima, Tetsuya Saito, Sosuke Myojin, Yusuke Kobari, Toshinobu Ryuzaki, Tatsuo Takahashi, Shinichi Goto, Shohei Imaeda, Yuta Konami, Shingo Sakata, Taku Inohara, Yoshinori Katsumata, Mitsuru Sago, Tatsuya Tsunaki, Yuya Adachi, Ryo Yamaguchi, Kazuki Shimizu, Yutaka Koyama, Tetsuro Shimura, Satoshi Tsujimoto, Ai Kagase, Toshihiro Kobayashi, Kenichi Shibata, Takahiro Tokuda, Tokuya Sakakura, Ryoutaku Kawahata, Hiroto Nishio, Masaomi Hayashi, Akihiro Isotani, Tomohiro Kawaguchi, Yoshio Arai, Tomohiko Taniguchi, Kenichi Ishizu, Shimpei Fujioka, Shintaro Mori, Takashi Morinaga, Masato Fukunaga, Hiroyuki Tabata, Kazuki Kitano, Yugo Nara, Hirofumi Hioki, Akihisa Kataoka, Hideyuki Kawashima, Fukuko Nagura, Makoto Nakashima, Hirosada Yamamoto, Nozomu Yukimitsu, Kazuya Sasaki, Shintaro Takamura, Taiga Katayama, Masaki Ito, Ruri Ishibashi, Junichi Nishikawa, Yosei Iseki, Takahiro Nomura, Yasuyuki Tsuchida, Kento Kito, Misako Fujii, Ayumi Harada, Yasuki Koyano, Satoru Mitomo, Hirokazu Onishi, Hiroyoshi Kawamoto, Masahiro Yamawaki, Yohsuke Honda, Kenji Makino, Takahide Nakano, Chinatsu Yamada, Yasunori Iida, Masaki Miyasaka, Yusuke Enta, Takashi Matsumoto, Masaki Nakashima, Yoshiko Munehisa, Arata Inoue, Kazunori Ishii, Takehiro Nomura, Makoto Saigan, Suguru Hirose, Shingo Mizuno, Tsuyoshi Yamabe, Shigeru Hattori, Hirokazu Miyashita, Kotaro Obunai, Masahiko Noguchi, Nahoko Kato, Hayato Morimura, Joji Ito, Makio Murahsi, Hidewo Amano, Shinsuke Kotani, Yuta Azumi, Nobuyuki Fukuda, Mitsuo Sobajima, Hiroshi Onoda, Hiroyuki Kuwahara, Shuhei Tanaka, Yohei Ueno, Kazuaki Fukahara, Toshio Doi, Shigeki Yokoyama, Teruhiko Imamura, Ryuichi Ushijima, Akira Oshima, Yuki Hida, Hiroaki Nishida, Kenichi Hashizume, Koji Ueno, Koki Ikebata, Masatoshi Oono, Kiwamu Sudo, Takesi Mori, and Erito Huruse

Subjects
Male, medicine.medical_specialty, Transcatheter aortic, Heart Ventricles, medicine.medical_treatment, Aortic Valve Replacement/Transcather Aortic Valve Implantation, heart failure, Elastance, Valve replacement, Internal medicine, medicine, Humans, Diseases of the circulatory (Cardiovascular) system, In patient, Ventricular arterial coupling, Original Research, ventricular‐aortic coupling, business.industry, Arteries, Prognosis, medicine.disease, Interventional Cardiology, Heart failure, RC666-701, Arterial elastance, Cardiology, transcatheter aortic valve replacement, Female, Cardiology and Cardiovascular Medicine, business
Abstract

