Search

Your search keyword '"Unión Europea. Comisión Europea. 7 Programa Marco"' showing total 3 results
Start Over Author "Unión Europea. Comisión Europea. 7 Programa Marco" Publisher wiley
3 results on '"Unión Europea. Comisión Europea. 7 Programa Marco"'

1. Integrative analysis of clinical and epigenetic biomarkers of mortality

Author

Huan, Tianxiao, Nguyen, Steve, Colicino, Elena, Ochoa-Rosales, Carolina, Hill, W David, Brody, Jennifer A, Soerensen, Mette, Zhang, Yan, Baldassari, Antoine, Elhadad, Mohamed Ahmed, Toshiko, Tanaka, Zheng, Yinan, Domingo-Relloso, Arce, Lee, Dong Heon, Ma, Jiantao, Yao, Chen, Liu, Chunyu, Hwang, Shih-Jen, Joehanes, Roby, Fornage, Myriam, Bressler, Jan, van Meurs, Joyce B J, Debrabant, Birgit, Mengel-From, Jonas, Hjelmborg, Jacob, Christensen, Kaare, Vokonas, Pantel, Schwartz, Joel, Gahrib, Sina A, Sotoodehnia, Nona, Sitlani, Colleen M, Kunze, Sonja, Gieger, Christian, Peters, Annette, Waldenberger, Melanie, Deary, Ian J, Ferrucci, Luigi, Qu, Yishu, Greenland, Philip, Lloyd-Jones, Donald M, Hou, Lifang, Bandinelli, Stefania, Voortman, Trudy, Hermann, Brenner, Baccarelli, Andrea, Whitsel, Eric, Pankow, James S, Levy, Daniel, Ochoa‐Rosales, Carolina, Hill, W. David, Brody, Jennifer A., Domingo‐Relloso, Arce, Hwang, Shih‐Jen, van Meurs, Joyce B.J., Mengel‐From, Jonas, Gahrib, Sina A., Sitlani, Colleen M., Deary, Ian J., Lloyd‐Jones, Donald M., Pankow, James S., Meurs, Joyce B.J., National Institutes of Health (Estados Unidos), NIH - National Heart, Lung, and Blood Institute (NHLBI) (Estados Unidos), NIH - Center for Information Technology (Estados Unidos), NIH - National Institute of Neurological Disorders and Stroke (NINDS) (Estados Unidos), NIH - National Institute on Aging (NIA) (Estados Unidos), Fundación Merck Salud, Laughlin Family, Alpha Phi Foundation, Locke Charitable Foundation, National Center for Advancing Translational Sciences (Estados Unidos), NIH - National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (Estados Unidos), Danish Council for Independent Research, Unión Europea. Comisión Europea. 7 Programa Marco, United States of Department of Health & Human Services, NIH - National Institute of Environmental Health Sciences (NIEHS) (Estados Unidos), Biotechnology and Biological Sciences Research Council (Reino Unido), Royal Society (Reino Unido), Scottish Government, Age UK (Reino Unido), Centre for Cognitive Ageing and Cognitive Epidemiology (Reino Unido), Wellcome Trust, University of Edinburgh (Reino Unido), University of Queensland (Australia), Medical Research Council (Reino Unido), United States Department of Veterans Affairs, Massachusetts Veterans Education Research and Information Center (MAVERIC), Epidemiology, and Internal Medicine

Subjects
Epigenomics, Male, Aging, DNA methylation, Cell Biology, DNA Methylation, Cardiovascular disease, Epigenesis, Genetic, SDG 3 - Good Health and Well-being, Cardiovascular Diseases, Neoplasms, Machine learning, Humans, Mortality, Dna Methylation, Cancer, Cardiovascular Disease, Machine Learning, Biomarkers
Abstract

DNA methylation (DNAm) has been reported to be associated with many diseases and with mortality. We hypothesized that the integration of DNAm with clinical risk factors would improve mortality prediction. We performed an epigenome-wide association study of whole blood DNAm in relation to mortality in 15 cohorts (n = 15,013). During a mean follow-up of 10 years, there were 4314 deaths from all causes including 1235 cardiovascular disease (CVD) deaths and 868 cancer deaths. Ancestry-stratified meta-analysis of all-cause mortality identified 163 CpGs in European ancestry (EA) and 17 in African ancestry (AA) participants at p

