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Eur J Clin Invest 2011; 41 (3): 241–255 Abstract Background Urea and creatinine are widely used as biomarkers for disease. However, these parameters have been criticized as markers for several reasons. Thus, we conducted this study to identify novel biomarkers that can be used as alternatives to urea and creatinine to estimate the adequate dialysis dose by metabolomic analyses of plasma samples from patients undergoing haemodialysis. Material and methods Liquid chromatography–electrospray ionization (ESI)–time-of-flight mass spectrometry (MS) was used to analyse low molecular weight molecules present in the plasma samples of 10 patients with end-stage renal disease (ESRD) who were being treated with haemodialysis, and in 16 healthy subjects. Results In plasma samples obtained after haemodialysis, the relative quantities of 54 peaks were significantly (P

Superconducting Bi,Pb–Sr–Ca–Cu–O material has been prepared by an improved coprecipitation method; mixed metal oxalates as the precursor were precipitated from a homogeneous acetic acid solution of the constituent metal acetates and dimethyl oxalate. This method permits easier fabrication of the superconducting material which is almost free from low-Tc phase.