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148 results on '"Walters, D"'

1. Met Office MOGREPS‐G initialisation using an ensemble of hybrid four‐dimensional ensemble variational (En‐4DEnVar) data assimilations

Author

Inverarity, G. W., primary, Tennant, W. J., additional, Anton, L., additional, Bowler, N. E., additional, Clayton, A. M., additional, Jardak, M., additional, Lorenc, A. C., additional, Rawlins, F., additional, Thompson, S. A., additional, Thurlow, M. S., additional, Walters, D. N., additional, and Wlasak, M. A., additional

Published
2023
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2. The Met Office winter testbed 2020/2021: Experimenting with an on‐demand 300‐m ensemble in a real‐time environment

Author

Bain, C. L., primary, Bush, M., additional, Buxmann, J. C., additional, Davies, P., additional, Finnenkoetter, A., additional, Flack, D. L. A., additional, Hanley, K., additional, Jones, R. W., additional, Lean, H. W., additional, Lewis, H., additional, McCabe, A., additional, Petch, J. C., additional, Porson, A., additional, Sanchez, C., additional, Stone, E. K., additional, Walters, D., additional, Webster, S., additional, and Willington, S., additional

Published
2022
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3. Female breast cancer treatment and survival in South Australia: Results from linked health data.

Author

Li, M, Roder, D, D'Onise, K, Walters, D, Farshid, G, Buckley, E, Karapetis, C, Joshi, R, Price, T, Townsend, A, Miller, C, Currow, D, Powell, K, Buranyi-Trevarton, D, Olver, I, Li, M, Roder, D, D'Onise, K, Walters, D, Farshid, G, Buckley, E, Karapetis, C, Joshi, R, Price, T, Townsend, A, Miller, C, Currow, D, Powell, K, Buranyi-Trevarton, D, and Olver, I

Abstract

Objective We investigated treatment and survival by clinical and sociodemographic characteristics for service evaluation using linked data. Method Data on invasive female breast cancers (n = 13,494) from the South Australian Cancer Registry (2000–2014 diagnoses) were linked to hospital inpatient, radiotherapy and universal health insurance data. Treatments ≤12 months from diagnosis and survival were analysed, using adjusted odds ratios (aORs) from logistic regression, and adjusted sub-hazard ratios (aSHRs) from competing risk regression. Results and conclusion Five-year disease-specific survival increased to 91% for 2010–2014. Most women had breast surgery (90%), systemic therapy (72%) and radiotherapy (60%). Less treatment applied for ages 80+ vs <50 years (aOR 0.10, 95% CI 0.05–0.20) and TNM stage IV vs stage I (aOR 0.13, 95% CI 0.08–0.22). Surgical treatment increased during the study period and strongly predicted higher survival. Compared with no surgery, aSHRs were 0.31 (95% CI 0.26–0.36) for women having breast-conserving surgery, 0.49 (95% CI 0.41–0.57) for mastectomy and 0.42 (95% CI 0.33–0.52) when both surgery types were received. Patients aged 80+ years had lower survival and less treatment. More trial evidence is needed to optimise trade-offs between benefits and harms in these older women. Survival differences were not found by residential remoteness and were marginal by socioeconomic status.

Published
2021

5. CD1d-mediated lipid presentation by CD11c(+) cells regulates intestinal homeostasis

Author

Sáez de Guinoa J, Jimeno R, Gaya M, Kipling D, Garzón MJ, Dunn-Walters D, Ubeda C, and Barral P

Subjects
microbiota, lipids (amino acids, peptides, and proteins), hemic and immune systems, chemical and pharmacologic phenomena, CD1d, NKT cell
Abstract

Intestinal homeostasis relies on a continuous dialogue between the commensal bacteria and the immune system. Natural killer T (NKT) cells, which recognize CD1d-restricted microbial lipids and self-lipids, contribute to the regulation of mucosal immunity, yet the mechanisms underlying their functions remain poorly understood. Here, we demonstrate that NKT cells respond to intestinal lipids and CD11c(+) cells (including dendritic cells (DCs) and macrophages) are essential to mediate lipid presentation within the gut ultimately controlling intestinal NKT cell homeostasis and activation. Conversely, CD1d and NKT cells participate in the control of the intestinal bacteria composition and compartmentalization, in the regulation of the IgA repertoire and in the induction of regulatory T cells within the gut. These changes in intestinal homeostasis require CD1d expression on DC/macrophage populations as mice with conditional deletion of CD1d on CD11c(+) cells exhibit dysbiosis and altered immune homeostasis. These results unveil the importance of CD11c(+) cells in controlling lipid-dependent immunity in the intestinal compartment and reveal an NKT cell-DC crosstalk as a key mechanism for the regulation of gut homeostasis.

Published
2018

7. Author reply

Author

Markham, R., primary, Murdoch, D., additional, Walters, D. L., additional, and Hamilton-Craig, C., additional

Published
2016
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9. Small Molecule Inhibitors of Constitutively Active Gsa

Author

Pals‐Rylaarsdam, Robin, primary, Carroll, Julie, additional, Ceja‐Ruiz, Victor, additional, Turcic, Kyle, additional, Jenkins, Evan, additional, Habbal, Renee, additional, Raub, Matthew, additional, Cruz, Joseph, additional, and Walters, D Eric, additional

Published
2015
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17. Motivation, rationale and key results from the GERBILS Saharan dust measurement campaign

Author

Haywood, J. M., primary, Johnson, B. T., additional, Osborne, S. R., additional, Baran, A. J., additional, Brooks, M., additional, Milton, S. F., additional, Mulcahy, J., additional, Walters, D., additional, Allan, R. P., additional, Klaver, A., additional, Formenti, P., additional, Brindley, H. E., additional, Christopher, S., additional, and Gupta, P., additional

Published
2011
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