Background Ventricular‐arterial coupling predicts outcomes in patients with heart failure. The arterial elastance to end‐systolic elastance ratio (Ea/Ees) is a noninvasively assessed index that reflects ventricular‐arterial coupling. We aimed to determine the prognostic value of ventricular‐arterial coupling assessed through Ea/Ees after transcatheter aortic valve replacement to predict clinical events. Methods and Results We retrieved data on 1378 patients (70% women) who underwent transcatheter aortic valve replacement between October 2013 and May 2017 from the OCEAN‐TAVI (Optimized transCathEter vAlvular iNtervention) Japanese multicenter registry. We determined the association between Ea/Ees and the composite end point of hospitalization for heart failure and cardiovascular death by classifying the patients into quartiles based on Ea/Ees values (group 1: 0.666) during the midterm follow‐up after transcatheter aortic valve replacement. During a median follow‐up period of 736 days (interquartile range, 414–956), there were 247 (17.9%) all‐cause deaths, 89 (6.5%) cardiovascular deaths, 130 (9.4%) hospitalizations for heart failure, and 199 (14.4%) composite events of hospitalization for heart failure and cardiovascular death. The incidence of the composite end point was significantly higher in group 2 (hazard ratio [HR], 1.76; 95% CI, 1.08–2.87 [ P =0.024]), group 3 (HR, 2.43; 95% CI, 1.53–3.86 [ P P P =0.015]). Conclusions These findings suggest that a higher Ea/Ees at discharge after transcatheter aortic valve replacement is associated with adverse clinical outcomes during midterm follow‐up. Registration URL: https://www.upload.umin.ac.jp/ . Unique identifier: UMIN000020423.

Published
2021

7. Comparison of ultrasound‐guided versus angiography‐guided endovascular treatment for femoropopliteal artery occlusive disease

Author

Takahiro Tokuda, Shinsuke Mori, Keisuke Hirano, Ryoji Koshida, Hiroaki Matsuda, Yasuhiro Oba, Akira Murata, Ai Kagase, Yoriyasu Suzuki, and Tatsuya Ito

Subjects
medicine.medical_specialty, medicine.medical_treatment, Occlusive disease, 030204 cardiovascular system & hematology, Revascularization, Lesion, Peripheral Arterial Disease, 03 medical and health sciences, 0302 clinical medicine, Humans, Medicine, Popliteal Artery, Radiology, Nuclear Medicine and imaging, 030212 general & internal medicine, Endovascular treatment, Ultrasonography, Interventional, Vascular Patency, Retrospective Studies, medicine.diagnostic_test, business.industry, Endovascular Procedures, Angiography, General Medicine, Ultrasound guided, Femoral Artery, Radiation exposure, Treatment Outcome, medicine.anatomical_structure, Radiology, medicine.symptom, Cardiology and Cardiovascular Medicine, business, Artery
Abstract

PURPOSE This study aimed to compare the efficacy of ultrasound-guided and angiography-guided intraluminal approach for femoropopliteal (FP) artery occlusive disease. METHODS A retrospective analysis was performed using the data collected regarding patients that underwent endovascular treatment (EVT) for FP artery occlusive disease between January 2010 and April 2018 at two centers. A total of 221 consecutive de novo lesions were analyzed according to the method of recanalization. Propensity score-matched analysis was performed to compare the clinical outcomes of recanalization methods for FP occlusive lesions. The prognostic value was analyzed based on the number of guidewires, wire cross time, distal puncture rate, radiation exposure, the amount of contrast media, primary patency, and clinically driven-target lesion revascularization (CD-TLR) at 1 year. RESULTS A total of 44 matched pairs of patients were analyzed after propensity score-matched analysis. The number of guidewires, distal puncture rate, wire passage time, radiation exposure, and the amount of contrast media were significantly lower in the ultrasound-guide group, with 3.4 vs. 4.7, 9.1% vs. 54.5%, 47 min vs. 83 min, 207 mGy vs. 821 mGy, 66 ml vs. 109 ml, respectively (p

Published
2020

8. Risk Factors and Clinical Impacts of Peri-Stent Contrast Staining After Second-Generation Drug-Eluting Stent Implantation

Author

Masahiro Yamawaki, Yoshiaki Ito, Motoharu Araki, Yasunari Sakamoto, Hideyuki Takimura, Keisuke Hirano, Shinsuke Mori, Takahiro Tokuda, and Norihiro Kobayashi

