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17 results on '"Ueda, Yuto"'

6. Antioxidant Effects of Herbal Tea Leaves from Yacon (Smallanthus sonchifolius) on Multiple Free Radical and Reducing Power Assays, Especially on Different Superoxide Anion Radical Generation Systems

Author

Sugahara, Shintaro, primary, Ueda, Yuto, additional, Fukuhara, Kumiko, additional, Kamamuta, Yuki, additional, Matsuda, Yasushi, additional, Murata, Tatsuro, additional, Kuroda, Yasuhiro, additional, Kabata, Kiyotaka, additional, Ono, Masateru, additional, Igoshi, Keiji, additional, and Yasuda, Shin, additional

Published
2015
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8. Increased lipid peroxidation in Down’s syndrome mouse models

Author

Ishihara, Keiichi, primary, Amano, Kenji, additional, Takaki, Eiichi, additional, Ebrahim, Abdul Shukkur, additional, Shimohata, Atsushi, additional, Shibazaki, Noriko, additional, Inoue, Ikuyo, additional, Takaki, Mayuko, additional, Ueda, Yuto, additional, Sago, Haruhiko, additional, Epstein, Charles J., additional, and Yamakawa, Kazuhiro, additional

Published
2009
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12. Collapse of extracellular glutamate regulation during epileptogenesis: down‐regulation and functional failure of glutamate transporter function in rats with chronic seizures induced by kainic acid

Author

Ueda, Yuto, primary, Doi, Taku, additional, Tokumaru, Jun, additional, Yokoyama, Hidekatsu, additional, Nakajima, Akira, additional, Mitsuyama, Yoshio, additional, Ohya‐Nishiguchi, Hiroaki, additional, Kamada, Hitoshi, additional, and Willmore, L. James, additional

Published
2001
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17. Lurasidone inhibits NMDA receptor antagonist-induced functional abnormality of thalamocortical glutamatergic transmission via 5-HT 7 receptor blockade.

Author

Okada M, Fukuyama K, and Ueda Y

Subjects
Animals, Antipsychotic Agents administration & dosage, Dizocilpine Maleate pharmacology, Glutamic Acid drug effects, Glutamic Acid metabolism, Lurasidone Hydrochloride administration & dosage, Male, Mediodorsal Thalamic Nucleus drug effects, Perfusion, Rats, Rats, Sprague-Dawley, Receptors, N-Methyl-D-Aspartate metabolism, Serotonin Antagonists administration & dosage, Synaptic Transmission drug effects, Thalamus drug effects, Thalamus metabolism, Antipsychotic Agents pharmacology, Dizocilpine Maleate antagonists & inhibitors, Lurasidone Hydrochloride pharmacology, Receptors, N-Methyl-D-Aspartate antagonists & inhibitors, Receptors, Serotonin metabolism, Serotonin Antagonists pharmacology
Abstract

Background and Purpose: Lurasidone is an atypical mood-stabilizing antipsychotic with a unique receptor-binding profile, including 5-HT 7 receptor antagonism; however, the detailed effects of 5-HT 7 receptor antagonism on various transmitter systems relevant to schizophrenia, particularly the thalamo-insular glutamatergic system and the underlying mechanisms, are yet to be clarified., Experimental Approach: We examined the mechanisms underlying the clinical effects of lurasidone by measuring the release of l-glutamate, GABA, dopamine, and noradrenaline in the reticular thalamic nucleus (RTN), mediodorsal thalamic nucleus (MDTN) and insula of freely moving rats in response to systemic injection or local infusion of lurasidone or MK-801 using multiprobe microdialysis with ultra-HPLC., Key Results: Systemic MK-801 (0.5 mg·kg -1 ) administration increased insular release of l-glutamate, dopamine, and noradrenaline but decreased GABA release. Systemic lurasidone (1 mg·kg -1 ) administration also increased insular release of l-glutamate, dopamine, and noradrenaline but without affecting GABA. Local lurasidone administration into the insula (3 μM) did not affect MK-801-induced insular release of l-glutamate or catecholamine, whereas local lurasidone administration into the MDTN (1 μM) inhibited MK-801-induced insular release of l-glutamate and catecholamine, similar to the 5-HT 7 receptor antagonist SB269970., Conclusions and Implications: The present results indicate that MK-801-induced insular l-glutamate release is generated by activation of thalamo-insular glutamatergic transmission via MDTN GABAergic disinhibition resulting from NMDA receptor inhibition in the MDTN and RTN. Lurasidone inhibited this MK-801-evoked insular l-glutamate release through inhibition of excitatory 5-HT 7 receptor in the MDTN. These effects on thalamo-insular glutamatergic transmission may contribute to the antipsychotic and mood-stabilizing actions of lurasidone., (© 2019 The British Pharmacological Society.)

Published
2019
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