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Summary 1.Ecosystem services (ES) from mountain forests are highly relevant for human societies. ES with a direct economic support function (e.g. timber production), regulatory services (e.g. protection from natural hazards) and cultural services (e.g. recreation) are likely to be affected strongly by a rapidly changing climate. To evaluate whether adverse climate change effects on ES can be counteracted by adapting management, dynamic models and indicator-based assessments are needed. 2.We applied a forest dynamic model in case study areas of four European mountain regions and evaluated the future supply of four ES - timber production, carbon sequestration, biodiversity, and protection against natural hazards - using state-of-the-art ES indicators. Forest dynamics were simulated under three management scenarios (no management, business-as-usual, and alternative management) and five climate change projections for selected representative stand types in each region. We analysed potential trade-offs and synergies between ES, and evaluated future changes among regions, forest stands, climate and management scenarios. 3.Impacts of climate change on the provision of multiple ES were found to be highly heterogeneous and to depend on the region, site, and future climate. In the absence of large-scale natural disturbance (not considered), protection services, carbon stock and deadwood abundance (proxy for biodiversity) benefitted from no management in all regions. Negative impacts of climate change were evident for the provision of multiple ES but limited to the most severe climate scenarios and low-elevation stands. Synergies and trade-offs between the majority of ES were found to be sensitive to the choice of management strategy and – in some regions – to climate change. 4.Synthesis and applications. Management regimes in European mountain forests should be regionally adapted to stand and site conditions. Although in some cases alternative management regimes may be more suitable than current management for supporting multiple ecosystem services, adaptation options should be evaluated carefully at the local scale due to the highly different magnitude of the impacts of climate change in different regions and along elevation gradients. This article is protected by copyright. All rights reserved.

Increased expression of the molecular chaperone Hsp27 is associated with the progression of prostate cancer (PCa) to castration-resistant disease, which is lethal due to metastatic spread of the prostate tumor. Metastasis requires epithelial to mesenchymal transition (EMT), which endows cancer cells with the ability to disseminate from the primary tumor and colonize new tissue sites. A wide variety of secreted factors promote EMT, and while overexpression and constitutive activation of epidermal growth factor (EGF) signaling is associated with poor prognosis of PCa, a precise role of EGF in PCa progression to metastasis remains unclear. Here, we show that Hsp27 is required for EGF-induced cell migration, invasion and MMPs activity as well as the expression of EMT markers including Fibronectin, Vimentin and Slug with concomitant decrease of E-cadherin. Mechanistically, we found that Hsp27 is required for EGF-induced AKT and GSK3β phosphorylation and β-catenin nuclear translocation. Moreover, silencing Hsp27 decreases EGF dependent phosphorylation of β-catenin on tyrosine 142 and 654, enhances β-catenin ubiquitination and degradation, prevents β-catenin nuclear translocation and binding to the Slug promoter. These data suggest that Hsp27 is required for EGF-mediated EMT via modulation of the β-catenin/Slug signaling pathway. Together, our findings underscore the importance of Hsp27 in EGF induced EMT in PCa and highlight the use of Hsp27 knockdown as a useful strategy for patients with advanced disease.