Subjects
medicine.medical_specialty, medicine.medical_treatment, 030204 cardiovascular system & hematology, Coronary artery disease, 03 medical and health sciences, 0302 clinical medicine, stomatognathic system, medicine.artery, medicine, Radiology, Nuclear Medicine and imaging, 030212 general & internal medicine, medicine.diagnostic_test, business.industry, Stent, Percutaneous coronary intervention, Retrospective cohort study, Odds ratio, medicine.disease, eye diseases, Surgery, stomatognathic diseases, Drug-eluting stent, Right coronary artery, Angiography, Cardiology and Cardiovascular Medicine, business
Abstract

Background Peri-stent contrast staining (PSS) after sirolimus-eluting stent implantation is associated with target lesion revascularization (TLR) and very late stent thrombosis. However, the risk factors and clinical sequelae of PSS after second-generation DES implantation remain unclear. Methods and Results This study comprised 2,090 patients with 2,883 lesions treated with second-generation DES from April 2009 to February 2013. Angiographic findings and clinical outcomes were compared between PSS and non-PSS groups. Follow-up angiography was available for 2,411 lesions. PSS was observed in 23 lesions: 4 in biolimus-eluting stents, 4 in zotarolimus-eluting stents (ZES), and 15 in everolimus-eluting stents (EES). Right coronary artery lesions, chronic total occlusion (CTO), and lesions with severe angulation (>90°) were more frequent in the PSS group compared with the non-PSS group. Lesions were longer and the cumulative TLR incidence at 3 years was higher in the PSS group than those in the non-PSS group (27.9 mm vs. 19.4 mm, P

Published
2016

9. Impact of ultra-long second-generation drug-eluting stent implantation

Author

Yohsuke Honda, Yoshiaki Ito, Norihiro Kobayashi, Shinsuke Mouri, Masahiro Yamawaki, Toshiya Muramatsu, Motoharu Araki, Takuro Takama, Takahiro Tokuda, Yasunari Sakamoto, Tsuyoshi Sakai, Kenji Makino, Hiroya Takafuji, Masakazu Tsutumi, Keisuke Hirano, and Hideyuki Takimura

Subjects
Target lesion, medicine.medical_specialty, Proportional hazards model, business.industry, medicine.medical_treatment, General Medicine, 030204 cardiovascular system & hematology, Surgery, Lesion, 03 medical and health sciences, 0302 clinical medicine, Drug-eluting stent, Internal medicine, Right coronary artery, medicine.artery, Clinical endpoint, medicine, Cardiology, Radiology, Nuclear Medicine and imaging, 030212 general & internal medicine, medicine.symptom, Cardiology and Cardiovascular Medicine, business, Mace, Target lesion revascularization
Abstract

Objectives This study investigated the safety and prognosis of ultra-long second DES (UL-2nd DES) implantation in real-world practice. Background Long stenting is a widely known predictor of stent thrombosis (ST) or target lesion revascularization (TLR) in first-generation drug-eluting stents (DES). Methods Participants were 1,669 patients (2,763 lesions) who had undergone successful second DES implantation; they were assigned to one of three groups: ultra-long 2nd DES (UL-DES; >50 mm, 166 patients, 259 lesions), long second DES (L-DES; 20–50 mm, 758 patients, 1,212 lesions), or short second DES (S-DES

Published
2015

10. Excitonic emissions of AgInS 2 crystals with chalcopyrite and orthorhombic structure

Author

Kazuhiro Honjo, Raul Paucar, Kenji Yoshino, YongGu Shim, Kazuki Wakita, Umihito Miyamoto, and Takahiro Tokuda

Subjects
Photoluminescence, Chemistry, Band gap, Astrophysics::High Energy Astrophysical Phenomena, Exciton, Analytical chemistry, Astrophysics::Cosmology and Extragalactic Astrophysics, Crystal structure, Condensed Matter::Mesoscopic Systems and Quantum Hall Effect, Condensed Matter Physics, Emission intensity, Condensed Matter::Materials Science, Orthorhombic crystal system, Emission spectrum, Luminescence, Astrophysics::Galaxy Astrophysics
Abstract

