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Your search keyword '"Wang, Xue‐Ding"' showing total 10 results
Start Over Author "Wang, Xue‐Ding" Publisher wiley
10 results on '"Wang, Xue‐Ding"'

1. DNA‐Thioguanine Nucleotides as a Marker for Thiopurine Induced Late Leukopenia after Dose Optimizing by NUDT15 C415T in Chinese Patients with IBD

Author

Zhu, Xia, primary, Chao, Kang, additional, Yang, Ting, additional, Wang, Xue‐ding, additional, Guan, Shaoxing, additional, Tang, Jian, additional, Xie, Wen, additional, Yu, Ai‐ming, additional, Yang, Qing fan, additional, Li, Miao, additional, Yang, Hong‐sheng, additional, Diao, Na, additional, Hu, Pin‐jin, additional, Gao, Xiang, additional, and Huang, Min, additional

Published
2022
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4. Simultaneous quantification of imatinib and its main metabolite N-demethyl-imatinib in human plasma by liquid chromatography-tandem mass spectrometry and its application to therapeutic drug monitoring in patients with gastrointestinal stromal tumor

Author

Zhuang, Wei, primary, Qiu, Hai-Bo, additional, Chen, Xin-Meng, additional, Yuan, Xiu-Hong, additional, Yang, Li-Fang, additional, Sun, Xiao-Wei, additional, Zhou, Xiao-Jun, additional, Huang, Min, additional, Wang, Xue-Ding, additional, and Zhou, Zhi-Wei, additional

Published
2017
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7. CYP4F2 rs2108622: a minor significant genetic factor of warfarin dose in Han Chinese patients with mechanical heart valve replacement

Author

Cen, Han-Jing, primary, Zeng, Wu-Tao, additional, Leng, Xiu-Yu, additional, Huang, Min, additional, Chen, Xiao, additional, Li, Jia-Li, additional, Huang, Zhi-Ying, additional, Bi, Hui-Chang, additional, Wang, Xue-Ding, additional, He, Yan-Ling, additional, He, Fan, additional, Zhou, Rui-Na, additional, Zheng, Qi-Shan, additional, and Zhao, Li-Zi, additional

Published
2010
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10. Study of the effect of Wuzhi tablet (Schisandra sphenanthera extract) on tacrolimus tissue distribution in rat by liquid chromatography tandem mass spectrometry method.

Author

Qin XL, Bi HC, Wang CX, Li JL, Wang XD, Liu LS, Chen X, and Huang M

Subjects
Animals, Drug Interactions, Linear Models, Male, Rats, Rats, Sprague-Dawley, Reproducibility of Results, Sensitivity and Specificity, Tacrolimus analogs & derivatives, Tacrolimus analysis, Tacrolimus chemistry, Tissue Distribution, Chromatography, High Pressure Liquid methods, Plant Extracts pharmacology, Schisandra chemistry, Tacrolimus pharmacokinetics, Tandem Mass Spectrometry methods
Abstract

A liquid chromatography/tandem mass spectrometry (LC-MS/MS) method was developed and validated for determining tacrolimus (FK506) in rat tissues to study the effect of Schisandra sphenanthera extract on FK506 tissue distribution. After a liquid-liquid extraction with ethyl acetate, FK506 and ascomycin (IS) were subjected to LC-MS/MS analysis using positive electrospray ionization under multiple reactions monitoring mode. Chromatographic separation of FK506 and ascomycin was achieved on a Hypersil BDS C(18) column with a mobile phase consisting of methanol-water (containing 2 mM ammonium acetate, 95 : 5, v/v). The intra- and inter-batch precision of the method were less than 8.8 and 9.8%, respectively. The intra- and inter-batch accuracies ranged from 97.5 to 104.0%. The lowest limit of quantification for FK506 was 0.5 ng/mL. The method was applied to a FK506 tissue distribution study with or without a dose of Wuzhi (WZ) tablet. Most of the FK506 tissue concentrations were slightly increased after a concomitant WZ tablet dose, but the whole blood concentration of FK506 was dramatically increased 3-fold after a concomitant WZ tablet dose. These results indicated that the LC-MS/MS method was rapid and sensitive enough to quantify FK506 in different rat tissues, and strict drug monitoring is recommended when co-administering WZ tablet in clinical use., (Copyright (c) 2009 John Wiley & Sons, Ltd.)

Published
2010
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