Published
2022

2. The RD-connect genome-phenome analysis platform: accelerating diagnosis, research, and gene discovery for rare diseases

Author

Laurie, Steven, Piscia, Davide, Matalonga, Leslie, Corvó, Alberto, Fernández-Callejo, Marcos, Garcia-Linares, Carles, Hernandez-Ferrer, Carles, Luengo, Cristina, Martínez, Inés, Papakonstantinou, Anastasios, Picó-Amador, Daniel, Protasio, Joan, Thompson, Rachel, Tonda, Raul, Bayés, Mònica, Bullich, Gemma, Camps-Puchadas, Jordi, Paramonov, Ida, Trotta, Jean-Rémi, Alonso, Angel, Attimonelli, Marcella, Béroud, Christophe, Bros-Facer, Virginie, Buske, Orion J, Cañada-Pallarés, Andrés, Fernández, José M, Hansson, Mats G, Horvath, Rita, Jacobsen, Julius O B, Kaliyaperumal, Rajaram, Lair-Préterre, Séverine, Licata, Luana, Lopes, Pedro, López-Martín, Estrella, Mascalzoni, Deborah, Monaco, Lucia, Pérez-Jurado, Luis A, Posada De la Paz, Manuel, Rambla, Jordi, Rath, Ana, Riess, Olaf, Robinson, Peter N, Salgado, David, Smedley, Damian, Spalding, Dylan, 't Hoen, Peter A C, Töpf, Ana, Zaharieva, Irina, Graessner, Holm, Gut, Ivo G, Lochmüller, Hanns, Beltran, Sergi, Corvo, Alberto, Garcia, Carles, Fernandez‐Callejo, Marcos, Hernandez, Carles, Ntalis, Anastasios Papakonstantinou, Protassio, Joan, Martinez, Ines, Pico, Daniel, Bayes, Monica, Camps, Jordi, Trotta, Jean‐Remi, Bros‐Facer, Virginie, Buske, Orion, Cañada, Andrés, Fernandez, Josè Maria, Hansson, Mats, Jacobsen, Julius, Lair, Severine, López‐Martin, Estrella, Jurado, Luis Pérez, Posada, Manuel, Robinson, Peter, Spalding, Dylan J., 't Hoen, Peter‐Bram, Gut, Ivo, Lochmúller, Hanns, Universidad Pública de Navarra. Departamento de Ciencias de la Salud, Nafarroako Unibertsitate Publikoa. Osasun Zientziak Saila, Gobierno de Navarra / Nafarroako Gobernua, Laurie, Steven [0000-0003-3913-5829], Piscia, Davide [0000-0002-0468-0408], Matalonga, Leslie [0000-0003-0807-2570], Corvó, Alberto [0000-0003-0174-2818], Fernández-Callejo, Marcos [0000-0002-9968-3766], Garcia-Linares, Carles [0000-0002-0558-2498], Hernandez-Ferrer, Carles [0000-0002-8029-7160], Luengo, Cristina [0000-0003-1612-8706], Martínez, Inés [0000-0002-2062-3120], Papakonstantinou, Anastasios [0000-0003-4301-3859], Picó-Amador, Daniel [0000-0001-5254-2184], Protasio, Joan [0000-0001-6342-8096], Thompson, Rachel [0000-0002-6889-0121], Tonda, Raul [0000-0001-7893-2404], Bayés, Mònica [0000-0002-8271-3076], Bullich, Gemma [0000-0002-0737-4422], Camps-Puchadas, Jordi [0000-0001-8763-9947], Paramonov, Ida [0000-0001-8666-6054], Trotta, Jean-Rémi [0000-0001-9548-8165], Alonso, Angel [0000-0001-5111-310X], Attimonelli, Marcella [0000-0003-2091-8364], Béroud, Christophe [0000-0003-2986-8738], Buske, Orion J [0000-0002-9064-092X], Cañada-Pallarés, Andrés [0000-0003-1284-3737], Fernández, José M [0000-0002-4806-5140], Hansson, Mats G [0000-0002-4053-8468], Horvath, Rita [0000-0002-9841-170X], Jacobsen, Julius OB [0000-0002-3265-1591], Kaliyaperumal, Rajaram [0000-0002-1215-167X], Licata, Luana [0000-0001-5084-9000], Lopes, Pedro [0000-0001-5330-6562], López-Martín, Estrella [0000-0003-3212-1424], Mascalzoni, Deborah [0000-0003-4156-1464], Monaco, Lucia [0000-0001-5620-1790], Posada de la Paz, Manuel [0000-0002-8372-4180], Rambla, Jordi [0000-0001-9091-257X], Rath, Ana [0000-0003-4308-6337], Riess, Olaf [0000-0002-7011-1369], Robinson, Peter N [0000-0002-0736-9199], Smedley, Damian [0000-0002-5836-9850], Spalding, Dylan [0000-0002-4285-2493], 't Hoen, Peter AC [0000-0003-4450-3112], Töpf, Ana [0000-0002-9227-2526], Zaharieva, Irina [0000-0002-7663-6297], Graessner, Holm [0000-0001-9803-7183], Gut, Ivo G [0000-0001-7219-632X], Lochmüller, Hanns [0000-0003-2324-8001], Beltran, Sergi [0000-0002-2810-3445], Apollo - University of Cambridge Repository, Unión Europea. Comisión Europea. H2020, Unión Europea. Comisión Europea. 7 Programa Marco, Instituto de Salud Carlos III, Instituto Nacional de Bioinformática (España), Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF), Government of Catalonia (España), Gobierno de Navarra (España), NIH - National Institute of Child Health and Human Development (NICHD) (Estados Unidos), Ministerio de Economía, Industria y Competitividad (España), Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España), Canadian Institutes of Health Research, Canadia, Comunidad Foral de Navarra (España), European Reference Network for Rare Neurological Diseases (ERN-RND), Muscular Dystrophy Canada, Canada Foundation for Innovation, and Canada Research Chairs

