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4. The clearance of cyclosporine by hemodialysis.

Author

Venkataramanan R, Ptachcinski RJ, Burckart GJ, Yang SL, Starzl TE, and Van Theil DH

Subjects
Adult, Humans, Kidney Cortex Necrosis etiology, Kidney Cortex Necrosis metabolism, Kinetics, Cyclosporins metabolism, Liver Transplantation, Renal Dialysis
Abstract

The pharmacokinetics of cyclosporine were studied in five liver transplant patients when they were on and off hemodialysis. There was no significant difference in the blood clearance of cyclosporine between these two periods. Less than 1 per cent of the dose of cyclosporine was recovered in the dialysate. The mean dialysis clearance was less than 1 ml/min. This represents less than 1 per cent of the total blood clearance of cyclosporine. Dosage alterations of cyclosporine during or after hemodialysis do not appear to be necessary.

Published
1984
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