1. Effects of grape products on inflammation and oxidative stress: A systematic review and meta‐analysis of randomized controlled trials
- Author
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Forough Farzollahpour, Marilyn S. Campbell, Hossein Khadem Haghighian, Shakiba Kolahdouz, Vihan Moodi, Omid Asbaghi, Mahsa Behrouzian, Mina Shirinbakhshmasoleh, Samira Sadat Ghalishourani, and Ehsan Ghaedi
- Subjects
Adult ,medicine.medical_specialty ,Phytochemicals ,Inflammation ,Cochrane Library ,medicine.disease_cause ,Gastroenterology ,Antioxidants ,law.invention ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Randomized controlled trial ,law ,Internal medicine ,medicine ,Humans ,Vitis ,Statistical analysis ,Randomized Controlled Trials as Topic ,Pharmacology ,0303 health sciences ,business.industry ,030302 biochemistry & molecular biology ,Malondialdehyde ,Oxidative Stress ,Antioxidant capacity ,chemistry ,030220 oncology & carcinogenesis ,Meta-analysis ,Dietary Supplements ,Cytokines ,medicine.symptom ,business ,Biomarkers ,Oxidative stress - Abstract
This systematic review and meta-analysis of randomized controlled trials (RCTs) were conducted to determine the effects of grapes and grape products on inflammation and oxidative stress among adults. PubMed, Scopus, ISI Web of Science, and Cochrane Library databases were searched up to July 2020 to identify RCTs investigating the effects of grape and grape products on inflammatory and oxidative stress markers. Weighted mean differences (WMD) were pooled using a random-effects model. Of the 8,962 identified studies, 24 RCTs (27 arms) were included in the statistical analysis. Grape products significantly reduced serum C-reactive protein (CRP) levels (WMD: -0.35 mg/L; 95% CI: -0.62, -0.09, p = .008), but they had no significant effect on serum tumor necrosis factor-alpha (TNF-α) (WMD = -1.08 pg/ml; 95% CI: -2.29, 0.11, p = .07), interleukin-6 (IL-6) (WMD = 0.13 pg/ml; 95% CI: -0.35, 0.60, p = .60), total antioxidant capacity (TAC) (WMD = 0.15; 95% CI: -0.35, 0.65, p = .54), or malondialdehyde (MDA) (WMD = 0.14; 95% CI: -0.64, 0.92, p = .72). The analysis indicated possible decreasing effects of grapes and grape products on CRP, but they might not be able to change IL-6, TNF-α, TAC, and MDA concentrations. Nonetheless, further studies are warranted before definitive conclusions may be reached.
- Published
- 2021