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45 results on '"Thomas, D G"'

44. Benign central neurocytoma.

Author

Ashkan K, Casey AT, D'Arrigo C, Harkness WF, and Thomas DG

Subjects
Adolescent, Adult, Aggression, Brain Neoplasms etiology, Child, Female, Follow-Up Studies, Humans, Immunohistochemistry, Ki-67 Antigen metabolism, Magnetic Resonance Imaging, Male, Microscopy, Middle Aged, Neurocytoma metabolism, Neurocytoma physiopathology, Neurocytoma surgery, Parietal Lobe pathology, Prospective Studies, Spinal Neoplasms etiology, Spine pathology, Brain Neoplasms diagnosis, Neurocytoma diagnosis, Spinal Neoplasms diagnosis
Abstract

Background: "Central neurocytoma" is classically considered as an intraventricular benign tumor, largely based on data from small retrospective series. The authors present prospective data on 12 patients with tumors diagnosed as central neurocytoma, to highlight the diverse nature of this tumor and challenge the classic notion., Methods: Between 1991 and 1997, 12 patients had tumors diagnosed prospectively as "central neurocytoma". Clinical, radiologic, and histologic data were collected, and Karnofsky performance score was evaluated for each patient. Proliferation marker studies were performed using Ki-67 labeling index., Results: In two patients, the tumors were located in atypical locations, namely, the parietal lobe and the spine. Aggressive behavior characterized by clinical and radiologic evidence of tumor progression was noted in two additional patients. In both these cases, unusually high proliferation rates of 5.3% and 11.2% were noted. Total excision of the tumor, when possible, was the treatment of choice. Postoperative radiotherapy to the residual tumor may be of benefit in patients with clinically aggressive tumors, or those with high proliferation rates., Conclusions: Given the findings of this study, it is suggested that the traditional concept of central neurocytoma as a benign intraventricular tumor warrants reconsideration.

Published
2000

45. Brain metabolites as 1H NMR markers of neuronal and glial disorders.

Author

Gill SS, Small RK, Thomas DG, Patel P, Porteous R, Van Bruggen N, Gadian DG, Kauppinen RA, and Williams SR

Subjects
Animals, Astrocytes analysis, Glioblastoma metabolism, Humans, In Vitro Techniques, Rats, Rats, Inbred Strains, Brain Neoplasms diagnosis, Glioblastoma diagnosis, Magnetic Resonance Spectroscopy
Abstract

1H NMR spectroscopy of human brain in vivo can be used to detect a number of cerebral metabolites including N-acetylaspartate, creatine + phosphocreatine and choline-containing compounds. We have used 1H NMR spectroscopy to analyse these signals in (i) biopsy material from both normal human brain and astrocytomas, and (ii) primary astrocyte cultures. On the basis of this analysis, we conclude that in vivo 1H NMR spectroscopy could play an important clinical role in the non-invasive assessment of neuronal degeneration and proliferation of non-neuronal cells.

Published
1989
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