Subjects
Settore BIO/18, data sharing, patient matchmaking, rare diseases, Genomics, Genome analysis, Rare diseases, Phenotype, Patient matchmaking, Data standardization, NGS, Genetics, diagnostics, Humans, Exome, Data sharing, data standardization, genome analysis, Medical Genetics, Diagnostics, Genetics (clinical), Genetic Association Studies, Medicinsk genetik
Abstract

Rare disease patients are more likely to receive a rapid molecular diagnosis nowadays thanks to the wide adoption of next-generation sequencing. However, many cases remain undiagnosed even after exome or genome analysis, because the methods used missed the molecular cause in a known gene, or a novel causative gene could not be identified and/or confirmed. To address these challenges, the RD-Connect Genome-Phenome Analysis Platform (GPAP) facilitates the collation, discovery, sharing, and analysis of standardized genome-phenome data within a collaborative environment. Authorized clinicians and researchers submit pseudonymised phenotypic profiles encoded using the Human Phenotype Ontology, and raw genomic data which is processed through a standardized pipeline. After an optional embargo period, the data are shared with other platform users, with the objective that similar cases in the system and queries from peers may help diagnose the case. Additionally, the platform enables bidirectional discovery of similar cases in other databases from the Matchmaker Exchange network. To facilitate genome-phenome analysis and interpretation by clinical researchers, the RD-Connect GPAP provides a powerful user-friendly interface and leverages tens of information sources. As a result, the resource has already helped diagnose hundreds of rare disease patients and discover new disease causing genes. We acknowledge the support of the developers of PhenoTips, which was used in the past by RD-Connect and NeurOmics as the primary tool to collate phenotypic data. We would also like to thank the leaders and members of the Instituto Nacional de Bioinformática (INB) and ELIXIR for their support and collaboration throughout the years. RD-Connect (RD-Connect, an integrated platform connecting registries, biobanks, and clinical bioinformatics) received funding from the Seventh Framework (FP7) Programme of the European Union under grant agreement No 305444. Data were analyzed using the RD-Connect GPAP, which received funding from EU projects Solve-RD, EJP-RD (grant numbers H2020 779257, H2020 825575), Instituto de Salud Carlos III (Grant numbers PT13/0001/0044, PT17/0009/0019; Instituto Nacional de Bioinformática, INB), ELIXIR-EXCELERATE (Grant number EU H2020 #676559) and ELIXIR Implementation Studies (Remote real-time visualization of human rare disease genomics data (RD-Connect) stored at the EGA ELIXIR. 2017-2018; ELIXIR IT-2017-INTEGRATION, Rare Disease Infrastructure ELIXIR, 2019-2020 and the Beacon ELIXIR, 2019-2021). The RD-Connect GPAP has leveraged developments funded through project VEIS (001-P-001647 co-financed by the European Regional Development Fund of the European Union in the framework of the Operational Program FEDER of Catalonia 2014-2020 with the support of the Secretaria d'Universitats i Recerca del Departament d'Empresa i Coneixement de la Generalitat de Catalunya) and URD-Cat (PERIS SLT002/16/00174, Departament de Salut, Generalitat de Catalunya). The research leading to these results has received funding from Consequitur (Newton Fund UK/Turkey, MR/N027302/1), BBMRI-LPC (EU FP7 #313010), NeurOmics (EU FP7 #305121), the Economic Development Department of the Navarra Government (Grant number 001114112017), the European Reference Network for Rare Neurological Diseases (Project ID number 739510) and NIH, National Institute of Child Health and Human Development (1R01HD103805-01). We acknowledge the support of the Spanish Ministry of Economy, Industry and Competitiveness (MEIC) to the EMBL partnership, the Centro de Excelencia Severo Ochoa, and the CERCA Program/Generalitat de Catalunya. We also acknowledge the support of the Generalitat de Catalunya through Departament de Salut and Departament d'Empresa i Coneixement and Co-financing by the Spanish Ministry of Economy, Industry and Competitiveness (MEIC) with funds from the European Regional Development Fund (ERDF) corresponding to the 2014-2020 Smart Growth Operating Program. HL receives support from the Canadian Institutes of Health Research (Foundation Grant FDN-167281), the Canadian Institutes of Health Research and Muscular Dystrophy Canada (Network Catalyst Grant for NMD4C), the Canada Foundation for Innovation (CFI-JELF 38412), and the Canada Research Chairs program (Canada Research Chair in Neuromuscular Genomics and Health, 950-232279).