Micro-structure of AgInS2 grown by the hot-press method has been examined by the properties of free-exciton emission using a scanning confocal-microscopy system. The crystal structures are distinguished by a two-dimensional image of free-exciton emission at RT. The excitonic emissions with the orthorhombic structure were also analyzed and a bound exciton emission was observed in addition to a free exciton emission. Furthermore, it is indicated that the two-dimensional image of decay-time constant is more insusceptible to resolve the structures than that of emission intensity. (© 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)

Published
2013

11. Optical charaterization of Ag/Ga composition ratio in AgGaSe 2 thin film

Author

Satoru Seto, Kenji Yoshino, Hitoshi Matsuo, Koichi Kakimoto, Tetsuo Ikari, Aya Kinoshita, and Takahiro Tokuda

Subjects
Photoluminescence, Chemistry, Band gap, Exciton, Analytical chemistry, Thin film, Condensed Matter Physics, Absorption (electromagnetic radiation), Stoichiometry, Spectral line, Vacuum evaporation
Abstract

AgGaSe2 thin films, changing the Ag/Ga ratio from 0.4 to 1.5, on glass substrates were successfully grown by vacuum evaporation method. Fundamental absorption bandedges were clearly observed except for Ag/Ga ratios of 0.4 and 1.5 in the optical transmittance spectra at RT. The optical bandgap increased with increasing Ag/Ga ratio. This was due to the Bernstein-Moss shifts. Photoluminescence spectrum was strongly observed in the stoichiometric sample in comparison to Ag- and Ga-rich samples. This means that nonradiative recombination transition was a few in the stoichiometric sample because there were few defects in the samples Two distinct peaks at 1.77 and 1.70 eV were clearly observed in the stoichiometric sample. They were due to bound exciton emission and donor-acceptor pair (DAP) emission, respectively. The DAP emission is due to recombination between Se- and Ga vacancies. (© 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)

Published
2009

12. Mn‐doping effect of photoluminescence on AgInS 2

Author

Naoki Ohtani, YongGu Shim, Raul Paucar, Kazuhiro Honjo, Takuya Seo, Kazuki Wakita, Umihito Miyamoto, Takahiro Tokuda, and Kenji Yoshino

Subjects
Condensed Matter::Materials Science, Photoluminescence, Chemistry, Band gap, Condensed Matter::Superconductivity, Analytical chemistry, Emission spectrum, Activation energy, Atmospheric temperature range, Condensed Matter Physics, Luminescence, Emission intensity, Spectral line
Abstract

The effects of Mn-doping on the photoluminescence spectra of AgInS2 bulk-crystals grown by the hot-press method have investigated by using a confocal microspectroscopy system. For Mn-doped crystals, the emission peak located at 1.568 eV appears in addition to two peaks which exist on non-doped samples. The lower energy peaks blow 1.8 eV are considered to be attributed to free-to-bound transition. We also examined temperature dependence of emission intensity of these peaks and obtained their activation energy. The energy values seem to correspond to energy levels related with the emissions because non-doped and Mn-doped samples indicated to be n-type (© 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)

Published
2012

13. P4‐296: Novel APLP1 Peptide In CSF Is Useful For Diagnosis Of Sporadic Alzheimer's Disease

Author

Masaki Ikeda, Shinji Tagami, Kensaku Kasuga, Kanta Yanagida, Harald Steiner, Takahiro Tokuda, Tetsuaki Arai, Takeshi Ikeuchi, Kentaro Deguchi, Kouhei Nishitomi, Ryozo Kuwano, Masayasu Okochi, Masaki Kondo, Masatoshi Takeda, and Christian Haass

Subjects
chemistry.chemical_classification, Epidemiology, business.industry, Health Policy, Peptide, Disease, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, chemistry, Immunology, Medicine, Neurology (clinical), APLP1, Geriatrics and Gerontology, business
Published
2009

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