Published
2022

3. HIV testing history and access to treatment among migrants living with HIV in Europe

Author

Giota Touloumi, Tullio Prestileo, Maria Prins, Ibidun Fakoya, Julia del Amo, Fiona Burns, Andrew Copas, Katharine Ea Darling, Henrique Barros, Anne-Francoise Gennotte, Debora Alvarez-del Arco, Alain Volny-Anne, Claudia Wengenroth, Susana Monge, Unión Europea. Comisión Europea. 7 Programa Marco, National Institute for Health Research (Reino Unido), Fundación para la Investigación y la Prevención del Sida en España, Centro de Investigación Biomedica en Red - CIBER, APH - Global Health, Infectious diseases, aMASE Study Team, Aerssens, A., Aguado, M., Alimi, B., Anagnostou, O., Anderson, J., Antoniadou, A., Arando, M., Barberà, M.J., Barthélemy, A., Belda-Ibáñez, J., Bertisch, B., Bil, J., Blanco, J.R., Block, K., Boesecke, C., Boura, M., Burgos, J., Cabo, J., Calabuig, E., Campbell, L., Cardoso, O., Claudia, W., Clumeck, N., Colucci, A., Corrao, S., Cuellar, S., Cunha, J., Daikos, G., Darling, K., Del Romero, J., Dellot, P., Domingo, P., Dronda, F., Ebeling, F., Engelhardt, A., Engler, B., Farrell, J., Fehr, J., Feijó, M., Fernández, E., Fernández García, E., Fernandez, T., Fortes, A.L., Fox, J., Garcia de Olalla, P., García, F., Gargalianos-Kakolyris, P., Germano, I., Gilleran, G., Gilson, R., Goepel, S., Gogos, H.A., Gómez Sirvent, J.L., Gountas, I., Gregg, A., Gutiérrez, F., Gutierrez, M.M., Hermans, I., Iribarren, J.A., Knobel, H., Koulai, L., Kourkounti, S., La Morté, C., LeCompte, T., Ledergerber, B., Leonidou, L., Ligero, M.C., Lindergard, G., Lino, S., Lopes, M.J., Lopez Lirola, A., Louhenapessy, M., Lourida, G., Luzi, A.M., Maltez, F., Manirankunda, L., Martín-Pérez, A., Martins, L., Masía, M., Mateu, M.G., Meireles, P., Mendes, A., Metallidis, S., Mguni, S., Milinkovic, A., Miró, J.M., Mohrmann, K., Montero, M., Mouhebati, T., Moutschen, M., Müller, M., Murphy, C., Nöstlinger, C., Ocaña, I., Okumu-Fransche, S., Onwuchekwa, G., Ospina, J.E., Otiko, D., Pacheco, P., Palacios, R., Paparizos, V., Papastamopoulos, V., Paredes, V., Patel, N., Pellicer, T., Peña, A., Petrosillo, N., Pinheiro, A., Poças, J., Portillo, A., Post, F., Prestileo, F., Prins, P., Protopapas, K., Psichogiou, M., Pulido, F., Rebollo, J., Ribeirinho, A., Río, I., Robau, M., Rockstroh, J.K., Rodrigues, E., Rodríguez, M., Sajani, C., Salavert, M., Salman, R., Sanz, N., Schuettfort, G., Schüttfort, G., Schwarze-Zander, C., Serrão, R., Silva, D., Silva, V., Silverio, P., Skoutelis, A., Staehelin, C., Stephan, C., Stretton, C., Styles, F., Sutre, A.F., Taylor, S., Teixeira, B., Thierfelder, C., Tsachouridou, O., Tudor, K., Valadas, E., van Frankenhuijsen, M., Vázquez, M., Velasco Arribas, M., Vera, M., Vinciana, P., Voudouri, N., Wasmuth, J.C., Wilkins, E., Young, L., Yurdakul, S., Zafra Espinosa, T., Zuilhof, W., and Zuure, F.

Subjects
Male, 0301 basic medicine, Cross-sectional study, HIV Infections, migrants, Logistic regression, Health Services Accessibility, Sexual and Gender Minorities, 0302 clinical medicine, Pregnancy, Health care, Medicine, 030212 general & internal medicine, 10. No inequality, Research Articles, Reproductive health, Transients and Migrants, AIDS Serodiagnosis, virus diseases, 3. Good health, Europe, Infectious Diseases, Anti-Retroviral Agents, behavior and behavior mechanisms, population characteristics, Bisexuality, Female, Viral load, geographic locations, Research Article, Adult, Sexual Behavior, Migrants, primary healthcare, 03 medical and health sciences, Humans, HIV serodiagnosis, ddc:610, Heterosexuality, Anti-Retroviral Agents/therapeutic use, Cross-Sectional Studies, Europe/epidemiology, HIV Infections/diagnosis, HIV Infections/drug therapy, Logistic Models, Primary Health Care, Sexual Behavior/statistics & numerical data, HIV, health services accessibility, business.industry, Health services accessibility, Public Health, Environmental and Occupational Health, social sciences, Treatment as prevention, 030112 virology, Residence, business, Primary healthcare, Demography
Abstract

INTRODUCTION: Migrants are overrepresented in the European HIV epidemic. We aimed to understand the barriers and facilitators to HIV testing and current treatment and healthcare needs of migrants living with HIV in Europe. METHODS: A cross-sectional study was conducted in 57 HIV clinics in nine countries (Belgium, Germany, Greece, Italy, The Netherlands, Portugal, Spain, Switzerland and United Kingdom), July 2013 to July 2015. HIV-positive patients were eligible for inclusion if they were as follows: 18 years or older; foreign-born residents and diagnosed within five years of recruitment. Questionnaires were completed electronically in one of 15 languages and linked to clinical records. Primary outcomes were access to primary care and previous negative HIV test. Data were analysed using random effects logistic regression. Outcomes of interest are presented for women, heterosexual men and gay/bisexual men. RESULTS: A total of 2093 respondents (658 women, 446 heterosexual men and 989 gay/bisexual men) were included. The prevalence of a previous negative HIV test was 46.7%, 43.4% and 82.0% for women, heterosexual and gay/bisexual men respectively. In multivariable analysis previous testing was positively associated with: receipt of post-migration antenatal care among women, permanent residency among heterosexual men and identifying as gay rather than bisexual among gay/bisexual men. Access to primary care was found to be high (>83%) in all groups and was strongly associated with country of residence. Late diagnosis was common for women and heterosexual men (60.8% and 67.1%, respectively) despite utilization of health services prior to diagnosis. Across all groups almost three-quarters of people on antiretrovirals had an HIV viral load

Published
2018

Catalog

Books, media, physical & digital resources
See catalog results